PT2707003T - Sais cristalinos da amida do ácido (4s,4as,5ar,12as)-4-dimetilamino-3,10,12,12a-tetra-hidroxi-7-[(metoxi(metil)amino]-metil]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octa-hidro-naftaceno-2-carboxílico e métodos de utilização dos mesmos - Google Patents

Sais cristalinos da amida do ácido (4s,4as,5ar,12as)-4-dimetilamino-3,10,12,12a-tetra-hidroxi-7-[(metoxi(metil)amino]-metil]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octa-hidro-naftaceno-2-carboxílico e métodos de utilização dos mesmos

Info

Publication number
PT2707003T
PT2707003T PT12782600T PT12782600T PT2707003T PT 2707003 T PT2707003 T PT 2707003T PT 12782600 T PT12782600 T PT 12782600T PT 12782600 T PT12782600 T PT 12782600T PT 2707003 T PT2707003 T PT 2707003T
Authority
PT
Portugal
Prior art keywords
methyl
naptacene
metoxy
crystaline
octa
Prior art date
Application number
PT12782600T
Other languages
English (en)
Portuguese (pt)
Inventor
Coulter Catherine
M Johnston Sean
Seyedi Farzaneh
Original Assignee
Paratek Pharm Innc
Allergan Pharmaceuticals Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharm Innc, Allergan Pharmaceuticals Int Ltd filed Critical Paratek Pharm Innc
Publication of PT2707003T publication Critical patent/PT2707003T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT12782600T 2011-05-12 2012-05-14 Sais cristalinos da amida do ácido (4s,4as,5ar,12as)-4-dimetilamino-3,10,12,12a-tetra-hidroxi-7-[(metoxi(metil)amino]-metil]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octa-hidro-naftaceno-2-carboxílico e métodos de utilização dos mesmos PT2707003T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161485179P 2011-05-12 2011-05-12

Publications (1)

Publication Number Publication Date
PT2707003T true PT2707003T (pt) 2019-08-05

Family

ID=47139728

Family Applications (1)

Application Number Title Priority Date Filing Date
PT12782600T PT2707003T (pt) 2011-05-12 2012-05-14 Sais cristalinos da amida do ácido (4s,4as,5ar,12as)-4-dimetilamino-3,10,12,12a-tetra-hidroxi-7-[(metoxi(metil)amino]-metil]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octa-hidro-naftaceno-2-carboxílico e métodos de utilização dos mesmos

Country Status (15)

Country Link
US (4) US9255068B2 (https=)
EP (2) EP2707003B1 (https=)
JP (5) JP6574572B2 (https=)
CA (1) CA2835876C (https=)
CY (1) CY1127230T1 (https=)
DK (1) DK2707003T3 (https=)
ES (2) ES2739626T3 (https=)
HR (1) HRP20191295T8 (https=)
HU (1) HUE044536T2 (https=)
LT (1) LT2707003T (https=)
PL (1) PL2707003T3 (https=)
PT (1) PT2707003T (https=)
SI (1) SI2707003T1 (https=)
TR (1) TR201911086T4 (https=)
WO (1) WO2012155146A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8856782B2 (en) 2007-03-01 2014-10-07 George Mason Research Foundation, Inc. On-demand disposable virtual work system
US9098698B2 (en) 2008-09-12 2015-08-04 George Mason Research Foundation, Inc. Methods and apparatus for application isolation
US9255068B2 (en) * 2011-05-12 2016-02-09 Warner Chilcott Company, Llc Crystalline salts of (4S,4AS,5AR,12AS)-4-dimethylamino-3,10,12,12A-tetrahydroxy-7-[methoxy(methyl)amino)-methyl] acid amide and methods of using the same
WO2013082437A1 (en) 2011-12-02 2013-06-06 Invincia, Inc. Methods and apparatus for control and detection of malicious content using a sandbox environment
CA2873412A1 (en) * 2012-05-14 2013-11-21 Paratek Pharmaceuticals, Inc. Methods of using (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide
HUE066360T2 (hu) * 2016-10-19 2024-07-28 Tetraphase Pharmaceuticals Inc Eravaciklin kristályformái
CN111343991A (zh) * 2017-07-21 2020-06-26 阿尔米雷尔有限责任公司 非炎性病变的治疗
AU2019248350B2 (en) * 2018-04-06 2023-07-27 Almirall, Llc Process for making sarecycline hydrochloride
JP7840880B2 (ja) * 2020-06-11 2026-04-06 パラテック ファーマシューティカルズ，インコーポレイテッド オマダサイクリンの結晶形態、その合成方法及びその使用方法
US12487293B2 (en) 2021-06-14 2025-12-02 Hioki E.E. Corporation Short circuit detection device and short circuit detection method

