PT88949A - Processo para a preparacao de inibidores de renina e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de inibidores de renina e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT88949A PT88949A PT88949A PT8894988A PT88949A PT 88949 A PT88949 A PT 88949A PT 88949 A PT88949 A PT 88949A PT 8894988 A PT8894988 A PT 8894988A PT 88949 A PT88949 A PT 88949A
- Authority
- PT
- Portugal
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- renin inhibitors
- preparing renin
- preparing
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000002461 renin inhibitor Substances 0.000 title 1
- 229940086526 renin-inhibitors Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/14—Angiotensins: Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3737498 | 1987-11-05 | ||
DE3818436 | 1988-05-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
PT88949A true PT88949A (pt) | 1988-12-01 |
PT88949B PT88949B (pt) | 1993-02-26 |
Family
ID=25861468
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT88949A PT88949B (pt) | 1987-11-05 | 1988-11-04 | Processo para a preparacao de inibidores de renina e de composicoes farmaceuticas que os contem |
Country Status (11)
Country | Link |
---|---|
US (1) | US5169841A (pt) |
EP (1) | EP0315574A3 (pt) |
JP (1) | JPH01163185A (pt) |
KR (1) | KR890008170A (pt) |
AU (1) | AU608379B2 (pt) |
DK (1) | DK617288A (pt) |
FI (1) | FI885068A (pt) |
IL (1) | IL88273A0 (pt) |
NO (1) | NO884925L (pt) |
NZ (1) | NZ226826A (pt) |
PT (1) | PT88949B (pt) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5242904A (en) * | 1987-06-05 | 1993-09-07 | The Dupont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
DE3827340A1 (de) * | 1988-08-12 | 1990-02-15 | Hoechst Ag | Verwendung von (alpha)-aminoboronsaeure-derivaten zur prophylaxe und behandlung von viruserkrankungen |
GB9017694D0 (en) * | 1990-08-13 | 1990-09-26 | Sandoz Ltd | Improvements in or relating to organic chemistry |
AU3959693A (en) * | 1992-04-16 | 1993-11-18 | Zeneca Limited | Alpha-aminoboronic acid peptides and their use as elastase inhibitors |
AU4077193A (en) * | 1992-04-16 | 1993-11-18 | Zeneca Limited | Alpha-aminoboronic acid peptides and their use as elastase inhibitors |
US5442100A (en) * | 1992-08-14 | 1995-08-15 | The Procter & Gamble Company | β-aminoalkyl and β-N-peptidylaminoalkyl boronic acids |
FR2701951B1 (fr) * | 1993-02-24 | 1995-06-09 | Adir | Nouveaux derives peptidiques de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
IL111175A0 (en) * | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them |
US6060462A (en) * | 1993-10-20 | 2000-05-09 | Dupont Pharmaceuticals Company | Electrophilic peptide analogs as inhibitors of trypsin-like enzymes |
US5693617A (en) * | 1994-03-15 | 1997-12-02 | Proscript, Inc. | Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein |
FR2718451B1 (fr) * | 1994-04-12 | 1996-05-10 | Synthelabo | Dérivés de peptides boroniques, leur préparation et leur application en thérapeutique. |
US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
US5639739A (en) * | 1995-03-24 | 1997-06-17 | The Dupont Merck Pharmaceutical Company | Imidazole containing aminoboronic acids |
FR2739858B1 (fr) * | 1995-10-11 | 1997-11-14 | Synthelabo | Derives de n-sulfonyl- et n-sulfamoylpeptidylprolinamide, leur preparation et leur application en therapeutique |
US6586615B1 (en) * | 2001-01-10 | 2003-07-01 | Bristol-Myers Squibb Company | α-aminoboronic acids prepared by novel synthetic methods |
