PT84356B - Processo para a preparacao de activador do plasminogenio tipo tecido a partir de celulas normais de colon humano - Google Patents

Processo para a preparacao de activador do plasminogenio tipo tecido a partir de celulas normais de colon humano

Info

Publication number
PT84356B
PT84356B PT84356A PT8435687A PT84356B PT 84356 B PT84356 B PT 84356B PT 84356 A PT84356 A PT 84356A PT 8435687 A PT8435687 A PT 8435687A PT 84356 B PT84356 B PT 84356B
Authority
PT
Portugal
Prior art keywords
tissue
preparation
type
normal cells
human colon
Prior art date
Application number
PT84356A
Other languages
English (en)
Other versions
PT84356A (en
Inventor
Raymond Allen Dwek
Thomas William Rademacher
Joseph Nmn Feder
William Robert Tolbert
Raj B Parekh
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of PT84356A publication Critical patent/PT84356A/pt
Publication of PT84356B publication Critical patent/PT84356B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT84356A 1986-02-26 1987-02-25 Processo para a preparacao de activador do plasminogenio tipo tecido a partir de celulas normais de colon humano PT84356B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83408086A 1986-02-26 1986-02-26
US06/929,950 US4751084A (en) 1986-02-26 1986-11-12 Tissue plasminogen activator from normal human colon cells

Publications (2)

Publication Number Publication Date
PT84356A PT84356A (en) 1987-03-01
PT84356B true PT84356B (pt) 1989-10-04

Family

ID=27125681

Family Applications (1)

Application Number Title Priority Date Filing Date
PT84356A PT84356B (pt) 1986-02-26 1987-02-25 Processo para a preparacao de activador do plasminogenio tipo tecido a partir de celulas normais de colon humano

Country Status (8)

Country Link
US (1) US4751084A (pt)
KR (1) KR900007084B1 (pt)
AU (2) AU598792B2 (pt)
DK (1) DK96787A (pt)
FI (1) FI870818A (pt)
NO (1) NO870772L (pt)
NZ (1) NZ219398A (pt)
PT (1) PT84356B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5108909A (en) * 1985-03-22 1992-04-28 Chiron Corporation Expression of TPA in mammalian cells
US5501853A (en) * 1985-12-23 1996-03-26 Chiron Corporation Peptide plasminogen activators
US5132214A (en) * 1986-04-09 1992-07-21 Monsanto Company Large scale production of plasminogen activator from normal human colon cells
US4927630A (en) * 1986-02-26 1990-05-22 Monsanto Company Tissue plasminogen activator from normal human colon cells
DK173067B1 (da) * 1986-06-27 1999-12-13 Univ Washington Humant erythropoietin-gen, fremgangsmåde til ekspression deraf i transficerede cellelinier, de transficerede cellelinier sa
US4891312A (en) * 1986-08-13 1990-01-02 Monsanto Company Monoclonal antibody specific for human colon fibroblast-derived t-PA
US4889922A (en) * 1986-08-13 1989-12-26 Monsanto Co. Monoclonal antibody specific for human colon fibroblast-derived T-PA
US4833085A (en) * 1986-08-13 1989-05-23 Monsanto Company Monoclonal antibody specific for human colon fibroblast-derived t-PA
JPH08840B2 (ja) * 1986-11-14 1996-01-10 興和株式会社 抗ｐｃｉモノクローナル抗体、これを用いた抗ｐｃｉの精製法及び免疫学的測定法
JPH03501921A (ja) * 1987-05-18 1991-05-09 インテグレイテッド・ジェネティクス・インク 改良タンパク質分子、並びにその製造及び活性化方法
WO1989005862A1 (en) * 1987-12-09 1989-06-29 Invitron Corporation Human cell life extension
WO1989009257A1 (en) * 1988-03-22 1989-10-05 Invitron Corporation METHOD TO ENHANCE tPA PRODUCTION
US5210037A (en) * 1988-03-22 1993-05-11 Centocor Incorporated Method to enhance TPA production
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
US5130143A (en) * 1988-11-04 1992-07-14 The Research Foundation Of State University Of New York Use of a low affinity-heparin fraction in conjunction with t-pa for thrombolytic therapy
US5070021A (en) * 1989-01-10 1991-12-03 Monsanto Company Method of modifying oligosaccharide structure of tissue plasminogen activator
US5089409A (en) * 1989-09-28 1992-02-18 Monsanto Company Method of increasing specific activity of t-pa
US5100778A (en) * 1989-10-03 1992-03-31 Monsanto Company Oligosaccharide sequencing
US5284558A (en) * 1990-07-27 1994-02-08 University Of Iowa Research Foundation Electrophoresis-based sequencing of oligosaccharides
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1423541A (en) * 1973-05-02 1976-02-04 Mitsui Petrochemical Ind Method of bonding rubber to plastics
US4190708A (en) * 1978-05-24 1980-02-26 Monsanto Company Production of urokinase
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
US4335215A (en) * 1980-08-27 1982-06-15 Monsanto Company Method of growing anchorage-dependent cells
AR241654A1 (es) * 1982-05-05 1992-10-30 Genentech Inc Procedimiento para producir activador de plasminogeno de tejido humano.
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
US4537860A (en) * 1982-12-08 1985-08-27 Monsanto Company Static cell culture maintenance system
AU572108B2 (en) * 1983-01-19 1988-05-05 Genentech Inc. Human tpa production using vectors coding for dhfr protein
US4550080A (en) * 1984-06-05 1985-10-29 Asahi Kasei Kogyo Kabushiki Kaisha Process for the preparation of a plasminogen activator

Also Published As

Publication number Publication date
DK96787D0 (da) 1987-02-25
AU6922987A (en) 1987-08-27
NZ219398A (en) 1990-02-26
FI870818A0 (fi) 1987-02-25
AU604425B2 (en) 1990-12-13
FI870818A (fi) 1987-08-27
NO870772D0 (no) 1987-02-25
DK96787A (da) 1987-10-23
AU598792B2 (en) 1990-07-05
KR900007084B1 (ko) 1990-09-28
NO870772L (no) 1987-08-27
AU4449289A (en) 1990-03-01
US4751084A (en) 1988-06-14
PT84356A (en) 1987-03-01
KR870008025A (ko) 1987-09-23

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Legal Events

Date Code Title Description
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19940930