PT2650007E - Utilização de inibidores peptídicos aos quais as células são permeáveis da via de transdução de sinal de jnk para o tratamento de várias doenças autoimunes - Google Patents
Utilização de inibidores peptídicos aos quais as células são permeáveis da via de transdução de sinal de jnk para o tratamento de várias doenças autoimunes Download PDFInfo
- Publication number
- PT2650007E PT2650007E PT130027923T PT13002792T PT2650007E PT 2650007 E PT2650007 E PT 2650007E PT 130027923 T PT130027923 T PT 130027923T PT 13002792 T PT13002792 T PT 13002792T PT 2650007 E PT2650007 E PT 2650007E
- Authority
- PT
- Portugal
- Prior art keywords
- cell
- treatment
- signal transduction
- autoimmune diseases
- transduction pathway
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2008/004341 WO2009143865A1 (en) | 2008-05-30 | 2008-05-30 | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2650007E true PT2650007E (pt) | 2015-08-04 |
Family
ID=40347935
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT12000665T PT2491942E (pt) | 2008-05-30 | 2009-06-02 | Utilização de inibidores peptídicos aos quais as células são permeáveis da via de transdução de sinal de jnk para o tratamento de várias doenças cardiovasculares |
PT130027923T PT2650007E (pt) | 2008-05-30 | 2009-06-02 | Utilização de inibidores peptídicos aos quais as células são permeáveis da via de transdução de sinal de jnk para o tratamento de várias doenças autoimunes |
PT12000663T PT2489361E (pt) | 2008-05-30 | 2009-06-02 | Utilização de inibidores peptídicos aos quais as células são permeáveis da via de transdução de sinal de jnk para o tratamento de diversas doenças |
PT13002793T PT2650008E (pt) | 2008-05-30 | 2009-06-02 | Utilização de inibidores peptídicos aos quais as células são permeáveis da via de transdução de sinal de jnk para o tratamento de várias doenças cancerígenas |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT12000665T PT2491942E (pt) | 2008-05-30 | 2009-06-02 | Utilização de inibidores peptídicos aos quais as células são permeáveis da via de transdução de sinal de jnk para o tratamento de várias doenças cardiovasculares |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT12000663T PT2489361E (pt) | 2008-05-30 | 2009-06-02 | Utilização de inibidores peptídicos aos quais as células são permeáveis da via de transdução de sinal de jnk para o tratamento de diversas doenças |
PT13002793T PT2650008E (pt) | 2008-05-30 | 2009-06-02 | Utilização de inibidores peptídicos aos quais as células são permeáveis da via de transdução de sinal de jnk para o tratamento de várias doenças cancerígenas |
Country Status (17)
Country | Link |
---|---|
US (2) | US9006185B2 (pt) |
EP (6) | EP2650008B1 (pt) |
JP (3) | JP5485265B2 (pt) |
CN (2) | CN102112149A (pt) |
AR (1) | AR070864A1 (pt) |
AU (1) | AU2009253346B2 (pt) |
CA (1) | CA2725545A1 (pt) |
CY (4) | CY1114725T1 (pt) |
DK (5) | DK2296684T3 (pt) |
ES (5) | ES2531963T3 (pt) |
HK (6) | HK1150305A1 (pt) |
HR (1) | HRP20150116T1 (pt) |
HU (1) | HUE026798T2 (pt) |
PL (5) | PL2491942T3 (pt) |
PT (4) | PT2491942E (pt) |
SI (1) | SI2650008T1 (pt) |
WO (2) | WO2009143865A1 (pt) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040082509A1 (en) | 1999-10-12 | 2004-04-29 | Christophe Bonny | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
US8183339B1 (en) | 1999-10-12 | 2012-05-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
WO2007031098A1 (en) | 2005-09-12 | 2007-03-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the jnk signal transduction pathway |
US8080517B2 (en) | 2005-09-12 | 2011-12-20 | Xigen Sa | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
TWI468417B (zh) | 2007-11-30 | 2015-01-11 | Genentech Inc | 抗-vegf抗體 |
WO2009143864A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases |
WO2009143865A1 (en) * | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
MX2011004306A (es) | 2008-10-22 | 2011-07-28 | Genentech Inc | Modulacion de degeneracion de axones. |
WO2010065850A2 (en) * | 2008-12-04 | 2010-06-10 | University Of Massachusetts | Interleukin 6 and tumor necrosis factor alpha as biomarkers of jnk inhibition |
WO2010072228A1 (en) | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
WO2011160653A1 (en) * | 2010-06-21 | 2011-12-29 | Xigen S.A. | Novel jnk inhibitor molecules |
PL2902035T3 (pl) * | 2010-10-14 | 2019-04-30 | Xigen Inflammation Ltd | Przechodzące przez komórkę peptydowe inhibitory szlaku przekazywania sygnałów przez JNK do zastosowania w leczeniu chorób zapalnych oka |
CA2807036C (en) * | 2010-10-14 | 2018-01-16 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases |
CN101974083A (zh) * | 2010-10-20 | 2011-02-16 | 中国医学科学院医学生物学研究所 | 抗hsv1病毒感染的人源hirrp蛋白分子 |
WO2013091670A1 (en) * | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
WO2015197097A1 (en) * | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
WO2014206427A1 (en) * | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
WO2015197193A2 (en) * | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
WO2014206563A2 (en) * | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
WO2014206426A1 (en) * | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
WO2016055160A2 (en) * | 2014-10-08 | 2016-04-14 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
WO2015197098A1 (en) * | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
CN103911462B (zh) * | 2014-04-03 | 2015-06-10 | 河北国际旅行卫生保健中心 | 黄热、乙型脑炎、基孔肯雅、西尼罗的鉴别检测方法及引物和探针 |
WO2015150934A1 (en) * | 2014-04-04 | 2015-10-08 | Feligioni Marco | Cell-permeable peptide system for treating diseases caused by glutamate excitotoxicity |
CN113509541A (zh) * | 2014-06-26 | 2021-10-19 | 埃克西金炎症有限公司 | Jnk信号转导途径的细胞穿透肽抑制剂用于治疗多种疾病的新用途 |
CN104250640A (zh) | 2014-08-22 | 2014-12-31 | 普莱柯生物工程股份有限公司 | 猪伪狂犬病病毒基因缺失株、疫苗组合物及其制备方法和应用 |
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2013
- 2013-02-18 HK HK13102059A patent/HK1174839A1/xx not_active IP Right Cessation
- 2013-02-21 HK HK13102221A patent/HK1175102A1/xx not_active IP Right Cessation
- 2013-12-18 CY CY20131101147T patent/CY1114725T1/el unknown
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2014
- 2014-01-07 HK HK14100161.7A patent/HK1186988A1/xx not_active IP Right Cessation
- 2014-01-07 HK HK14100164.4A patent/HK1186989A1/xx not_active IP Right Cessation
- 2014-02-19 JP JP2014029875A patent/JP5824085B2/ja not_active Expired - Fee Related
- 2014-07-03 CY CY20141100500T patent/CY1115357T1/el unknown
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2015
- 2015-01-30 HR HRP20150116AT patent/HRP20150116T1/hr unknown
- 2015-02-19 CY CY20151100178T patent/CY1116175T1/el unknown
- 2015-03-06 US US14/640,759 patent/US9610330B2/en active Active
- 2015-07-17 JP JP2015143202A patent/JP2015232008A/ja active Pending
- 2015-07-23 CY CY20151100649T patent/CY1116633T1/el unknown
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2016
- 2016-08-11 HK HK16109616.7A patent/HK1221413A1/zh unknown
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