PT85662A - Process for preparing aza indole and indolizine derivatives and pharmaceutical compositions containing them - Google Patents
Process for preparing aza indole and indolizine derivatives and pharmaceutical compositions containing themInfo
- Publication number
- PT85662A PT85662A PT85662A PT8566287A PT85662A PT 85662 A PT85662 A PT 85662A PT 85662 A PT85662 A PT 85662A PT 8566287 A PT8566287 A PT 8566287A PT 85662 A PT85662 A PT 85662A
- Authority
- PT
- Portugal
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- indolizine derivatives
- aza indole
- preparing aza
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90589786A | 1986-09-10 | 1986-09-10 | |
| US06/945,750 US4751235A (en) | 1986-12-23 | 1986-12-23 | Anti-atherosclerotic indolizine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT85662A true PT85662A (en) | 1987-10-01 |
| PT85662B PT85662B (pt) | 1990-06-29 |
Family
ID=27129444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT85662A PT85662B (pt) | 1986-09-10 | 1987-09-08 | Processo para a preparacao de derivados de aza-indol e de indolizina e de composicoes farmaceuticas que os contem |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0265640A3 (pt) |
| JP (1) | JPH01500834A (pt) |
| KR (1) | KR880701719A (pt) |
| AU (1) | AU606621B2 (pt) |
| DK (1) | DK254488A (pt) |
| FI (1) | FI882160A0 (pt) |
| HU (1) | HU200769B (pt) |
| IL (1) | IL83821A0 (pt) |
| NZ (1) | NZ221717A (pt) |
| PL (1) | PL267646A1 (pt) |
| PT (1) | PT85662B (pt) |
| WO (1) | WO1988001997A2 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0352575A3 (de) * | 1988-07-28 | 1991-08-21 | Bayer Ag | Substituierte anellierte Pyrrole |
| MY105067A (en) * | 1988-10-13 | 1994-07-30 | Novartis Ag | Process for the preparation of 7-substituted-hept-6-enoic and -heptanoic acids and derivatives and intermediates thereof. |
| JPH04270285A (ja) * | 1988-11-14 | 1992-09-25 | Nissan Chem Ind Ltd | ピラゾロピリミジン系メバロノラクトン類 |
| US5124453A (en) * | 1990-03-02 | 1992-06-23 | E. R. Squibb & Sons, Inc. | Process for preparing certain 5,6,7,8-tetrahydroindolizinyl (ethyl or ethynyl)-hydroxy or methoxy-phosphinyl-3-hydroxy-butanoates and derivatives thereof |
| US5025000A (en) * | 1990-03-02 | 1991-06-18 | E. R. Squibb & Sons, Inc. | Phosphorus-containing HMG-CoA reductase inhibitor compounds |
| WO1992019239A1 (en) * | 1991-05-01 | 1992-11-12 | University Of New Mexico | Treatment of aberrant cellular states with biomodulators |
| WO1992019240A1 (en) * | 1991-05-01 | 1992-11-12 | University Of New Mexico | Treatment of aberrant cellular states with biomodulators |
| FR2687402B1 (fr) * | 1992-02-14 | 1995-06-30 | Lipha | Nouveaux azaindoles, procedes de preparation et medicaments les contenant. |
| US7582651B2 (en) | 2002-07-11 | 2009-09-01 | Takeda Pharmaceutical Company Limited | Pyrrolopyridine derivative and use thereof |
| EP2332940B1 (en) | 2004-03-30 | 2012-10-31 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of JAK and other protein kinases |
| RU2453548C2 (ru) | 2006-01-17 | 2012-06-20 | Вертекс Фармасьютикалз Инкорпорейтед | Азаиндолы, полезные в качестве ингибиторов янус-киназ |
| JP5406039B2 (ja) | 2006-12-21 | 2014-02-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼ阻害剤として有用な５−シアノ−４−（ピロロ［２，３ｂ］ピリジン−３−イル）−ピリミジン誘導体 |
