PT3062811T - Intervenções à base de angiopoietina para o tratamento da malária cerebral - Google Patents
Intervenções à base de angiopoietina para o tratamento da malária cerebralInfo
- Publication number
- PT3062811T PT3062811T PT14800207T PT14800207T PT3062811T PT 3062811 T PT3062811 T PT 3062811T PT 14800207 T PT14800207 T PT 14800207T PT 14800207 T PT14800207 T PT 14800207T PT 3062811 T PT3062811 T PT 3062811T
- Authority
- PT
- Portugal
- Prior art keywords
- angiopoietin
- cerebral malaria
- treating cerebral
- based interventions
- interventions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/49—Cinchonan derivatives, e.g. quinine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
- A61K38/1866—Vascular endothelial growth factor [VEGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1891—Angiogenesic factors; Angiogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/515—Angiogenesic factors; Angiogenin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361898539P | 2013-11-01 | 2013-11-01 | |
| US201462040514P | 2014-08-22 | 2014-08-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3062811T true PT3062811T (pt) | 2019-06-11 |
Family
ID=51932597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT14800207T PT3062811T (pt) | 2013-11-01 | 2014-10-31 | Intervenções à base de angiopoietina para o tratamento da malária cerebral |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US9592271B2 (pt) |
| EP (1) | EP3062811B1 (pt) |
| JP (1) | JP2016537416A (pt) |
| KR (1) | KR20160099085A (pt) |
| CN (1) | CN105873599A (pt) |
| AU (1) | AU2014342162B2 (pt) |
| CA (1) | CA2928852A1 (pt) |
| CY (1) | CY1121710T1 (pt) |
| DK (1) | DK3062811T3 (pt) |
| ES (1) | ES2727532T3 (pt) |
| HR (1) | HRP20191070T1 (pt) |
| HU (1) | HUE044660T2 (pt) |
| LT (1) | LT3062811T (pt) |
| MX (1) | MX2016005446A (pt) |
| PL (1) | PL3062811T3 (pt) |
| PT (1) | PT3062811T (pt) |
| RS (1) | RS59000B1 (pt) |
| SI (1) | SI3062811T1 (pt) |
| WO (1) | WO2015066426A2 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2494108C2 (ru) | 2006-04-07 | 2013-09-27 | Аерпио Терапетикс, Инк. | Антитела, которые связывают человеческий белок бета-тирозин фосфатазу (нртрвета), и их использование |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| MX2011007420A (es) | 2009-07-06 | 2011-12-14 | Akebia Therapeutics Inc | Compuestos, composiciones y metodos para prevenir la metastasis de las celulas cancerigenas. |
| CN104039351A (zh) | 2011-10-13 | 2014-09-10 | 阿尔皮奥治疗学股份有限公司 | 用于治疗血管渗漏综合征和癌症的方法 |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| LT3062811T (lt) | 2013-11-01 | 2019-05-10 | Regeneron Pharmaceuticals, Inc. | Intervencijos angiopoietino pagrindu cerebrinės maliarijos gydymui |
| JP6483148B2 (ja) | 2014-03-14 | 2019-03-13 | エアーピオ セラピューティクス インコーポレイテッド | ＨＰＴＰ−β阻害剤 |
| EP3352856B1 (en) | 2015-09-23 | 2021-08-18 | Aerpio Pharmaceuticals, Inc. | Activators of tie-2 for use in treating intraocular pressure |
| EP3370757B1 (en) * | 2015-11-06 | 2021-04-14 | Regeneron Pharmaceuticals, Inc. | Angiopoietins for use in promoting blood coagulation and in the treatment of blood coagulation disorders |
| US20220010281A1 (en) | 2018-10-29 | 2022-01-13 | Ottawa Hospital Research Institute | Genetically-engineered mesenchymal stem cells overexpressing aoah and uses thereof |
| WO2020159444A1 (en) * | 2019-01-30 | 2020-08-06 | Agency For Science, Technology And Research | Use of igfbp7 for treating malaria |
| AU2020264969A1 (en) | 2019-04-29 | 2021-12-09 | EyePoint Pharmaceuticals, Inc. | Tie-2 activators targeting the schlemm's canal |
| CN110687289B (zh) * | 2019-10-17 | 2023-04-18 | 中国人民解放军陆军军医大学 | Fgl2蛋白作为疟疾感染标志物的应用 |
| US20230103583A1 (en) * | 2020-02-28 | 2023-04-06 | Northwestern University | Method of enhancing aqueous humor outflow and reducing intraocular pressure |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1025193A (en) | 1911-03-01 | 1912-05-07 | Oliver Jefferson Kennedy | Foldable holder for writing-pads. |
