PT83247B - Processo para a preparacao de hidroxialquil-fenoxi-propan-2-olaminas uteis como beta-bloqueadores oculosselectivos - Google Patents

Processo para a preparacao de hidroxialquil-fenoxi-propan-2-olaminas uteis como beta-bloqueadores oculosselectivos

Info

Publication number
PT83247B
PT83247B PT83247A PT8324786A PT83247B PT 83247 B PT83247 B PT 83247B PT 83247 A PT83247 A PT 83247A PT 8324786 A PT8324786 A PT 8324786A PT 83247 B PT83247 B PT 83247B
Authority
PT
Portugal
Prior art keywords
sup
sub
propan
phenoxy
beta
Prior art date
Application number
PT83247A
Other languages
English (en)
Other versions
PT83247A (en
Inventor
John J Baldwin
Gerald S Ponticello
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PT83247A publication Critical patent/PT83247A/pt
Publication of PT83247B publication Critical patent/PT83247B/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Medicinal Preparation (AREA)
  • Paper (AREA)
  • Detergent Compositions (AREA)
  • Luminescent Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Catalysts (AREA)
PT83247A 1985-08-29 1986-08-25 Processo para a preparacao de hidroxialquil-fenoxi-propan-2-olaminas uteis como beta-bloqueadores oculosselectivos PT83247B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/770,479 US4665094A (en) 1985-08-29 1985-08-29 Oculoselective beta-blockers for treatment of elevated intraocular pressure

Publications (2)

Publication Number Publication Date
PT83247A PT83247A (en) 1986-09-01
PT83247B true PT83247B (pt) 1989-03-30

Family

ID=25088683

Family Applications (1)

Application Number Title Priority Date Filing Date
PT83247A PT83247B (pt) 1985-08-29 1986-08-25 Processo para a preparacao de hidroxialquil-fenoxi-propan-2-olaminas uteis como beta-bloqueadores oculosselectivos

Country Status (18)