PT1355910E (pt) * | 2001-01-25 | 2011-03-24 | Us Of America Represented By The Secretary Dept Of Health And Human Services | Formulação de compostos do ácido borónico |
BR0210112A (pt) | 2001-05-30 | 2004-06-08 | Novartis Ag | Derivados do ácido 2-{[n-(2-amino-3-(heteroarila ou arila)propionil)-aminoacil]-amino}-alquilborÈnico |
US20050282757A1 (en) * | 2002-09-09 | 2005-12-22 | Trigen Limited | Peptide boronic acid compounds useful in anticoagulation |
US20050288253A1 (en) * | 2002-09-09 | 2005-12-29 | Trigen Limited | Boronic acid salts |
BR0314450A (pt) | 2002-09-09 | 2005-07-26 | Trigen Ltd | Sais de ácido borÈnico com adição de uma base farmaceuticamente aceitável, formulação farmacêutica, e uso dos referidos sais para preparar uma formulação farmacêutica |
US20060084592A1 (en) * | 2002-09-09 | 2006-04-20 | Trigen Limited | Peptide boronic acid inhibitors |
US20050176651A1 (en) * | 2002-09-09 | 2005-08-11 | Trigen Limited | Peptide boronic acids useful in making salts thereof |
US20050119226A1 (en) * | 2003-09-09 | 2005-06-02 | Trigen Limited | Methods for synthesizing organoboronic compounds and products thereof |
US7223745B2 (en) | 2003-08-14 | 2007-05-29 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US7576206B2 (en) * | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
GB0405272D0 (en) * | 2004-03-09 | 2004-04-21 | Trigen Ltd | Compounds |
RS65253B1 (sr) | 2004-03-30 | 2024-03-29 | Millennium Pharm Inc | Sinteza jedinjenja estra organoborne kiseline i organoborne kiseline |
US7468383B2 (en) | 2005-02-11 | 2008-12-23 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US20070059382A1 (en) * | 2005-09-09 | 2007-03-15 | Board Of Regents, Univ. And Comm. College System Of Nevada... | Medical treatment of breast cancer with boric acid materials |
KR20160040735A (ko) | 2007-08-06 | 2016-04-14 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 프로테아좀 억제제 |
US7838673B2 (en) * | 2007-10-16 | 2010-11-23 | Millennium Pharmaceuticals, Inc. | Proteasome inhibitors |
US9212155B2 (en) | 2008-03-19 | 2015-12-15 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
US9206143B2 (en) | 2008-03-19 | 2015-12-08 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
US10793515B2 (en) | 2008-03-19 | 2020-10-06 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
EA027346B1 (ru) | 2008-06-17 | 2017-07-31 | Милленниум Фармасьютикалз, Инк. | Соединения боронатного эфира и его фармацевтические составы |
AR075090A1 (es) | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
WO2010039762A2 (en) * | 2008-10-01 | 2010-04-08 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions comprising boronic acid compounds |
EP2270019A1 (en) | 2009-06-19 | 2011-01-05 | LEK Pharmaceuticals d.d. | New synthetic route for the preparation of alpha-amino boronic esters |
EP2280016A1 (en) | 2009-07-27 | 2011-02-02 | LEK Pharmaceuticals d.d. | New synthetic route for the preparation of alpha-amino boronic esters via substituted alk-1-ynes |
JP2012530116A (ja) | 2009-06-19 | 2012-11-29 | レツク・フアーマシユーテイカルズ・デー・デー | 脱ハロゲン化なしにハロゲノアルケンを水素化する方法 |
US20120149663A1 (en) | 2009-08-18 | 2012-06-14 | Georgetown University | Boronic acid compositions and methods related to cancer |
EP2516449A1 (en) | 2009-12-22 | 2012-10-31 | Cephalon, Inc. | Proteasome inhibitors and processes for their preparation, purification and use |
