PT2229148E - Processo para preparação de uma substância farmacológica particulada e substancialmente cristalina - Google Patents

Processo para preparação de uma substância farmacológica particulada e substancialmente cristalina Download PDF

Info

Publication number
PT2229148E
PT2229148E PT88594122T PT08859412T PT2229148E PT 2229148 E PT2229148 E PT 2229148E PT 88594122 T PT88594122 T PT 88594122T PT 08859412 T PT08859412 T PT 08859412T PT 2229148 E PT2229148 E PT 2229148E
Authority
PT
Portugal
Prior art keywords
particulate
preparing
drug substance
crystalline drug
crystalline
Prior art date
Application number
PT88594122T
Other languages
English (en)
Portuguese (pt)
Inventor
Dilraj Singh
Gerhard Muhrer
Norbert Rasenack
Thomas Kieckbusch
Ranjit Thakur
Kurt Schaffluetzel
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39387173&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2229148(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT2229148E publication Critical patent/PT2229148E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Quinoline Compounds (AREA)
PT88594122T 2007-12-13 2008-12-11 Processo para preparação de uma substância farmacológica particulada e substancialmente cristalina PT2229148E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07123165 2007-12-13

Publications (1)

Publication Number Publication Date
PT2229148E true PT2229148E (pt) 2014-05-26

Family

ID=39387173

Family Applications (1)

Application Number Title Priority Date Filing Date
PT88594122T PT2229148E (pt) 2007-12-13 2008-12-11 Processo para preparação de uma substância farmacológica particulada e substancialmente cristalina

Country Status (13)

Country Link
US (1) US20100266696A1 (enExample)
EP (1) EP2229148B1 (enExample)
JP (1) JP2011506400A (enExample)
KR (1) KR20100095587A (enExample)
CN (1) CN101896165B (enExample)
AU (1) AU2008334547B2 (enExample)
BR (1) BRPI0820745A2 (enExample)
CA (1) CA2707594C (enExample)
ES (1) ES2460576T3 (enExample)
PL (1) PL2229148T3 (enExample)
PT (1) PT2229148E (enExample)
RU (1) RU2496479C2 (enExample)
WO (1) WO2009074666A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012053654A1 (en) 2010-10-18 2012-04-26 Dainippon Sumitomo Pharma Co., Ltd. Sustained-release formulation for injection
ES2612257T3 (es) * 2011-05-03 2017-05-16 Chiesi Farmaceutici S.P.A. Formulación de suspensión mejorada de dipropionato de beclometasona para administración mediante inhalación
GB201307659D0 (en) 2013-04-26 2013-06-12 Korea Coast Guard Commissioner Preparation of drug particles by micronisation
US9393202B2 (en) 2013-04-26 2016-07-19 Chiesi Farmaceutici S.P.A Particle size reduction of an antimuscarinic compound
PT107433B (pt) * 2014-01-28 2018-12-04 Hovione Farm S A Processo de redução e controlo do tamanho de partícula
SI3191081T1 (sl) 2014-09-09 2020-07-31 Vectura Limited Formulacija, ki vsebuje glikopirolat, postopek in naprava
CN106749008A (zh) * 2015-11-23 2017-05-31 北京九和药业有限公司 一种马来酸茚达特罗的微粉化方法及其应用
PT109030B (pt) 2015-12-15 2019-09-25 Hovione Farmaciência, S.A. Preparação de partículas inaláveis de zafirlucaste
US9925168B2 (en) * 2016-01-22 2018-03-27 Chiesi Farmaceutici S.P.A. Preparation of micronized particles of an antimuscarinic compound by hydrodynamic cavitation
WO2018019803A1 (en) 2016-07-29 2018-02-01 Laboratorios Lesvi, S.L. Particle size stabilization process
CN112137957B (zh) * 2019-06-26 2022-07-29 长风药业股份有限公司 一种药用吸入气雾剂及其制备方法
WO2021216577A1 (en) * 2020-04-20 2021-10-28 Board Of Regents, The University Of Texas System Lipid nanoparticle (lnp) delivery systems and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4440337A1 (de) 1994-11-11 1996-05-15 Dds Drug Delivery Services Ges Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit
IT1303692B1 (it) * 1998-11-03 2001-02-23 Chiesi Farma Spa Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione.
GB0008660D0 (en) * 2000-04-07 2000-05-31 Arakis Ltd The treatment of respiratory diseases
GB0016040D0 (en) * 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
US8048451B2 (en) * 2000-11-30 2011-11-01 Vectura Limited Pharmaceutical compositions for inhalation
ITMI20020681A1 (it) * 2002-03-29 2003-09-29 Acs Dobfar Spa Procedimento per la produzione di nanoparticelle di paclitaxel ed albumina
ITMI20022674A1 (it) * 2002-12-18 2004-06-19 Chiesi Farma Spa Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione.
CA2559915C (en) * 2004-03-23 2013-07-02 Novartis Ag Micronization of pharmaceutically active agents
GB0409703D0 (en) * 2004-04-30 2004-06-02 Vectura Ltd Pharmaceutical compositions
EP1834624A4 (en) * 2005-01-07 2011-05-04 Eisai R&D Man Co Ltd MEDICAL COMPOSITION AND MANUFACTURING METHOD THEREFOR
WO2006105401A2 (en) * 2005-03-30 2006-10-05 Schering Corporation Medicaments and methods combining an anticholinergic, a corticosteroid, and a long acting beta agonist
WO2007024183A1 (en) * 2005-08-26 2007-03-01 Astrazeneca Ab A combination of compounds, which can be used in the treatment of respiratory diseases, especially chronic obstructive pulmonary disease (copd) and asthma
US8530463B2 (en) * 2007-05-07 2013-09-10 Hale Biopharma Ventures Llc Multimodal particulate formulations

