PT4008329T - Compostos de isoxazolina para utilização no tratamento da demodicose - Google Patents
Compostos de isoxazolina para utilização no tratamento da demodicoseInfo
- Publication number
- PT4008329T PT4008329T PT212131908T PT21213190T PT4008329T PT 4008329 T PT4008329 T PT 4008329T PT 212131908 T PT212131908 T PT 212131908T PT 21213190 T PT21213190 T PT 21213190T PT 4008329 T PT4008329 T PT 4008329T
- Authority
- PT
- Portugal
- Prior art keywords
- isoxazoline compounds
- demodicosis
- treating
- treating demodicosis
- isoxazoline
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14199562 | 2014-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT4008329T true PT4008329T (pt) | 2025-07-30 |
Family
ID=52146273
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT212131908T PT4008329T (pt) | 2014-12-22 | 2015-12-21 | Compostos de isoxazolina para utilização no tratamento da demodicose |
| PT158173039T PT3236960T (pt) | 2014-12-22 | 2015-12-21 | Fluralaner para utilização no tratamento da demodicose |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT158173039T PT3236960T (pt) | 2014-12-22 | 2015-12-21 | Fluralaner para utilização no tratamento da demodicose |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20170348286A1 (enExample) |
| EP (3) | EP4008329B1 (enExample) |
| JP (1) | JP6706262B2 (enExample) |
| CN (2) | CN106999475B (enExample) |
| AU (3) | AU2015371175B2 (enExample) |
| BR (1) | BR112017013286A2 (enExample) |
| CA (1) | CA2971296A1 (enExample) |
| DK (2) | DK4008329T3 (enExample) |
| ES (2) | ES3037078T3 (enExample) |
| FI (2) | FI3236960T3 (enExample) |
| PL (2) | PL4008329T3 (enExample) |
| PT (2) | PT4008329T (enExample) |
| RU (1) | RU2709198C2 (enExample) |
| WO (1) | WO2016102437A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170232024A1 (en) | 2014-08-04 | 2017-08-17 | Jerry Tan Eye Surgery Pte Ltd | Pharmaceutical compositions for demodex related blepharitis and eyelid crusting |
| DK4008329T3 (da) | 2014-12-22 | 2025-08-18 | Intervet Int Bv | Isoxazolinforbindelser til anvendelse i behandling af demodicose |
| WO2018039508A1 (en) * | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| CN107501199A (zh) * | 2017-08-16 | 2017-12-22 | 南京农业大学 | 氟雷拉纳单体化合物的提取和纯化方法 |
| CN119157876A (zh) * | 2017-12-15 | 2024-12-20 | 塔苏斯制药有限公司 | 用于治疗睑炎的异恶唑啉驱虫剂制剂和方法 |
| US12502377B2 (en) | 2019-04-04 | 2025-12-23 | Tarsus Pharmaceuticals, Inc. | Method of eradicating ticks that attach to humans using lotilaner formulations |
| US11880349B2 (en) | 2019-04-30 | 2024-01-23 | Salesforce, Inc. | System or method to query or search a metadata driven distributed ledger or blockchain |
| JP2022537389A (ja) * | 2019-06-19 | 2022-08-25 | ターサス ファーマシューティカルズ， インコーポレイテッド | 眼瞼炎を治療するためのイソキサゾリン寄生虫駆除剤の処方及び方法 |
| US12497370B2 (en) | 2019-12-18 | 2025-12-16 | Elanco Tiergesundheit Ag | Isoxazoline derivatives |
| US12655138B2 (en) | 2020-07-24 | 2026-06-16 | Elanco Us Inc. | Process for making an isoxazoline compound and intermediate thereof |
| AU2021335500A1 (en) | 2020-09-04 | 2023-05-04 | Elanco Us Inc. | Palatable formulations |
| CN115785017B (zh) * | 2022-12-06 | 2023-12-08 | 海利尔药业集团股份有限公司 | 一种取代的苯酰胺异噁唑啉衍生物或其作为农药可接受的盐、组合物及其用途 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2067863C1 (ru) * | 1994-05-25 | 1996-10-20 | Казанский государственный технологический университет | Акарицидный состав для лечения чесотки домашних животных |
| BRPI0508140B1 (pt) | 2004-03-05 | 2015-03-17 | Nissan Chemical Ind Ltd | Composto benzamida substituída por isoxazolina da fórmula (1); da fórmula (2) substituído por 3,5-bis (aril substituído); da fórmula (4) substituída por alquinibenzeno ou um sal do mesmo; "pesticida, agroquímico, inseticida, parasiticida contendo como ingrediente ativo um ou mais composto benzamida substituída por isoxazolina e sal do mesmo" |
