PT3486249T - 99mtc-edda/hynic-ipsma como um radiofármaco para a deteção da hiperexpressão do antigénio da membrana específico da próstata - Google Patents
99mtc-edda/hynic-ipsma como um radiofármaco para a deteção da hiperexpressão do antigénio da membrana específico da próstataInfo
- Publication number
- PT3486249T PT3486249T PT178157723T PT17815772T PT3486249T PT 3486249 T PT3486249 T PT 3486249T PT 178157723 T PT178157723 T PT 178157723T PT 17815772 T PT17815772 T PT 17815772T PT 3486249 T PT3486249 T PT 3486249T
- Authority
- PT
- Portugal
- Prior art keywords
- ipsma
- edda
- hynic
- 99mtc
- radiopharmaceutical
- Prior art date
Links
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 title 1
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 title 1
- 230000002018 overexpression Effects 0.000 title 1
- 229940121896 radiopharmaceutical Drugs 0.000 title 1
- 239000012217 radiopharmaceutical Substances 0.000 title 1
- 230000002799 radiopharmaceutical effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
- A61K35/04—Tars; Bitumens; Mineral oils; Ammonium bituminosulfonate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Oncology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2016008466A MX2016008466A (es) | 2016-06-24 | 2016-06-24 | 99mtc-edda/hynic-ipsma como un radiofarmaco para la deteccion de la sobre-expresion del antigeno prostatico de membrana. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3486249T true PT3486249T (pt) | 2022-02-02 |
Family
ID=60783979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT178157723T PT3486249T (pt) | 2016-06-24 | 2017-06-21 | 99mtc-edda/hynic-ipsma como um radiofármaco para a deteção da hiperexpressão do antigénio da membrana específico da próstata |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10918745B2 (pt) |
| EP (2) | EP4083049A3 (pt) |
| CN (1) | CN109641924B (pt) |
| BR (1) | BR112018076593B1 (pt) |
| CA (1) | CA3059545C (pt) |
| DK (1) | DK3486249T3 (pt) |
| EA (1) | EA201892668A1 (pt) |
| ES (1) | ES2906332T3 (pt) |
| HU (1) | HUE057891T2 (pt) |
| MA (1) | MA45687A (pt) |
| MX (1) | MX2016008466A (pt) |
| PL (1) | PL3486249T3 (pt) |
| PT (1) | PT3486249T (pt) |
| WO (1) | WO2017222362A1 (pt) |
| ZA (1) | ZA201807828B (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2018003175A (es) * | 2018-03-14 | 2019-09-16 | Instituto Nac De Investigaciones Nucleares | 177lu-dota-hynic-ipsma como un radiofarmaco terapeutico dirigido al antigeno prostatico especifico de membrana. |
| PL239934B1 (pl) * | 2019-04-12 | 2022-01-31 | Narodowe Centrum Badan Jadrowych Osrodek Radioizotopow Polatom | Pochodne inhibitorów PSMA do znakowania ⁹⁹ᵐTc poprzez HYNIC, zestaw radiofarmaceutyczny, preparat radiofarmaceutyczny oraz ich zastosowanie w diagnostyce raka prostaty |
| CN111233758B (zh) * | 2020-03-02 | 2021-04-23 | 北京大学第一医院 | 一种psma抑制剂及其应用和靶向psma的核素成像试剂 |
| CN111253465A (zh) * | 2020-03-03 | 2020-06-09 | 复旦大学附属肿瘤医院 | 一种psma结合剂及其用途 |
| JP2023522983A (ja) * | 2020-04-24 | 2023-06-01 | ラジオメディックス インコーポレイテッド | 前立腺がんの診断および処置のための組成物、キットおよび方法 |
| MX2021005089A (es) * | 2021-04-30 | 2022-11-01 | Instituto Nac De Investigaciones Nucleares | Radiofarmacos basados en el acido ((r)-1-((6-hidrazinilnicotinoil) d-alanil)pirrolidin-2-il)boronico (hynic-ifap) para la deteccion de la sobreexpresion de la proteina de activacion de fibrolastos. |
