PT2884258T - Discriminação da citometria de fluxo melhorada com transformação geométrica implementada por computador - Google Patents

Discriminação da citometria de fluxo melhorada com transformação geométrica implementada por computador

Info

Publication number
PT2884258T
PT2884258T PT151538949T PT15153894T PT2884258T PT 2884258 T PT2884258 T PT 2884258T PT 151538949 T PT151538949 T PT 151538949T PT 15153894 T PT15153894 T PT 15153894T PT 2884258 T PT2884258 T PT 2884258T
Authority
PT
Portugal
Prior art keywords
computer
flow cytometry
geometric transformation
enhancing flow
discrimination
Prior art date
Application number
PT151538949T
Other languages
English (en)
Inventor
C Malachowski George
Barclay Purcell Paul
Stanton Edward
Original Assignee
Beckman Coulter Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35787799&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2884258(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Beckman Coulter Inc filed Critical Beckman Coulter Inc
Publication of PT2884258T publication Critical patent/PT2884258T/pt

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429Signal processing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429Signal processing
    • G01N15/1433Signal processing using image recognition
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434Optical arrangements
    • G01N15/1436Optical arrangements the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/149Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/1006Investigating individual particles for cytology

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Signal Processing (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PT151538949T 2004-07-27 2005-07-27 Discriminação da citometria de fluxo melhorada com transformação geométrica implementada por computador PT2884258T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59195704P 2004-07-27 2004-07-27

Publications (1)

Publication Number Publication Date
PT2884258T true PT2884258T (pt) 2016-12-13

Family

ID=35787799

Family Applications (2)

Application Number Title Priority Date Filing Date
PT151538949T PT2884258T (pt) 2004-07-27 2005-07-27 Discriminação da citometria de fluxo melhorada com transformação geométrica implementada por computador
PT57756710T PT1771729E (pt) 2004-07-27 2005-07-27 Acentuação da discriminação da citometria de fluxo com transformação geométrica

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT57756710T PT1771729E (pt) 2004-07-27 2005-07-27 Acentuação da discriminação da citometria de fluxo com transformação geométrica

Country Status (8)

