DK1333846T3 - Fremstilling og xenotransplantation af porcine øer - Google Patents
Fremstilling og xenotransplantation af porcine øerInfo
- Publication number
- DK1333846T3 DK1333846T3 DK01979134.2T DK01979134T DK1333846T3 DK 1333846 T3 DK1333846 T3 DK 1333846T3 DK 01979134 T DK01979134 T DK 01979134T DK 1333846 T3 DK1333846 T3 DK 1333846T3
- Authority
- DK
- Denmark
- Prior art keywords
- pancreas
- preparation
- islets
- culture
- xenotransplantation
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 4
- 238000002689 xenotransplantation Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 abstract 5
- 210000000496 pancreas Anatomy 0.000 abstract 4
- 238000002513 implantation Methods 0.000 abstract 2
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 102000008186 Collagen Human genes 0.000 abstract 1
- 108010035532 Collagen Proteins 0.000 abstract 1
- 102000029816 Collagenase Human genes 0.000 abstract 1
- 108060005980 Collagenase Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 108010005991 Pork Regular Insulin Proteins 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229920001436 collagen Polymers 0.000 abstract 1
- 229960002424 collagenase Drugs 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 238000003306 harvesting Methods 0.000 abstract 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000002906 microbiologic effect Effects 0.000 abstract 1
- 230000035935 pregnancy Effects 0.000 abstract 1
- 210000000717 sertoli cell Anatomy 0.000 abstract 1
- 238000007920 subcutaneous administration Methods 0.000 abstract 1
- 230000003319 supportive effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ50761600A NZ507616A (en) | 2000-10-17 | 2000-10-17 | Preparation and xenotransplantation of porcine islets in the presence of sertoli cells, for treatment of diabetes |
NZ50796300 | 2000-11-02 | ||
PCT/NZ2001/000228 WO2002032437A1 (en) | 2000-10-17 | 2001-10-16 | Preparation and xenotransplantation or porcine islets |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1333846T3 true DK1333846T3 (da) | 2012-08-06 |
Family
ID=26652219
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01979134.2T DK1333846T3 (da) | 2000-10-17 | 2001-10-16 | Fremstilling og xenotransplantation af porcine øer |
Country Status (7)
Country | Link |
---|---|
US (2) | US20040014212A1 (da) |
EP (1) | EP1333846B1 (da) |
AT (1) | ATE553766T1 (da) |
AU (2) | AU1112202A (da) |
DK (1) | DK1333846T3 (da) |
ES (1) | ES2386505T3 (da) |
WO (1) | WO2002032437A1 (da) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
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US7399751B2 (en) * | 1999-11-04 | 2008-07-15 | Sertoli Technologies, Inc. | Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells |
US20090047325A1 (en) * | 1999-04-30 | 2009-02-19 | Neurotrophincell Pty. Limited | Xenotransplant for cns therapy |
DE60044431D1 (en) * | 1999-04-30 | 2010-07-01 | Neurotrophincell Pty Ltd | Xenotransplant für zns therapie |
US20050265977A1 (en) * | 1999-04-30 | 2005-12-01 | Elliott Robert B | Xenotransplant for CNS therapy |
US20030108539A1 (en) * | 2000-02-14 | 2003-06-12 | Christophe Bonny | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
AU780366B2 (en) * | 2000-01-20 | 2005-03-17 | Diatranz Otsuka Limited | Preparation and xenotransplantation of porcine islets |
EP1438395B1 (en) * | 2001-09-28 | 2011-11-30 | Diabcell Pty Limited | Growing xenotransplant material in culture |
NZ515310A (en) * | 2001-11-07 | 2004-08-27 | Diabcell Pty Ltd | Methods of treatment and delivery modes |
CA2529573A1 (en) * | 2003-06-24 | 2004-12-29 | Diabcell Pty Limited | Porcine islets cultured with porcine sertoli cells for xenotransplantation |
CA2848954A1 (en) * | 2003-07-03 | 2005-03-03 | Sertoli Technologies, Llc | Compositions containing sertoli cells and myoid cells and use thereof in cellular transplants |
