PT2358355E - Composição farmacêutica de um inibidor potente de vhc para administração oral - Google Patents

Composição farmacêutica de um inibidor potente de vhc para administração oral Download PDF

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Publication number
PT2358355E
PT2358355E PT97603955T PT09760395T PT2358355E PT 2358355 E PT2358355 E PT 2358355E PT 97603955 T PT97603955 T PT 97603955T PT 09760395 T PT09760395 T PT 09760395T PT 2358355 E PT2358355 E PT 2358355E
Authority
PT
Portugal
Prior art keywords
pharmaceutical composition
oral administration
hcv inhibitor
potent hcv
potent
Prior art date
Application number
PT97603955T
Other languages
English (en)
Inventor
Feng-Jing Chen
Juan Francisco Gel
Maria Fernanda Villagra
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41650279&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2358355(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PT2358355E publication Critical patent/PT2358355E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
PT97603955T 2008-11-21 2009-11-18 Composição farmacêutica de um inibidor potente de vhc para administração oral PT2358355E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11678908P 2008-11-21 2008-11-21

Publications (1)

Publication Number Publication Date
PT2358355E true PT2358355E (pt) 2014-01-08

Family

ID=41650279

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97603955T PT2358355E (pt) 2008-11-21 2009-11-18 Composição farmacêutica de um inibidor potente de vhc para administração oral

Country Status (35)

Country Link
US (2) US20120101049A1 (pt)
EP (1) EP2358355B1 (pt)
JP (1) JP5553839B2 (pt)
KR (1) KR20110087297A (pt)
CN (1) CN102223875A (pt)
AR (1) AR074391A1 (pt)
AU (1) AU2009316755B2 (pt)
BR (1) BRPI0921070A2 (pt)
CA (1) CA2738732A1 (pt)
CL (1) CL2011000878A1 (pt)
CO (1) CO6361900A2 (pt)
CY (1) CY1114892T1 (pt)
DK (1) DK2358355T3 (pt)
EA (1) EA022272B1 (pt)
EC (1) ECSP11011065A (pt)
ES (1) ES2445516T3 (pt)
HR (1) HRP20140097T1 (pt)
IL (1) IL211832A (pt)
MA (1) MA32812B1 (pt)
ME (1) ME01614B (pt)
MX (1) MX2011005151A (pt)
MY (1) MY155402A (pt)
NZ (1) NZ592383A (pt)
PE (1) PE20120032A1 (pt)
PL (1) PL2358355T3 (pt)
PT (1) PT2358355E (pt)
RS (1) RS53121B (pt)
SG (1) SG171771A1 (pt)
SI (1) SI2358355T1 (pt)
TN (1) TN2011000258A1 (pt)
TW (1) TWI469801B (pt)
UA (1) UA105777C2 (pt)
UY (1) UY32252A (pt)
WO (1) WO2010059667A1 (pt)
ZA (1) ZA201102029B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
CN102470103B (zh) 2009-07-07 2016-09-07 贝林格尔.英格海姆国际有限公司 用作丙型肝炎病毒蛋白酶抑制剂的药物组合物
KR20130116245A (ko) 2010-09-30 2013-10-23 베링거 인겔하임 인터내셔날 게엠베하 Ｈｃｖ 감염 치료용 병용 요법
AU2011311880B2 (en) * 2010-10-08 2014-07-24 Novartis Ag Vitamin E formulations of sulfamide NS3 inhibitors
WO2012092409A2 (en) 2010-12-30 2012-07-05 Enanta Phararmaceuticals, Inc Macrocyclic hepatitis c serine protease inhibitors
AU2011352145A1 (en) 2010-12-30 2013-07-18 Abbvie Inc. Phenanthridine macrocyclic hepatitis C serine protease inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
WO2013059630A1 (en) 2011-10-21 2013-04-25 Abbvie Inc. Methods for treating hcv comprising at least two direct acting antiviral agent, ribavirin but not interferon.
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
PT107924A (pt) 2011-10-21 2014-12-03 Abbvie Inc Tratamento de combinação de daa (eg. com abt-072 ou abt-333) para utilização no tratamento de hcv
CN104244926A (zh) 2012-01-12 2014-12-24 勃林格殷格翰国际有限公司 作为强效的hcv 抑制剂的稳定的药物制剂
JP2015509980A (ja) 2012-03-14 2015-04-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｈｃｖ−ｈｉｖ同時感染患者集団のｈｃｖ感染症を治療するための併用療法
WO2013147750A1 (en) 2012-03-27 2013-10-03 Boehringer Ingelheim International Gmbh Oral combination therapy for treating hcv infection in specific patient sub-population
WO2013147749A1 (en) 2012-03-27 2013-10-03 Boehringer Ingelheim International Gmbh Oral combination therapy for treating hcv infection in specific patient subgenotype populations
WO2013143581A1 (en) 2012-03-28 2013-10-03 Boehringer Ingelheim International Gmbh Combination therapy for treating hcv infection in specific patient subgenotype sub-population
WO2013169577A1 (en) * 2012-05-07 2013-11-14 Bristol-Myers Squibb Company Oral solid dosage formulation of 1,1-dimethylethyl [(1s)-1-{[(2s,4r)-4-(7-chloro-4methoxyisoquinolin-1-yloxy)-2-({(1r,2s)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}carbamoyl)pyrrolidin-1-yl]carbonyl}-2,2-dimethylpropyl]carbamate
UA119315C2 (uk) 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
WO2014138374A1 (en) 2013-03-08 2014-09-12 Boehringer Ingelheim International Gmbh Oral combination therapy for treating hcv infection in specific patient sub-population
JP6511432B2 (ja) 2013-03-15 2019-05-15 ギリアード サイエンシーズ， インコーポレイテッド Ｃ型肝炎ウイルスの大環状二環式阻害剤
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
WO2017062840A1 (en) * 2015-10-09 2017-04-13 Trek Therapeutics, Pbc Combination therapy for the treatment of hepatitis c virus
WO2017189978A1 (en) 2016-04-28 2017-11-02 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323180B1 (en) * 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
GB0008785D0 (en) * 2000-04-10 2000-05-31 Novartis Ag Organic compounds
WO2003045326A2 (en) * 2001-11-26 2003-06-05 Supergen, Inc Method for preparing and using polyoxyethylated castor oil in pharmaceutical compositions
CZ294371B6 (cs) * 2002-06-10 2004-12-15 Pliva - Lachema, A. S. Stabilizovaná farmaceutická kompozice na bázi polyoxyethylovaného ricinového oleje a způsob její přípravy
RS51294B (sr) 2003-05-21 2010-12-31 Boehringer Ingelheim International Gmbh. Inhibitorna jedinjenja za hepatitis c
EP1753775B1 (en) * 2004-05-25 2012-12-26 Boehringer Ingelheim International GmbH Process for preparing acyclic hcv protease inhibitors

