PT3341355T - Ácido (s)-3-amino-4-(difluorometilenil)ciclopent-1-eno-1-carboxílico e compostos relacionados como inativadores de gaba aminotransferase para o tratamento de epilepsia, dependência e carcinoma hepatocelar - Google Patents
Ácido (s)-3-amino-4-(difluorometilenil)ciclopent-1-eno-1-carboxílico e compostos relacionados como inativadores de gaba aminotransferase para o tratamento de epilepsia, dependência e carcinoma hepatocelarInfo
- Publication number
- PT3341355T PT3341355T PT168545317T PT16854531T PT3341355T PT 3341355 T PT3341355 T PT 3341355T PT 168545317 T PT168545317 T PT 168545317T PT 16854531 T PT16854531 T PT 16854531T PT 3341355 T PT3341355 T PT 3341355T
- Authority
- PT
- Portugal
- Prior art keywords
- difluoromethylenyl
- cyclopent
- addiction
- epilepsy
- ene
- Prior art date
Links
- 108010060511 4-Aminobutyrate Transaminase Proteins 0.000 title 1
- 102100035923 4-aminobutyrate aminotransferase, mitochondrial Human genes 0.000 title 1
- 206010012335 Dependence Diseases 0.000 title 1
- FBLNZOCTNRXJQD-YFKPBYRVSA-N N[C@H]1C=C(CC1=C(F)F)C(O)=O Chemical compound N[C@H]1C=C(CC1=C(F)F)C(O)=O FBLNZOCTNRXJQD-YFKPBYRVSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 206010015037 epilepsy Diseases 0.000 title 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 title 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 title 1
- 230000000937 inactivator Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562239330P | 2015-10-09 | 2015-10-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3341355T true PT3341355T (pt) | 2020-10-21 |
Family
ID=58488679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT168545317T PT3341355T (pt) | 2015-10-09 | 2016-10-10 | Ácido (s)-3-amino-4-(difluorometilenil)ciclopent-1-eno-1-carboxílico e compostos relacionados como inativadores de gaba aminotransferase para o tratamento de epilepsia, dependência e carcinoma hepatocelar |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US9670141B2 (pt) |
| EP (1) | EP3341355B1 (pt) |
| JP (1) | JP6841821B2 (pt) |
| KR (1) | KR20180052782A (pt) |
| CN (1) | CN108137484B (pt) |
| AU (1) | AU2016334396B2 (pt) |
| BR (1) | BR112018007026B1 (pt) |
| CA (1) | CA3001330A1 (pt) |
| CL (1) | CL2018000914A1 (pt) |
| CO (1) | CO2018003828A2 (pt) |
| DK (1) | DK3341355T3 (pt) |
| ES (1) | ES2825349T3 (pt) |
| HK (1) | HK1253002A1 (pt) |
| HU (1) | HUE053429T2 (pt) |
| IL (1) | IL258516A (pt) |
| LT (1) | LT3341355T (pt) |
| MX (1) | MX2018004302A (pt) |
| PE (1) | PE20190349A1 (pt) |
| PL (1) | PL3341355T3 (pt) |
| PT (1) | PT3341355T (pt) |
| WO (1) | WO2017062942A2 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3341355T3 (pl) * | 2015-10-09 | 2021-03-08 | Northwestern University | Kwas (S)-3-amino-4-(difluorometylenylo)cyklopent-1-eno-1-karboksylowy i związki pokrewne jako dezaktywatory aminotransferazy GABA do leczenia padaczki, uzależnienia oraz raka wątrobowokomórkowego |
| IL310065A (en) * | 2017-02-08 | 2024-03-01 | Ovid Therapeutics Inc | Methods for treating seizure disorders and Prader-Willi syndrome |
| US11771671B2 (en) | 2018-02-08 | 2023-10-03 | Ovid Therapeutics Inc. | Use of (1S,3S)-3-amino-4-(difluoromethylidene) cyclopentane-1-carboxylic acid and (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid in the treatment of tinnitus, acute sensorineural hearing loss, Meniere's disease, Tourette's syndrome, attention deficit hyperactivity disorder and addiction |
| JP2021512920A (ja) * | 2018-02-08 | 2021-05-20 | オービッド・セラピューティクス・インコーポレイテッドＯｖｉｄ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 耳鳴、急性感音性難聴、メニエール病、トゥレット症候群、注意欠陥多動性障害、および嗜癖の治療における（１ｓ，３ｓ）−３−アミノ−４−（ジフルオロメチリデン）シクロペンタン−１−カルボン酸および（ｓ）−３−アミノ−４−（ジフルオロメチルエニル）シクロペンタ−１−エン−１−カルボン酸の使用 |
