PT3122722T - Forma amorfa de um derivado de tiocolquicina - Google Patents
Forma amorfa de um derivado de tiocolquicinaInfo
- Publication number
- PT3122722T PT3122722T PT15713860T PT15713860T PT3122722T PT 3122722 T PT3122722 T PT 3122722T PT 15713860 T PT15713860 T PT 15713860T PT 15713860 T PT15713860 T PT 15713860T PT 3122722 T PT3122722 T PT 3122722T
- Authority
- PT
- Portugal
- Prior art keywords
- amorphous form
- thiocolchicine derivative
- thiocolchicine
- derivative
- amorphous
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/38—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with the sulfur atom of the thio group bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
- C07C323/44—X or Y being nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
- C07C2603/34—Benzoheptalenes; Hydrogenated benzoheptalenes
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14161945.2A EP2924022A1 (en) | 2014-03-27 | 2014-03-27 | Amorphous form of a thiocolchicine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3122722T true PT3122722T (pt) | 2018-10-18 |
Family
ID=50389871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT15713860T PT3122722T (pt) | 2014-03-27 | 2015-03-26 | Forma amorfa de um derivado de tiocolquicina |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9688625B2 (pt) |
| EP (2) | EP2924022A1 (pt) |
| JP (1) | JP6538711B2 (pt) |
| KR (1) | KR102302055B1 (pt) |
| CN (1) | CN106132927B (pt) |
| AU (1) | AU2015238266B2 (pt) |
| CA (1) | CA2943699C (pt) |
| DK (1) | DK3122722T3 (pt) |
| ES (1) | ES2686882T3 (pt) |
| HU (1) | HUE040059T2 (pt) |
| IL (1) | IL247968B (pt) |
| PL (1) | PL3122722T3 (pt) |
| PT (1) | PT3122722T (pt) |
| RU (1) | RU2684925C2 (pt) |
| SG (1) | SG11201607947XA (pt) |
| SI (1) | SI3122722T1 (pt) |
| WO (1) | WO2015144857A1 (pt) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1291550B1 (it) * | 1997-04-11 | 1999-01-11 | Indena Spa | Derivati della colchicina e della tiocolchicina ad attivita' antinfiammatoria e miorilassante |
| IT1318401B1 (it) * | 2000-03-17 | 2003-08-25 | Indena Spa | Derivati di n-desacetiltiocolchicina e composizioni farmaceutiche cheli contengono. |
| KR100603974B1 (ko) * | 2003-12-05 | 2006-07-25 | 김갑식 | 고체상 지질을 용매로 이용한 나노수준의 또는 비결정질입자의 제조 방법 |
| NZ554541A (en) * | 2004-10-28 | 2011-01-28 | Warner Lambert Co | Process for forming amorphous atorvastatin |
| CA3054535A1 (en) * | 2005-02-18 | 2006-08-24 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| CA2598213C (en) * | 2005-02-18 | 2011-04-19 | Abraxis Bioscience, Inc. | Drugs with improved hydrophobicity for incorporation in medical devices |
| US20070166388A1 (en) * | 2005-02-18 | 2007-07-19 | Desai Neil P | Combinations and modes of administration of therapeutic agents and combination therapy |
| AU2007246277A1 (en) * | 2006-05-04 | 2007-11-15 | Bio-Synectics Inc. | Method for preparing nano-scale particle of active material |
| US20080280987A1 (en) * | 2006-08-31 | 2008-11-13 | Desai Neil P | Methods of inhibiting angiogenesis and treating angiogenesis-associated diseases |
| JP2010502603A (ja) * | 2006-08-31 | 2010-01-28 | アブラクシス バイオサイエンス， エルエルシー | 血管形成を阻害し、血管形成関連疾患を処置する方法 |
| CN101730526A (zh) * | 2007-03-07 | 2010-06-09 | 阿布拉科斯生物科学有限公司 | 作为抗癌剂的包含雷帕霉素和白蛋白的纳米颗粒 |
| CA2755121A1 (en) * | 2009-03-13 | 2010-09-16 | Neil P. Desai | Combination therapy with thiocolchicine derivatives |
-
2014
- 2014-03-27 EP EP14161945.2A patent/EP2924022A1/en not_active Withdrawn
-
2015
- 2015-03-26 KR KR1020167026456A patent/KR102302055B1/ko active IP Right Grant
- 2015-03-26 CA CA2943699A patent/CA2943699C/en active Active
- 2015-03-26 ES ES15713860.3T patent/ES2686882T3/es active Active
- 2015-03-26 DK DK15713860.3T patent/DK3122722T3/en active
- 2015-03-26 PL PL15713860T patent/PL3122722T3/pl unknown
- 2015-03-26 JP JP2016558744A patent/JP6538711B2/ja active Active
- 2015-03-26 EP EP15713860.3A patent/EP3122722B1/en active Active
- 2015-03-26 CN CN201580015791.8A patent/CN106132927B/zh active Active
- 2015-03-26 HU HUE15713860A patent/HUE040059T2/hu unknown
- 2015-03-26 PT PT15713860T patent/PT3122722T/pt unknown
- 2015-03-26 WO PCT/EP2015/056658 patent/WO2015144857A1/en active Application Filing
- 2015-03-26 SG SG11201607947XA patent/SG11201607947XA/en unknown
- 2015-03-26 SI SI201530398T patent/SI3122722T1/sl unknown
- 2015-03-26 AU AU2015238266A patent/AU2015238266B2/en active Active
- 2015-03-26 RU RU2016137943A patent/RU2684925C2/ru active
- 2015-03-26 US US15/124,679 patent/US9688625B2/en active Active
-
2016
- 2016-09-22 IL IL247968A patent/IL247968B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| SI3122722T1 (sl) | 2018-10-30 |
| RU2016137943A (ru) | 2018-04-27 |
| CN106132927B (zh) | 2018-07-27 |
| KR20160138423A (ko) | 2016-12-05 |
| CA2943699A1 (en) | 2015-10-01 |
| KR102302055B1 (ko) | 2021-09-15 |
| DK3122722T3 (en) | 2018-08-13 |
| RU2684925C2 (ru) | 2019-04-16 |
| AU2015238266B2 (en) | 2019-03-07 |
| RU2016137943A3 (pt) | 2018-10-10 |
| ES2686882T3 (es) | 2018-10-22 |
| US9688625B2 (en) | 2017-06-27 |
| HUE040059T2 (hu) | 2019-02-28 |
| EP2924022A1 (en) | 2015-09-30 |
| SG11201607947XA (en) | 2016-10-28 |
| EP3122722B1 (en) | 2018-07-04 |
| AU2015238266A1 (en) | 2016-10-13 |
| JP6538711B2 (ja) | 2019-07-03 |
| JP2017510584A (ja) | 2017-04-13 |
| PL3122722T3 (pl) | 2018-11-30 |
| IL247968B (en) | 2019-03-31 |
| CN106132927A (zh) | 2016-11-16 |
| CA2943699C (en) | 2022-07-12 |
| WO2015144857A1 (en) | 2015-10-01 |
| US20170022155A1 (en) | 2017-01-26 |
| EP3122722A1 (en) | 2017-02-01 |
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