Country Link
US (7) USRE46559E1 (pt)
EP (2) EP2884258B1 (pt)
DK (2) DK1771729T3 (pt)
ES (2) ES2555126T3 (pt)
HK (1) HK1211696A1 (pt)
PL (2) PL1771729T3 (pt)
PT (2) PT2884258T (pt)
WO (1) WO2006015056A2 (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE298084T1 (de) 1997-01-31 2005-07-15 Horticulture & Food Res Inst Optische vorrichtung und methode
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US7094527B2 (en) 2000-11-29 2006-08-22 Xy, Inc. System for in-vitro fertilization with spermatozoa separated into X-chromosome and Y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
EP1545203B1 (en) 2002-08-01 2016-10-19 Xy, Llc Low pressure sperm cell separation system
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
AU2003265471B2 (en) 2002-08-15 2009-08-06 Xy, Llc. High resolution flow cytometer
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
EP3511693B1 (en) 2003-03-28 2022-08-24 Inguran, LLC Apparatus for detecting the breakoff point of a droplet generation system
AU2004242121B2 (en) 2003-05-15 2010-06-24 Xy, Llc. Efficient haploid cell sorting for flow cytometer systems
WO2005095590A2 (en) 2004-03-29 2005-10-13 Monsanto Technology Llc Sperm suspensions for sorting into x or y chromosome-bearing enriched populations
CA2574499C (en) 2004-07-22 2016-11-29 Monsanto Technology Llc Process for enriching a population of sperm cells
PL1771729T3 (pl) 2004-07-27 2016-02-29 Beckman Coulter Inc Poprawa zdolności dyskryminacji w cytometrii przepływowej przy użyciu transformacji geometrycznej
US8214157B2 (en) * 2006-03-31 2012-07-03 Nodality, Inc. Method and apparatus for representing multidimensional data
US20090269800A1 (en) * 2008-04-29 2009-10-29 Todd Covey Device and method for processing cell samples
US20100030719A1 (en) * 2008-07-10 2010-02-04 Covey Todd M Methods and apparatus related to bioinformatics data analysis
US20100014741A1 (en) * 2008-07-10 2010-01-21 Banville Steven C Methods and apparatus related to gate boundaries within a data space
GB2474613A (en) * 2008-07-10 2011-04-20 Nodality Inc Methods and apparatus related to management of experiments
US9183237B2 (en) 2008-07-10 2015-11-10 Nodality, Inc. Methods and apparatus related to gate boundaries within a data space
FR2935802B1 (fr) * 2008-09-05 2012-12-28 Horiba Abx Sas Procede et dispositif de classification, de visualisation et d'exploration de donnees biologiques
US9034257B2 (en) 2008-10-27 2015-05-19 Nodality, Inc. High throughput flow cytometry system and method
US20100204973A1 (en) * 2009-01-15 2010-08-12 Nodality, Inc., A Delaware Corporation Methods For Diagnosis, Prognosis And Treatment
CN103998915B (zh) * 2011-12-20 2016-10-26 贝克顿·迪金森公司 用于改进分选颗粒的产量的系统和方法
JP5994337B2 (ja) 2012-03-30 2016-09-21 ソニー株式会社 微小粒子分取装置及びディレイタイム決定方法
JP5924077B2 (ja) 2012-03-30 2016-05-25 ソニー株式会社 微小粒子分取装置及び微小粒子分取装置における軌道方向判定方法
EP2950079B1 (en) * 2013-01-28 2021-06-16 Sony Corporation Fine particle fractionation device, fine particle fractionation method and program
JP2016515211A (ja) * 2013-03-15 2016-05-26 ベックマン コールター, インコーポレイテッド フローサイトメーター用の光学系
JP6465036B2 (ja) 2014-02-13 2019-02-06 ソニー株式会社 粒子分取装置、粒子分取方法、プログラム及び粒子分取システム
WO2017068822A1 (ja) 2015-10-19 2017-04-27 ソニー株式会社 画像処理装置、微小粒子分取装置及び画像処理方法
US10466158B2 (en) * 2017-04-11 2019-11-05 Sony Corporation Microparticle sorting apparatus and delay time determination method
US10593082B2 (en) 2017-07-18 2020-03-17 Becton, Dickinson And Company Dynamic display of multi-parameter quantitative biological data
US10636182B2 (en) 2017-07-18 2020-04-28 Becton, Dickinson And Company Dynamic interactive display of multi-parameter quantitative biological data
US10803637B2 (en) 2017-07-18 2020-10-13 Becton, Dickinson And Company Dynamic interactive display of multi-parameter quantitative biological data
JP7528087B2 (ja) * 2018-12-28 2024-08-05 ベクトン・ディキンソン・アンド・カンパニー サンプルの蛍光物質をスペクトル的に分解する方法及びシステム
JP2021143988A (ja) * 2020-03-13 2021-09-24 ソニーグループ株式会社 粒子解析システムおよび粒子解析方法
CN111521549B (zh) * 2020-05-13 2021-01-01 洹仪科技(上海)有限公司 一种颗粒分选装置及方法
WO2021236339A1 (en) * 2020-05-18 2021-11-25 Becton, Dickinson And Company Resolution indices for detecting heterogeneity in data and methods of use thereof
EP4425235A2 (en) * 2020-06-17 2024-09-04 IDEXX Laboratories, Inc. Flow cytometer and laser optics assembly thereof
EP4267938A4 (en) * 2020-12-23 2024-06-05 Engender Technologies Limited PARTICLE CLASSIFICATION AND SORTING SYSTEMS AND METHODS

