PT3572405T - Benzoimidazol-1,2-ilamidas como ativadores de canal kv7 - Google Patents
Benzoimidazol-1,2-ilamidas como ativadores de canal kv7Info
- Publication number
- PT3572405T PT3572405T PT191853191T PT19185319T PT3572405T PT 3572405 T PT3572405 T PT 3572405T PT 191853191 T PT191853191 T PT 191853191T PT 19185319 T PT19185319 T PT 19185319T PT 3572405 T PT3572405 T PT 3572405T
- Authority
- PT
- Portugal
- Prior art keywords
- benzoimidazol
- amides
- channel activators
- activators
- channel
- Prior art date
Links
- 239000012190 activator Substances 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462050023P | 2014-09-12 | 2014-09-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3572405T true PT3572405T (pt) | 2023-10-26 |
Family
ID=55454102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT191853191T PT3572405T (pt) | 2014-09-12 | 2015-09-14 | Benzoimidazol-1,2-ilamidas como ativadores de canal kv7 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US9481653B2 (pt) |
| EP (3) | EP3572405B9 (pt) |
| DK (2) | DK3572405T3 (pt) |
| ES (2) | ES2960991T3 (pt) |
| FI (1) | FI3572405T3 (pt) |
| HR (1) | HRP20231071T1 (pt) |
| HU (1) | HUE064331T2 (pt) |
| LT (1) | LT3572405T (pt) |
| PL (1) | PL3572405T3 (pt) |
| PT (1) | PT3572405T (pt) |
| RS (1) | RS64708B1 (pt) |
| SI (1) | SI3572405T1 (pt) |
| WO (2) | WO2016040952A2 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2885424T3 (es) * | 2013-03-15 | 2021-12-13 | Knopp Biosciences Llc | Imidazo(4,5-B)piridin-2-il amidas como activadores del canal Kv7 |
| ES2960991T3 (es) | 2014-09-12 | 2024-03-07 | Biohaven Therapeutics Ltd | Benzoimidazol-1,2-ilamidas como activadores del canal Kv7 |
| US10590067B2 (en) | 2018-02-20 | 2020-03-17 | H. Lundbeck A/S | Alcohol derivatives of carboxamides as Kv7 potassium channel openers |
| HUE063567T2 (hu) * | 2018-02-20 | 2024-01-28 | H Lundbeck As | Alkoholszármazékok mint KV7 káliumcsatorna nyitók |
| KR20200133259A (ko) * | 2018-03-19 | 2020-11-26 | 놉 바이오사이언시스 엘엘씨 | Kv7 채널 활성화제 조성물 및 이의 사용 방법 |
| AR119521A1 (es) | 2019-08-02 | 2021-12-22 | H Lundbeck As | DERIVADOS DE ALCOHOL COMO ABRIDORES DEL CANAL DE POTASIO Kv7 |
| WO2021041536A1 (en) * | 2019-08-28 | 2021-03-04 | Ferro Therapeutics, Inc. | Benzimidazole and hydrogenated carbazole derivatives as gpx4 inhibitors |
| CA3150501A1 (en) * | 2019-09-17 | 2021-03-25 | Michael E. Bozik | METHODS OF USING KV7 CHANNEL ACTIVATORS |
| WO2023133256A1 (en) * | 2022-01-07 | 2023-07-13 | Biohaven Therapeutics Ltd. | Pyrazolo[1,5-a]pyridin-2,3-yl amides as kv7 channel activators |
| WO2024054811A1 (en) * | 2022-09-06 | 2024-03-14 | Biohaven Therapeutics Ltd. | Combination therapies including metal channel activators |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1022554A (en) | 1973-03-07 | 1977-12-13 | Haukur Kristinsson | 1-carbamoyl-2-alkoxycarbonylaminoimidazo (4,5-b) pyridines |
| US4002623A (en) | 1974-08-07 | 1977-01-11 | Pfizer Inc. | Anti-inflammatory 1-[3-(dialkylamino)propyl]-2-acylaminobenzimidazoles and 2-acylamino-3-[3-(dialkylamino)-propyl]imidazo[4,5-b]pyridines |
| ES473201A1 (es) | 1977-09-26 | 1979-03-16 | Degussa | Procedimiento para la preparacion de 7-azabencimidazoles |
