PT3507287T - Antagonistas do recetor de p2x7 derivados de n-[2-(4- fenoxipiperidin-1-il)-2-(1,3-tiazol-5-il)etil]benzamida e n-[2-(4-benziloxipiperidin-1-il)-2-(1,3-tiazol-5- il)etil]benzamida substituídos - Google Patents
Antagonistas do recetor de p2x7 derivados de n-[2-(4- fenoxipiperidin-1-il)-2-(1,3-tiazol-5-il)etil]benzamida e n-[2-(4-benziloxipiperidin-1-il)-2-(1,3-tiazol-5- il)etil]benzamida substituídosInfo
- Publication number
- PT3507287T PT3507287T PT177551108T PT17755110T PT3507287T PT 3507287 T PT3507287 T PT 3507287T PT 177551108 T PT177551108 T PT 177551108T PT 17755110 T PT17755110 T PT 17755110T PT 3507287 T PT3507287 T PT 3507287T
- Authority
- PT
- Portugal
- Prior art keywords
- thiazol
- ethyl
- benzamide
- benzyloxypiperidin
- phenoxypiperidin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16186655.3A EP3290416A1 (en) | 2016-08-31 | 2016-08-31 | Substituted n-[2-(4-phenoxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide and n-[2-(4-benzyloxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide derivatives and their use as p2x7 receptor antagonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3507287T true PT3507287T (pt) | 2020-09-04 |
Family
ID=56852153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT177551108T PT3507287T (pt) | 2016-08-31 | 2017-08-09 | Antagonistas do recetor de p2x7 derivados de n-[2-(4- fenoxipiperidin-1-il)-2-(1,3-tiazol-5-il)etil]benzamida e n-[2-(4-benziloxipiperidin-1-il)-2-(1,3-tiazol-5- il)etil]benzamida substituídos |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10669267B2 (pt) |
| EP (2) | EP3290416A1 (pt) |
| JP (1) | JP6957595B2 (pt) |
| CN (1) | CN109689650B (pt) |
| CA (1) | CA3031354A1 (pt) |
| DK (1) | DK3507287T3 (pt) |
| ES (1) | ES2816204T3 (pt) |
| HU (1) | HUE050040T2 (pt) |
| IL (1) | IL264708B (pt) |
| PL (1) | PL3507287T3 (pt) |
| PT (1) | PT3507287T (pt) |
| RU (1) | RU2755705C2 (pt) |
| SI (1) | SI3507287T1 (pt) |
| WO (1) | WO2018041563A1 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4015039A1 (en) | 2020-12-18 | 2022-06-22 | AXXAM S.p.A. | Heterocyclic derivatives as p2x7 receptor antagonists |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10237722A1 (de) * | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
| DE602004005033T2 (de) | 2003-05-12 | 2007-08-09 | Pfizer Products Inc., Groton | Benzamidinhibitoren des p2x7-rezeptors |
| WO2009108551A2 (en) | 2008-02-25 | 2009-09-03 | H. Lundbeck A/S | Heteroaryl amide analogues |
| KR101598397B1 (ko) | 2008-04-22 | 2016-02-29 | 얀센 파마슈티카 엔.브이. | 퀴놀린 또는 이소퀴놀린 치환된 피2엑스7 안타고니스트 |
| US9718774B2 (en) * | 2012-12-12 | 2017-08-01 | Idorsia Pharmaceuticals Ltd | Indole carboxamide derivatives as P2X7 receptor antagonist |
| JP6285736B2 (ja) | 2014-02-04 | 2018-02-28 | 株式会社ソニー・インタラクティブエンタテインメント | 情報処理装置および入力デバイスの割当方法 |
| EP2905282A1 (en) | 2014-02-05 | 2015-08-12 | AXXAM S.p.A. | Substituted thiazole or oxazole as P2X7 receptor antagonists |
-
2016
- 2016-08-31 EP EP16186655.3A patent/EP3290416A1/en not_active Withdrawn
-
2017
- 2017-08-09 PL PL17755110T patent/PL3507287T3/pl unknown
- 2017-08-09 JP JP2019503211A patent/JP6957595B2/ja active Active
- 2017-08-09 DK DK17755110.8T patent/DK3507287T3/da active
- 2017-08-09 HU HUE17755110A patent/HUE050040T2/hu unknown
- 2017-08-09 EP EP17755110.8A patent/EP3507287B1/en active Active
- 2017-08-09 CA CA3031354A patent/CA3031354A1/en active Pending
- 2017-08-09 CN CN201780049645.6A patent/CN109689650B/zh active Active
- 2017-08-09 ES ES17755110T patent/ES2816204T3/es active Active
- 2017-08-09 PT PT177551108T patent/PT3507287T/pt unknown
- 2017-08-09 US US16/327,854 patent/US10669267B2/en active Active
- 2017-08-09 RU RU2019106209A patent/RU2755705C2/ru active
- 2017-08-09 WO PCT/EP2017/070163 patent/WO2018041563A1/en active Search and Examination
- 2017-08-09 SI SI201730370T patent/SI3507287T1/sl unknown
-
2019
- 2019-02-07 IL IL264708A patent/IL264708B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JP6957595B2 (ja) | 2021-11-02 |
| RU2019106209A3 (pt) | 2020-10-01 |
| EP3507287A1 (en) | 2019-07-10 |
| CN109689650B (zh) | 2022-11-25 |
| SI3507287T1 (sl) | 2020-09-30 |
| PL3507287T3 (pl) | 2020-12-28 |
| CA3031354A1 (en) | 2018-03-08 |
| IL264708B (en) | 2021-04-29 |
| RU2755705C2 (ru) | 2021-09-20 |
| CN109689650A (zh) | 2019-04-26 |
| RU2019106209A (ru) | 2020-10-01 |
| US10669267B2 (en) | 2020-06-02 |
| HUE050040T2 (hu) | 2020-11-30 |
| EP3507287B1 (en) | 2020-07-15 |
| US20190194180A1 (en) | 2019-06-27 |
| ES2816204T3 (es) | 2021-03-31 |
| EP3290416A1 (en) | 2018-03-07 |
| JP2019524750A (ja) | 2019-09-05 |
| DK3507287T3 (da) | 2020-08-24 |
| WO2018041563A1 (en) | 2018-03-08 |
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