Family Cites Families (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3229354A (en) * 1961-04-24 1966-01-18 Gen Electric Method of assembling a mercury button switch
US3299354A (en) 1962-07-05 1967-01-17 Coulter Electronics Aperture tube structure for particle study apparatus
US3810010A (en) 1968-11-02 1974-05-07 Telefunken Patent Particle analysis method and apparatus wherein liquid containing particles is sucked into a constricted flow path
US3661460A (en) 1970-08-28 1972-05-09 Technicon Instr Method and apparatus for optical analysis of the contents of a sheathed stream
US3833796A (en) 1971-10-13 1974-09-03 Georgia Tech Res Inst Method and apparatus for chromosome digitizing
BE793185A (fr) 1971-12-23 1973-04-16 Atomic Energy Commission Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques
US3826364A (en) 1972-05-22 1974-07-30 Univ Leland Stanford Junior Particle sorting method and apparatus
US3761941A (en) 1972-10-13 1973-09-25 Mead Corp Phase control for a drop generating and charging system
US4070617A (en) 1974-05-08 1978-01-24 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Device for controlling the particle flow in an apparatus for measuring the properties of particles suspended in liquid
US3973196A (en) 1974-05-24 1976-08-03 Coulter Electronics, Inc. Method and apparatus for ejecting a metered amount of particulate sample
US3963606A (en) 1974-06-03 1976-06-15 Coulter Electronics, Inc. Semi-automatic adjusting delay for an electronic particle separator
US4014611A (en) 1975-04-30 1977-03-29 Coulter Electronics, Inc. Aperture module for use in particle testing apparatus
US3960449A (en) 1975-06-05 1976-06-01 The Board Of Trustees Of Leland Stanford Junior University Measurement of angular dependence of scattered light in a flowing stream
US4302166A (en) 1976-04-22 1981-11-24 Coulter Electronics, Inc. Droplet forming apparatus for use in producing uniform particles
US4162282A (en) 1976-04-22 1979-07-24 Coulter Electronics, Inc. Method for producing uniform particles
US4074809A (en) 1976-07-19 1978-02-21 Coors Container Company Apparatus and methods for inspection of can bodies by use of light
US4230558A (en) 1978-10-02 1980-10-28 Coulter Electronics, Inc. Single drop separator
US4341471A (en) 1979-01-02 1982-07-27 Coulter Electronics, Inc. Apparatus and method for measuring the distribution of radiant energy produced in particle investigating systems
US4317520A (en) 1979-08-20 1982-03-02 Ortho Diagnostics, Inc. Servo system to control the spatial position of droplet formation of a fluid jet in a cell sorting apparatus
US4318481A (en) 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method for automatically setting the correct phase of the charge pulses in an electrostatic flow sorter
US4325483A (en) 1979-08-20 1982-04-20 Ortho Diagnostics, Inc. Method for detecting and controlling flow rates of the droplet forming stream of an electrostatic particle sorting apparatus
US4318482A (en) 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method for measuring the velocity of a perturbed jetting fluid in an electrostatic particle sorting system
US4318480A (en) 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method and apparatus for positioning the point of droplet formation in the jetting fluid of an electrostatic sorting device
US4318483A (en) 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Automatic relative droplet charging time delay system for an electrostatic particle sorting system using a relatively moveable stream surface sensing system
US4400764A (en) 1980-02-05 1983-08-23 The Boeing Company Low backscatter illumination system
US4325706A (en) * 1980-08-15 1982-04-20 Ortho Diagnostic Systems Inc. Automated detection of platelets and reticulocytes in whole blood
US4350410A (en) 1980-10-08 1982-09-21 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Multiprism collimator
US4691829A (en) 1980-11-03 1987-09-08 Coulter Corporation Method of and apparatus for detecting change in the breakoff point in a droplet generation system
US4487320A (en) 1980-11-03 1984-12-11 Coulter Corporation Method of and apparatus for detecting change in the breakoff point in a droplet generation system
US4395676A (en) 1980-11-24 1983-07-26 Coulter Electronics, Inc. Focused aperture module