Also Published As

Publication number Publication date
BRPI0820745A2 (pt) 2015-06-16
WO2009074666A1 (en) 2009-06-18
EP2229148B1 (en) 2014-03-05
CA2707594A1 (en) 2009-06-18
RU2010128248A (ru) 2012-01-20
PL2229148T3 (pl) 2014-08-29
US20100266696A1 (en) 2010-10-21
EP2229148A1 (en) 2010-09-22
KR20100095587A (ko) 2010-08-31
AU2008334547B2 (en) 2011-06-30
CN101896165B (zh) 2013-07-17
JP2011506400A (ja) 2011-03-03
CN101896165A (zh) 2010-11-24
ES2460576T3 (es) 2014-05-13
AU2008334547A1 (en) 2009-06-18
CA2707594C (en) 2015-08-18
RU2496479C2 (ru) 2013-10-27

Similar Documents

Publication Publication Date Title
PT2229148E (pt) Processo para preparação de uma substância farmacológica particulada e substancialmente cristalina
IL205759A (en) History of isoxazolo-pyridine, a process for their preparation and the drugs containing them
EP2185159A4 (en) BORTEZOMIB AND MANUFACTURING METHOD THEREFOR
ZA201102760B (en) Process for preparing chlorins and their pharmaceutical uses
EP2046751A4 (en) PROCESS FOR PRODUCING SOLIFENACIN AND ITS SALTS
IL205348A0 (en) Indolinone derivatives and process for their manufacture
IL212639A0 (en) Piperazine salt and a process for the preparation thereof
IL181607A0 (en) Novel process for preparing montelukast and salts thereof
ZA201101005B (en) A process for preparing a particulate filter
ZA200806799B (en) Novel pyrone-indole derivatives and process for their preparation
PL2213654T3 (pl) Sposób wytwarzania pochodnych 2-amino-5-bromobenzamidu
EP2318479A4 (en) METHOD AND SYSTEMS FOR THE PRODUCTION OF MATERIALS FOR SUCRALOSEPRODUCTION
GB0704335D0 (en) Process for preparing an encapsulated particulate solid
IL188512A0 (en) Process for preparing malathion for pharmaceutical use
ZA200808308B (en) Process for preparing linezolid
GB0719248D0 (en) Compounds and methods for pharmaceutical use
GB0614133D0 (en) Process for preparing a pharmaceutical compound
PL2274303T3 (pl) Sposoby otrzymywania sunitynibu i jego soli
EP2181109A4 (en) CRYSTALLINE PARTICLES OF EPROSARTAN MESYLATE AND PROCESS FOR PREPARING PURE EPROSARTAN
GB0716298D0 (en) Process for pharmaceutical compound
IL196719A0 (en) Process for preparing amorphous lercanidipine hydrochloride
ZA200907810B (en) Process for preparing valsartan
EP2114883A4 (en) PROCESS FOR THE PREPARATION OF LERCANIDIPINE HYDROCHLORIDE
GB0612695D0 (en) Process for preparing a solid dosage form
EP2181422A4 (en) PROCESS FOR SETTING ATTRIBUTES IN A SYSTEM