CN107266485A (zh) | 2010-03-31 | 2017-10-20 | 米伦纽姆医药公司 | 1‑氨基‑2‑环丙基乙硼酸衍生物 |
WO2012047845A1 (en) | 2010-10-05 | 2012-04-12 | App Pharmaceuticals | Bortezomib formulations stabilised with boric |
AU2013227219A1 (en) | 2012-03-02 | 2014-10-23 | Dr. Reddy's Laboratories Limited | Pharmaceutical compositions comprising boronic acid compounds |
WO2014072985A1 (en) | 2012-11-06 | 2014-05-15 | Natco Pharma Limited | Novel boronic acid derivatives as anti cancer agents |
IN2013MU01431A (pt) | 2013-04-16 | 2015-06-26 | Cipla Ltd | |
US10478445B2 (en) | 2013-07-03 | 2019-11-19 | Georgetown University | Boronic acid derivatives of resveratrol for activating deacetylase enzymes |
WO2015117136A1 (en) | 2014-02-03 | 2015-08-06 | Ohio State Innovation Foundation | Boronic acid esters and pharmaceutical formulations thereof |
NZ725948A (en) | 2014-05-20 | 2024-01-26 | Takeda Pharmaceuticals Co | Boron-containing proteasome inhibitors for use after primary cancer therapy |
MA41505A (fr) | 2015-02-11 | 2017-12-19 | Millennium Pharm Inc | Nouvelle forme cristalline d'un inhibiteur de protéasome |
US20180243217A1 (en) | 2015-03-17 | 2018-08-30 | Leon-Nanodrugs Gmbh | Nanoparticles comprising a stabilized boronic acid compound |
WO2016205790A2 (en) | 2015-06-19 | 2016-12-22 | Hanlin Scientific, Inc. | Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis |
EP3472151A4 (en) | 2016-06-21 | 2020-03-04 | Orion Ophthalmology LLC | CARBOCYCLIC PROLINAMIDE DERIVATIVES |
JP7179721B2 (ja) | 2016-06-21 | 2022-11-29 | オリオン・オフサルモロジー・エルエルシー | 複素環式プロリンアミド誘導体 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4499082A (en) * | 1983-12-05 | 1985-02-12 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid peptides |
US5187157A (en) * | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
DE3827340A1 (de) * | 1988-08-12 | 1990-02-15 | Hoechst Ag | Verwendung von (alpha)-aminoboronsaeure-derivaten zur prophylaxe und behandlung von viruserkrankungen |
-
1988
- 1988-10-29 EP EP88710042A patent/EP0315574A3/de not_active Withdrawn
- 1988-11-03 FI FI885068A patent/FI885068A/fi not_active Application Discontinuation
- 1988-11-03 NZ NZ226826A patent/NZ226826A/en unknown
- 1988-11-03 IL IL88273A patent/IL88273A0/xx unknown
- 1988-11-03 US US07/266,960 patent/US5169841A/en not_active Expired - Fee Related
- 1988-11-04 NO NO88884925A patent/NO884925L/no unknown
- 1988-11-04 DK DK617288A patent/DK617288A/da not_active Application Discontinuation
- 1988-11-04 PT PT88949A patent/PT88949B/pt not_active IP Right Cessation
- 1988-11-04 JP JP63277568A patent/JPH01163185A/ja active Pending
- 1988-11-04 AU AU24693/88A patent/AU608379B2/en not_active Ceased
- 1988-11-04 KR KR1019880014478A patent/KR890008170A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR890008170A (ko) | 1989-07-10 |
FI885068A0 (fi) | 1988-11-03 |
AU608379B2 (en) | 1991-03-28 |
PT88949B (pt) | 1993-02-26 |
NO884925D0 (no) | 1988-11-04 |
IL88273A0 (en) | 1989-06-30 |
DK617288D0 (da) | 1988-11-04 |
FI885068A (fi) | 1989-05-06 |
DK617288A (da) | 1989-05-06 |
EP0315574A2 (de) | 1989-05-10 |
EP0315574A3 (de) | 1990-08-22 |
US5169841A (en) | 1992-12-08 |
JPH01163185A (ja) | 1989-06-27 |
AU2469388A (en) | 1989-05-11 |
NZ226826A (en) | 1991-06-25 |
NO884925L (no) | 1989-05-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG3A | Patent granted, date of granting |
Effective date: 19920820 |
|
MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19940228 |