US4361400A (en) 1980-11-26 1982-11-30 The United States Of America As Represented By The United States Department Of Energy Fluidic assembly for an ultra-high-speed chromosome flow sorter
US4818103A (en) 1981-05-15 1989-04-04 Ratcom Flow cytometry
US4673288A (en) 1981-05-15 1987-06-16 Ratcom, Inc. Flow cytometry
US4515274A (en) 1981-12-02 1985-05-07 Coulter Corporation Particle analyzing and sorting apparatus
SU1056008A1 (ru) 1982-01-25 1983-11-23 Предприятие П/Я Р-6681 Проточный цитофлуориметр
US4498766A (en) 1982-03-25 1985-02-12 Becton, Dickinson And Company Light beam focal spot elongation in flow cytometry devices
US4501336A (en) 1982-06-03 1985-02-26 Kemp Billy W Method and apparatus of a self-aligning sleeve for the correction of the direction of deviated boreholes
US4523809A (en) 1983-08-04 1985-06-18 The United States Of America As Represented By The Secretary Of The Air Force Method and apparatus for generating a structured light beam array
US4538733A (en) 1983-10-14 1985-09-03 Becton, Dickinson And Company Particle sorter with neutralized collection wells and method of using same
JPS617447A (ja) 1983-12-24 1986-01-14 イノテツク、アクチエンゲゼルシヤフト 光案内集光方法およびその装置
US4631483A (en) 1984-02-01 1986-12-23 Coulter Electronics, Inc. Particle analyzing apparatus and method of moving particles in suspension through such apparatus
US4600302A (en) 1984-03-26 1986-07-15 Becton, Dickinson And Company Flow cytometry apparatus with uniform incoherent light excitation
US4660971A (en) 1984-05-03 1987-04-28 Becton, Dickinson And Company Optical features of flow cytometry apparatus
US4598408A (en) 1984-10-22 1986-07-01 Trw Inc. High extraction efficiency cylindrical ring resonator
JPS61139747A (ja) 1984-12-12 1986-06-27 Canon Inc 粒子解析装置
JPS61159135A (ja) 1984-12-31 1986-07-18 Canon Inc 粒子解析装置
SU1260778A1 (ru) 1985-01-31 1986-09-30 Центральный научно-исследовательский рентгено-радиологический институт Устройство дл флуоресцентного анализа отдельных микрочастиц в потоке
US4702598A (en) 1985-02-25 1987-10-27 Research Corporation Flow cytometer
US4877965A (en) 1985-07-01 1989-10-31 Diatron Corporation Fluorometer
US4744090A (en) 1985-07-08 1988-05-10 Trw Inc. High-extraction efficiency annular resonator
US4794086A (en) 1985-11-25 1988-12-27 Liquid Air Corporation Method for measurement of impurities in liquids
US4983038A (en) 1987-04-08 1991-01-08 Hitachi, Ltd. Sheath flow type flow-cell device
JPS63262565A (ja) 1987-04-20 1988-10-28 Hitachi Ltd フロ−セル
US4987539A (en) 1987-08-05 1991-01-22 Stanford University Apparatus and method for multidimensional characterization of objects in real time
US4758729A (en) 1987-08-28 1988-07-19 Spectra-Physics, Inc. Apparatus and method for measuring the included angle of a reflective cone
US4831385A (en) 1987-10-14 1989-05-16 Burlington Industries, Inc. Vacuum tray fluid-jet start-up system
US4845025A (en) 1987-11-10 1989-07-04 Coulter Corporation Biological sample mixing apparatus and method
JPH0224535A (ja) 1988-07-12 1990-01-26 Canon Inc 粒子解析装置
JPH0718785B2 (ja) 1988-09-19 1995-03-06 株式会社日立製作所 フローセル装置
US4981580A (en) 1989-05-01 1991-01-01 Coulter Corporation Coincidence arbitration in a flow cytomery sorting system
DE69028526T2 (de) 1989-05-10 1997-02-06 The United States of America, represented by the Secretary, U.S. Department of Commerce, Washington, D.C. Verfahren zur vorwahl des geschlechts der nachkommenschaft
US4942305A (en) 1989-05-12 1990-07-17 Pacific Scientific Company Integrating sphere aerosol particle detector
JPH0353164A (ja) 1989-07-20 1991-03-07 Canon Inc サンプル供給装置及びこれを用いたサンプル測定装置
US5098657A (en) 1989-08-07 1992-03-24 Tsi Incorporated Apparatus for measuring impurity concentrations in a liquid
US5030002A (en) 1989-08-11 1991-07-09 Becton, Dickinson And Company Method and apparatus for sorting particles with a moving catcher tube
US5005981A (en) 1989-09-08 1991-04-09 Becton, Dickinson And Company Apparatus for method for causing vortices in a test tube
US5215376A (en) 1989-09-08 1993-06-01 Becton, Dickinson And Company Method for causing vortices in a test tube
US5167926A (en) 1989-09-13 1992-12-01 Kabushiki Kaisha Tiyoda Seisakusho Apparatus for pretreating cells for flow cytometry
EP0422616B1 (en) 1989-10-11 1996-02-07 Canon Kabushiki Kaisha Apparatus for and method of fractionating particle in particle-suspended liquid in conformity with the properties thereof