| EP1141294B1 (en) | 1998-12-23 | 2005-03-02 | Regeneron Pharmaceuticals, Inc. | Method of enhancing the biological activity of ligands |
| EP2457578B1 (en) | 2004-09-28 | 2015-08-19 | Aprogen, Inc. | Chimeric molecule comprising angiopoietin-1 and a coiled-coil domain for use in treating penile erectile dysfunction |
| US20070154482A1 (en) | 2005-09-12 | 2007-07-05 | Beth Israel Deaconess Medical Center | Methods and compositions for the treatment and diagnosis of diseases characterized by vascular leak, hypotension, or a procoagulant state |
| US20120189635A1 (en) | 2009-07-29 | 2012-07-26 | Regeneron Pharmaceuticals, Inc. | Methods for Treating or Preventing Malaria by Administering an Antibody that Specifically Binds Angiopoietin-2 (Ang-2) |
| JO3182B1 (ar) * | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
| WO2011093851A1 (en) | 2010-01-26 | 2011-08-04 | Scott And White Memorial Hospital And Scott, Sherwood, And Brindley Foundation | Method for treatment of vascular hyperpermeability |
| KR20140054303A (ko) | 2011-08-19 | 2014-05-08 | 리제너론 파아마슈티컬스, 인크. | 항-Ｔｉｅ２ 항체 및 이의 용도 |
| LT3062811T (lt) | 2013-11-01 | 2019-05-10 | Regeneron Pharmaceuticals, Inc. | Intervencijos angiopoietino pagrindu cerebrinės maliarijos gydymui |
-
2014
- 2014-10-31 LT LTEP14800207.4T patent/LT3062811T/lt unknown
- 2014-10-31 HU HUE14800207 patent/HUE044660T2/hu unknown
- 2014-10-31 PT PT14800207T patent/PT3062811T/pt unknown
- 2014-10-31 SI SI201431185T patent/SI3062811T1/sl unknown
- 2014-10-31 US US14/529,677 patent/US9592271B2/en active Active
- 2014-10-31 PL PL14800207T patent/PL3062811T3/pl unknown
- 2014-10-31 EP EP14800207.4A patent/EP3062811B1/en active Active
- 2014-10-31 CN CN201480058778.6A patent/CN105873599A/zh active Pending
- 2014-10-31 DK DK14800207.4T patent/DK3062811T3/da active
- 2014-10-31 AU AU2014342162A patent/AU2014342162B2/en not_active Ceased
- 2014-10-31 MX MX2016005446A patent/MX2016005446A/es active IP Right Grant
- 2014-10-31 CA CA2928852A patent/CA2928852A1/en not_active Abandoned
- 2014-10-31 KR KR1020167014463A patent/KR20160099085A/ko not_active Application Discontinuation
- 2014-10-31 JP JP2016552251A patent/JP2016537416A/ja active Pending
- 2014-10-31 ES ES14800207T patent/ES2727532T3/es active Active
- 2014-10-31 RS RS20190841A patent/RS59000B1/sr unknown
- 2014-10-31 WO PCT/US2014/063347 patent/WO2015066426A2/en active Application Filing
-
2017
- 2017-01-25 US US15/414,925 patent/US9968653B2/en not_active Expired - Fee Related
-
2018
- 2018-04-10 US US15/949,472 patent/US10251938B2/en not_active Expired - Fee Related
-
2019
- 2019-02-21 US US16/282,199 patent/US10525106B2/en not_active Expired - Fee Related
- 2019-05-06 CY CY20191100475T patent/CY1121710T1/el unknown
- 2019-06-13 HR HRP20191070TT patent/HRP20191070T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2928852A1 (en) | 2015-05-07 |
| KR20160099085A (ko) | 2016-08-19 |
| MX2016005446A (es) | 2017-01-05 |
| JP2016537416A (ja) | 2016-12-01 |
| HUE044660T2 (hu) | 2019-11-28 |
| EP3062811B1 (en) | 2019-04-03 |
| DK3062811T3 (da) | 2019-05-13 |
| CY1121710T1 (el) | 2020-07-31 |
| CN105873599A (zh) | 2016-08-17 |
| LT3062811T (lt) | 2019-05-10 |
| SI3062811T1 (sl) | 2020-07-31 |
| PL3062811T3 (pl) | 2019-10-31 |
| US9968653B2 (en) | 2018-05-15 |
| US20160045566A1 (en) | 2016-02-18 |
| US10525106B2 (en) | 2020-01-07 |
| US10251938B2 (en) | 2019-04-09 |
| US20190175699A1 (en) | 2019-06-13 |
| WO2015066426A3 (en) | 2015-07-23 |
| US20170136090A1 (en) | 2017-05-18 |
| US9592271B2 (en) | 2017-03-14 |
| EP3062811A2 (en) | 2016-09-07 |
| HRP20191070T1 (hr) | 2019-09-20 |
| RS59000B1 (sr) | 2019-08-30 |
| AU2014342162A1 (en) | 2016-05-26 |
| AU2014342162B2 (en) | 2020-01-02 |
| WO2015066426A2 (en) | 2015-05-07 |
| US20180228870A1 (en) | 2018-08-16 |
| ES2727532T3 (es) | 2019-10-16 |
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