PT2575467T - Compostos macrocíclicos úteis como inibidores de histona desacetilases - Google Patents
Compostos macrocíclicos úteis como inibidores de histona desacetilases Download PDFInfo
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- PT2575467T PT2575467T PT117874628T PT11787462T PT2575467T PT 2575467 T PT2575467 T PT 2575467T PT 117874628 T PT117874628 T PT 117874628T PT 11787462 T PT11787462 T PT 11787462T PT 2575467 T PT2575467 T PT 2575467T
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- cycloalkyl
- alkyl
- heterocycloalkyl
- independently
- heteroaryl
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- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Molecular Biology (AREA)
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- Mycology (AREA)
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- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US34897810P | 2010-05-27 | 2010-05-27 |
Publications (1)
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PT2575467T true PT2575467T (pt) | 2016-10-14 |
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PT117874628T PT2575467T (pt) | 2010-05-27 | 2011-05-26 | Compostos macrocíclicos úteis como inibidores de histona desacetilases |
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US (2) | US8754050B2 (zh) |
EP (1) | EP2575467B1 (zh) |
JP (1) | JP5931850B2 (zh) |
KR (2) | KR102028850B1 (zh) |
CN (1) | CN102946732B (zh) |
AU (1) | AU2011258110B2 (zh) |
BR (1) | BR112012030193B1 (zh) |
CA (1) | CA2800958C (zh) |
DK (1) | DK2575467T3 (zh) |
ES (1) | ES2594500T3 (zh) |
HK (1) | HK1181613A1 (zh) |
HU (1) | HUE030812T2 (zh) |
LT (1) | LT2575467T (zh) |
MX (1) | MX2012013507A (zh) |
PL (1) | PL2575467T3 (zh) |
PT (1) | PT2575467T (zh) |
RU (1) | RU2565076C2 (zh) |
WO (1) | WO2011150283A1 (zh) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102391359B (zh) * | 2011-11-17 | 2014-07-16 | 南京优科生物医药研究有限公司 | 组蛋白去乙酰化酶抑制剂及其合成方法和制药用途 |
CN103232474A (zh) * | 2013-04-16 | 2013-08-07 | 中国药科大学 | 组蛋白去乙酰化酶抑制剂 |
CN106800589B (zh) * | 2013-09-02 | 2021-01-12 | 李铁旦 | 一类环肽类化合物、其制备方法、药物组合物及用途 |
DK3578179T3 (da) * | 2014-05-27 | 2021-03-15 | Onkure Inc | Process for the preparation of cyclic depsipeptides |
JP6785801B2 (ja) * | 2015-03-06 | 2020-11-18 | コロラド ステート ユニバーシティー リサーチ ファウンデーション | 新しいキャップ基ラルガゾールの類似体の合成及び使用 |
CA2978698A1 (en) | 2015-03-06 | 2016-09-15 | Colorado State University Research Foundation | Method for preparing largazole analogs and uses thereof |
CN105131082A (zh) * | 2015-09-17 | 2015-12-09 | 广州康缔安生物科技有限公司 | 环肽类化合物及其应用 |
CN106674252B (zh) * | 2015-11-11 | 2019-10-29 | 复旦大学 | 海洋天然产物环酯肽的氟代烯烃类似物、其制备方法和用途 |
JP6691958B2 (ja) * | 2016-05-20 | 2020-05-13 | オンキュアー,インコーポレイテッド | ヒストンデアセチラーゼの阻害剤としての大環状分子のチオエステルプロドラッグ |
CN107286223B (zh) * | 2017-07-17 | 2019-12-20 | 湖北大学 | 一种用于检测组蛋白位点乙酰化的重组蛋白及其应用 |
CN111269245B (zh) * | 2018-12-04 | 2021-08-27 | 杭州百新生物医药科技有限公司 | 一种环状氨基嘧啶衍生物及其抑制激酶的活性和用途 |