Country Link
US (1) US4665094A (pt)
EP (1) EP0221788B1 (pt)
JP (1) JPS6251649A (pt)
KR (1) KR900003508B1 (pt)
CN (1) CN86105229A (pt)
AT (1) ATE53006T1 (pt)
AU (1) AU6202686A (pt)
CA (1) CA1286313C (pt)
DE (1) DE3671429D1 (pt)
DK (1) DK409186A (pt)
ES (1) ES2002729A6 (pt)
FI (1) FI863384A (pt)
GR (1) GR862186B (pt)
IL (1) IL79794A0 (pt)
NO (1) NO863448L (pt)
NZ (1) NZ217281A (pt)
PT (1) PT83247B (pt)
ZA (1) ZA866530B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229127A (en) * 1989-03-03 1993-07-20 Mckinzie James W Rapid miosis with control of intraocular pressure using a mixture of a cetylcholine and carbachol derivatives
TW275614B (pt) * 1993-02-15 1996-05-11 Senju Pharma Co
JPH0797373A (ja) * 1994-03-07 1995-04-11 Torcan Chem Ltd フェノールエーテルの製造のための環状中間体
CN103864653A (zh) * 2012-12-10 2014-06-18 韩冰 一类降低眼压的化合物及其用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459782A (en) * 1963-08-26 1969-08-05 Boehringer Sohn Ingelheim 1-substituted phenoxy-2-hydroxy-3-isopropylamino-propanes
DE1593762A1 (de) * 1967-02-06 1972-06-08 Boehringer Sohn Ingelheim Verfahren zur Herstellung von neuen substituierten 1-Phenoxy-2-hydroxy-3-alkylaminopropanen
US3541130A (en) * 1967-02-06 1970-11-17 Boehringer Sohn Ingelheim 1-(cyanophenoxy)-2-hydroxy-3-tert.-butylamine propanes
DE1643262C3 (de) * 1967-12-13 1975-06-26 C.H. Boehringer Sohn, 6507 Ingelheim i-Phenoxy^-hydroxy-S-alklyaminopropane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DK129447B (da) * 1967-12-18 1974-10-14 Boehringer Sohn Ingelheim Analogifremgangsmåde til fremstilling af racemiske eller optisk aktive 1-phenoxy-2-hydroxy-3-sek.-alkylaminopropaner eller syreadditionssalte heraf.
GB1285038A (en) * 1969-02-21 1972-08-09 Ici Ltd Alkanolamine derivatives
DE1966513A1 (de) * 1969-08-19 1973-05-24 Boehringer Sohn Ingelheim 1-(3-hydroxymethyl-phenoxy)-2hydroxy-3-sek.-butylaminopropan, dessen saeureadditionssalze, verfahren zu deren herstellung und diese enthaltende praeparate
FR2119844B1 (pt) * 1970-12-28 1974-03-22 Laroche Navarro Labo
JPS4911847A (pt) * 1972-05-20 1974-02-01
SE386892B (sv) * 1972-07-06 1976-08-23 Haessle Ab Forfarande for framstellning av oxaminoforeningar
US4066768A (en) * 1973-12-27 1978-01-03 Cassella Farbwerke Mainkur Aktiengesellschaft Derivatives of 1-phenoxy-3-amino-propan-2-ol
DE2540552A1 (de) * 1974-09-12 1976-03-25 American Cyanamid Co Cycloalkylderivate von 1-aryloxy-3- amino-2-propanolen
DE2645710C2 (de) * 1976-10-09 1985-06-27 Merck Patent Gmbh, 6100 Darmstadt Phenoxy-amino-propanole, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung
FI59985C (fi) * 1980-05-26 1982-01-08 Farmos Oy Foerfarande foer framstaellning av terapeutiskt aktiv 1-isopropylamino-3-(4-(2-metoxietyl)fenoxi)-2-propanol samt dess syra-additionssalter
FR2512443A1 (fr) * 1981-09-10 1983-03-11 Synthelabo Derives de phenoxy-3 propanol-2, leur preparation et leur application en therapeutique
DE3151201A1 (de) * 1981-12-23 1983-07-28 Beiersdorf Ag, 2000 Hamburg Substituierte phenoxyalkanolamine und phenoxyalkanol-cycloalkylamine, verfahren zu ihrer herstellung, diese verbindungen enthaltende pharmazeutische zubereitungen und zwischenprodukte
US4450172A (en) * 1982-03-10 1984-05-22 E. I. Du Pont De Nemours And Company Antihypertensive polyhalohydroxyisopropyl phenylalka(e)noic acid esters of alkylaminohydroxypropyloxyphenylalkyl alcohols
EP0105996A1 (en) * 1982-10-15 1984-04-25 Merck & Co. Inc. Ophthalmic compositions for treating elevated intraocular pressure

Also Published As

Publication number Publication date
FI863384A (fi) 1987-03-01
DE3671429D1 (de) 1990-06-28
DK409186A (da) 1987-03-01
EP0221788A1 (en) 1987-05-13
NO863448L (no) 1987-03-02
ES2002729A6 (es) 1988-10-01
ATE53006T1 (de) 1990-06-15
GR862186B (en) 1986-12-23
FI863384A0 (fi) 1986-08-21
KR870002050A (ko) 1987-03-28
ZA866530B (en) 1987-04-29
JPS6251649A (ja) 1987-03-06
DK409186D0 (da) 1986-08-28
PT83247A (en) 1986-09-01
NZ217281A (en) 1989-10-27
KR900003508B1 (ko) 1990-05-21
EP0221788B1 (en) 1990-05-23
NO863448D0 (no) 1986-08-28
AU6202686A (en) 1987-03-05
CN86105229A (zh) 1987-04-22
US4665094A (en) 1987-05-12
CA1286313C (en) 1991-07-16
IL79794A0 (en) 1986-11-30

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Effective date: 19940331