PT2114927T - Processo para a preparação de (r)-5-(2-aminoetil)-1-(6, 8- difluorocroman-3-il)-1, 3-dihidroimidazol-2-tiona - Google Patents

Processo para a preparação de (r)-5-(2-aminoetil)-1-(6, 8- difluorocroman-3-il)-1, 3-dihidroimidazol-2-tiona

Info

Publication number
PT2114927T
PT2114927T PT87126884T PT08712688T PT2114927T PT 2114927 T PT2114927 T PT 2114927T PT 87126884 T PT87126884 T PT 87126884T PT 08712688 T PT08712688 T PT 08712688T PT 2114927 T PT2114927 T PT 2114927T
Authority
PT
Portugal
Prior art keywords
difluorochroman
dihydroimidazole
thione
aminoethyl
preparation
Prior art date
Application number
PT87126884T
Other languages
English (en)
Inventor
Manuel Vieira Araújo Soares Da Silva Patrício
Alexander Learmonth David
Beliaev Alexander
Original Assignee
BIAL-PORTELA & Cª S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIAL-PORTELA & Cª S A filed Critical BIAL-PORTELA & Cª S A
Publication of PT2114927T publication Critical patent/PT2114927T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
PT87126884T 2007-02-01 2008-01-31 Processo para a preparação de (r)-5-(2-aminoetil)-1-(6, 8- difluorocroman-3-il)-1, 3-dihidroimidazol-2-tiona PT2114927T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0701966.4A GB0701966D0 (en) 2007-02-01 2007-02-01 Process

Publications (1)

Publication Number Publication Date
PT2114927T true PT2114927T (pt) 2017-11-24

Family

ID=37891143

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87126884T PT2114927T (pt) 2007-02-01 2008-01-31 Processo para a preparação de (r)-5-(2-aminoetil)-1-(6, 8- difluorocroman-3-il)-1, 3-dihidroimidazol-2-tiona

Country Status (16)

Country Link
US (1) US8158666B2 (pt)
EP (1) EP2114927B1 (pt)
JP (2) JP2010518000A (pt)
KR (1) KR20090104899A (pt)
CN (1) CN101636396A (pt)
AR (1) AR065109A1 (pt)
AU (1) AU2008211847A1 (pt)
BR (1) BRPI0806428A2 (pt)
CA (1) CA2677204C (pt)
ES (1) ES2648223T3 (pt)
GB (1) GB0701966D0 (pt)
IL (1) IL200183A0 (pt)
MX (1) MX2009008245A (pt)
PT (1) PT2114927T (pt)
RU (1) RU2009132667A (pt)
WO (1) WO2008094056A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0701966D0 (en) 2007-02-01 2007-03-14 Portela & Ca Sa Process

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5438150A (en) * 1994-04-26 1995-08-01 Syntex (U.S.A.) Inc. Process for making 1-benzocycloalkyl-1,3-dihydroimidazole-2-thione derivatives
US7125904B2 (en) * 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
GB0701966D0 (en) 2007-02-01 2007-03-14 Portela & Ca Sa Process

Also Published As

Publication number Publication date
ES2648223T3 (es) 2017-12-29
RU2009132667A (ru) 2011-03-10
WO2008094056A1 (en) 2008-08-07
CN101636396A (zh) 2010-01-27
JP2010518000A (ja) 2010-05-27
US8158666B2 (en) 2012-04-17
MX2009008245A (es) 2009-08-12
GB0701966D0 (en) 2007-03-14
EP2114927B1 (en) 2017-08-23
CA2677204C (en) 2015-06-23
JP5789687B2 (ja) 2015-10-07
EP2114927A1 (en) 2009-11-11
KR20090104899A (ko) 2009-10-06
BRPI0806428A2 (pt) 2011-09-13
AU2008211847A1 (en) 2008-08-07
AR065109A1 (es) 2009-05-13
JP2014193858A (ja) 2014-10-09
CA2677204A1 (en) 2008-08-07
US20100121073A1 (en) 2010-05-13
IL200183A0 (en) 2010-04-15

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