| ES2604667T3 (es) | 2009-06-17 | 2017-03-08 | Vertex Pharmaceuticals Incorporated | Inhibidores de la replicación de virus de influenza |
| CA2822057A1 (en) | 2010-12-16 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| EP3068776B1 (en) | 2013-11-13 | 2019-05-29 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| MX2016006200A (es) | 2013-11-13 | 2016-08-08 | Vertex Pharma | Metodos para preparar inhibidores de la replicacion de virus de influenza. |
| EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
| EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI61030C (fi) * | 1976-02-19 | 1982-05-10 | Sanofi Sa | Foerfarande foer framstaellning av terapeutiskt verkande 2-substituerade-1- eller 3-benzoyl-indolizinderivat |
| JPS5559180A (en) * | 1978-10-30 | 1980-05-02 | Sankyo Co Ltd | 4-hydroxy-2-pyrone ring compound, its preparation, and remedy for hyperlipemia comprising it as active constituent |
| US4474971A (en) * | 1982-09-29 | 1984-10-02 | Sandoz, Inc. | (Tetrahydropyran-2-yl)-aldehydes |
| WO1984002131A1 (en) * | 1982-11-22 | 1984-06-07 | Sandoz Ag | Analogs of mevalolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals |
| EP0117228B1 (en) * | 1983-01-24 | 1986-11-05 | Sandoz Ag | Analogs of mevalonolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals |
| US4571428A (en) * | 1983-07-08 | 1986-02-18 | Sandoz, Inc. | 6-Substituted-4-hydroxy-tetrahydropyran-2-ones |
| KR890001651B1 (ko) * | 1984-06-22 | 1989-05-12 | 산도즈 파마슈티칼스 코포레이션 | 메발로노락톤의 피라졸 동족체 및 이의 유도체의 제조방법 |
| US4677211A (en) * | 1984-06-29 | 1987-06-30 | Sandoz Pharmaceuticals Corp. | Preparation of lactones |
| US4668794A (en) * | 1985-05-22 | 1987-05-26 | Sandoz Pharm. Corp. | Intermediate imidazole acrolein analogs |
-
1987
- 1987-09-08 NZ NZ221717A patent/NZ221717A/xx unknown
- 1987-09-08 IL IL83821A patent/IL83821A0/xx unknown
- 1987-09-08 PT PT85662A patent/PT85662B/pt not_active IP Right Cessation
- 1987-09-09 JP JP62505829A patent/JPH01500834A/ja active Pending
- 1987-09-09 HU HU875259A patent/HU200769B/hu not_active IP Right Cessation
- 1987-09-09 EP EP87113159A patent/EP0265640A3/en not_active Withdrawn
- 1987-09-09 WO PCT/EP1987/000511 patent/WO1988001997A2/en active Application Filing
- 1987-09-09 AU AU80221/87A patent/AU606621B2/en not_active Expired - Fee Related
- 1987-09-09 PL PL1987267646A patent/PL267646A1/xx unknown
-
1988
- 1988-05-09 DK DK254488A patent/DK254488A/da not_active Application Discontinuation
- 1988-05-09 FI FI882160A patent/FI882160A0/fi not_active Application Discontinuation
- 1988-05-10 KR KR1019880700517A patent/KR880701719A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL267646A1 (en) | 1988-07-21 |
| WO1988001997A3 (en) | 1988-04-07 |
| PT85662B (pt) | 1990-06-29 |
| DK254488A (da) | 1988-06-24 |
| EP0265640A3 (en) | 1988-05-18 |
| HU200769B (en) | 1990-08-28 |
| HUT46914A (en) | 1988-12-28 |
| FI882160A (fi) | 1988-05-09 |
| AU606621B2 (en) | 1991-02-14 |
| KR880701719A (ko) | 1988-11-04 |
| AU8022187A (en) | 1988-04-07 |
| DK254488D0 (da) | 1988-05-09 |
| NZ221717A (en) | 1990-08-28 |
| IL83821A0 (en) | 1988-02-29 |
| EP0265640A2 (en) | 1988-05-04 |
| JPH01500834A (ja) | 1989-03-23 |
| FI882160A0 (fi) | 1988-05-09 |
| WO1988001997A2 (en) | 1988-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19920630 |