PT3168230T - Mutante de gdf-5 para induzir formação de cartilagem - Google Patents
Mutante de gdf-5 para induzir formação de cartilagemInfo
- Publication number
- PT3168230T PT3168230T PT16203435T PT16203435T PT3168230T PT 3168230 T PT3168230 T PT 3168230T PT 16203435 T PT16203435 T PT 16203435T PT 16203435 T PT16203435 T PT 16203435T PT 3168230 T PT3168230 T PT 3168230T
- Authority
- PT
- Portugal
- Prior art keywords
- gdf
- mutant
- cartilage formation
- inducing cartilage
- inducing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11191973.4A EP2602264A1 (en) | 2011-12-05 | 2011-12-05 | GDF-5 mutant for inducing cartilage formation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3168230T true PT3168230T (pt) | 2019-01-30 |
Family
ID=47278877
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT16203435T PT3168230T (pt) | 2011-12-05 | 2012-12-05 | Mutante de gdf-5 para induzir formação de cartilagem |
| PT127950111T PT2788374T (pt) | 2011-12-05 | 2012-12-05 | Mutante de gdf-5 para induzir formação de cartilagem |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT127950111T PT2788374T (pt) | 2011-12-05 | 2012-12-05 | Mutante de gdf-5 para induzir formação de cartilagem |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US9718867B2 (pt) |
| EP (3) | EP2602264A1 (pt) |
| JP (1) | JP6185926B2 (pt) |
| KR (1) | KR102067724B1 (pt) |
| CN (1) | CN104039820B (pt) |
| AU (1) | AU2012347305B2 (pt) |
| BR (1) | BR112014013122A2 (pt) |
| CA (1) | CA2856458C (pt) |
| DK (2) | DK2788374T3 (pt) |
| EA (1) | EA028554B1 (pt) |
| ES (2) | ES2630853T3 (pt) |
| HK (1) | HK1198768A1 (pt) |
| HR (2) | HRP20170205T1 (pt) |
| HU (2) | HUE042191T2 (pt) |
| IN (1) | IN2014KN01026A (pt) |
| LT (2) | LT3168230T (pt) |
| MX (1) | MX351809B (pt) |
| PL (2) | PL2788374T3 (pt) |
| PT (2) | PT3168230T (pt) |
| RS (2) | RS55686B1 (pt) |
| SI (2) | SI2788374T1 (pt) |
| TR (1) | TR201901263T4 (pt) |
| WO (1) | WO2013083649A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101639269B1 (ko) | 2015-12-02 | 2016-07-13 | 주식회사 셀루메드 | 알칼라인 포스파타아제 어세이를 개선하기 위한 방법 |
| EP4076502A1 (en) | 2019-12-18 | 2022-10-26 | Merck Patent GmbH | Use of the gdf-5 mutant for the treatment of pain and cartilage destruction |
| CN111701075A (zh) * | 2020-06-24 | 2020-09-25 | 亘元(天津)生物医药科技有限公司 | 一种软骨修复材料、软骨重建生物支架及制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1439190A1 (en) | 1993-01-12 | 2004-07-21 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-5 |
| IL110589A0 (en) | 1993-08-10 | 1994-11-11 | Bioph Biotech Entw Pharm Gmbh | Growth/differentiation factor of the TGF- beta family |
| EP0733109B9 (en) | 1993-12-07 | 2006-07-05 | Genetics Institute, LLC | Bmp-12, bmp-13 and tendon-inducing compositions thereof |
| WO1996014335A1 (en) | 1994-11-07 | 1996-05-17 | The Government Of The United States Of America, Asrepresented By The Secretary, Department Of Health And Human Services | Cartilage-derived morphogenetic proteins |
| BR9608019A (pt) | 1995-04-19 | 1999-11-30 | Hoechst Japan | Uma nova proteína e um processo para a preparação da mesma' |
| JPH0931098A (ja) | 1995-07-24 | 1997-02-04 | Hoechst Japan Ltd | 新規なタンパク質ｈｍｗヒトｍｐ５２ |
| ZA966489B (en) | 1995-08-03 | 1997-02-26 | Bioph Biotech Entw Pharm Gmbh | New protein human MP52 Arg. |
| DE19647853A1 (de) | 1996-11-19 | 1998-05-20 | Bioph Biotech Entw Pharm Gmbh | Verbindungen mit verbesserter knorpel- und/oder knocheninduzierender Aktivität |
| EP1074620A1 (en) | 1999-08-06 | 2001-02-07 | HyGene AG | Monomeric protein of the TGF-beta family |
| JPH11335398A (ja) | 1998-05-22 | 1999-12-07 | Hoechst Marion Roussel Kk | 新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬 |
| JP2000119192A (ja) | 1998-10-09 | 2000-04-25 | Aventis Pharma Ltd | 骨誘導因子アンタゴニスト活性を有する成熟型蛋白質 |
| DE10026713A1 (de) | 2000-05-30 | 2001-12-06 | Walter Sebald | Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta |
| KR100530299B1 (ko) * | 2003-08-11 | 2005-11-22 | 산도즈 게엠베하 | 변이 세팔로스포린 ｃ 아실라제 및 이를 이용한 7-ａｃａ 제조방법 |
| EP1571159A1 (en) | 2004-03-04 | 2005-09-07 | Bayerische Julius-Maximilians-Universität Würzburg | Mutein of a bone morphogenetic protein and use thereof |
| EP1698691A1 (en) * | 2005-03-04 | 2006-09-06 | Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH | Growth factor mutants with improved biological activity |
| EP1721909A1 (en) | 2005-05-10 | 2006-11-15 | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH | Growth factor mutants with altered biological attributes |
| JP2007054013A (ja) * | 2005-08-26 | 2007-03-08 | Research Institute Of Innovative Technology For The Earth | 耐熱性ｌ−スレオニンアルドラ−ゼおよびそれをコードする遺伝子 |
| AU2006314713B2 (en) * | 2005-11-18 | 2011-10-06 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | High activity growth factor mutants |
| CN103641916A (zh) | 2006-03-27 | 2014-03-19 | 医学免疫有限公司 | Gm-csf受体结合元件 |
| EP1915986A1 (en) | 2006-10-23 | 2008-04-30 | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH | Lipid growth factor formulations |
| CN103079585B (zh) | 2010-08-20 | 2015-09-30 | 惠氏有限责任公司 | 经设计的成骨蛋白 |
-
2011
- 2011-12-05 EP EP11191973.4A patent/EP2602264A1/en not_active Ceased
-
2012
- 2012-12-05 SI SI201230892A patent/SI2788374T1/sl unknown
- 2012-12-05 CA CA2856458A patent/CA2856458C/en active Active
- 2012-12-05 HU HUE16203435A patent/HUE042191T2/hu unknown
- 2012-12-05 WO PCT/EP2012/074549 patent/WO2013083649A1/en active Application Filing
- 2012-12-05 TR TR2019/01263T patent/TR201901263T4/tr unknown
- 2012-12-05 HU HUE12795011A patent/HUE033025T2/en unknown
- 2012-12-05 ES ES12795011.1T patent/ES2630853T3/es active Active
- 2012-12-05 EP EP16203435.9A patent/EP3168230B1/en active Active
- 2012-12-05 MX MX2014006465A patent/MX351809B/es active IP Right Grant
- 2012-12-05 ES ES16203435T patent/ES2708675T3/es active Active
- 2012-12-05 LT LTEP16203435.9T patent/LT3168230T/lt unknown
- 2012-12-05 IN IN1026KON2014 patent/IN2014KN01026A/en unknown
- 2012-12-05 EA EA201491119A patent/EA028554B1/ru not_active IP Right Cessation
- 2012-12-05 RS RS20170146A patent/RS55686B1/sr unknown
- 2012-12-05 KR KR1020147017053A patent/KR102067724B1/ko active IP Right Grant
- 2012-12-05 RS RS20190038A patent/RS58253B1/sr unknown
- 2012-12-05 JP JP2014543942A patent/JP6185926B2/ja active Active
- 2012-12-05 EP EP12795011.1A patent/EP2788374B1/en active Active
- 2012-12-05 PL PL12795011T patent/PL2788374T3/pl unknown
- 2012-12-05 DK DK12795011.1T patent/DK2788374T3/en active
- 2012-12-05 SI SI201231517T patent/SI3168230T1/sl unknown
- 2012-12-05 PL PL16203435T patent/PL3168230T3/pl unknown
- 2012-12-05 AU AU2012347305A patent/AU2012347305B2/en not_active Ceased
- 2012-12-05 DK DK16203435.9T patent/DK3168230T3/en active
- 2012-12-05 CN CN201280058254.8A patent/CN104039820B/zh active Active
- 2012-12-05 PT PT16203435T patent/PT3168230T/pt unknown
- 2012-12-05 PT PT127950111T patent/PT2788374T/pt unknown
- 2012-12-05 BR BR112014013122-8A patent/BR112014013122A2/pt not_active Application Discontinuation
- 2012-12-05 US US14/362,691 patent/US9718867B2/en active Active
- 2012-12-05 LT LTEP12795011.1T patent/LT2788374T/lt unknown
-
2014
- 2014-12-04 HK HK14112248.9A patent/HK1198768A1/xx not_active IP Right Cessation
-
2017
- 2017-02-08 HR HRP20170205TT patent/HRP20170205T1/hr unknown
-
2019
- 2019-01-23 HR HRP20190160TT patent/HRP20190160T8/hr unknown
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