CN106999475B - 异噁唑啉化合物用于治疗蠕形螨病的用途 - Google Patents

异噁唑啉化合物用于治疗蠕形螨病的用途 Download PDF

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Publication number
CN106999475B
CN106999475B CN201580069964.4A CN201580069964A CN106999475B CN 106999475 B CN106999475 B CN 106999475B CN 201580069964 A CN201580069964 A CN 201580069964A CN 106999475 B CN106999475 B CN 106999475B
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treatment
dogs
demodex
dog
demodicosis
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Chinese (zh)
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CN106999475A (zh
Inventor
H.威廉斯
A.R.赫克罗斯
J.坦兹勒
R.J.A.弗伦艾斯
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Intervet International BV
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Intervet International BV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN201580069964.4A 2014-12-22 2015-12-21 异噁唑啉化合物用于治疗蠕形螨病的用途 Active CN106999475B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210404756.7A CN114681453A (zh) 2014-12-22 2015-12-21 异噁唑啉化合物用于治疗蠕形螨病的用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14199562.1 2014-12-22
EP14199562 2014-12-22
PCT/EP2015/080744 WO2016102437A1 (en) 2014-12-22 2015-12-21 Use of isoxazoline compounds for treating demodicosis

Related Child Applications (1)

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CN202210404756.7A Division CN114681453A (zh) 2014-12-22 2015-12-21 异噁唑啉化合物用于治疗蠕形螨病的用途

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CN106999475A CN106999475A (zh) 2017-08-01
CN106999475B true CN106999475B (zh) 2022-10-25

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CN202210404756.7A Pending CN114681453A (zh) 2014-12-22 2015-12-21 异噁唑啉化合物用于治疗蠕形螨病的用途

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US (3) US20170348286A1 (enExample)
EP (3) EP4008329B1 (enExample)
JP (1) JP6706262B2 (enExample)
CN (2) CN106999475B (enExample)
AU (3) AU2015371175B2 (enExample)
BR (1) BR112017013286A2 (enExample)
CA (1) CA2971296A1 (enExample)
DK (2) DK4008329T3 (enExample)
ES (2) ES3018234T3 (enExample)
FI (2) FI3236960T3 (enExample)
PL (2) PL3236960T3 (enExample)
PT (2) PT4008329T (enExample)
RU (1) RU2709198C2 (enExample)
WO (1) WO2016102437A1 (enExample)

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WO2016022066A1 (en) 2014-08-04 2016-02-11 Jerry Tan Eye Surgery Pte Ltd Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
PL3236960T3 (pl) 2014-12-22 2025-07-07 Intervet International B.V. Fluralaner do zastosowania w leczeniu demodekozy
WO2018039508A1 (en) * 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
CN107501199A (zh) * 2017-08-16 2017-12-22 南京农业大学 氟雷拉纳单体化合物的提取和纯化方法
KR20250065422A (ko) * 2017-12-15 2025-05-12 타르서스 파마수티칼스, 아이엔씨. 안검염을 치료하기 위한 이속사졸린 구충제 제제 및 방법
US11880349B2 (en) 2019-04-30 2024-01-23 Salesforce, Inc. System or method to query or search a metadata driven distributed ledger or blockchain
EP4077286A1 (en) 2019-12-18 2022-10-26 Elanco Tiergesundheit AG Isoxazoline derivatives as pesticides
WO2022020585A1 (en) 2020-07-24 2022-01-27 Elanco Us Inc. Process for making an isoxazoline compound and intermediate thereof
CN115785017B (zh) * 2022-12-06 2023-12-08 海利尔药业集团股份有限公司 一种取代的苯酰胺异噁唑啉衍生物或其作为农药可接受的盐、组合物及其用途

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JP4883296B2 (ja) 2004-03-05 2012-02-22 日産化学工業株式会社 イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤
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TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
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KR101992589B1 (ko) 2010-12-27 2019-06-24 인터벳 인터내셔널 비.브이. 글리코푸롤을 포함하는 국소 적용 이속사졸린 제제
BR112013023068B8 (pt) * 2011-03-10 2022-11-22 Zoetis Llc Derivados de isoxazolina espirocíclica, seu uso e seu processo de preparação, e composições veterinárias
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Publication number Publication date
EP4599830A3 (en) 2025-11-19
RU2017126029A (ru) 2019-01-24
RU2017126029A3 (enExample) 2019-06-20
JP6706262B2 (ja) 2020-06-03
FI4008329T3 (fi) 2025-08-22
AU2023219972B2 (en) 2025-05-29
CA2971296A1 (en) 2016-06-30
US20180318265A1 (en) 2018-11-08
PL3236960T3 (pl) 2025-07-07
FI3236960T3 (fi) 2025-04-05
PL4008329T3 (pl) 2025-11-17
CN114681453A (zh) 2022-07-01
PT4008329T (pt) 2025-07-30
EP4008329B1 (en) 2025-06-11
RU2709198C2 (ru) 2019-12-17
US20200405692A1 (en) 2020-12-31
BR112017013286A2 (pt) 2018-03-06
PT3236960T (pt) 2025-04-08
AU2015371175A1 (en) 2017-06-15
US10799483B2 (en) 2020-10-13
AU2021203686A1 (en) 2021-07-01
DK3236960T3 (da) 2025-03-31
EP4599830A2 (en) 2025-08-13
ES3018234T3 (en) 2025-05-14
AU2015371175B2 (en) 2021-03-04
WO2016102437A1 (en) 2016-06-30
AU2023219972A1 (en) 2023-09-14
US20170348286A1 (en) 2017-12-07
EP3236960A1 (en) 2017-11-01
EP4008329A1 (en) 2022-06-08
DK4008329T3 (da) 2025-08-18
EP3236960B1 (en) 2025-01-29
ES3037078T3 (en) 2025-09-26
JP2017538767A (ja) 2017-12-28
CN106999475A (zh) 2017-08-01

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