PT87615A - Process for the preparation of leukotriene antagonists and of pharmaceutical compounds - Google Patents

Process for the preparation of leukotriene antagonists and of pharmaceutical compounds

Info

Publication number
PT87615A
PT87615A PT87615A PT8761588A PT87615A PT 87615 A PT87615 A PT 87615A PT 87615 A PT87615 A PT 87615A PT 8761588 A PT8761588 A PT 8761588A PT 87615 A PT87615 A PT 87615A
Authority
PT
Portugal
Prior art keywords
alkyl
preparation
leukotriene antagonists
alkoxy
pharmaceutical compounds
Prior art date
Application number
PT87615A
Other languages
English (en)
Other versions
PT87615B (pt
Inventor
James Simpson Frazee
John Gerald Gleason
Ralph Floyd Hall
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of PT87615A publication Critical patent/PT87615A/pt
Publication of PT87615B publication Critical patent/PT87615B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
PT87615A 1987-06-24 1988-05-30 Processo de preparacao de antagonistas do leucotrieno e de composicoes farmaceuticasd PT87615B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6658887A 1987-06-24 1987-06-24

Publications (2)

Publication Number Publication Date
PT87615A true PT87615A (pt) 1988-06-01
PT87615B PT87615B (pt) 1992-09-30

Family

ID=22070455

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87615A PT87615B (pt) 1987-06-24 1988-05-30 Processo de preparacao de antagonistas do leucotrieno e de composicoes farmaceuticasd

Country Status (14)

Country Link
EP (1) EP0296732B1 (pt)
JP (1) JPS6434955A (pt)
CN (1) CN1030074A (pt)
AT (1) ATE68176T1 (pt)
AU (1) AU620037B2 (pt)
CA (1) CA1334200C (pt)
DE (1) DE3865373D1 (pt)
DK (1) DK327088A (pt)
FI (1) FI882866A (pt)
HU (1) HU201521B (pt)
NO (1) NO882607L (pt)
NZ (1) NZ225021A (pt)
PT (1) PT87615B (pt)
ZA (1) ZA884272B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4937253A (en) * 1985-04-19 1990-06-26 Smithkline Beecham Corporation Ester prodrugs
US4954513A (en) * 1988-12-23 1990-09-04 Smithkline Beecham Corporation Leukotriene antagonists
DE3905518A1 (de) * 1989-02-23 1990-10-11 Bayer Ag Substituierte phenoxyphenylpropionsaeure-derivate
CA2018437A1 (en) * 1989-06-14 1990-12-14 James Simpson Frazee Leukotriene antagonists
ATE96149T1 (de) * 1989-07-27 1993-11-15 Bayer Ag Arylalkensaeurederivate als leukotrienantagonisten.
US5266713A (en) * 1989-07-27 1993-11-30 Miles Inc. Aryl alkenoic acid derivatives as leukotriene antagonists
WO1991018889A1 (en) * 1990-06-06 1991-12-12 Smithkline Beecham Corporation Leukotriene antagonists
EP0541706B1 (en) * 1990-08-01 1995-09-13 Smithkline Beecham Corporation Process and intermediate for the preparation of 2-hydroxy-3-sulfido-3-phenyl propanoic acids
DE19943634A1 (de) 1999-09-13 2001-04-12 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4874792A (en) * 1985-04-19 1989-10-17 Smithkline Beckman Corporation Thiophenyl Alkanoic acids useful as leukotriene antagonists
ATE90330T1 (de) * 1985-04-19 1993-06-15 Smithkline Beecham Corp Zwischenprodukte fuer die herstellung von leukotrien-antagonisten.

Also Published As

Publication number Publication date
NZ225021A (en) 1991-02-26
CN1030074A (zh) 1989-01-04
PT87615B (pt) 1992-09-30
DE3865373D1 (de) 1991-11-14
AU620037B2 (en) 1992-02-13
JPS6434955A (en) 1989-02-06
AU1759588A (en) 1989-01-05
NO882607D0 (no) 1988-06-14
EP0296732A1 (en) 1988-12-28
FI882866A (fi) 1988-12-25
ATE68176T1 (de) 1991-10-15
FI882866A0 (fi) 1988-06-15
HU201521B (en) 1990-11-28
DK327088A (da) 1988-12-25
ZA884272B (en) 1989-06-28
EP0296732B1 (en) 1991-10-09
DK327088D0 (da) 1988-06-15
NO882607L (no) 1988-12-27
CA1334200C (en) 1995-01-31
HUT47242A (en) 1989-02-28

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920312

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19960930