PT2785834T - Composição de células estaminais melhorada - Google Patents

Composição de células estaminais melhorada

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Publication number
PT2785834T
PT2785834T PT128542388T PT12854238T PT2785834T PT 2785834 T PT2785834 T PT 2785834T PT 128542388 T PT128542388 T PT 128542388T PT 12854238 T PT12854238 T PT 12854238T PT 2785834 T PT2785834 T PT 2785834T
Authority
PT
Portugal
Prior art keywords
stem cell
cell composition
enhanced stem
enhanced
composition
Prior art date
Application number
PT128542388T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Fate Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fate Therapeutics Inc filed Critical Fate Therapeutics Inc
Publication of PT2785834T publication Critical patent/PT2785834T/pt

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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0647Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/51Umbilical cord; Umbilical cord blood; Umbilical stem cells
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/02Compounds of the arachidonic acid pathway, e.g. prostaglandins, leukotrienes
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30Hormones
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    • C12N2501/39Steroid hormones

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PT128542388T 2011-12-02 2012-11-29 Composição de células estaminais melhorada PT2785834T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161566492P 2011-12-02 2011-12-02

Publications (1)

Publication Number Publication Date
PT2785834T true PT2785834T (pt) 2020-11-13

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Application Number Title Priority Date Filing Date
PT128542388T PT2785834T (pt) 2011-12-02 2012-11-29 Composição de células estaminais melhorada

Country Status (9)

Country Link
US (4) US9452186B2 (cg-RX-API-DMAC7.html)
EP (2) EP3785767A1 (cg-RX-API-DMAC7.html)
JP (7) JP6220791B2 (cg-RX-API-DMAC7.html)
CN (3) CN104066837B (cg-RX-API-DMAC7.html)
AU (1) AU2012321088B8 (cg-RX-API-DMAC7.html)
CA (1) CA2857640C (cg-RX-API-DMAC7.html)
ES (1) ES2836976T3 (cg-RX-API-DMAC7.html)
PT (1) PT2785834T (cg-RX-API-DMAC7.html)
WO (1) WO2013082243A1 (cg-RX-API-DMAC7.html)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3785767A1 (en) 2011-12-02 2021-03-03 Fate Therapeutics, Inc. Enhanced stem cell composition
ES2682255T3 (es) 2011-12-02 2018-09-19 Fate Therapeutics, Inc. Métodos mejorados de tratamiento de isquemia
HUE037262T2 (hu) 2012-04-16 2018-08-28 Univ Case Western Reserve Készítmények és 15-PGDH aktivitás modulálási módszerek
US9801863B2 (en) 2012-04-16 2017-10-31 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis
WO2014150602A1 (en) * 2013-03-15 2014-09-25 Fate Therapeutics, Inc. Cell potency assay for therapeutic potential
