PT2948455T - N-acil-(3-substituído)-(8-substituído)-5,6-diidro-[1,2,4]triazolo[4,3-a]pirazinas como antagonistas de recetor nk-3 seletivos, composição farmacêutica, métodos para utilização em distúrbios mediados por recetor nk-3 - Google Patents

N-acil-(3-substituído)-(8-substituído)-5,6-diidro-[1,2,4]triazolo[4,3-a]pirazinas como antagonistas de recetor nk-3 seletivos, composição farmacêutica, métodos para utilização em distúrbios mediados por recetor nk-3

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Publication number
PT2948455T
PT2948455T PT147138440T PT14713844T PT2948455T PT 2948455 T PT2948455 T PT 2948455T PT 147138440 T PT147138440 T PT 147138440T PT 14713844 T PT14713844 T PT 14713844T PT 2948455 T PT2948455 T PT 2948455T
Authority
PT
Portugal
Prior art keywords
substituted
pyrazines
triazolo
disturbances
dihydro
Prior art date
Application number
PT147138440T
Other languages
English (en)
Portuguese (pt)
Inventor
Fraser Graeme
Dutheuil Guillaume
Hoveyda Hamid
Original Assignee
Ogeda S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ogeda S A filed Critical Ogeda S A
Publication of PT2948455T publication Critical patent/PT2948455T/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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PT147138440T 2013-03-29 2014-03-28 N-acil-(3-substituído)-(8-substituído)-5,6-diidro-[1,2,4]triazolo[4,3-a]pirazinas como antagonistas de recetor nk-3 seletivos, composição farmacêutica, métodos para utilização em distúrbios mediados por recetor nk-3 PT2948455T (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13161863 2013-03-29
EP13193025 2013-11-15
EP14154303 2014-02-07

Publications (1)

Publication Number Publication Date
PT2948455T true PT2948455T (pt) 2017-11-15

Family

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Application Number Title Priority Date Filing Date
PT147138440T PT2948455T (pt) 2013-03-29 2014-03-28 N-acil-(3-substituído)-(8-substituído)-5,6-diidro-[1,2,4]triazolo[4,3-a]pirazinas como antagonistas de recetor nk-3 seletivos, composição farmacêutica, métodos para utilização em distúrbios mediados por recetor nk-3

Country Status (31)

Country Link
US (3) US9422299B2 (enExample)
EP (2) EP3219715A1 (enExample)
JP (2) JP6316932B2 (enExample)
KR (2) KR102218621B1 (enExample)
CN (1) CN105229008B (enExample)
AU (1) AU2014242906B2 (enExample)
BR (1) BR112015024907B1 (enExample)
CA (1) CA2907809C (enExample)
CY (2) CY1119576T1 (enExample)
DK (1) DK2948455T5 (enExample)
EA (1) EA027570B1 (enExample)
ES (1) ES2646488T3 (enExample)
FI (1) FIC20240019I1 (enExample)
FR (1) FR24C1020I1 (enExample)
HK (1) HK1244273A1 (enExample)
HR (1) HRP20171688T1 (enExample)
HU (2) HUE035870T2 (enExample)
IL (1) IL241473B (enExample)
LT (2) LT2948455T (enExample)
MX (1) MX370000B (enExample)
NL (1) NL301272I2 (enExample)
NO (1) NO2948455T3 (enExample)
NZ (1) NZ712802A (enExample)
PL (1) PL2948455T3 (enExample)
PT (1) PT2948455T (enExample)
RS (1) RS56501B1 (enExample)
SG (1) SG11201508005XA (enExample)
SI (1) SI2948455T1 (enExample)
SM (1) SMT201700526T1 (enExample)
WO (1) WO2014154895A1 (enExample)
ZA (1) ZA201506234B (enExample)

Families Citing this family (31)

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SI2552920T1 (sl) 2010-04-02 2017-07-31 Ogeda Sa Nove nk-3 receptor selektivne antagonist spojine, farmacevtski sestavki in postopki za uporabo pri nk-3 receptor posredovanih motnjah
CN105175421B (zh) 2011-10-03 2018-07-13 欧歌达有限公司 用于合成选择性nk-3受体拮抗剂的中间体化合物及其用途
US10183948B2 (en) 2013-03-29 2019-01-22 Ogeda Sa N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
JP6316932B2 (ja) * 2013-03-29 2018-04-25 オゲダ エス．エー． 選択的ＮＫ−３受容体拮抗薬としての新規なＮ−アシル−（３位置換）−（８位置換）−５，６−ジヒドロ−［１，２，４］トリアゾロ［４，３−ａ］ピラジン、医薬組成物、ＮＫ−３受容体媒介性障害における使用方法
ES2711143T3 (es) * 2013-03-29 2019-04-30 Ogeda Sa N-acil-(3-sustituido)-5,6,7,8-tetrahidro-[1,2,4]triazolo[4,3-a]pirazinas como antagonistas selectivos del receptor de NK-3, composición farmacéutica, métodos para su uso en los trastornos mediados por el receptor de NK-3
ES2721018T3 (es) 2013-03-29 2019-07-26 Ogeda S A N-Acil-(3-sustituido)-(8-metil)-5,6-dihidro-[1,2,4]triazolo[4,3-a]pirazinas como antagonistas selectivos del receptor NK-3, composición farmacéutica, métodos para su uso en trastornos mediados por el receptor de NK-3
PT3197876T (pt) 2014-09-25 2019-02-21 Ogeda Sa Nova síntese quiral de n-acyl-(3-substituído)-(8-substituído)-5,6-di-hidro-[1,2,4]triazolo[4,3-a]pirazinas
KR20170124566A (ko) * 2015-03-16 2017-11-10 오게다 에스.에이. 체지방 과다의 치료적 또는 미용적 치료를 위한 nk-3 수용체 길항제
KR102122470B1 (ko) 2016-12-08 2020-06-12 주식회사 엘지화학 변성제 및 이로부터 유래된 작용기를 포함하는 변성 공액디엔계 중합체
EP3428168A1 (en) * 2017-07-12 2019-01-16 Ogeda Sa Deuterated fezolinetant
JP2021014404A (ja) * 2017-10-13 2021-02-12 アステラス製薬株式会社 トリアゾロピラジン誘導体の塩及び結晶
IL276959B2 (en) 2018-03-14 2024-07-01 Kandy Therapeutics Ltd Novel pharmaceutical formulation comprising dual nk-1/nk-3 receptor antagonists
JP2020050814A (ja) * 2018-09-28 2020-04-02 住友ベークライト株式会社 フェノール変性リグニン樹脂を含む樹脂材料、それを用いたフェノール変性リグニン樹脂組成物および構造体
CA3123757A1 (en) 2018-12-21 2020-06-25 Ogeda Sa Synthesis of 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or of the methyl-d3 deuterated form thereof
CN112272670B (zh) * 2019-04-16 2023-12-12 上海翰森生物医药科技有限公司 含二并环类衍生物抑制剂、其制备方法和应用
CN113527307B (zh) * 2020-04-20 2024-10-11 上海翰森生物医药科技有限公司 含三唑基的并环类衍生物抑制剂、其制备方法和应用
CN113549074A (zh) * 2020-04-26 2021-10-26 上海翰森生物医药科技有限公司 含三唑基的并环类衍生物抑制剂、其制备方法和应用
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