PT618965E - Processo de geracao de uma diversidade estrutural e funcional numa sequencia peptidica - Google Patents

Processo de geracao de uma diversidade estrutural e funcional numa sequencia peptidica

Info

Publication number
PT618965E
PT618965E PT93902325T PT93902325T PT618965E PT 618965 E PT618965 E PT 618965E PT 93902325 T PT93902325 T PT 93902325T PT 93902325 T PT93902325 T PT 93902325T PT 618965 E PT618965 E PT 618965E
Authority
PT
Portugal
Prior art keywords
pct
sequence
functional diversity
peptide sequence
structural
Prior art date
Application number
PT93902325T
Other languages
English (en)
Inventor
Kallenbach Sacha
Doyen Noelle
Rougeon Francois
Original Assignee
Pasteur Institut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut filed Critical Pasteur Institut
Publication of PT618965E publication Critical patent/PT618965E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C12N15/1024—In vivo mutagenesis using high mutation rate "mutator" host strains by inserting genetic material, e.g. encoding an error prone polymerase, disrupting a gene for mismatch repair
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1264—DNA nucleotidylexotransferase (2.7.7.31), i.e. terminal nucleotidyl transferase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
PT93902325T 1991-12-11 1992-12-11 Processo de geracao de uma diversidade estrutural e funcional numa sequencia peptidica PT618965E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9115389A FR2685004A1 (fr) 1991-12-11 1991-12-11 Procede de generation d'une diversite structurale et fonctionnelle dans une sequence peptidique.

Publications (1)

Publication Number Publication Date
PT618965E true PT618965E (pt) 2006-08-31

Family

ID=9419935

Family Applications (1)

Application Number Title Priority Date Filing Date
PT93902325T PT618965E (pt) 1991-12-11 1992-12-11 Processo de geracao de uma diversidade estrutural e funcional numa sequencia peptidica

Country Status (11)

Country Link
US (1) US5756323A (pt)
EP (1) EP0618965B1 (pt)
JP (1) JPH07504086A (pt)
AT (1) ATE322543T1 (pt)
CA (1) CA2125192A1 (pt)
DE (1) DE69233612T2 (pt)
DK (1) DK0618965T3 (pt)
ES (1) ES2260753T3 (pt)
FR (1) FR2685004A1 (pt)
PT (1) PT618965E (pt)
WO (1) WO1993012228A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
DK2204447T3 (en) * 1998-10-09 2016-09-12 Medical Res Council A method for generating diversity
US7122339B2 (en) 1998-10-09 2006-10-17 Medical Research Council Method for generating diversity
EP1010763A1 (en) * 1998-12-11 2000-06-21 Institut Pasteur Enhanced expression of heterologous proteins in recombinant bacteria through reduced growth temperature and co-expression of rare tRNA's
US6977245B2 (en) * 1999-04-12 2005-12-20 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxynucleotide and its use to induce an immune response
US7604995B2 (en) * 2003-07-11 2009-10-20 New York University Compositions, kits, and methods for stimulation of homologous recombination
WO2008103475A1 (en) 2007-02-20 2008-08-28 Anaptysbio, Inc. Somatic hypermutation systems
US8012714B2 (en) * 2008-04-14 2011-09-06 Innovative Targeting Solutions, Inc. Sequence diversity generation in immunoglobulins
EP2412806B1 (en) 2010-07-28 2014-01-08 Institut Pasteur Use of terminal deoxynucleotidyl transferase for mutagenic DNA repair to generate variability, at a determined position in DNA
US9718871B2 (en) * 2012-03-14 2017-08-01 Innovative Targeting Solutions Inc. Generating targeted sequence diversity in proteins
WO2013134881A1 (en) 2012-03-14 2013-09-19 Innovative Targeting Solutions Inc. Generating targeted sequence diversity in fusion proteins

Also Published As

Publication number Publication date
FR2685004A1 (fr) 1993-06-18
DE69233612D1 (de) 2006-05-18
JPH07504086A (ja) 1995-05-11
EP0618965B1 (fr) 2006-04-05
CA2125192A1 (fr) 1993-06-24
ES2260753T3 (es) 2006-11-01
DE69233612T2 (de) 2007-07-05
EP0618965A1 (fr) 1994-10-12
FR2685004B1 (pt) 1995-01-06
DK0618965T3 (da) 2006-08-14
WO1993012228A1 (fr) 1993-06-24
ATE322543T1 (de) 2006-04-15
US5756323A (en) 1998-05-26

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