HUE050040T2 - Szubsztituált n-[2-(4-fenoxipiperidin-1-il)-2-(1,3-tiazol-5-il)etil]benzamid és n-[2-(4-benziloxipiperidin-1-il)-2-(1,3-tiazol-5-il)etil]benzamid származékok mint P2X7 receptor antagonisták - Google Patents
Szubsztituált n-[2-(4-fenoxipiperidin-1-il)-2-(1,3-tiazol-5-il)etil]benzamid és n-[2-(4-benziloxipiperidin-1-il)-2-(1,3-tiazol-5-il)etil]benzamid származékok mint P2X7 receptor antagonistákInfo
- Publication number
- HUE050040T2 HUE050040T2 HUE17755110A HUE17755110A HUE050040T2 HU E050040 T2 HUE050040 T2 HU E050040T2 HU E17755110 A HUE17755110 A HU E17755110A HU E17755110 A HUE17755110 A HU E17755110A HU E050040 T2 HUE050040 T2 HU E050040T2
- Authority
- HU
- Hungary
- Prior art keywords
- thiazol
- ethyl
- benzamide
- benzyloxypiperidin
- phenoxypiperidin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16186655.3A EP3290416A1 (en) | 2016-08-31 | 2016-08-31 | Substituted n-[2-(4-phenoxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide and n-[2-(4-benzyloxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide derivatives and their use as p2x7 receptor antagonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE050040T2 true HUE050040T2 (hu) | 2020-11-30 |
Family
ID=56852153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE17755110A HUE050040T2 (hu) | 2016-08-31 | 2017-08-09 | Szubsztituált n-[2-(4-fenoxipiperidin-1-il)-2-(1,3-tiazol-5-il)etil]benzamid és n-[2-(4-benziloxipiperidin-1-il)-2-(1,3-tiazol-5-il)etil]benzamid származékok mint P2X7 receptor antagonisták |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10669267B2 (hu) |
| EP (2) | EP3290416A1 (hu) |
| JP (1) | JP6957595B2 (hu) |
| CN (1) | CN109689650B (hu) |
| CA (1) | CA3031354A1 (hu) |
| DK (1) | DK3507287T3 (hu) |
| ES (1) | ES2816204T3 (hu) |
| HU (1) | HUE050040T2 (hu) |
| IL (1) | IL264708B (hu) |
| PL (1) | PL3507287T3 (hu) |
| PT (1) | PT3507287T (hu) |
| RU (1) | RU2755705C2 (hu) |
| SI (1) | SI3507287T1 (hu) |
| WO (1) | WO2018041563A1 (hu) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4015039A1 (en) | 2020-12-18 | 2022-06-22 | AXXAM S.p.A. | Heterocyclic derivatives as p2x7 receptor antagonists |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10237722A1 (de) * | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
| ES2396565T3 (es) | 2003-05-12 | 2013-02-22 | Pah Usa 15 Llc | Inhibidores benzamida del receptor P2X7 |
| WO2009108551A2 (en) | 2008-02-25 | 2009-09-03 | H. Lundbeck A/S | Heteroaryl amide analogues |
| ATE533762T1 (de) | 2008-04-22 | 2011-12-15 | Janssen Pharmaceutica Nv | Chinolin- oder isochinolinsubstituierte p2x7- antagonisten |
| AU2013356850B2 (en) * | 2012-12-12 | 2018-02-01 | Idorsia Pharmaceuticals Ltd | Indole carboxamide derivatives as P2X7 receptor antagonists |
| JP6285736B2 (ja) | 2014-02-04 | 2018-02-28 | 株式会社ソニー・インタラクティブエンタテインメント | 情報処理装置および入力デバイスの割当方法 |
| EP2905282A1 (en) | 2014-02-05 | 2015-08-12 | AXXAM S.p.A. | Substituted thiazole or oxazole as P2X7 receptor antagonists |
-
2016
- 2016-08-31 EP EP16186655.3A patent/EP3290416A1/en not_active Withdrawn
-
2017
- 2017-08-09 CN CN201780049645.6A patent/CN109689650B/zh active Active
- 2017-08-09 HU HUE17755110A patent/HUE050040T2/hu unknown
- 2017-08-09 CA CA3031354A patent/CA3031354A1/en active Pending
- 2017-08-09 RU RU2019106209A patent/RU2755705C2/ru active
- 2017-08-09 ES ES17755110T patent/ES2816204T3/es active Active
- 2017-08-09 DK DK17755110.8T patent/DK3507287T3/da active
- 2017-08-09 WO PCT/EP2017/070163 patent/WO2018041563A1/en active Search and Examination
- 2017-08-09 EP EP17755110.8A patent/EP3507287B1/en active Active
- 2017-08-09 US US16/327,854 patent/US10669267B2/en active Active
- 2017-08-09 PT PT177551108T patent/PT3507287T/pt unknown
- 2017-08-09 PL PL17755110T patent/PL3507287T3/pl unknown
- 2017-08-09 JP JP2019503211A patent/JP6957595B2/ja active Active
- 2017-08-09 SI SI201730370T patent/SI3507287T1/sl unknown
-
2019
- 2019-02-07 IL IL264708A patent/IL264708B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ES2816204T3 (es) | 2021-03-31 |
| PT3507287T (pt) | 2020-09-04 |
| JP2019524750A (ja) | 2019-09-05 |
| RU2019106209A3 (hu) | 2020-10-01 |
| JP6957595B2 (ja) | 2021-11-02 |
| US20190194180A1 (en) | 2019-06-27 |
| EP3507287B1 (en) | 2020-07-15 |
| PL3507287T3 (pl) | 2020-12-28 |
| CA3031354A1 (en) | 2018-03-08 |
| EP3290416A1 (en) | 2018-03-07 |
| RU2019106209A (ru) | 2020-10-01 |
| WO2018041563A1 (en) | 2018-03-08 |
| CN109689650B (zh) | 2022-11-25 |
| SI3507287T1 (sl) | 2020-09-30 |
| DK3507287T3 (da) | 2020-08-24 |
| EP3507287A1 (en) | 2019-07-10 |
| IL264708B (en) | 2021-04-29 |
| US10669267B2 (en) | 2020-06-02 |
| CN109689650A (zh) | 2019-04-26 |
| RU2755705C2 (ru) | 2021-09-20 |
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