PT4008329T - Compostos de isoxazolina para utilização no tratamento da demodicose - Google Patents

Compostos de isoxazolina para utilização no tratamento da demodicose

Info

Publication number
PT4008329T
PT4008329T PT212131908T PT21213190T PT4008329T PT 4008329 T PT4008329 T PT 4008329T PT 212131908 T PT212131908 T PT 212131908T PT 21213190 T PT21213190 T PT 21213190T PT 4008329 T PT4008329 T PT 4008329T
Authority
PT
Portugal
Prior art keywords
isoxazoline compounds
demodicosis
treating
treating demodicosis
isoxazoline
Prior art date
Application number
PT212131908T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Intervet Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intervet Int Bv filed Critical Intervet Int Bv
Publication of PT4008329T publication Critical patent/PT4008329T/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
PT212131908T 2014-12-22 2015-12-21 Compostos de isoxazolina para utilização no tratamento da demodicose PT4008329T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14199562 2014-12-22

Publications (1)

Publication Number Publication Date
PT4008329T true PT4008329T (pt) 2025-07-30

Family

ID=52146273

Family Applications (2)

Application Number Title Priority Date Filing Date
PT212131908T PT4008329T (pt) 2014-12-22 2015-12-21 Compostos de isoxazolina para utilização no tratamento da demodicose
PT158173039T PT3236960T (pt) 2014-12-22 2015-12-21 Fluralaner para utilização no tratamento da demodicose

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT158173039T PT3236960T (pt) 2014-12-22 2015-12-21 Fluralaner para utilização no tratamento da demodicose

Country Status (14)

Country Link
US (3) US20170348286A1 (enExample)
EP (3) EP3236960B1 (enExample)
JP (1) JP6706262B2 (enExample)
CN (2) CN106999475B (enExample)
AU (3) AU2015371175B2 (enExample)
BR (1) BR112017013286A2 (enExample)
CA (1) CA2971296A1 (enExample)
DK (2) DK4008329T3 (enExample)
ES (2) ES3037078T3 (enExample)
FI (2) FI4008329T3 (enExample)
PL (2) PL3236960T3 (enExample)
PT (2) PT4008329T (enExample)
RU (1) RU2709198C2 (enExample)
WO (1) WO2016102437A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170232024A1 (en) 2014-08-04 2017-08-17 Jerry Tan Eye Surgery Pte Ltd Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
US20170348286A1 (en) 2014-12-22 2017-12-07 Intervet Inc. Use of isoxazoline compounds for treating demodicosis
WO2018039508A1 (en) * 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
CN107501199A (zh) * 2017-08-16 2017-12-22 南京农业大学 氟雷拉纳单体化合物的提取和纯化方法
MX2020006309A (es) 2017-12-15 2021-01-29 Tarsus Pharmaceuticals Inc Fórmulaciones de parasiticida de isoxazolina y métodos para el tratamiento de la blefaritis.
US11880349B2 (en) 2019-04-30 2024-01-23 Salesforce, Inc. System or method to query or search a metadata driven distributed ledger or blockchain
JP7724845B2 (ja) 2020-07-24 2025-08-18 エランコ・ユーエス・インコーポレイテッド イソオキサゾリン化合物及びその中間体を作製するための方法
CN115785017B (zh) * 2022-12-06 2023-12-08 海利尔药业集团股份有限公司 一种取代的苯酰胺异噁唑啉衍生物或其作为农药可接受的盐、组合物及其用途

