DK3694526T3 - Genotype-agnostisk redning af cystisk fibrose med småmolekylære bicarbonatkanaler - Google Patents
Genotype-agnostisk redning af cystisk fibrose med småmolekylære bicarbonatkanaler Download PDFInfo
- Publication number
- DK3694526T3 DK3694526T3 DK18865483.4T DK18865483T DK3694526T3 DK 3694526 T3 DK3694526 T3 DK 3694526T3 DK 18865483 T DK18865483 T DK 18865483T DK 3694526 T3 DK3694526 T3 DK 3694526T3
- Authority
- DK
- Denmark
- Prior art keywords
- agnostic
- genotype
- rescue
- bicarbonate
- channels
- Prior art date
Links
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 title 1
- 201000003883 Cystic fibrosis Diseases 0.000 title 1
- 150000003384 small molecules Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762570795P | 2017-10-11 | 2017-10-11 | |
| PCT/US2018/055435 WO2019075214A2 (en) | 2017-10-11 | 2018-10-11 | INDEPENDENT RESCUEING OF THE GENOTYPE OF CYSTIC FIBROSIS WITH BICARBONATE CHANNELS WITH SMALL MOLECULES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3694526T3 true DK3694526T3 (da) | 2025-02-03 |
Family
ID=66100102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18865483.4T DK3694526T3 (da) | 2017-10-11 | 2018-10-11 | Genotype-agnostisk redning af cystisk fibrose med småmolekylære bicarbonatkanaler |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US12090164B2 (enExample) |
| EP (1) | EP3694526B1 (enExample) |
| JP (2) | JP7355335B2 (enExample) |
| AU (2) | AU2018348214C1 (enExample) |
| CA (1) | CA3076246A1 (enExample) |
| DK (1) | DK3694526T3 (enExample) |
| ES (1) | ES3009563T3 (enExample) |
| FI (1) | FI3694526T3 (enExample) |
| PT (1) | PT3694526T (enExample) |
| WO (1) | WO2019075214A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018348214C1 (en) | 2017-10-11 | 2025-01-30 | The Board Of Trustees Of The University Of Illinois | Genotype-agnostic rescue of cystic fibrosis with small molecule bicarbonate channels |
| AU2023238751A1 (en) | 2022-03-21 | 2024-10-31 | Cystetic Medicines, Inc. | Ion channel prosthetic compositions comprising lipid-coated crystals of amphotericin b |
| WO2025019806A2 (en) * | 2023-07-19 | 2025-01-23 | The Board Of Trustees Of The University Of Illinois | Restoring physiology with small molecule mimics of missing proteins |
| WO2025064626A1 (en) * | 2023-09-20 | 2025-03-27 | The Board Of Trustees Of The University Of Illinois | Additive effects for molecular prosthetcs and cftr modulators in cf epithelia |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU598958B2 (en) * | 1987-11-12 | 1990-07-05 | Vestar, Inc. | Improved amphotericin b liposome preparation |
| AU643141B2 (en) | 1991-03-15 | 1993-11-04 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| US5451569A (en) | 1994-04-19 | 1995-09-19 | Hong Kong University Of Science And Technology R & D Corporation Limited | Pulmonary drug delivery system |
| MX353044B (es) * | 2002-10-29 | 2017-12-18 | Insmed Inc | Liberacion sostenida de anti-infecciosos. |
| TWI249408B (en) * | 2003-12-10 | 2006-02-21 | Ind Tech Res Inst | New antifungal formulation and manufacturing method thereof |
| US20070218119A1 (en) | 2004-06-11 | 2007-09-20 | Verma Jitendra N | Sterol enriched mixed lammelarity amphotericin intercalating liposomes in saline and the process for their preparation |
| WO2011050311A1 (en) * | 2009-10-22 | 2011-04-28 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Use of endostatin peptides for the treatment of fibrosis |
| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| JP6796581B2 (ja) | 2014-11-04 | 2020-12-09 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ | ミッシングタンパク質の小分子模倣体を用いた生理機能の回復 |
| WO2017177228A1 (en) * | 2016-04-08 | 2017-10-12 | The Board Of Trustees Of The University Of Illinois | Small molecule-mediated restoration of airway surface physiology in human cystic fibrosis lung epithelia |
| EP3442512A4 (en) * | 2016-04-15 | 2020-07-22 | The UAB Research Foundation | METHODS AND COMPOUNDS FOR STIMULATING THE TRANSLECTURE OF PREMATURE TERMINATION CODONS |
| AU2018348214C1 (en) | 2017-10-11 | 2025-01-30 | The Board Of Trustees Of The University Of Illinois | Genotype-agnostic rescue of cystic fibrosis with small molecule bicarbonate channels |
-
2018
- 2018-10-11 AU AU2018348214A patent/AU2018348214C1/en active Active
- 2018-10-11 CA CA3076246A patent/CA3076246A1/en active Pending
- 2018-10-11 PT PT188654834T patent/PT3694526T/pt unknown
- 2018-10-11 US US16/754,651 patent/US12090164B2/en active Active
- 2018-10-11 WO PCT/US2018/055435 patent/WO2019075214A2/en not_active Ceased
- 2018-10-11 JP JP2020517886A patent/JP7355335B2/ja active Active
- 2018-10-11 ES ES18865483T patent/ES3009563T3/es active Active
- 2018-10-11 EP EP18865483.4A patent/EP3694526B1/en active Active
- 2018-10-11 DK DK18865483.4T patent/DK3694526T3/da active
- 2018-10-11 FI FIEP18865483.4T patent/FI3694526T3/fi active
-
2023
- 2023-07-06 JP JP2023111218A patent/JP2023126932A/ja active Pending
-
2024
- 2024-09-16 US US18/886,316 patent/US20250000886A1/en active Pending
- 2024-09-16 US US18/886,318 patent/US20250009775A1/en active Pending
- 2024-11-06 AU AU2024259758A patent/AU2024259758A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3694526A2 (en) | 2020-08-19 |
| EP3694526A4 (en) | 2021-06-09 |
| US20250009775A1 (en) | 2025-01-09 |
| AU2018348214C1 (en) | 2025-01-30 |
| US20200352970A1 (en) | 2020-11-12 |
| WO2019075214A2 (en) | 2019-04-18 |
| FI3694526T3 (fi) | 2025-02-06 |
| AU2024259758A1 (en) | 2024-11-21 |
| EP3694526B1 (en) | 2024-12-04 |
| AU2018348214B2 (en) | 2024-08-08 |
| WO2019075214A3 (en) | 2020-04-02 |
| US12090164B2 (en) | 2024-09-17 |
| AU2018348214A1 (en) | 2020-04-23 |
| JP2020536859A (ja) | 2020-12-17 |
| PT3694526T (pt) | 2025-01-20 |
| CA3076246A1 (en) | 2019-04-18 |
| ES3009563T3 (en) | 2025-03-27 |
| US20250000886A1 (en) | 2025-01-02 |
| JP2023126932A (ja) | 2023-09-12 |
| JP7355335B2 (ja) | 2023-10-03 |
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