| EP3758693A4 (en) * | 2018-03-29 | 2021-06-02 | Ovid Therapeutics Inc. | USE OF (1S, 3S) -3-AMINO-4- (DIFLUOROMETHYLIDENE) CYCLOPENTANE-1-CARBOXYLIC ACID AND (S) -3-AMINO-4- (DIFLUOROMETHYLENYL) CYCLOPENT-1-ENE-1 -CARBOXYLIC IN THE TREATMENT OF EYE DISORDERS |
| US10822301B2 (en) | 2018-04-12 | 2020-11-03 | Northwestern University | 3-carbon substituted 4-aminocyclopent-1-ene-1-carboxylic acid compounds as inhibitors of gamma-aminobutyric acid (GABA) aminotransferase |
| MX2020012691A (es) * | 2018-05-25 | 2021-02-15 | Univ Northwestern | Proceso para la sintesis del acido (s)-3-amino-4-(difluorometileni l)ciclopent-1-eno-1-carboxilico. |
| AU2019280980A1 (en) * | 2018-06-07 | 2021-01-07 | Ovid Therapeutics Inc. | Use of (S)-3-amino-4-(difluoromethylenyl) cyclopent-1-ene-1-carboxylic acid and related compounds, (1S,3S)-3-amino-4-(difluoromethylidene) cyclopentane-1-carboxylic acid and vigabatrin in the treatment of developmental disorders |
| US11203596B2 (en) | 2019-02-25 | 2021-12-21 | Northwestern University | Analogs of 3-amino-4-(propan-2-ylidene)cyclopentane-1-carboxylic acid and uses thereof for treating diseases and disorders associated with ornithine aminotransferase activity |
| WO2020206234A1 (en) | 2019-04-03 | 2020-10-08 | Northwestern University | 2-difluoro substituted 4-aminocyclopentanecarboxylic acids as inhibitors of gamma-aminobutyric acid aminotransferase and human ornithine aminotransferase |
| CN110935495B (zh) * | 2019-11-29 | 2021-02-23 | 中国科学院电子学研究所 | Gaba和电生理微纳同步传感检测芯片及其制备方法 |
| US11993569B2 (en) | 2020-01-23 | 2024-05-28 | Northwestern University | 3-amino-4-halocyclopentene carboxylic acids as inactivators of aminotransferases |
| EP4301724A1 (en) * | 2021-03-03 | 2024-01-10 | Northwestern University | (s)-3-amino-4,4-dihalocyclopent-1-enecarboxylic acid as selective inactivators of human ornithine aminotransferase |
| US20240009160A1 (en) * | 2022-07-06 | 2024-01-11 | Ovid Therapeutics, Inc. | Use of (s)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid in the treatment of cancer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6794413B1 (en) * | 2002-07-19 | 2004-09-21 | Northwestern University | Compounds and related methods for inhibition of γ-aminobutyric acid aminotransferase |
| IL177609A (en) * | 2006-08-21 | 2015-11-30 | Yaron Ilan | Use of gobacoline or its analogue to produce a drug to treat liver carcinoma |
| EP2542234A4 (en) * | 2010-02-25 | 2013-07-31 | Univ Northwestern | METHODS OF USING (1S, 3S) -3-AMINO-4-DIFLUOROMETHYLENYL-1-CYCLOPENTANOIC ACID |
| AR087700A1 (es) * | 2011-08-30 | 2014-04-09 | Gilead Sciences Inc | Inhibidores de aldh-2 en el tratamiento de adicciones |
| PL3341355T3 (pl) * | 2015-10-09 | 2021-03-08 | Northwestern University | Kwas (S)-3-amino-4-(difluorometylenylo)cyklopent-1-eno-1-karboksylowy i związki pokrewne jako dezaktywatory aminotransferazy GABA do leczenia padaczki, uzależnienia oraz raka wątrobowokomórkowego |
-
2016
- 2016-10-10 PL PL16854531T patent/PL3341355T3/pl unknown
- 2016-10-10 LT LTEP16854531.7T patent/LT3341355T/lt unknown
- 2016-10-10 DK DK16854531.7T patent/DK3341355T3/da active
- 2016-10-10 ES ES16854531T patent/ES2825349T3/es active Active
- 2016-10-10 JP JP2018517734A patent/JP6841821B2/ja active Active
- 2016-10-10 CA CA3001330A patent/CA3001330A1/en active Pending
- 2016-10-10 CN CN201680059069.9A patent/CN108137484B/zh active Active
- 2016-10-10 HU HUE16854531A patent/HUE053429T2/hu unknown
- 2016-10-10 EP EP16854531.7A patent/EP3341355B1/en active Active
- 2016-10-10 AU AU2016334396A patent/AU2016334396B2/en active Active
- 2016-10-10 PT PT168545317T patent/PT3341355T/pt unknown