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2990331A (en) 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
US2980584A (en) 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US3062717A (en) 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
US3165531A (en) 1962-03-08 1965-01-12 Pfizer & Co C 13-substituted-6-deoxytetracyclines and process utilizing the same
US3454697A (en) 1965-06-08 1969-07-08 American Cyanamid Co Tetracycline antibiotic compositions for oral use
NL6607516A (https=) 1966-05-31 1967-12-01
DE1767891C3 (de) 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
US3957980A (en) 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
DE2442829A1 (de) 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
US4018889A (en) 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
US4126680A (en) 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
DK0599397T3 (da) 1992-11-17 1996-09-16 Univ New York State Res Found Tetracycliner, herunder non-mikrobielle, kemisk-modificerede tetracycliner, inhiberer overdreven collagentværbinding ved diabetes
WO1995022529A1 (en) 1994-02-17 1995-08-24 Pfizer Inc. 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
US5789395A (en) 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
US6277061B1 (en) 1998-03-31 2001-08-21 The Research Foundation Of State University Of New York Method of inhibiting membrane-type matrix metalloproteinase
CA2892739A1 (en) * 2006-12-21 2008-07-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
WO2008079339A2 (en) 2006-12-21 2008-07-03 Paratek Pharmaceuticals, Inc. Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections
CA2717703A1 (en) * 2008-03-05 2009-09-11 Paratek Pharmaceuticals, Inc. Minocycline compounds and methods of use thereof
TWI680117B (zh) * 2008-05-19 2019-12-21 派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
US9255068B2 (en) * 2011-05-12 2016-02-09 Warner Chilcott Company, Llc Crystalline salts of (4S,4AS,5AR,12AS)-4-dimethylamino-3,10,12,12A-tetrahydroxy-7-[methoxy(methyl)amino)-methyl] acid amide and methods of using the same
CA2873412A1 (en) * 2012-05-14 2013-11-21 Paratek Pharmaceuticals, Inc. Methods of using (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

Also Published As

Publication number Publication date
HRP20191295T1 (hr) 2019-10-18
HRP20191295T8 (hr) 2020-02-07
CA2835876A1 (en) 2012-11-15
CA2835876C (en) 2020-04-14
JP6574572B2 (ja) 2019-09-11
EP2707003A4 (en) 2014-11-12
US20200024223A1 (en) 2020-01-23
LT2707003T (lt) 2019-10-10
PL2707003T3 (pl) 2019-11-29
EP3574908B1 (en) 2024-07-31
JP2019142867A (ja) 2019-08-29
JP6876082B2 (ja) 2021-05-26
EP3574908B8 (en) 2024-09-11
DK2707003T3 (da) 2019-08-05
EP2707003B1 (en) 2019-05-01
JP2014520077A (ja) 2014-08-21
JP2023093519A (ja) 2023-07-04
ES2739626T3 (es) 2020-02-03
JP2021098695A (ja) 2021-07-01
JP2017132775A (ja) 2017-08-03
US20190040002A1 (en) 2019-02-07
WO2012155146A1 (en) 2012-11-15
HUE044536T2 (hu) 2019-10-28
EP3574908A1 (en) 2019-12-04
SI2707003T1 (sl) 2019-10-30
EP2707003A1 (en) 2014-03-19
CY1127230T1 (el) 2026-02-25
ES2985493T3 (es) 2024-11-06
US20130012480A1 (en) 2013-01-10
US20160200671A1 (en) 2016-07-14
TR201911086T4 (tr) 2019-08-21
US9255068B2 (en) 2016-02-09