US9943545B2 (en) 2013-03-15 2018-04-17 Fate Therapeutics, Inc. Stem cell culture media and methods of enhancing cell survival
AU2014342811B2 (en) 2013-10-15 2019-01-03 Board Of Regents Of The University Of Texas System Compositions and methods of modulating short-chain dehydrogenase activity
EP3104867B1 (en) * 2014-02-12 2022-01-19 7 Hills Pharma LLC Compositions and methods to improve the homing and grafting of hematopoetic stem cells
CN112481211B (zh) * 2015-01-26 2024-07-05 儿童医院公司 免疫调节性提高的细胞及其使用和生产方法
JP6800859B2 (ja) 2015-01-26 2020-12-16 フェイト セラピューティクス,インコーポレイテッド 造血細胞分化を誘導するための方法および組成物
CN118059093A (zh) 2015-03-08 2024-05-24 卡斯西部储备大学 用于治疗纤维症的短链脱氢酶活性的抑制剂
JP2018520688A (ja) 2015-07-21 2018-08-02 ザ チルドレンズ メディカル センター コーポレーション Pd−l1発現造血幹細胞およびその使用
US20170095593A1 (en) * 2015-10-02 2017-04-06 Sharon Patricia McQuillan Adipose-derived stem cell product
EP3371314B1 (en) 2015-11-04 2023-07-05 Fate Therapeutics, Inc. Genomic engineering of pluripotent cells
KR20250033315A (ko) 2015-11-04 2025-03-07 페이트 세러퓨틱스, 인코포레이티드 조혈 세포 분화를 유도하기 위한 방법 및 조성물
US11525119B2 (en) 2016-09-06 2022-12-13 The Children's Medical Center Corporation Immune cells derived from induced pluripotent stem cell
KR102035478B1 (ko) * 2016-10-14 2019-10-23 제주대학교 산학협력단 시클레소나이드를 포함하는, 암 줄기세포 성장 억제용 조성물
JP7595413B2 (ja) 2016-11-30 2024-12-06 ケース ウエスタン リザーブ ユニバーシティ 15-pgdh阻害剤とコルチコステロイドおよび/またはtnf阻害剤との組み合わせならびにその使用
EP3576737A4 (en) 2017-02-06 2021-04-21 Case Western Reserve University COMPOSITIONS AND METHODS OF MODULATING THE ACTIVITY OF SHORT CHAIN DEHYDROGENASE
US11879137B2 (en) 2017-09-22 2024-01-23 The Children's Medical Center Corporation Treatment of type 1 diabetes and autoimmune diseases or disorders
US11285177B2 (en) 2018-01-03 2022-03-29 Globus Medical, Inc. Allografts containing viable cells and methods thereof
WO2020021538A1 (en) 2018-07-22 2020-01-30 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of brain diseases
WO2020021535A1 (en) 2018-07-22 2020-01-30 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of ocular diseases
US12329781B2 (en) 2018-07-22 2025-06-17 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of renal diseases
EP3823647A4 (en) 2018-07-22 2022-06-01 Minovia Therapeutics Ltd. MITOCHONDRIAL AUGMENTATION THERAPY FOR PRIMARY MITOCHONDRIAL DISEASES
EP3883577A4 (en) 2018-11-21 2022-06-15 Case Western Reserve University COMPOSITIONS AND METHODS FOR MODULATION OF SHORT CHAIN DEHYDROGENASE ACTIVITY
CN113069460B (zh) * 2021-03-24 2022-02-08 兰州大学 哈西奈德及其衍生物用于制备治疗和/或预防脑血管疾病药物中的应用
CN114848675A (zh) * 2022-06-24 2022-08-05 南开大学 Pge2赋能的间充质干细胞制剂在制备治疗肺损伤药物中的应用
GB202211232D0 (en) 2022-08-02 2022-09-14 Heptares Therapeutics Ltd Prostaglandin EP4 receptor agonist compounds
WO2025155768A1 (en) * 2024-01-17 2025-07-24 Rhode Island Hospital A motile injectable cell that accelerates musculoskeletal connective tissue repair

