PT83606B - Process for the preparation of thieno-isoxazoles and pyrazoles of antihypertensive effect of their intermediates and of pharmaceutical compositions containing them - Google Patents
Process for the preparation of thieno-isoxazoles and pyrazoles of antihypertensive effect of their intermediates and of pharmaceutical compositions containing themInfo
- Publication number
- PT83606B PT83606B PT83606A PT8360686A PT83606B PT 83606 B PT83606 B PT 83606B PT 83606 A PT83606 A PT 83606A PT 8360686 A PT8360686 A PT 8360686A PT 83606 B PT83606 B PT 83606B
- Authority
- PT
- Portugal
- Prior art keywords
- isoxazoles
- thieno
- pyrazoles
- intermediates
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/791,019 US4728651A (en) | 1985-10-24 | 1985-10-24 | Antihypertensive thieno-isoxazoles and -pyrazoles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT83606A PT83606A (en) | 1986-11-01 |
| PT83606B true PT83606B (en) | 1988-11-15 |
Family
ID=25152414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT83606A PT83606B (en) | 1985-10-24 | 1986-10-23 | Process for the preparation of thieno-isoxazoles and pyrazoles of antihypertensive effect of their intermediates and of pharmaceutical compositions containing them |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4728651A (pt) |
| EP (1) | EP0221414A1 (pt) |
| JP (1) | JPS62103086A (pt) |
| KR (1) | KR870004037A (pt) |
| AU (1) | AU6433786A (pt) |
| DK (1) | DK507986A (pt) |
| HU (1) | HU198058B (pt) |
| IL (1) | IL80394A0 (pt) |
| PT (1) | PT83606B (pt) |
| ZA (1) | ZA868065B (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9808663D0 (en) * | 1998-04-23 | 1998-06-24 | Merck Sharp & Dohme | Therapeutic agents |
| US7091199B1 (en) | 1999-09-14 | 2006-08-15 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
| AR032134A1 (es) * | 1999-09-14 | 2003-10-29 | Aventis Pharma Sa | Compuestos derivados de propilo tienoisoxazolil- y tienilpirrazolil-fenoxi-substituidos utiles como antagonistas d4, composiciones farmaceuticas, procedimientos de preparacion, compuestos intermediarios y usos en la fabricacion de medicamentos |
| HUP0202712A3 (en) * | 1999-09-14 | 2004-12-28 | Aventis Pharmaceuticals Inc Br | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists, their intermediates, process for their preparation and pharmaceutical compositions containing the compounds |
| US7253165B2 (en) * | 1999-09-14 | 2007-08-07 | Aventis Pharmaceuticals Inc. | Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists |
| US7125903B1 (en) * | 1999-09-14 | 2006-10-24 | Aventis Pharmaceuticals Inc. | Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists |
| US6825220B2 (en) | 2000-11-10 | 2004-11-30 | Eli Lilly And Company | 3-Substituted oxindole β 3 agonists |
| WO2003016307A1 (en) * | 2001-08-14 | 2003-02-27 | Eli Lilly And Company | β3 ADRENERGIC AGONISTS |
| DE60211199T2 (de) | 2001-08-14 | 2007-02-01 | Eli Lilly And Co., Indianapolis | 3-substituierte oxindol-beta-3-agonisten |
| JP2005518357A (ja) | 2001-11-20 | 2005-06-23 | イーライ・リリー・アンド・カンパニー | ベータ３アドレナリンアゴニスト |
| JP2005514366A (ja) | 2001-11-20 | 2005-05-19 | イーライ・リリー・アンド・カンパニー | ３−置換オキシインドールβ３アゴニスト |
| EP1467733A1 (en) | 2002-01-11 | 2004-10-20 | Eli Lilly And Company | 2-oxo-benzimidazolyl substituted ethanolamine derivatives and their use as beta3 agonists |
| KR20040020457A (ko) * | 2002-08-30 | 2004-03-09 | 주식회사 대웅 | 3-｛2-[4-(6-플루오로벤조[ｄ]이속사졸-3-일)피페리디노]에틸｝-2-메틸-6,7,8,9-테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘-4-온 또는 그 산부가염의 제조방법 |
| MX2015012803A (es) | 2013-03-15 | 2016-08-19 | Epizyme Inc | Inhibidores de la carm1 y usos de los mismos. |
| CN113072562B (zh) * | 2021-04-06 | 2022-01-14 | 山东大学 | 一种GSK-3β抑制剂及其制备方法与应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3655661A (en) * | 1968-05-22 | 1972-04-11 | Frosst & Co Charles E | Benzothiadiazole compounds |
| AU518487B2 (en) * | 1975-07-16 | 1981-10-01 | Boehringer Ingelheim International Gmbh | 5-aryl-thieno-(2,3-e)-4,1-oxazepin-2-ones |
| US4245104A (en) * | 1978-12-01 | 1981-01-13 | Hoffmann-La Roche Inc. | Isoxazolines and isoxazolidines |
| US4247704A (en) * | 1979-05-29 | 1981-01-27 | Hoffmann-La Roche Inc. | Hexahydro thieno imadazole intermediates for the synthesis of biotin |
| DE2926517A1 (de) * | 1979-06-30 | 1981-01-15 | Beiersdorf Ag | Substituierte 3-aryl-pyrazole und 5-aryl-isoxazole und verfahren zu ihrer herstellung |
| CA1156661A (en) * | 1980-02-25 | 1983-11-08 | Hoffmann-La Roche Limited | Phenoxy-aminopropanol derivatives |
| DE3101456A1 (de) * | 1981-01-19 | 1982-09-02 | Basf Ag, 6700 Ludwigshafen | Phenylpiperazinyl-propanole von hetarylphenolen, ihre herstellung und diese enthaltende therapeutische mittel |
| JPS5846079A (ja) * | 1981-09-12 | 1983-03-17 | Santen Pharmaceut Co Ltd | ベンゾチアゾリン環を有するエ−テル類 |
-
1985
- 1985-10-24 US US06/791,019 patent/US4728651A/en not_active Expired - Lifetime
-
1986
- 1986-10-16 EP EP86114314A patent/EP0221414A1/en not_active Withdrawn
- 1986-10-22 IL IL80394A patent/IL80394A0/xx unknown
- 1986-10-23 JP JP61250937A patent/JPS62103086A/ja active Pending
- 1986-10-23 AU AU64337/86A patent/AU6433786A/en not_active Abandoned
- 1986-10-23 PT PT83606A patent/PT83606B/pt unknown
- 1986-10-23 DK DK507986A patent/DK507986A/da not_active Application Discontinuation
- 1986-10-23 ZA ZA868065A patent/ZA868065B/xx unknown
- 1986-10-23 KR KR1019860008875A patent/KR870004037A/ko not_active Application Discontinuation
- 1986-10-23 HU HU864456A patent/HU198058B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU198058B (en) | 1989-07-28 |
| AU6433786A (en) | 1987-04-30 |
| HUT45061A (en) | 1988-05-30 |
| US4728651A (en) | 1988-03-01 |
| KR870004037A (ko) | 1987-05-07 |
| JPS62103086A (ja) | 1987-05-13 |
| EP0221414A1 (en) | 1987-05-13 |
| DK507986D0 (da) | 1986-10-23 |
| PT83606A (en) | 1986-11-01 |
| DK507986A (da) | 1987-04-25 |
| IL80394A0 (en) | 1987-01-30 |
| ZA868065B (en) | 1987-06-24 |
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