Similar Documents

Publication Publication Date Title
PT2707003T (pt) Sais cristalinos da amida do ácido (4s,4as,5ar,12as)-4-dimetilamino-3,10,12,12a-tetra-hidroxi-7-[(metoxi(metil)amino]-metil]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octa-hidro-naftaceno-2-carboxílico e métodos de utilização dos mesmos
BR112013020002A2 (pt) peptídeo de fórmula geral r1-wn-xm-aa1-aa2-aa3-aa4-aa5-aa6-yp-zq-r2, seus estereoisômeros, misturas dos mesmos e/ou seus sais aceitáveis de modo cosmético ou farmacêutico e composição cosmética ou farmacêutica
IL220545B (en) Derivatives of -n cycloalkylalkyl- n, (2-carboxy-5-alkynyl-thiane--3 yl), cycloalkane-amide and their uses for the treatment of flaviviridae virus infection
IL254879B (en) History of dolastatin associated with unnatural amino acids and pharmaceutical preparations containing them
IL229353B (en) Dolestatin derivatives related to unnatural amino acids and medicinal preparations that include them
BR112012001164A2 (pt) aminoácido de carbamato e pró-fármacos de peptídeo de opioides e usos dos mesmos
BR112013011868A2 (pt) compostos de pirimidina hidróxi amida como inibidores da proteína desacetilase, composição farmacêutica e uso dos referidos compostos
EP2768854A4 (en) STABILIZED ETANERCEPT FORMULATIONS WITH AMINO ACIDS
CO6862148A2 (es) Composiciones transdérmicas de ibuprofeno y métodos de uso de las mismas
BR112014001991A2 (pt) certos inibidores de quinurenina-3-monooxigenase, composições farmacêuticas e métodos de uso dos mesmos
EP2668180A4 (en) BCL-2 / BCL-XL-INHIBITORS AND THESE USE THERAPEUTIC PROCEDURES
BR112013013756A2 (pt) conjunto de fixação pedicular multiaxial e método de uso
BR112014010631A2 (pt) inibidores de pak para o tratamento da síndrome do x frágil
BRPI1012766A2 (pt) sais de amida e/ou éster de amônio quaternário
ECSP13012928A (es) Derivados de fluoro-piridinona útiles como agentes antibacterianos
EP2718265A4 (en) PROCESS FOR THE PREPARATION OF [(3-HYDROXYPYRIDINE-2-CARBONYL-) AMINO-] ALKANIC ACIDS, ETHERS AND AMMUNES
BR112014003774A2 (pt) inibidores de dyrk1 e usos dos mesmos
EA201200728A1 (ru) Новые сокристаллы агомелатина, способ их получения и фармацевтические композиции, которые их содержат
BR112013008211A2 (pt) cocristais e sais de inibidores de ccr3
EP2762011A4 (en) AMINO ACID SPICE COMPOSITION WITH L-GLUTAMIC ACID AND BASIC AMINO ACIDS
EP2777713A4 (en) POLYETHYLENE GLYCOL AMINO ACID OLIGOPEPTIDE IRINOTECAN MEDICAMENT CONJUGATE AND MEDICAMENT COMPOSITION THEREOF
BRPI1015118A2 (pt) sais de ácido pentilfenilacético e usos farmacêuticos dos mesmos
BR112012001551A2 (pt) profármacos de aminoácido galantamina e peptídeo e usos dos mesmos
EP2667872A4 (en) SMALL MOLECULAR RNASE INHIBITORS AND METHOD OF USE THEREOF
EP2575903A4 (en) Covering and method for trapping of emissions from surfaces