NZ539491A (en) | 2005-04-15 | 2008-04-30 | Living Cell Products Pty Ltd | Swine population and uses thereof |
NZ536009A (en) | 2005-04-18 | 2007-01-26 | Neurotrophincell Pty Ltd | Choroid plexus preparation and uses thereof |
NZ540597A (en) * | 2005-06-08 | 2007-02-23 | Neurotrophincell Pty Ltd | A method for preventing the onset of type I diabetes comprising administering an implantable composition comprising living choroid plexus cells |
WO2007031098A1 (en) | 2005-09-12 | 2007-03-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the jnk signal transduction pathway |
CA2658951A1 (en) * | 2006-07-28 | 2008-01-31 | Sertocell Biotechnology (Us) Corp. | Adult sertoli cells and uses thereof |
WO2009143864A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases |
WO2009143865A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
WO2010072228A1 (en) | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
EA025142B1 (ru) | 2009-08-28 | 2016-11-30 | Сернова Корпорэйнш | Способ и устройство для клеточной трансплантации |
WO2011160653A1 (en) | 2010-06-21 | 2011-12-29 | Xigen S.A. | Novel jnk inhibitor molecules |
CA2807036C (en) | 2010-10-14 | 2018-01-16 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases |
US20130336940A1 (en) | 2011-02-23 | 2013-12-19 | Universite Catholique De Louvain | Modified pig islets for diabetes treatment |
US9557433B2 (en) * | 2011-03-23 | 2017-01-31 | Seismic Global Ambient, Llc | Fracture imaging methods employing skeletonization of seismic emission tomography data |
US9389326B2 (en) * | 2011-03-23 | 2016-07-12 | Global Ambient Seismic, Inc. | Methods, systems and devices for near-well fracture monitoring using tomographic fracture imaging techniques |
US9442205B2 (en) * | 2011-03-23 | 2016-09-13 | Global Ambient Seismic, Inc. | Method for assessing the effectiveness of modifying transmissive networks of natural reservoirs |
US9810803B2 (en) * | 2011-03-23 | 2017-11-07 | Seismic Global Ambient, Llc | Method for subsurface mapping using seismic emissions |
WO2013091670A1 (en) | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
WO2015197097A1 (en) | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
AU2014301631A1 (en) | 2013-06-26 | 2015-08-27 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of various diseases |
WO2014206427A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
JP6621420B2 (ja) | 2014-04-11 | 2019-12-18 | ウニベルシテ カソリーク デ ルーベン | 糖尿病を治療するためのトランスジェニックブタ膵島およびその使用 |
EP4098269A4 (en) * | 2020-01-28 | 2024-02-28 | Otsuka Pharma Factory Inc | METHOD FOR PRODUCING CAPSULES CONTAINING PANCREAS ISLE CELLS |
US20230183649A1 (en) * | 2020-06-17 | 2023-06-15 | Otsuka Pharmaceutical Factory, Inc. | Encapsulated pancreatic islet |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
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US5266480A (en) * | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
US4850993A (en) * | 1986-12-22 | 1989-07-25 | Miles Laboratories, Inc. | Blood bag system incorporating quinolone carboxylic, acid derivatives |
US5871472A (en) * | 1987-11-17 | 1999-02-16 | Brown University Research Foundation | Planting devices for the focal release of neuroinhibitory compounds |
US5283187A (en) * | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
US5650148A (en) * | 1988-12-15 | 1997-07-22 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system |
CA2109085C (en) * | 1991-04-25 | 2003-03-11 | Keith E. Dionne | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
US6231881B1 (en) * | 1992-02-24 | 2001-05-15 | Anton-Lewis Usala | Medium and matrix for long-term proliferation of cells |
PT696205E (pt) * | 1993-04-13 | 2002-07-31 | Us Gov Health & Human Serv | Utilizacao de linhas celulares fetais nauro-derivadas para terapia de transplantacao |
