PT3868758T - Derivados de tiadiazole e sua utilização como inibidores gls1 de para o tratamento de cancro - Google Patents
Derivados de tiadiazole e sua utilização como inibidores gls1 de para o tratamento de cancroInfo
- Publication number
- PT3868758T PT3868758T PT198742686T PT19874268T PT3868758T PT 3868758 T PT3868758 T PT 3868758T PT 198742686 T PT198742686 T PT 198742686T PT 19874268 T PT19874268 T PT 19874268T PT 3868758 T PT3868758 T PT 3868758T
- Authority
- PT
- Portugal
- Prior art keywords
- thiadiazole derivative
- gls1 inhibitor
- gls1
- inhibitor
- thiadiazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811202713 | 2018-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3868758T true PT3868758T (pt) | 2023-02-16 |
Family
ID=70284303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT198742686T PT3868758T (pt) | 2018-10-16 | 2019-10-15 | Derivados de tiadiazole e sua utilização como inibidores gls1 de para o tratamento de cancro |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11230544B1 (pt) |
| EP (1) | EP3868758B1 (pt) |
| JP (1) | JP7026852B2 (pt) |
| KR (1) | KR102379226B1 (pt) |
| CN (1) | CN112888686B (pt) |
| AU (1) | AU2019363115B2 (pt) |
| CA (1) | CA3116440C (pt) |
| ES (1) | ES2939506T3 (pt) |
| PT (1) | PT3868758T (pt) |
| WO (1) | WO2020078350A1 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115594683B (zh) * | 2021-11-02 | 2023-06-16 | 杭州禹胜医药科技有限公司 | 谷氨酰胺酶gls1抑制剂及其制备方法与应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8604016B2 (en) * | 2011-11-21 | 2013-12-10 | Calithera Biosciences Inc. | Heterocyclic inhibitors of glutaminase |
| CA2856386C (en) * | 2011-11-21 | 2022-05-31 | Calithera Biosciences Inc. | Heterocyclic inhibitors of glutaminase |
| GB201409624D0 (en) | 2014-05-30 | 2014-07-16 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
| CN107921044B (zh) | 2015-06-30 | 2022-01-21 | 德州大学系统董事会 | 用于治疗疾病的gls1抑制剂 |
| TW201731511A (zh) * | 2015-11-30 | 2017-09-16 | 阿斯特捷利康公司 | １，３，４-噻二唑化合物及其在治療癌症中之用途 |
| TW201733587A (zh) | 2015-11-30 | 2017-10-01 | 阿斯特捷利康公司 | 1,3,4-噻二唑化合物及其在治療癌症中之用途 |
| TW201730188A (zh) | 2015-11-30 | 2017-09-01 | 阿斯特捷利康公司 | 1,3,4-噻二唑化合物及其在治療癌症中之用途 |
| CN106890184B (zh) | 2015-12-18 | 2019-06-25 | 诺言医药科技(上海)有限公司 | 抗肿瘤的谷氨酰胺酶抑制剂和肿瘤血管生成抑制剂药物组合物及其应用 |
-
2019
- 2019-10-15 JP JP2021521183A patent/JP7026852B2/ja active Active
- 2019-10-15 ES ES19874268T patent/ES2939506T3/es active Active
- 2019-10-15 PT PT198742686T patent/PT3868758T/pt unknown
- 2019-10-15 AU AU2019363115A patent/AU2019363115B2/en active Active
- 2019-10-15 CN CN201980066987.8A patent/CN112888686B/zh active Active
- 2019-10-15 WO PCT/CN2019/111232 patent/WO2020078350A1/zh unknown
- 2019-10-15 EP EP19874268.6A patent/EP3868758B1/en active Active
- 2019-10-15 US US17/284,806 patent/US11230544B1/en active Active
- 2019-10-15 KR KR1020217014579A patent/KR102379226B1/ko active IP Right Grant
- 2019-10-15 CA CA3116440A patent/CA3116440C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20210066010A (ko) | 2021-06-04 |
| CA3116440C (en) | 2022-03-08 |
| WO2020078350A1 (zh) | 2020-04-23 |
| ES2939506T3 (es) | 2023-04-24 |
| EP3868758A4 (en) | 2021-11-03 |
| EP3868758A1 (en) | 2021-08-25 |
| JP7026852B2 (ja) | 2022-02-28 |
| AU2019363115A1 (en) | 2021-05-27 |
| US11230544B1 (en) | 2022-01-25 |
| CN112888686B (zh) | 2022-04-19 |
| JP2021531331A (ja) | 2021-11-18 |
| AU2019363115B2 (en) | 2021-12-09 |
| CA3116440A1 (en) | 2020-04-23 |
| CN112888686A (zh) | 2021-06-01 |
| KR102379226B1 (ko) | 2022-03-25 |
| EP3868758B1 (en) | 2023-01-04 |
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