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4839032B1 (cg-RX-API-DMAC7.html) 1964-09-11 1973-11-21
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5077049A (en) 1989-07-24 1991-12-31 Vipont Pharmaceutical, Inc. Biodegradable system for regenerating the periodontium
SG43009A1 (en) 1989-10-16 1997-10-17 Amgen Inc Stem cell factor
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5635387A (en) 1990-04-23 1997-06-03 Cellpro, Inc. Methods and device for culturing human hematopoietic cells and their precursors
CA2123094C (en) 1991-11-06 1999-08-10 Paulo N. Correa Cell culture medium
JP2795014B2 (ja) 1991-11-29 1998-09-10 東洋インキ製造株式会社 保存温度管理用インジケーター
US5460964A (en) 1992-04-03 1995-10-24 Regents Of The University Of Minnesota Method for culturing hematopoietic cells
US5442033A (en) 1993-07-20 1995-08-15 Ethicon, Inc. Liquid copolymers of epsilon-caprolactone and lactide
SG52619A1 (en) 1993-08-23 1998-09-28 Baxter Int In vitro growth of neutrophil and megakaryocte precursors in serum-free media
US5409813A (en) 1993-09-30 1995-04-25 Systemix, Inc. Method for mammalian cell separation from a mixture of cell populations
US5648331A (en) 1994-08-26 1997-07-15 G.D. Searle & Co. Method of inhibiting tissue ischemia and reperfusion injury
US5677136A (en) 1994-11-14 1997-10-14 Systemix, Inc. Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof
US5753516A (en) 1995-02-03 1998-05-19 Heagy; Wyrta E. Screening method for ligands of the EBI-1 receptor
AU6125396A (en) 1995-06-07 1996-12-30 Novartis Ag Serum-free media for primitive hematopoietic cells and metho ds of use thereof
US5709472A (en) 1995-10-23 1998-01-20 Lifelines Technology, Inc. Time-temperature indicator device and method of manufacture
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5945337A (en) 1996-10-18 1999-08-31 Quality Biological, Inc. Method for culturing CD34+ cells in a serum-free medium
US6372796B1 (en) 1996-11-13 2002-04-16 Cold Spring Harbor Laboratory Therapeutic uses for nitric oxide inhibitors
US6191109B1 (en) 1997-10-31 2001-02-20 Children's Hospital, Inc. Methods of treating intestinal ischemia using heparin-binding epidermal growth factor
DE69817995T2 (de) 1998-01-05 2004-07-22 Mitra Industries Ltd. Flexibler, zusammenfaltbarer Blutbeutel
IL125532A0 (en) * 1998-07-27 1999-03-12 Yeda Res & Dev Hematopoietic cell composition for use in transplantation
WO2000038663A2 (en) 1998-12-24 2000-07-06 Alcon Laboratories, Inc. Ep4 receptor agonists for treatment of dry eye
US6946293B1 (en) 1999-02-10 2005-09-20 Es Cell International Pte Ltd. Progenitor cells, methods and uses related thereto
GB9904281D0 (en) 1999-02-24 1999-04-21 Reneuron Ltd Transplantation
WO2001012596A1 (fr) 1999-08-13 2001-02-22 Taisho Pharmaceutical Co., Ltd. Derives de prostaglandine
TWI247606B (en) 1999-11-24 2006-01-21 Ono Pharmaceutical Co Treating agent for osteopenic diseases
BR0015781A (pt) 1999-11-24 2002-12-31 Ono Pharmaceutical Co Composição farmacêutica para tratamento de doenças associadas à diminuição de massa óssea
DK1132086T3 (da) 2000-01-31 2006-08-28 Pfizer Prod Inc Anvendelse af prostaglandin (PGE2) selektive receptor 4 (EP4) agonister til behandling af akut og kronisk nyresvigt
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
FR2825261B1 (fr) 2001-06-01 2003-09-12 Maco Pharma Sa Ligne de prelevement du sang placentaire comprenant une poche de rincage
US7179643B2 (en) 2001-06-14 2007-02-20 Reliance Life Sciences Pvt. Ltd. Device and a process for expansion of haemopoeitic stem cells for therapeutic use
EP1458854B1 (en) 2001-12-21 2010-04-14 Mount Sinai Hospital Cellular compositions and methods of making and using them
EP1348758A1 (en) * 2002-03-28 2003-10-01 Boehringer Ingelheim Pharma GmbH & Co.KG Host cells having improved cell survival properties and methods to generate such cells
RU2205627C1 (ru) 2002-05-30 2003-06-10 Открытое акционерное общество "Косметическое объединение "Свобода" Крем для лица, выводящий токсины
AU2003272963A1 (en) 2002-10-10 2004-05-04 Ono Pharmaceutical Co., Ltd. Endogenous repair factor production promoters
EP1601351A1 (en) 2003-03-04 2005-12-07 Pfizer Products Inc. Use of ep2 selective receptor agonists in medical treatment