| US4391811A (en) | 1981-10-02 | 1983-07-05 | Sterling Drug Inc. | 2-Amino-6-(pyridinyl)-3H-imidazo[4,5-b]pyridines and their cardiotonic use |
| JPH0772181B2 (ja) * | 1989-06-26 | 1995-08-02 | 株式会社大塚製薬工場 | ベンズイミダゾール誘導体 |
| JPH0772181A (ja) | 1993-09-03 | 1995-03-17 | Advantest Corp | 電位波形測定方法および装置 |
| GB9413724D0 (en) * | 1994-07-07 | 1994-08-24 | Wellcome Found | Therapeutic nucleosides |
| WO1999016438A1 (en) | 1997-09-26 | 1999-04-08 | Asta Medica Aktiengesellschaft | Azabenzimidazole-based compounds for modulating serine/threonine protein kinase function |
| US20030109549A1 (en) * | 1999-08-05 | 2003-06-12 | Fumitaka Ito | 2-Substituted-1-piperidyl benzimidazole compounds as ORL1-receptor agonists |
| JP2001199968A (ja) | 2000-01-18 | 2001-07-24 | Teijin Ltd | アミノベンズイミダゾール誘導体 |
| US6384049B1 (en) | 2000-05-25 | 2002-05-07 | The Procter & Gamble Company | Cancer treatment |
| US6855714B2 (en) | 2001-07-06 | 2005-02-15 | Schering Aktiengesellschaft | 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives |
| FR2846656B1 (fr) | 2002-11-05 | 2004-12-24 | Servier Lab | Nouveaux derives d'imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| SE0301701D0 (sv) * | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| WO2005021547A2 (en) | 2003-08-28 | 2005-03-10 | Pharmaxis Pty Ltd. | Heterocyclic cannabinoid cb2 receptor antagonists |
| EP1838690A2 (en) | 2004-12-21 | 2007-10-03 | Devgen N.V. | Compounds with kv4 ion channel activity |
| US20080146536A1 (en) | 2005-08-16 | 2008-06-19 | Pharmacopeia, Inc. | 2-Aminoimidazopyridines for treating neurodegenerative diseases |
| ES2274712B1 (es) | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
| EP2186804B1 (en) * | 2007-08-10 | 2015-06-17 | Nippon Soda Co., Ltd. | Nitrogen-containing heterocyclic compound and pest control agent |
| WO2009026254A1 (en) | 2007-08-17 | 2009-02-26 | Icagen, Inc. | Heterocycles as potassium channel modulators |
| DK2409975T3 (en) * | 2007-11-22 | 2015-08-03 | Zenyaku Kogyo Kk | Solid dispersions comprising an amorphous body composed of a heterocyclic anti-tumor compound |
| GB0723794D0 (en) | 2007-12-05 | 2008-01-16 | Lectus Therapeutics Ltd | Potassium ion channel modulators and uses thereof |
| EP2231661A1 (en) * | 2007-12-19 | 2010-09-29 | Amgen, Inc. | Inhibitors of pi3 kinase |
| US20110269783A1 (en) * | 2008-11-10 | 2011-11-03 | Neurosearch A/S | Novel 2,3-diamino-quinazolinone derivatives and their medical use |
| KR101685718B1 (ko) * | 2008-12-19 | 2016-12-12 | 제넨테크, 인크. | 헤테로시클릭 화합물 및 사용 방법 |
| WO2010094645A1 (en) | 2009-02-17 | 2010-08-26 | Neurosearch A/S | Substituted pyridine derivatives and their medical use |
| BR112012010186B8 (pt) | 2009-10-29 | 2021-05-25 | Palau Pharma Sa | derivados de heteroarila contendo n como inibidores de quinase jak3 e composição farmacêutica compreendendo os mesmos |
| WO2012003576A1 (en) | 2010-07-06 | 2012-01-12 | Université de Montréal | Imidazopyridine, imidazopyrimidine and imidazopyrazine derivatives as melanocortin-4 receptor modulators |
| AU2011275393B2 (en) * | 2010-07-08 | 2014-04-10 | Pfizer Inc. | Piperidinyl pyrimidine amides as Kv7 potassium channel openers |