US6090400A (en) * | 1994-02-07 | 2000-07-18 | The Trustees Of The Childhood Diabetes Transplant Research Trust | Pharmaceutical preparation and method for treatment of diabetes |
US5849285A (en) * | 1994-04-13 | 1998-12-15 | Research Corporation Technologies, Inc. | Autoimmune disease treatment with sertoli cells and in vitro co-culture of mammal cells with sertoli cells |
US5550050A (en) * | 1994-04-15 | 1996-08-27 | Cytotherapeutics, Inc. | Method for implanting encapsulated cells in a host |
US6001647A (en) * | 1994-04-28 | 1999-12-14 | Ixion Biotechnology, Inc. | In vitro growth of functional islets of Langerhans and in vivo uses thereof |
US5587309A (en) * | 1994-04-29 | 1996-12-24 | The United States Of America As Represented By The Department Of Health And Human Services | Method of stimulating proliferation and differentiation of human fetal pancreatic cells ex vivo |
US5561108A (en) * | 1994-07-29 | 1996-10-01 | Bayer Corporation | Preparation of α1 -antichymotrypsin |
US5853385A (en) * | 1994-08-26 | 1998-12-29 | Cytotherapeutics, Inc. | Encapsulated PC12 cell transplants for treatment of Parkinson's disease |
US5898066A (en) * | 1994-08-26 | 1999-04-27 | Children's Medical Center Corporation | Trophic factors for central nervous system regeneration |
US6225310B1 (en) * | 1996-01-17 | 2001-05-01 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine derivatives, their preparation and use |
CA2179341A1 (en) * | 1996-04-12 | 1997-10-13 | Gregory S. Korbutt | Methods for isolating, enriching and increasing the maturation of cells |
AU8186498A (en) * | 1997-08-26 | 1999-03-11 | Diatranz Limited | Treatment for diabetes |
US5968829A (en) * | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
US6432710B1 (en) * | 1998-05-22 | 2002-08-13 | Isolagen Technologies, Inc. | Compositions for regenerating tissue that has deteriorated, and methods for using such compositions |
ES2270626T3 (es) * | 1998-12-15 | 2007-04-01 | Universidad Nacional Autonoma De Mexico | Procedimiento y dispositivo para favorecer el implante material biologico. |
US6365385B1 (en) * | 1999-03-22 | 2002-04-02 | Duke University | Methods of culturing and encapsulating pancreatic islet cells |
US20040213768A1 (en) * | 1999-04-30 | 2004-10-28 | Elliott Robert Bartlett | Preparation for biotransplantation and xenotransplantion and uses thereof |
US20050265977A1 (en) * | 1999-04-30 | 2005-12-01 | Elliott Robert B | Xenotransplant for CNS therapy |
AU780366B2 (en) * | 2000-01-20 | 2005-03-17 | Diatranz Otsuka Limited | Preparation and xenotransplantation of porcine islets |
NZ515310A (en) * | 2001-11-07 | 2004-08-27 | Diabcell Pty Ltd | Methods of treatment and delivery modes |
-
2001
- 2001-10-16 ES ES01979134T patent/ES2386505T3/es not_active Expired - Lifetime
- 2001-10-16 EP EP01979134A patent/EP1333846B1/en not_active Expired - Lifetime
- 2001-10-16 US US10/398,744 patent/US20040014212A1/en not_active Abandoned
- 2001-10-16 WO PCT/NZ2001/000228 patent/WO2002032437A1/en active IP Right Grant
- 2001-10-16 AT AT01979134T patent/ATE553766T1/de active
- 2001-10-16 AU AU1112202A patent/AU1112202A/xx active Pending
- 2001-10-16 AU AU2002211122A patent/AU2002211122B2/en not_active Ceased
- 2001-10-16 DK DK01979134.2T patent/DK1333846T3/da active
-
2007
- 2007-07-10 US US11/775,797 patent/US20080070301A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1333846A1 (en) | 2003-08-13 |
ATE553766T1 (de) | 2012-05-15 |
ES2386505T3 (es) | 2012-08-22 |
AU1112202A (en) | 2002-04-29 |
US20080070301A1 (en) | 2008-03-20 |
WO2002032437A1 (en) | 2002-04-25 |
EP1333846A4 (en) | 2008-02-20 |
US20040014212A1 (en) | 2004-01-22 |
AU2002211122B2 (en) | 2005-06-23 |
EP1333846B1 (en) | 2012-04-18 |
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