| US20240238460A1 (en) | 2021-05-31 | 2024-07-18 | Telix Pharmaceuticals (Innovations) Pty Ltd | Improved prostate-specific membrane antigen targeting radiopharmaceuticals and uses thereof |
| WO2023030509A1 (zh) * | 2021-09-03 | 2023-03-09 | 晶核生物医药科技(南京)有限公司 | 一种肽脲素衍生物、含其的药物组合物及其应用 |
| CN114569744A (zh) * | 2022-03-08 | 2022-06-03 | 安徽淮仁堂药业股份有限公司 | 一种锝前列腺标特异性膜抗原显像剂试剂盒及其制备方法和应用 |
| CN115260155B (zh) * | 2022-08-08 | 2023-11-10 | 北京师范大学 | 一种含三唑环和肼基尼古酰胺基的谷氨酸-脲衍生物及其应用 |
| CN117434270B (zh) * | 2023-09-11 | 2024-05-07 | 江苏省人民医院（南京医科大学第一附属医院） | 一种可携带放射性信号的蛋白质支架及其抗体检测中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9044468B2 (en) | 2007-06-26 | 2015-06-02 | The Johns Hopkins University | Labeled inhibitors of prostate specific membrane antigen (PSMA), biological evaluation, and use as imaging agents |
| MX336322B (es) | 2010-04-08 | 2016-01-12 | Inst Nac De Investigaciones Nucleares | 99mtc-edda/hynic-ggc-aunp-manosa como un nuevo radiofarmaco para la deteccion del ganglio centinela en cancer de mama. |
| CN102949735B (zh) * | 2011-08-30 | 2015-06-10 | 北京大基康明医疗设备有限公司 | 放射性药物的制备方法及系统 |
| CN104244991A (zh) * | 2012-04-10 | 2014-12-24 | 蓝瑟斯医学影像公司 | 放射性药物合成方法 |
| WO2016062370A1 (en) * | 2014-10-20 | 2016-04-28 | Deutsches Krebsforschungszentrum | 18f-tagged inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
-
2016
- 2016-06-24 MX MX2016008466A patent/MX2016008466A/es unknown
-
2017
- 2017-06-21 US US16/310,744 patent/US10918745B2/en active Active
- 2017-06-21 DK DK17815772.3T patent/DK3486249T3/da active
- 2017-06-21 HU HUE17815772A patent/HUE057891T2/hu unknown
- 2017-06-21 MA MA045687A patent/MA45687A/fr unknown
- 2017-06-21 CA CA3059545A patent/CA3059545C/en active Active
- 2017-06-21 CN CN201780049494.4A patent/CN109641924B/zh active Active
- 2017-06-21 ES ES17815772T patent/ES2906332T3/es active Active
- 2017-06-21 EA EA201892668A patent/EA201892668A1/ru unknown
- 2017-06-21 EP EP21205156.9A patent/EP4083049A3/en active Pending
- 2017-06-21 BR BR112018076593-7A patent/BR112018076593B1/pt active IP Right Grant
- 2017-06-21 WO PCT/MX2017/000068 patent/WO2017222362A1/es unknown
- 2017-06-21 EP EP17815772.3A patent/EP3486249B1/en active Active
- 2017-06-21 PL PL17815772T patent/PL3486249T3/pl unknown
- 2017-06-21 PT PT178157723T patent/PT3486249T/pt unknown
-
2018
- 2018-11-20 ZA ZA2018/07828A patent/ZA201807828B/en unknown
-
2020
- 2020-12-28 US US17/135,424 patent/US11547767B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3486249A1 (en) | 2019-05-22 |
| ES2906332T3 (es) | 2022-04-18 |
| MX2016008466A (es) | 2017-12-25 |
| WO2017222362A1 (es) | 2017-12-28 |
| US20210187132A1 (en) | 2021-06-24 |
| BR112018076593A2 (pt) | 2019-04-16 |
| EP4083049A2 (en) | 2022-11-02 |
| DK3486249T3 (da) | 2022-02-07 |
| CA3059545C (en) | 2021-07-27 |
| EP3486249A4 (en) | 2020-03-11 |
| PL3486249T3 (pl) | 2022-05-23 |
| BR112018076593B1 (pt) | 2022-05-24 |
| US20190343970A1 (en) | 2019-11-14 |
| HUE057891T2 (hu) | 2022-06-28 |
| EP4083049A3 (en) | 2022-12-21 |
| MA45687A (fr) | 2021-03-31 |
| CA3059545A1 (en) | 2017-12-28 |
| US10918745B2 (en) | 2021-02-16 |
| EA201892668A1 (ru) | 2019-10-31 |
| US11547767B2 (en) | 2023-01-10 |
| CN109641924A (zh) | 2019-04-16 |
| ZA201807828B (en) | 2021-03-31 |
| CN109641924B (zh) | 2022-02-25 |
| EP3486249B1 (en) | 2021-11-10 |
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