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2067863C1 (ru) * 1994-05-25 1996-10-20 Казанский государственный технологический университет Акарицидный состав для лечения чесотки домашних животных
CN102558082B (zh) 2004-03-05 2015-09-30 日产化学工业株式会社 异噁唑啉取代苯甲酰胺化合物的制备中间体
DE102004053964A1 (de) * 2004-11-09 2006-05-11 Bayer Healthcare Ag Mittel gegen Demodikose
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
MX368680B (es) 2007-06-27 2019-10-11 Du Pont Administración subcutánea de un derivado de isoxazol-benzamida para usarse en un método para proteger un mamífero de una pulga.
TWI556741B (zh) * 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
TWI411395B (zh) 2007-12-24 2013-10-11 Syngenta Participations Ag 殺蟲化合物
CA2747060A1 (en) 2008-12-18 2010-07-15 Novartis Ag Isoxazolines derivatives and their use as pesticide
TWI454472B (zh) * 2008-12-19 2014-10-01 Novartis Ag 有機化合物
RU2602189C2 (ru) 2010-12-27 2016-11-10 Интервет Интернэшнл Б.В. Изоксазолиновый состав, содержащий гликофурол для наружного и местного применения
CN105616406B (zh) 2010-12-27 2019-12-13 英特维特国际股份有限公司 外用局部异噁唑啉制剂
MX2013010336A (es) 2011-03-10 2013-10-03 Zoetis Llc Derivados espirociclicos de isoxazolina como agentes antiparasitarios.
DK3172964T3 (da) * 2011-09-12 2020-11-30 Boehringer Ingelheim Animal Health Usa Inc Parasitiske sammensætninger indeholdende et isoxazolinaktivstof, fremgangsmåde og anvendelser deraf
RU2763496C2 (ru) 2012-02-06 2021-12-29 БЁРИНГЕР ИНГЕЛЬХАЙМ ЭНИМАЛ ХЕЛТ ЮЭсЭй ИНК. Паразитицидные пероральные ветеринарные композиции, включающие системно действующие активные агенты, способы и применение этих композиций и способов
CN108685894B (zh) 2012-04-04 2022-04-26 英特维特国际股份有限公司 软咀嚼药用产品
WO2014090918A1 (en) * 2012-12-13 2014-06-19 Novartis Ag Process for the enantiomeric enrichment of diaryloxazoline derivatives
ES2971061T3 (es) * 2013-12-20 2024-06-03 Intervet Int Bv Composiciones de isoxazolina y uso de las mismas en la prevención o el tratamiento de infestaciones parasitarias en animales
US20170348286A1 (en) 2014-12-22 2017-12-07 Intervet Inc. Use of isoxazoline compounds for treating demodicosis

Also Published As

Publication number Publication date
RU2709198C2 (ru) 2019-12-17
ES3018234T3 (en) 2025-05-14
PT3236960T (pt) 2025-04-08
ES3037078T3 (en) 2025-09-26
EP3236960B1 (en) 2025-01-29
AU2015371175B2 (en) 2021-03-04
US20180318265A1 (en) 2018-11-08
US20170348286A1 (en) 2017-12-07
US10799483B2 (en) 2020-10-13
AU2021203686A1 (en) 2021-07-01
RU2017126029A (ru) 2019-01-24
AU2023219972A1 (en) 2023-09-14
AU2023219972B2 (en) 2025-05-29
PL3236960T3 (pl) 2025-07-07
EP4008329B1 (en) 2025-06-11
FI3236960T3 (fi) 2025-04-05
CN106999475A (zh) 2017-08-01
CN106999475B (zh) 2022-10-25
FI4008329T3 (fi) 2025-08-22
EP4599830A2 (en) 2025-08-13
BR112017013286A2 (pt) 2018-03-06
US20200405692A1 (en) 2020-12-31
RU2017126029A3 (enExample) 2019-06-20
WO2016102437A1 (en) 2016-06-30
PL4008329T3 (pl) 2025-11-17
DK4008329T3 (da) 2025-08-18
EP4599830A3 (en) 2025-11-19
EP4008329A1 (en) 2022-06-08
JP6706262B2 (ja) 2020-06-03
CA2971296A1 (en) 2016-06-30
EP3236960A1 (en) 2017-11-01
DK3236960T3 (da) 2025-03-31
AU2015371175A1 (en) 2017-06-15
CN114681453A (zh) 2022-07-01
JP2017538767A (ja) 2017-12-28

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