Also Published As

Publication number Publication date
EA201100795A1 (ru) 2012-01-30
JP5553839B2 (ja) 2014-07-16
NZ592383A (en) 2012-11-30
CA2738732A1 (en) 2010-05-27
CN102223875A (zh) 2011-10-19
SI2358355T1 (sl) 2014-02-28
SG171771A1 (en) 2011-07-28
UA105777C2 (uk) 2014-06-25
ZA201102029B (en) 2011-11-30
TW201023859A (en) 2010-07-01
EP2358355A1 (en) 2011-08-24
TWI469801B (zh) 2015-01-21
CL2011000878A1 (es) 2011-09-02
ME01614B (me) 2014-09-20
MY155402A (en) 2015-10-15
HRP20140097T1 (hr) 2014-03-14
ES2445516T3 (es) 2014-03-03
UY32252A (es) 2010-06-30
KR20110087297A (ko) 2011-08-02
BRPI0921070A2 (pt) 2019-09-24
RS53121B (en) 2014-06-30
AR074391A1 (es) 2011-01-12
IL211832A0 (en) 2011-06-30
DK2358355T3 (da) 2013-12-16
MX2011005151A (es) 2011-05-30
AU2009316755A1 (en) 2010-05-27
US20150038532A1 (en) 2015-02-05
AU2009316755B2 (en) 2015-10-08
MA32812B1 (fr) 2011-11-01
WO2010059667A1 (en) 2010-05-27
IL211832A (en) 2015-02-26
EP2358355B1 (en) 2013-11-06
PE20120032A1 (es) 2012-02-12
EA022272B1 (ru) 2015-12-30
ECSP11011065A (es) 2011-06-30
TN2011000258A1 (en) 2012-12-17
US20120101049A1 (en) 2012-04-26
PL2358355T3 (pl) 2014-04-30
CO6361900A2 (es) 2012-01-20
JP2012509336A (ja) 2012-04-19
CY1114892T1 (el) 2016-12-14

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