US5034613A (en) 1989-11-14 1991-07-23 Cornell Research Foundation, Inc. Two-photon laser microscopy
US5101978A (en) 1989-11-27 1992-04-07 The United States Of America As Represented By The Secretary Of The Army Fluidic sorting device for two or more materials suspended in a fluid
JP3049254B2 (ja) 1990-02-08 2000-06-05 シスメックス株式会社 2種類の光源を備えた光学式粒子分析装置
US5150313A (en) 1990-04-12 1992-09-22 Regents Of The University Of California Parallel pulse processing and data acquisition for high speed, low error flow cytometry
US5224058A (en) * 1990-05-01 1993-06-29 Becton, Dickinson And Company Method for data transformation
JPH0716392B2 (ja) 1990-06-20 1995-03-01 株式会社ピーシーシーテクノロジー 細胞融合及び融合細胞選別システム
JPH0710226B2 (ja) 1990-06-20 1995-02-08 株式会社ピーシーシーテクノロジー プロトプラスト攪拌装置並びにそれを含む細胞融合装置及びフローサイトメーター装置
JP2939647B2 (ja) 1990-07-24 1999-08-25 シスメックス株式会社 フローイメージングサイトメータにおける自動焦点調整方法
US5259593A (en) 1990-08-30 1993-11-09 University Of Southern California Apparatus for droplet stream manufacturing
JPH04126064A (ja) 1990-09-14 1992-04-27 Nitto Shokai:Kk 二重包餡食品の製造法
JPH0738838Y2 (ja) 1990-09-28 1995-09-06 東亜医用電子株式会社 粒子分析装置及び該装置に用いるフローセル
DE69132273D1 (de) 1990-10-10 2000-08-03 Univ Maryland Verfahren und vorrichtung zur bestimmung von lebensdauer von fluoreszenz in der durchflusscytometrie
JP2874746B2 (ja) 1990-11-22 1999-03-24 シスメックス株式会社 フローイメージングサイトメータにおけるフローセル機構
JPH0734012B2 (ja) 1991-02-27 1995-04-12 東亜医用電子株式会社 フローイメージサイトメータ
JP3121849B2 (ja) 1991-02-27 2001-01-09 シスメックス株式会社 フローイメージサイトメータ
US5144224A (en) 1991-04-01 1992-09-01 Larsen Lawrence E Millimeter wave flow cytometer
US5199576A (en) 1991-04-05 1993-04-06 University Of Rochester System for flexibly sorting particles
US5412466A (en) 1991-07-26 1995-05-02 Toa Medical Electronics Co., Ltd. Apparatus for forming flattened sample flow for analyzing particles
JP3212647B2 (ja) 1991-10-24 2001-09-25 シスメックス株式会社 イメージングフローサイトメータ
US5370842A (en) 1991-11-29 1994-12-06 Canon Kabushiki Kaisha Sample measuring device and sample measuring system
US5558998A (en) 1992-02-25 1996-09-24 The Regents Of The Univ. Of California DNA fragment sizing and sorting by laser-induced fluorescence
US5298967A (en) 1992-06-02 1994-03-29 Pacific Scientific Company Measurement of concentrations of dissolved solvent
US5466572A (en) 1992-09-03 1995-11-14 Systemix, Inc. High speed flow cytometric separation of viable cells
US5359907A (en) 1992-11-12 1994-11-01 Horiba Instruments, Inc. Method and apparatus for dry particle analysis
FR2699678A1 (fr) 1992-12-23 1994-06-24 Unceia Procédé cytométrique de séparation de spermatozoïdes X et Y en fonction de leur contenu en ADN.
US5467189A (en) 1993-01-22 1995-11-14 Venturedyne, Ltd. Improved particle sensor and method for assaying a particle
US5367474A (en) 1993-02-08 1994-11-22 Coulter Corporation Flow cytometer
WO1994020883A1 (en) 1993-03-01 1994-09-15 General Signal Corporation Variable annular illuminator for photolithographic projection imager
DE69418248T2 (de) 1993-06-03 1999-10-14 Hamamatsu Photonics Kk Optisches Laser-Abtastsystem mit Axikon
US5483469A (en) 1993-08-02 1996-01-09 The Regents Of The University Of California Multiple sort flow cytometer
EP0649014B1 (en) 1993-09-16 2005-11-23 Sysmex Corporation Particle analyzing apparatus
US5503994A (en) 1993-10-08 1996-04-02 The Board Of Trustees Of The Leland Stanford Junior University System for sample detection with compensation for difference in sensitivity to detection of components moving at different velocities
GB9324938D0 (en) 1993-12-04 1994-01-26 Atomic Energy Authority Uk Aerosol generator
FI96452C (fi) 1994-01-26 1996-06-25 Pekka Haenninen Menetelmä väriaineiden virittämiseksi
DE4414940C2 (de) 1994-04-28 1998-07-02 Pekka Haenninen Lumineszenz-Rastermikroskop mit zwei Photonen Anregung
EP0687956B2 (de) 1994-06-17 2005-11-23 Carl Zeiss SMT AG Beleuchtungseinrichtung
US5700692A (en) 1994-09-27 1997-12-23 Becton Dickinson And Company Flow sorter with video-regulated droplet spacing
US5602349A (en) 1994-10-14 1997-02-11 The University Of Washington Sample introduction system for a flow cytometer
US5602039A (en) 1994-10-14 1997-02-11 The University Of Washington Flow cytometer jet monitor system
US5643796A (en) 1994-10-14 1997-07-01 University Of Washington System for sensing droplet formation time delay in a flow cytometer
