PT830353E - Processo para a preparacao de um inibidor da protease de hiv - Google Patents

Processo para a preparacao de um inibidor da protease de hiv

Info

Publication number
PT830353E
PT830353E PT96915755T PT96915755T PT830353E PT 830353 E PT830353 E PT 830353E PT 96915755 T PT96915755 T PT 96915755T PT 96915755 T PT96915755 T PT 96915755T PT 830353 E PT830353 E PT 830353E
Authority
PT
Portugal
Prior art keywords
preparation
amino
protease inhibitor
hiv protease
thiazolyl
Prior art date
Application number
PT96915755T
Other languages
English (en)
Inventor
Arthur J Cooper
Jien-Heh Tien
Jerome A Menzia
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of PT830353E publication Critical patent/PT830353E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
PT96915755T 1995-06-06 1996-05-13 Processo para a preparacao de um inibidor da protease de hiv PT830353E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/469,965 US5567823A (en) 1995-06-06 1995-06-06 Process for the preparation of an HIV protease inhibiting compound

Publications (1)

Publication Number Publication Date
PT830353E true PT830353E (pt) 2002-10-31

Family

ID=23865732

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96915755T PT830353E (pt) 1995-06-06 1996-05-13 Processo para a preparacao de um inibidor da protease de hiv

Country Status (11)

Country Link
US (1) US5567823A (pt)
EP (1) EP0830353B1 (pt)
JP (2) JP4580044B2 (pt)
AT (1) ATE216696T1 (pt)
CA (1) CA2219983C (pt)
DE (1) DE69620882T2 (pt)
DK (1) DK0830353T3 (pt)
ES (1) ES2176456T3 (pt)
MX (1) MX9709454A (pt)
PT (1) PT830353E (pt)
WO (1) WO1996039398A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0727419T3 (da) 1992-12-29 2002-06-10 Abbott Lab Mellemprodukter til fremstilling af forbindelser, som inhiberer retroviral protease
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
US6180634B1 (en) * 1997-11-13 2001-01-30 Merck & Co., Inc. Combination therapy for the treatment of AIDS
US6803466B1 (en) * 1997-12-08 2004-10-12 The Scripps Research Institute HIV/FIV protease inhibitors having a small P3 residue
WO1999029311A1 (en) * 1997-12-08 1999-06-17 The Scripps Research Institute Hiv/fiv protease inhibitors having a small p3 residue
MY121765A (en) * 1998-07-20 2006-02-28 Abbott Lab Polymorph of ritonavir
US6894171B1 (en) * 1998-07-20 2005-05-17 Abbott Laboratories Polymorph of a pharmaceutical
TR200103488T2 (tr) * 1999-06-04 2002-04-22 Abbott Laboratories Geliştirilmiş farmasötik formülasyonlar.
IT1313624B1 (it) * 1999-09-21 2002-09-09 Archimica Spa Ora Clariant Lif Procedimento per la sintesi del ritonavir
JP5767429B2 (ja) * 1999-11-12 2015-08-19 アッヴィ・インコーポレイテッド 固体分散剤中の結晶化阻害剤
CA2395987C (en) * 2000-01-19 2009-12-22 Abbott Laboratories Improved pharmaceutical formulations
DE10026698A1 (de) * 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
BRPI0401742B8 (pt) * 2004-05-13 2021-05-25 Cristalia Produtos Quim Farmaceuticos Ltda composto análogo do ritonavir útil como inibidor de protease retroviral, preparação do composto análogo do ritonavir e composição farmacêutica do composto análogo do ritonavir
EP2308490A1 (en) * 2005-12-30 2011-04-13 Gilead Sciences, Inc. Methods for improving the pharmacokinetics of hiv integrase inhibitors
EP2049506B2 (en) 2006-07-07 2024-05-08 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
WO2008041176A2 (en) * 2006-10-03 2008-04-10 Ranbaxy Laboratories Limited Process for the preparation of form i and form ii of ritonavir
WO2008067164A2 (en) * 2006-11-15 2008-06-05 Abbott Laboratories Solid pharmaceutical dosage formulations
LT2487166T (lt) 2007-02-23 2016-11-10 Gilead Sciences, Inc. Terapinių agentų farmakokinetinių savybių moduliatoriai
CA2710679A1 (en) * 2008-01-04 2009-07-16 Gilead Sciences, Inc. Inhibitors of cytochrome p450
CN101967130B (zh) * 2010-07-02 2012-12-26 厦门市亨瑞生化有限公司 利托那韦中间体的合成方法
CN102786494B (zh) * 2012-07-26 2016-01-06 合肥华方医药科技有限公司 利托那韦异构体杂质的合成研究及控制方法
IN2014CH00872A (pt) * 2014-02-21 2015-08-28 Mylan Lab Ltd
CN104311503B (zh) * 2014-11-03 2017-01-25 东北制药集团股份有限公司 一种制备抗hiv药物利托那韦的方法
CN111646953A (zh) * 2020-04-23 2020-09-11 厦门蔚嘉制药有限公司 一种合成利托那韦的新方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142056A (en) * 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
DK0727419T3 (da) * 1992-12-29 2002-06-10 Abbott Lab Mellemprodukter til fremstilling af forbindelser, som inhiberer retroviral protease

Also Published As

Publication number Publication date
DK0830353T3 (da) 2002-07-29
JPH11507029A (ja) 1999-06-22
JP2010270123A (ja) 2010-12-02
JP5390477B2 (ja) 2014-01-15
DE69620882D1 (de) 2002-05-29
CA2219983C (en) 2007-09-18
MX9709454A (es) 1998-02-28
ATE216696T1 (de) 2002-05-15
WO1996039398A1 (en) 1996-12-12
EP0830353A1 (en) 1998-03-25
JP4580044B2 (ja) 2010-11-10
ES2176456T3 (es) 2002-12-01
DE69620882T2 (de) 2002-12-12
US5567823A (en) 1996-10-22
EP0830353B1 (en) 2002-04-24
CA2219983A1 (en) 1996-12-12

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