PT758328E - Compostos anti-cancro contendo um anel de ciclopentaquinazolina - Google Patents

Compostos anti-cancro contendo um anel de ciclopentaquinazolina

Info

Publication number
PT758328E
PT758328E PT95917433T PT95917433T PT758328E PT 758328 E PT758328 E PT 758328E PT 95917433 T PT95917433 T PT 95917433T PT 95917433 T PT95917433 T PT 95917433T PT 758328 E PT758328 E PT 758328E
Authority
PT
Portugal
Prior art keywords
pct
alkyl
compounds containing
hydroxyalkyl
alkoxy
Prior art date
Application number
PT95917433T
Other languages
English (en)
Inventor
Laurent Francois And Hennequin
Francis Thomas Boyle
Vassilios Bavetsias
Jonathan Hugh Marriott
Original Assignee
Btg Int Ltd
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Btg Int Ltd, Astrazeneca Uk Ltd filed Critical Btg Int Ltd
Publication of PT758328E publication Critical patent/PT758328E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT95917433T 1994-05-05 1995-05-04 Compostos anti-cancro contendo um anel de ciclopentaquinazolina PT758328E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9408936A GB9408936D0 (en) 1994-05-05 1994-05-05 Anti-cancer compounds

Publications (1)

Publication Number Publication Date
PT758328E true PT758328E (pt) 2003-11-28

Family

ID=10754612

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95917433T PT758328E (pt) 1994-05-05 1995-05-04 Compostos anti-cancro contendo um anel de ciclopentaquinazolina

Country Status (11)

Country Link
US (1) US5747499A (pt)
EP (1) EP0758328B1 (pt)
JP (1) JP4173911B2 (pt)
AT (1) ATE245154T1 (pt)
CA (1) CA2187449C (pt)
DE (1) DE69531296T2 (pt)
DK (1) DK0758328T3 (pt)
ES (1) ES2203639T3 (pt)
GB (2) GB9408936D0 (pt)
PT (1) PT758328E (pt)
WO (1) WO1995030673A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1346982B1 (en) * 2000-12-28 2011-09-14 Daiichi Pharmaceutical Co., Ltd. Vla-4 inhibitors
EP1420809B1 (en) 2001-08-31 2011-09-28 BTG International Limited Use of cyclopenta[g]quinazoline derivatives for treating cancer
GB0121214D0 (en) * 2001-08-31 2001-10-24 Btg Int Ltd Synthetic method
WO2003020748A1 (en) * 2001-08-31 2003-03-13 Btg International Limited Anti-cancer cyclopenta[g]quinazoline compounds
EP1481967B1 (en) 2002-03-05 2011-05-04 Sumitomo Chemical Company, Limited Process for the preparation of biaryl compounds
CA2770493A1 (en) 2003-07-24 2005-02-03 Daiichi Pharmaceutical Co., Ltd. Cyclohexanecarboxylic acid compound
JP5599773B2 (ja) * 2008-03-18 2014-10-01 ビーティージー・インターナショナル・リミテッド リウマチ様関節炎又は急性骨髄性白血病の治療のためのシクロペンタ［ｇ］キナゾリン誘導体
SG187011A1 (en) * 2010-07-19 2013-02-28 Onyx Pharma Inc Synthesis of cyclopentaquinazolines
CA2819510A1 (en) * 2010-12-22 2012-06-28 Onyx Pharmaceuticals, Inc. Efficient peptide couplings and their use in the synthesis and isolation of a cyclopenta(g)quinazoline trisodium salt
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use
MX2020002010A (es) 2017-08-21 2020-07-13 Celgene Corp Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo.