DE69530072T2 (de) 1994-12-08 2004-03-04 Molecular Dynamics, Sunnyvale System zur fluoreszenzabbildung unter verwendung eines objektivs mit makroabtastung
DE69533469T2 (de) 1994-12-26 2005-09-22 Sysmex Corp. Durchflusszytometer
US5835262A (en) 1994-12-28 1998-11-10 Research Development Corporation Of Japan Multi-wavelength optical microscope
US5786560A (en) 1995-03-31 1998-07-28 Panasonic Technologies, Inc. 3-dimensional micromachining with femtosecond laser pulses
US5641457A (en) 1995-04-25 1997-06-24 Systemix Sterile flow cytometer and sorter with mechanical isolation between flow chamber and sterile enclosure
US5650847A (en) 1995-06-14 1997-07-22 Erkki Soini Method and device for determination of parameters of individual microparticles
CA2231114A1 (en) 1995-09-06 1997-03-13 The Research Foundation Of State University Of New York Two-photon upconverting dyes and applications
DE19533092A1 (de) 1995-09-07 1997-03-13 Basf Ag Vorrichtung zur parallelisierten Zweiphotonen-Fluoreszenz-Korrelations-Spektroskopie (TPA-FCS) und deren Verwendung zum Wirkstoff-Screening
WO1997014785A2 (en) 1995-10-19 1997-04-24 Advanced Reproduction Technologies, Inc. Methods and compositions to improve germ cell and embryo survival and function
DE19549015C1 (de) 1995-12-28 1997-04-03 Siemens Ag Verfahren und Anordnung zur Überwachung eines abreißenden Flüssigkeitstrahls
US5707808A (en) 1996-04-15 1998-01-13 The Regents Of The University Of California Optical selection and collection of DNA fragments
JP2963393B2 (ja) 1996-06-14 1999-10-18 浜松ホトニクス株式会社 光電子増倍管用電圧分割回路
US5759767A (en) 1996-10-11 1998-06-02 Joseph R. Lakowicz Two-photon and multi-photon measurement of analytes in animal and human tissues and fluids
US5885840A (en) * 1997-02-10 1999-03-23 Compucyte Corp. Multiple assays of cell specimens
US5985216A (en) 1997-07-24 1999-11-16 The United States Of America, As Represented By The Secretary Of Agriculture Flow cytometry nozzle for high efficiency cell sorting
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6248590B1 (en) 1998-02-27 2001-06-19 Cytomation, Inc. Method and apparatus for flow cytometry
AUPP737298A0 (en) 1998-11-30 1998-12-24 University Of Queensland, The Combinatorial libraries
US8131053B2 (en) * 1999-01-25 2012-03-06 Amnis Corporation Detection of circulating tumor cells using imaging flow cytometry
EP1227898A4 (en) 1999-10-21 2011-11-16 Beckman Coulter Inc SYSTEM FOR ANALYSIS BY FLOW CYTOMETRY WITH TEMPORARY DYNAMICS
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
IL152714A (en) * 2000-05-09 2014-03-31 Xy Llc High-purity spermatozoa populations carrying chromosome-x and chromosome-y
EP2565826B1 (en) 2000-05-11 2019-11-06 Becton Dickinson and Company System for indentifying clusters in scatter plots using smoothed polygons with optimal boundaries
JP4708605B2 (ja) 2000-07-24 2011-06-22 シスメックス株式会社 粒子分析装置とその粒子分画方法
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US7043500B2 (en) 2001-04-25 2006-05-09 Board Of Regents, The University Of Texas Syxtem Subtractive clustering for use in analysis of data
US6763149B2 (en) * 2001-04-25 2004-07-13 Amnis Corporation Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging
US6630990B2 (en) * 2001-06-05 2003-10-07 Abbott Laboratories Optical method and apparatus for red blood cell differentiation on a cell-by-cell basis, and simultaneous analysis of white blood cell differentiation
US7756305B2 (en) 2002-01-23 2010-07-13 The Regents Of The University Of California Fast 3D cytometry for information in tissue engineering
US7201875B2 (en) * 2002-09-27 2007-04-10 Becton Dickinson And Company Fixed mounted sorting cuvette with user replaceable nozzle
EP3511693B1 (en) * 2003-03-28 2022-08-24 Inguran, LLC Apparatus for detecting the breakoff point of a droplet generation system
AU2004242121B2 (en) 2003-05-15 2010-06-24 Xy, Llc. Efficient haploid cell sorting for flow cytometer systems
US7603199B2 (en) 2003-11-27 2009-10-13 Honda Motor Co., Ltd. Control device for mobile body
PL1771729T3 (pl) 2004-07-27 2016-02-29 Beckman Coulter Inc Poprawa zdolności dyskryminacji w cytometrii przepływowej przy użyciu transformacji geometrycznej
WO2006090283A2 (en) 2005-02-25 2006-08-31 Dako Denmark A/S Cell counting
US7113266B1 (en) * 2005-03-30 2006-09-26 Beckman Coulter, Inc. Flow cytometer for differentiating small particles in suspension