US20220017520A1 (en) * | 2018-12-19 | 2022-01-20 | Keythera (Suzhou) Pharmaceuticals Co. Ltd. | Macrocyclic compound as cdk inhibitor, preparation method therefor, and use thereof in medicine |
EP3941457A4 (en) | 2019-03-21 | 2023-04-26 | Merck Sharp & Dohme LLC | HISTONE-DEACETYLASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF HIV INFECTION |
KR102436309B1 (ko) * | 2020-05-26 | 2022-08-25 | 연세대학교 산학협력단 | 암의 예방 또는 치료용 약학적 조성물 |
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GB8920304D0 (en) | 1989-09-08 | 1989-10-25 | Fujisawa Pharmaceutical Co | Fr901375 substance and preparation thereof |
US7098186B2 (en) * | 2002-08-30 | 2006-08-29 | Astellas Pharma Inc | Depsipeptide compound |
KR20050074547A (ko) * | 2002-11-12 | 2005-07-18 | 알콘, 인코퍼레이티드 | 눈의 퇴행성 질환을 치료하기 위한 히스톤 디아세틸라제저해제 |
US20060128660A1 (en) * | 2004-12-10 | 2006-06-15 | Wisconsin Alumni Research Foundation | FK228 analogs and methods of making and using the same |
US8865655B2 (en) * | 2006-11-22 | 2014-10-21 | Karus Therapeutics Limited | Depsipeptides and their therapeutic use |
GB0623388D0 (en) * | 2006-11-23 | 2007-01-03 | Univ Southampton | Chemical compounds |
GB0715750D0 (en) * | 2007-08-13 | 2007-09-19 | Karus Therapeutics Ltd | Chemical compounds |
EP2276757B1 (en) * | 2008-04-11 | 2016-01-06 | University of Florida Research Foundation, Inc. | Macrocyclic compounds and methods of treatment |
US8217076B2 (en) * | 2008-07-17 | 2012-07-10 | Colorado State University Research Foundation | Method for preparing largazole analogs and uses thereof |
CN102391359B (zh) * | 2011-11-17 | 2014-07-16 | 南京优科生物医药研究有限公司 | 组蛋白去乙酰化酶抑制剂及其合成方法和制药用途 |
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2011
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2013
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US9422340B2 (en) | 2016-08-23 |
WO2011150283A1 (en) | 2011-12-01 |
AU2011258110A1 (en) | 2013-01-10 |
EP2575467A1 (en) | 2013-04-10 |
HUE030812T2 (en) | 2017-05-29 |
US20130203681A1 (en) | 2013-08-08 |
US20150010541A1 (en) | 2015-01-08 |
CN102946732B (zh) | 2014-11-26 |
MX2012013507A (es) | 2013-03-12 |
BR112012030193B1 (pt) | 2020-11-17 |
BR112012030193A2 (pt) | 2015-09-29 |
AU2011258110B2 (en) | 2015-07-16 |
KR102028850B1 (ko) | 2019-10-04 |
CN102946732A (zh) | 2013-02-27 |
CA2800958A1 (en) | 2011-12-01 |
KR20130123301A (ko) | 2013-11-12 |
ES2594500T3 (es) | 2016-12-20 |
EP2575467B1 (en) | 2016-07-06 |
RU2012157293A (ru) | 2014-07-10 |
PL2575467T3 (pl) | 2017-10-31 |
RU2565076C2 (ru) | 2015-10-20 |
CA2800958C (en) | 2018-09-04 |
HK1181613A1 (zh) | 2013-11-15 |
US8754050B2 (en) | 2014-06-17 |
JP2013528182A (ja) | 2013-07-08 |
KR20180081153A (ko) | 2018-07-13 |
EP2575467A4 (en) | 2014-10-15 |
DK2575467T3 (en) | 2016-09-26 |
LT2575467T (lt) | 2017-01-10 |
JP5931850B2 (ja) | 2016-06-08 |
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