- 2016-10-10 BR BR112018007026-2A patent/BR112018007026B1/pt active IP Right Grant
- 2016-10-10 KR KR1020187013228A patent/KR20180052782A/ko not_active Application Discontinuation
- 2016-10-10 US US15/289,480 patent/US9670141B2/en active Active
- 2016-10-10 MX MX2018004302A patent/MX2018004302A/es unknown
- 2016-10-10 PE PE2018000517A patent/PE20190349A1/es unknown
- 2016-10-10 WO PCT/US2016/056245 patent/WO2017062942A2/en active Application Filing
-
2017
- 2017-05-04 US US15/586,730 patent/US9993449B2/en active Active
-
2018
- 2018-04-05 IL IL258516A patent/IL258516A/en active IP Right Grant
- 2018-04-09 CL CL2018000914A patent/CL2018000914A1/es unknown
- 2018-04-10 CO CONC2018/0003828A patent/CO2018003828A2/es unknown
- 2018-05-29 US US15/991,323 patent/US20180271816A1/en not_active Abandoned
- 2018-09-26 HK HK18112366.1A patent/HK1253002A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUE053429T2 (hu) | 2021-07-28 |
| JP2018531941A (ja) | 2018-11-01 |
| US20170239202A1 (en) | 2017-08-24 |
| CO2018003828A2 (es) | 2018-07-19 |
| BR112018007026B1 (pt) | 2022-06-21 |
| LT3341355T (lt) | 2020-11-10 |
| EP3341355A4 (en) | 2019-04-10 |
| KR20180052782A (ko) | 2018-05-18 |
| ES2825349T3 (es) | 2021-05-17 |
| CL2018000914A1 (es) | 2018-08-31 |
| AU2016334396A1 (en) | 2018-04-19 |
| CN108137484B (zh) | 2021-02-12 |
| PE20190349A1 (es) | 2019-03-07 |
| WO2017062942A3 (en) | 2018-03-01 |
| EP3341355B1 (en) | 2020-09-30 |
| JP6841821B2 (ja) | 2021-03-10 |
| US9670141B2 (en) | 2017-06-06 |
| IL258516A (en) | 2018-05-31 |
| US20180271816A1 (en) | 2018-09-27 |
| MX2018004302A (es) | 2018-11-09 |
| CA3001330A1 (en) | 2017-04-13 |
| US9993449B2 (en) | 2018-06-12 |
| BR112018007026A2 (pt) | 2018-10-16 |
| US20170101364A1 (en) | 2017-04-13 |
| PL3341355T3 (pl) | 2021-03-08 |
| HK1253002A1 (zh) | 2019-06-06 |
| WO2017062942A2 (en) | 2017-04-13 |
| CN108137484A (zh) | 2018-06-08 |
| AU2016334396B2 (en) | 2021-04-08 |
| EP3341355A2 (en) | 2018-07-04 |
| DK3341355T3 (da) | 2020-10-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1253002A1 (zh) | 作為用於治療癲癇、成癮和肝細胞癌的gaba氨基轉移酶滅活劑的(s)-3-氨基-4-(二氟亞甲基)環戊-1-烯-1-羧酸及有關化合物 | |
| ZA201708039B (en) | Adenoassociated virus vectors for the treatment of mucopolysaccharidoses | |
| FI3906789T3 (fi) | Initioivia huputettuja oligonukleotidialukkeita 5’-huputettujen RNA:iden syntetisoimiseksi | |
| IL248538A0 (en) | Vector viruses unrelated to the treatment of lysosomal storage disorders | |
| LT3109223T (lt) | Junginys, skirtas karbamido turinčių trąšų apdorojimui | |
| HK1252996A1 (zh) | 用於治療癲癇的方法 | |
| IL252042B (en) | Ornithine aminotransferase inhibition with gaba analogs for the treatment of hepatocellular carcinoma | |
| PT3519569T (pt) | Vetores de vírus adenoassociados para o tratamento de mucopolissacaridoses | |
| IL264950B1 (en) | Combined treatments for the treatment of malignant liver cell carcinoma | |
| HK1258449A1 (zh) | 伊非曲班治療系統性硬化 | |
| ZA201803046B (en) | Process for recovering metals | |
| EP3624800A4 (en) | TREATMENT OF HEPATOCELLULAR CARCINOMA | |
| SG11201708198SA (en) | Methods for the treatment of cardiovascular disorders | |
| GB201603752D0 (en) | Treatment of hypothyroidism | |
| GB201523188D0 (en) | Furan-2-furan diniconazole medicine intermediate acrylonitrile synthesis method | |
| GB201506228D0 (en) | Methods For The Treatment Of Cardivascular Disorders | |
| GB201513991D0 (en) | Methods for the treatment of cardiovascular disorders | |
| GB201513344D0 (en) | Methods for the treatment of Cardiovascular disorders | |
| GB201507109D0 (en) | Methods for the treatment of cardiovascular disorders | |
| ZA201408372B (en) | Therapeutic biologic for treatment of hepatocellular carcinoma |