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925939A (en) * 1989-01-05 1990-05-15 Sloan-Kettering Institute For Cancer Research 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives
CA2021042A1 (en) * 1989-07-21 1991-01-22 Fabrizio Marazza Salts of n ,n -methylene-5,6,7,8-tetrahydrofolic acid
US5077404A (en) * 1989-08-29 1991-12-31 Piper James R Cyclized 5,10-dideazaaminopterin compounds
EP0438261A3 (en) * 1990-01-16 1992-02-26 Takeda Chemical Industries, Ltd. Condensed heterocyclic glutamic acid derivatives, their production and use
FR2659330B1 (fr) * 1990-03-09 1994-02-11 Sapec Sa Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.
GB9013615D0 (en) * 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
ZA917355B (en) * 1990-09-17 1992-08-26 Agouron Pharma Antiproliferative substituted naphthalene compounds
YU155791A (sh) * 1990-09-25 1994-01-20 Agouron Pharmaceuticals Inc. Antiproliferativna supstituisana triciklična jedinjenja
GB9105771D0 (en) * 1991-03-19 1991-05-01 Cancer Res Inst Royal Anti-cancer compounds
GB9205320D0 (en) * 1992-03-11 1992-04-22 Ici Plc Anti-tumour compounds
AU4632893A (en) * 1992-07-29 1994-03-03 Agouron Pharmaceuticals, Inc. Antiproliferative tricyclic compounds
GB9220571D0 (en) * 1992-09-30 1992-11-11 Ici Plc Quinazoline derivatives
GB2272217B (en) * 1992-11-06 1996-07-31 Zeneca Ltd Anti-cancer cyclopentaquinazoline tricyclic derivatives
GB9320113D0 (en) * 1993-09-29 1993-11-17 Zeneca Ltd Tricyclic derivatives

Also Published As

Publication number Publication date
US5747499A (en) 1998-05-05
JP4173911B2 (ja) 2008-10-29
CA2187449A1 (en) 1995-11-16
GB9509261D0 (en) 1995-06-28
WO1995030673A1 (en) 1995-11-16
GB9408936D0 (en) 1994-06-22
DK0758328T3 (da) 2003-11-03
JPH09512812A (ja) 1997-12-22
EP0758328A1 (en) 1997-02-19
CA2187449C (en) 2006-01-03
DE69531296D1 (de) 2003-08-21
GB2290082B (en) 1997-10-29
DE69531296T2 (de) 2004-04-22
EP0758328B1 (en) 2003-07-16
ATE245154T1 (de) 2003-08-15
GB2290082A (en) 1995-12-13
ES2203639T3 (es) 2004-04-16

Similar Documents

Publication Publication Date Title
CY1112143T1 (el) Χρηση παραγωγων kykλοπenta[g]kinαζολινης για θεραπεια καρκινου
PL328310A1 (en) Derivatives of quinazoline
PT758328E (pt) Compostos anti-cancro contendo um anel de ciclopentaquinazolina
ES2176235T3 (es) Pirazolitriazinas con actividad inhibidora de la interleuquina-1 y delfactor de necrosis tumoral.
CA2263319A1 (en) Quinazoline derivatives and pharmaceutical compositions containing them
YU40300A (sh) Aril fuzirana azapoliciklična jedinjenja
ES2157337T3 (es) Derivados de morfolina y su uso como agentes terapeuticos.
DK0644883T3 (da) Enniatiner og enniatinderivater til bekæmpelse af endoparasitter
IL115903A0 (en) Use of dioxomorpholines for combating endoparasites new dioxomorpholines and processes for their preparation
ES2062558T3 (es) Compuestos contra el cancer.
AR024145A1 (es) Derivados de 5-fenil-pirimidina
RU97117350A (ru) Ингибитор гипертрофии интимы, применение оксиндолового производного для получения ингибитора гипертрофии интимы, композиция для ингибирования гипертрофии интимы, способ предупреждения и лечения гипертрофии интимы
EP1140900A4 (en) PYRAZOLE COMPOUNDS AND USE OF SUCH COMPOUNDS
EA199801028A1 (ru) Применение производных п-аминофенола для проготовления фармацевтических композиций, используемых при лечении нейродегенеративных заболеваний
GB9602029D0 (en) New heterocyclic compounds
NO171060C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive n-cykloalkylalkyl-benzylaminer
EA199800085A1 (ru) Способ лечения боли висцерального происхождения, способ лечения воспалительного колита
DK0675895T3 (da) Etoposidderivater, fremgangsmåde til fremstilling deraf, anvendelse deraf som lægemiddel og anvendelse deraf til fremstilling af et lægemiddel til anticancerbehandling
IT1300056B1 (it) Eterocicli con anello a 6 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmaci
DE69203445D1 (de) Neuro-schützende Mittel.
AR042571A1 (es) L-arabino disacaridos de antraciclinas, sus procesos de preparacion y composiciones farmaceuticas que los contienen y su uso para la preparacion de composisiones farmaceuticas