PT3694526T - Resgate independente do genótipo da fibrose quística com canais de bicarbonato de moléculas pequenas - Google Patents

Resgate independente do genótipo da fibrose quística com canais de bicarbonato de moléculas pequenas

Info

Publication number
PT3694526T
PT3694526T PT188654834T PT18865483T PT3694526T PT 3694526 T PT3694526 T PT 3694526T PT 188654834 T PT188654834 T PT 188654834T PT 18865483 T PT18865483 T PT 18865483T PT 3694526 T PT3694526 T PT 3694526T
Authority
PT
Portugal
Prior art keywords
agnostic
genotype
rescue
bicarbonate
channels
Prior art date
Application number
PT188654834T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Univ Illinois
Univ Iowa Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois, Univ Iowa Res Found filed Critical Univ Illinois
Publication of PT3694526T publication Critical patent/PT3694526T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT188654834T 2017-10-11 2018-10-11 Resgate independente do genótipo da fibrose quística com canais de bicarbonato de moléculas pequenas PT3694526T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762570795P 2017-10-11 2017-10-11

Publications (1)

Publication Number Publication Date
PT3694526T true PT3694526T (pt) 2025-01-20

Family

ID=66100102

Family Applications (1)

Application Number Title Priority Date Filing Date
PT188654834T PT3694526T (pt) 2017-10-11 2018-10-11 Resgate independente do genótipo da fibrose quística com canais de bicarbonato de moléculas pequenas

Country Status (10)

Country Link
US (3) US12090164B2 (enExample)
EP (1) EP3694526B1 (enExample)
JP (2) JP7355335B2 (enExample)
AU (2) AU2018348214C1 (enExample)
CA (1) CA3076246A1 (enExample)
DK (1) DK3694526T3 (enExample)
ES (1) ES3009563T3 (enExample)
FI (1) FI3694526T3 (enExample)
PT (1) PT3694526T (enExample)
WO (1) WO2019075214A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3694526T (pt) 2017-10-11 2025-01-20 Univ Illinois Resgate independente do genótipo da fibrose quística com canais de bicarbonato de moléculas pequenas
IL315719A (en) 2022-03-21 2024-11-01 Univ Illinois Prosthetic assemblies of ion channels containing lipid-coated amphotericin B crystals
WO2025019806A2 (en) * 2023-07-19 2025-01-23 The Board Of Trustees Of The University Of Illinois Restoring physiology with small molecule mimics of missing proteins
EP4780466A1 (en) * 2023-09-20 2026-07-29 The Board Of Trustees Of The University Of Illinois Additive effects for molecular prosthetcs and cftr modulators in cf epithelia

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU598958B2 (en) * 1987-11-12 1990-07-05 Vestar, Inc. Improved amphotericin b liposome preparation
JP3507486B2 (ja) 1991-03-15 2004-03-15 アムジエン・インコーポレーテツド 顆粒球コロニー刺激因子の肺内投与
US5451569A (en) 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
AU2003304204B2 (en) * 2002-10-29 2009-12-24 Insmed Incorporated Sustained release of antiinfectives
TWI249408B (en) 2003-12-10 2006-02-21 Ind Tech Res Inst New antifungal formulation and manufacturing method thereof
CN101014322A (zh) * 2004-06-11 2007-08-08 吉藤德拉·纳提·维玛 盐水中富含固醇的添加两性霉素的混合层状脂质体及其制备方法
US8507441B2 (en) 2009-10-22 2013-08-13 University of Pittsburgh—Of the Commonwealth Systems of Higher Education Use of endostatin peptides for the treatment of fibrosis
US8945605B2 (en) * 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
JP6796581B2 (ja) * 2014-11-04 2020-12-09 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイThe Board Of Trustees Of The University Of Illinois ミッシングタンパク質の小分子模倣体を用いた生理機能の回復
ES2983639T3 (es) 2016-04-08 2024-10-24 The Board Of Trustees Of The Univ Illinois Restauración mediada por moléculas pequeñas de la fisiología de la superficie de las vías respiratorias en epitelios pulmonares humanos de fibrosis quística
US10960018B2 (en) * 2016-04-15 2021-03-30 The Uab Research Foundation Methods and compounds for stimulating read-through of premature termination codons
PT3694526T (pt) 2017-10-11 2025-01-20 Univ Illinois Resgate independente do genótipo da fibrose quística com canais de bicarbonato de moléculas pequenas

Also Published As

Publication number Publication date
US20250000886A1 (en) 2025-01-02
WO2019075214A3 (en) 2020-04-02
ES3009563T3 (en) 2025-03-27
JP7355335B2 (ja) 2023-10-03
CA3076246A1 (en) 2019-04-18
FI3694526T3 (fi) 2025-02-06
US20250009775A1 (en) 2025-01-09
JP2020536859A (ja) 2020-12-17
AU2018348214B2 (en) 2024-08-08
EP3694526A4 (en) 2021-06-09
DK3694526T3 (da) 2025-02-03
JP2023126932A (ja) 2023-09-12
EP3694526A2 (en) 2020-08-19
US12090164B2 (en) 2024-09-17
US20200352970A1 (en) 2020-11-12
AU2024259758A1 (en) 2024-11-21
AU2018348214C1 (en) 2025-01-30
AU2018348214A1 (en) 2020-04-23
EP3694526B1 (en) 2024-12-04
WO2019075214A2 (en) 2019-04-18

Similar Documents

Publication Publication Date Title
IL279460A (en) Modulators of the cystic fibrosis transmembrane conductance regulator
IL272032A (en) Methods of treatment for cystic fibrosis
IL271181A (en) Methods of treatment for cystic fibrosis
PL3436446T3 (pl) Modulatory mukowiscydozowego przezbłonowego regulatora przewodnictwa
EP3012003A4 (en) Combined toy gyroscope capable of being freely assembled
ZA201901252B (en) Activity-triggered provisioning of portable wireless networks
ZA201902929B (en) Gas inflatable balloons
IL252818A0 (en) Cyclopropanecarboxamides that modulate cystic fibrosis transmembrane conductance regulation
EP3012004A4 (en) Toy gyroscope with gyroscope ring capable of being mounted on both sides
IL262141B (en) A method for diagnosing cystic fibrosis
DK3694526T3 (da) Genotype-agnostisk redning af cystisk fibrose med småmolekylære bicarbonatkanaler
CA3291070A1 (en) Portable foam brush
EP3536343A4 (en) SKIN FIBROSIS TREATMENT AGENT
EP3392424A4 (en) LIGHTWEIGHT WALL BODY FRAME
EP3596067C0 (en) NEW PYRAZOLE DERIVATIVES FOR THE TREATMENT OF CYSTIC FIBROSIS
EP3508630A4 (en) SHELL FABRIC WITH MOTION TRACKING
EP3240461A4 (en) Personal applicator
GB201721718D0 (en) Treatment of cystic fibrosis
ZA201807388B (en) Pesticidally active mixtures of tioxazafen
HK40089592A (en) Modulators of cystic fibrosis transmembrane conductance regulator
TWM533984U (en) Detachable massage roller structure
EP3326662A4 (en) USE OF POROUS MATERIAL
AU201816640S (en) Hedgehog toy
HK1245655A1 (en) Cyclopropanecarboxamide modulators of cystic fibrosis transmembrane conductance regulator
GB201700824D0 (en) Sustained propulsion