| DE102004053964A1 (de) * | 2004-11-09 | 2006-05-11 | Bayer Healthcare Ag | Mittel gegen Demodikose |
| TWI412322B (zh) | 2005-12-30 | 2013-10-21 | 杜邦股份有限公司 | 控制無脊椎害蟲之異唑啉 |
| TWI430995B (zh) | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| DK2182945T3 (en) | 2007-06-27 | 2015-11-16 | Du Pont | PROCEDURE TO COMBAT PESTS WITH ANIMALS |
| TWI556741B (zh) * | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | 異唑啉組成物及其作為抗寄生蟲藥上的應用 |
| TWI411395B (zh) | 2007-12-24 | 2013-10-11 | Syngenta Participations Ag | 殺蟲化合物 |
| ES2442342T3 (es) | 2008-12-18 | 2014-02-11 | Novartis Ag | Derivados de las isoxazolinas y su uso como pesticida |
| AR074790A1 (es) * | 2008-12-19 | 2011-02-09 | Novartis Ag | Derivados de isooxazol sustituidos, composiciones farmaceuticas y para el control de parasitos que los comprenden y su uso en metodos para controlar parasitos en y sobre animales de sangre caliente. |
| JP6002148B2 (ja) | 2010-12-27 | 2016-10-05 | インターベット インターナショナル ベー． フェー． | 経表面局所イソオキサゾリン製剤 |
| CN103260620A (zh) | 2010-12-27 | 2013-08-21 | 英特维特国际股份有限公司 | 包含三缩四乙二醇的外用局部异噁唑啉制剂 |
| PT2683723T (pt) | 2011-03-10 | 2016-08-05 | Zoetis Services Llc | Derivados espirocíclicos de isoxazolina como agentes antiparasitários |
| HUE042360T2 (hu) * | 2011-09-12 | 2019-06-28 | Merial Inc | Izoxazolin hatóanyagot tartalmazó parazitaellenes készítmények, ezek elõállítása és alkalmazása |
| AP2014007874A0 (en) | 2012-02-06 | 2014-08-31 | Merial Ltd | Parasiticidal oral veterinary compositions comprising systemetically- acting active agents, methods and uses thereof |
| CN108685894B (zh) | 2012-04-04 | 2022-04-26 | 英特维特国际股份有限公司 | 软咀嚼药用产品 |
| WO2014090918A1 (en) * | 2012-12-13 | 2014-06-19 | Novartis Ag | Process for the enantiomeric enrichment of diaryloxazoline derivatives |
| MX373872B (es) * | 2013-12-20 | 2020-03-26 | Intervet Int Bv | Composiciones de isoxazolina y uso de las mismas en la prevención o tratamiento de infestaciones parasitarias en animales. |
| DK4008329T3 (da) | 2014-12-22 | 2025-08-18 | Intervet Int Bv | Isoxazolinforbindelser til anvendelse i behandling af demodicose |
-
2015
- 2015-12-21 DK DK21213190.8T patent/DK4008329T3/da active
- 2015-12-21 AU AU2015371175A patent/AU2015371175B2/en active Active
- 2015-12-21 JP JP2017533378A patent/JP6706262B2/ja active Active
- 2015-12-21 EP EP21213190.8A patent/EP4008329B1/en active Active
- 2015-12-21 WO PCT/EP2015/080744 patent/WO2016102437A1/en not_active Ceased
- 2015-12-21 PL PL21213190.8T patent/PL4008329T3/pl unknown
- 2015-12-21 CN CN201580069964.4A patent/CN106999475B/zh active Active
- 2015-12-21 CN CN202210404756.7A patent/CN114681453A/zh active Pending
- 2015-12-21 CA CA2971296A patent/CA2971296A1/en active Pending
- 2015-12-21 ES ES21213190T patent/ES3037078T3/es active Active
- 2015-12-21 BR BR112017013286-9A patent/BR112017013286A2/pt not_active Application Discontinuation
- 2015-12-21 PT PT212131908T patent/PT4008329T/pt unknown
- 2015-12-21 EP EP25179725.4A patent/EP4599830A3/en active Pending
- 2015-12-21 PT PT158173039T patent/PT3236960T/pt unknown
- 2015-12-21 FI FIEP15817303.9T patent/FI3236960T3/fi active
- 2015-12-21 RU RU2017126029A patent/RU2709198C2/ru active
- 2015-12-21 FI FIEP21213190.8T patent/FI4008329T3/fi active
- 2015-12-21 ES ES15817303T patent/ES3018234T3/es active Active
- 2015-12-21 PL PL15817303.9T patent/PL3236960T3/pl unknown
- 2015-12-21 DK DK15817303.9T patent/DK3236960T3/da active
- 2015-12-21 US US15/537,547 patent/US20170348286A1/en not_active Abandoned
- 2015-12-21 EP EP15817303.9A patent/EP3236960B1/en active Active
-
2018
- 2018-04-04 US US15/944,967 patent/US10799483B2/en active Active
-
2020
- 2020-09-09 US US17/015,263 patent/US20200405692A1/en not_active Abandoned
-
2021
- 2021-06-04 AU AU2021203686A patent/AU2021203686A1/en not_active Abandoned
-
2023
- 2023-08-25 AU AU2023219972A patent/AU2023219972B2/en active Active
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