| KR20130108543A (ko) * | 2010-08-05 | 2013-10-04 | 암젠 인코포레이션 | 역형성 림프종 키나제를 억제하는 벤즈이미다졸 및 아자벤즈이미다졸 화합물 |
| ES2885424T3 (es) | 2013-03-15 | 2021-12-13 | Knopp Biosciences Llc | Imidazo(4,5-B)piridin-2-il amidas como activadores del canal Kv7 |
| ES2960991T3 (es) | 2014-09-12 | 2024-03-07 | Biohaven Therapeutics Ltd | Benzoimidazol-1,2-ilamidas como activadores del canal Kv7 |
| KR20200133259A (ko) * | 2018-03-19 | 2020-11-26 | 놉 바이오사이언시스 엘엘씨 | Kv7 채널 활성화제 조성물 및 이의 사용 방법 |
-
2015
- 2015-09-14 ES ES19185319T patent/ES2960991T3/es active Active
- 2015-09-14 US US14/853,815 patent/US9481653B2/en active Active
- 2015-09-14 LT LTEP19185319.1T patent/LT3572405T/lt unknown
- 2015-09-14 EP EP19185319.1A patent/EP3572405B9/en active Active
- 2015-09-14 DK DK19185319.1T patent/DK3572405T3/da active
- 2015-09-14 HR HRP20231071TT patent/HRP20231071T1/hr unknown
- 2015-09-14 RS RS20230951A patent/RS64708B1/sr unknown
- 2015-09-14 PL PL19185319.1T patent/PL3572405T3/pl unknown
- 2015-09-14 EP EP23182255.2A patent/EP4289822A3/en active Pending
- 2015-09-14 HU HUE19185319A patent/HUE064331T2/hu unknown
- 2015-09-14 DK DK15840730.4T patent/DK3191457T3/da active
- 2015-09-14 ES ES15840730T patent/ES2749103T3/es active Active
- 2015-09-14 SI SI201531964T patent/SI3572405T1/sl unknown
- 2015-09-14 PT PT191853191T patent/PT3572405T/pt unknown
- 2015-09-14 WO PCT/US2015/050027 patent/WO2016040952A2/en active Application Filing
- 2015-09-14 FI FIEP19185319.1T patent/FI3572405T3/fi active
- 2015-09-14 EP EP15840730.4A patent/EP3191457B1/en active Active
-
2016
- 2016-10-31 US US15/339,590 patent/US9914708B2/en active Active
-
2017
- 2017-10-31 WO PCT/US2017/059393 patent/WO2018081825A1/en active Application Filing
-
2018
- 2018-01-25 US US15/879,792 patent/US10385025B2/en active Active
-
2019
- 2019-07-02 US US16/460,449 patent/US10906877B2/en active Active
-
2020
- 2020-12-18 US US17/127,231 patent/US11834418B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PL3572405T3 (pl) | 2023-11-13 |
| US11834418B2 (en) | 2023-12-05 |
| US10906877B2 (en) | 2021-02-02 |
| US20170114022A1 (en) | 2017-04-27 |
| US9914708B2 (en) | 2018-03-13 |
| ES2960991T3 (es) | 2024-03-07 |
| EP3572405B9 (en) | 2023-12-06 |
| FI3572405T3 (fi) | 2023-09-22 |
| EP3191457A2 (en) | 2017-07-19 |
| EP4289822A3 (en) | 2024-01-24 |
| EP3191457B1 (en) | 2019-07-10 |
| US20160075663A1 (en) | 2016-03-17 |
| EP3572405B8 (en) | 2023-09-06 |
| HUE064331T2 (hu) | 2024-03-28 |
| EP3572405A1 (en) | 2019-11-27 |
| EP3191457A4 (en) | 2018-02-07 |
| US20210188782A1 (en) | 2021-06-24 |
| WO2016040952A2 (en) | 2016-03-17 |
| SI3572405T1 (sl) | 2023-12-29 |
| WO2018081825A1 (en) | 2018-05-03 |
| HRP20231071T1 (hr) | 2024-03-01 |
| EP4289822A2 (en) | 2023-12-13 |
| US10385025B2 (en) | 2019-08-20 |
| US9481653B2 (en) | 2016-11-01 |
| DK3191457T3 (da) | 2019-10-07 |
| EP3572405B1 (en) | 2023-07-26 |
| US20200002292A1 (en) | 2020-01-02 |
| LT3572405T (lt) | 2023-10-25 |
| WO2016040952A3 (en) | 2016-05-06 |
| DK3572405T3 (da) | 2023-10-16 |
| ES2749103T3 (es) | 2020-03-19 |
| US20180148419A1 (en) | 2018-05-31 |
| RS64708B1 (sr) | 2023-11-30 |
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