AU2004217699B2 (en) 2003-03-07 2008-07-03 Gamida-Cell Ltd. Expansion of renewable stem cell populations using modulators of PI 3-kinase
WO2004081196A2 (en) 2003-03-11 2004-09-23 Qlt Usa Inc. Formulations for cell- schedule dependent anticancer agents
EP1613742A2 (en) 2003-04-08 2006-01-11 YEDA RESEARCH AND DEVELOPMENT Co. LTD. Stem cells having increased sensitivity to a chemoattractant and methods of generating and using same
US6747037B1 (en) 2003-06-06 2004-06-08 Allergan, Inc. Piperidinyl prostaglandin E analogs
US8309608B2 (en) 2003-11-06 2012-11-13 Sanofi-Aventis Deutschland Gmbh Use of eNOS transcription enhancers in the cell therapy of ischemic heart diseases
IL158868A0 (en) * 2003-11-13 2004-05-12 Yeda Res & Dev Methods of generating and using stem cells enriched with immature primitive progenitor
EP1701729B1 (en) 2003-12-31 2018-05-02 Warsaw Orthopedic, Inc. Improved bone matrix compositions and methods
JP2005220089A (ja) 2004-02-06 2005-08-18 Menicon Co Ltd 組織等価物用パッケージ
US20050176140A1 (en) 2004-02-10 2005-08-11 Benedict Daniel J. Method and apparatus for cell culture using a two liquid phase bioreactor
US7004621B2 (en) 2004-06-17 2006-02-28 Cryovac, Inc. Method of monitoring temperature exposure
JP4086816B2 (ja) 2004-07-01 2008-05-14 株式会社Nec情報システムズ Bga部品搭載基板の層数見積もり装置及び方法並びに層数見積もりプログラム
US7147626B2 (en) 2004-09-23 2006-12-12 Celgene Corporation Cord blood and placenta collection kit
AU2005287855B2 (en) * 2004-09-24 2011-06-16 Mesoblast, Inc. Method of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC)
EP1812555B1 (en) * 2004-10-25 2015-04-22 Cellerant Therapeutics, Inc. Methods of expanding myeloid cell populations and uses thereof
AU2005299473B2 (en) 2004-10-26 2012-06-28 Allergan, Inc. Therapeutic and delivery methods of prostaglandin EP4 agonists
WO2006078886A2 (en) 2005-01-18 2006-07-27 Irm Llc Compounds and compositions as wnt signaling pathway modulators
WO2006086639A1 (en) 2005-02-10 2006-08-17 Regents Of The University Of Minnesota Vascular/lymphatic endothelial cells
JP4839032B2 (ja) * 2005-07-13 2011-12-14 国立大学法人 岡山大学 ケモカイン受容体作用増強剤
AU2006311637A1 (en) 2005-11-07 2007-05-18 The General Hospital Corporation Methods and compositions for modulation of stem cell aging
DE102005062741A1 (de) 2005-12-22 2007-06-28 Bayer Schering Pharma Ag Fluorene und Carbazole als Liganden des EP2 Rezeptors
US8318489B2 (en) 2005-12-22 2012-11-27 Bruce Paul Davidson Prostacyclin directed differentiation of cardiomyocytes from human embryonic stem cells
US8630016B2 (en) 2006-02-08 2014-01-14 Becton, Dickinson And Company Label processor and method relating thereto
JP5247675B2 (ja) 2006-03-24 2013-07-24 チルドレンズ メディカル センター コーポレーション 造血性幹細胞の増殖を調節する方法
US7819934B2 (en) 2006-07-14 2010-10-26 Xcellerex, Inc. Environmental containment systems
WO2008021475A2 (en) 2006-08-16 2008-02-21 The General Hospital Corporation Compositions and methods for hematopoietic stem cell expansion or for modulating angiogenesis
WO2008056963A1 (en) 2006-11-10 2008-05-15 Chanil Moon Method for proliferating stem cells with leptin
WO2008073748A1 (en) 2006-12-08 2008-06-19 University Of Rochester Expansion of hematopoietic stem cells
US8871752B2 (en) 2008-02-19 2014-10-28 Sucampo Ag Method for modulating stem cell growth
US20110165128A1 (en) 2008-03-07 2011-07-07 Columbia University In The City Of New York Homing in mesenchymal stem cells
ES2845641T3 (es) * 2008-11-06 2021-07-27 Univ Indiana Res & Tech Corp Materiales y métodos para mejorar procedimientos de injerto funcionante de células madre hematopoyéticas
JP5705127B2 (ja) 2008-12-03 2015-04-22 アモーサイト インコーポレイテッド 梗塞領域灌流改善組成物および血管損傷修復の方法
WO2010108028A2 (en) 2009-03-19 2010-09-23 Fate Therapeutics, Inc. Compositions comprising cyclic amp enhancers and/or ep ligands, and methods of preparing and using the same
EP2275442A1 (en) * 2009-07-06 2011-01-19 Ludwig-Maximilians-Universität München Detection and vizualization of the cell cycle in living cells
BR112013003366A2 (pt) * 2010-08-12 2020-08-04 Fate Therapeutics, Inc. terapia aperfeiçoada de células tronco hematopoiéticas e progenitoras
EP3785767A1 (en) 2011-12-02 2021-03-03 Fate Therapeutics, Inc. Enhanced stem cell composition
ES2682255T3 (es) 2011-12-02 2018-09-19 Fate Therapeutics, Inc. Métodos mejorados de tratamiento de isquemia

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