Also Published As

Publication number Publication date
PT1771729E (pt) 2015-12-31
PL2884258T3 (pl) 2017-04-28
EP2884258B1 (en) 2016-10-12
DK1771729T3 (en) 2015-11-23
US10495562B2 (en) 2019-12-03
DK2884258T3 (da) 2017-01-02
US11927523B2 (en) 2024-03-12
WO2006015056A3 (en) 2006-11-09
EP1771729B1 (en) 2015-09-09
US20200158622A1 (en) 2020-05-21
US20170184482A1 (en) 2017-06-29
US11408813B2 (en) 2022-08-09
EP1771729A2 (en) 2007-04-11
US20180180526A1 (en) 2018-06-28
ES2555126T3 (es) 2015-12-29
WO2006015056A2 (en) 2006-02-09
EP2884258A1 (en) 2015-06-17
US9625367B2 (en) 2017-04-18
US9134220B2 (en) 2015-09-15
US20230168177A1 (en) 2023-06-01
EP1771729A4 (en) 2011-09-28
US20160033387A1 (en) 2016-02-04
PL1771729T3 (pl) 2016-02-29
HK1211696A1 (en) 2016-05-27
USRE46559E1 (en) 2017-09-26
US20090287421A1 (en) 2009-11-19
ES2607527T3 (es) 2017-03-31
US9835541B2 (en) 2017-12-05

Similar Documents

Publication Publication Date Title
HK1211696A1 (en) Enhancing flow cytometry discrimination with computer-implemented geometric transformation
TWI350762B (en) Particulates
IL188088A0 (en) Cd19 antibodies and their uses
GB0501650D0 (en) Flow meter
ZA200606647B (en) Particulates
GB0506128D0 (en) Closure with integral gas barrier
GB2411236B (en) Electromagnetic flow meter insert
GB0514675D0 (en) Flow cytometry method
EP1881869A4 (en) METAL OXIDES WITH IMPROVED REDUCTION RESISTANCE
EP1757686A4 (en) INDUCER OF CELL DEATH
AU308504S (en) Lunch purse with zip
CA114056S (en) Teapot
GB0401832D0 (en) Metal oxide particles
ZA200710916B (en) CD19 antibodies and their uses
PL1844377T3 (pl) Regulator przepływu
IL191609A0 (en) Nanoparticle and methods therefor
GB2412928B (en) Closure member
AU300739S (en) Skirted closure
IL178065A0 (en) Combination therapies with epothilones and carboplatin
GB2415500B (en) Flow meter
TWM287933U (en) Flow-meter
GB0405126D0 (en) Dealing with upset tankers
CA114776S (en) Spout
GB0513608D0 (en) Improved engine and fluid therefor
ZA200401621B (en) Closure member.