PT2101777E - Composição para tratar uma hipertensão pulmonar - Google Patents

Composição para tratar uma hipertensão pulmonar Download PDF

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Publication number
PT2101777E
PT2101777E PT78550654T PT07855065T PT2101777E PT 2101777 E PT2101777 E PT 2101777E PT 78550654 T PT78550654 T PT 78550654T PT 07855065 T PT07855065 T PT 07855065T PT 2101777 E PT2101777 E PT 2101777E
Authority
PT
Portugal
Prior art keywords
ambrisentan
subjects
composition
placebo
subject
Prior art date
Application number
PT78550654T
Other languages
English (en)
Portuguese (pt)
Inventor
Michael J Gerber
Christopher Dufton
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39092031&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2101777(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of PT2101777E publication Critical patent/PT2101777E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT78550654T 2006-12-12 2007-12-11 Composição para tratar uma hipertensão pulmonar PT2101777E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86966706P 2006-12-12 2006-12-12

Publications (1)

Publication Number Publication Date
PT2101777E true PT2101777E (pt) 2015-09-18

Family

ID=39092031

Family Applications (1)

Application Number Title Priority Date Filing Date
PT78550654T PT2101777E (pt) 2006-12-12 2007-12-11 Composição para tratar uma hipertensão pulmonar

Country Status (15)

Country Link
US (7) US20080139593A1 (cg-RX-API-DMAC10.html)
EP (2) EP2952193A1 (cg-RX-API-DMAC10.html)
JP (1) JP2010512414A (cg-RX-API-DMAC10.html)
AU (1) AU2007333115B2 (cg-RX-API-DMAC10.html)
CA (1) CA2669536C (cg-RX-API-DMAC10.html)
CY (1) CY2016017I1 (cg-RX-API-DMAC10.html)
DK (1) DK2101777T3 (cg-RX-API-DMAC10.html)
ES (1) ES2544724T3 (cg-RX-API-DMAC10.html)
HK (1) HK1218393A1 (cg-RX-API-DMAC10.html)
HU (2) HUE025355T2 (cg-RX-API-DMAC10.html)
LU (1) LU93081I2 (cg-RX-API-DMAC10.html)
PL (1) PL2101777T3 (cg-RX-API-DMAC10.html)
PT (1) PT2101777E (cg-RX-API-DMAC10.html)
SI (1) SI2101777T1 (cg-RX-API-DMAC10.html)
WO (1) WO2008073928A1 (cg-RX-API-DMAC10.html)

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JP2010512414A (ja) * 2006-12-12 2010-04-22 ギリード・コロラド・インコーポレーテッド 肺高血圧を処置するための組成物
CN101815534A (zh) 2007-07-11 2010-08-25 莱西肯医药有限公司 用于治疗肺动脉高压以及相关疾病和病症的方法和组合物
CN101801936B (zh) * 2007-07-31 2012-10-03 吉利德科罗拉多公司 安立生坦的代谢物和衍生物
WO2010062640A1 (en) * 2008-10-28 2010-06-03 Gilead Colorado, Inc. Methods for treating idiopathic pulmonary fibrosis and associated complications
KR20130088834A (ko) * 2010-06-30 2013-08-08 길리애드 사이언시즈, 인코포레이티드 폐 고혈압의 치료를 위한 a2b 아데노신 수용체 길항제의 용도
EA026074B1 (ru) * 2010-10-15 2017-02-28 Джилид Сайэнс, Инк. Способы, включающие применение композиции амбризентана и тадалафила для лечения легочной артериальной гипертензии
WO2013024022A1 (en) * 2011-08-12 2013-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of pulmonary hypertension
US20130225595A1 (en) * 2012-02-29 2013-08-29 Gilead Sciences, Inc. Method for treating pulmonary arterial hypertension in a patient not having idiopathic pulmonary fibrosis
US20130224306A1 (en) * 2012-02-29 2013-08-29 Gilead Sciences, Inc. Method for treating a pulmonary hypertension condition without companion diagnosis
WO2014003678A1 (en) * 2012-06-28 2014-01-03 Xspray Microparticles Ab Pharmaceutical compositions comprising ambrisentan and solid dispersion particles containing tadalafil
US10518112B2 (en) 2014-06-18 2019-12-31 Sonivie Ltd. Method for treating secondary pulmonary hypertension
US10576083B2 (en) * 2015-08-13 2020-03-03 Cipla (UK) Limited Method of treating pulmonary arterial hypertension
AU2017296040C1 (en) 2016-07-15 2023-06-22 Acceleron Pharma Inc. Compositions and methods for treating pulmonary hypertension
US20200238107A1 (en) 2017-03-20 2020-07-30 Sonie Vie Ltd. Pulmonary hypertension treatment method and/or system
JP2020532521A (ja) * 2017-08-30 2020-11-12 ベレロフォン パルス テクノロジーズ エルエルシー 右室及び/又は左室機能の改善のための吸入用一酸化窒素の使用
MX2020006741A (es) * 2017-12-28 2020-11-24 Bellerophon Pulse Tech Llc Uso de oxigeno y oxido nitrico inhalado para el tratamiento de la hipertension pulmonar.
EP3965767A1 (en) * 2019-05-06 2022-03-16 Actelion Pharmaceuticals Ltd Methods for treating sarcoidosis-associated pulmonary hypertension
JP2023507626A (ja) 2019-12-16 2023-02-24 テナックス・セラピューティクス,インコーポレイテッド 駆出率が保たれた心不全を伴う肺高血圧症(PH-HF-pEF)を治療するためのレボシメンダン
RU2729033C1 (ru) * 2020-02-03 2020-08-03 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр кардиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ кардиологии" Минздрава России) Способ прогнозирования эффективности длительной специфической терапии у пациентов с идиопатической легочной гипертензией и неоперабельной хронической тромбоэмболической легочной гипертензией
EP3906928A1 (en) * 2020-05-06 2021-11-10 Noorik Biopharmaceuticals AG Treatment of pulmonary complications of coronavirus
US20230174620A1 (en) 2020-04-28 2023-06-08 Acceleron Pharma Inc. Actrii proteins and use in treating post-capillary pulmonary hypertension
EP4142731A1 (en) * 2020-04-28 2023-03-08 Noorik Biopharmaceuticals AG Treatment of pulmonary complications of coronavirus infections
CN114324900A (zh) * 2021-12-03 2022-04-12 上海市肺科医院 一种促卵泡激素的应用
EP4456897A4 (en) 2021-12-31 2025-12-10 Tenax Therapeutics Inc ORAL FORMULATIONS OF LEVOSIMENDAN FOR THE TREATMENT OF PULMONARY HYPERTENSION WITH HEART FAILURE AND PRESERVED EJECTION FRACTION
EP4648761A1 (en) * 2023-01-09 2025-11-19 scPharmaceuticals Inc. Methods of treatment using loop diuretics
EP4684777A1 (en) 2024-07-24 2026-01-28 Adalvo Limited A fixed-dose pharmaceutical composition comprising (2s)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid and (6r,12ar)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino{1',2:1,6]pyrido[3,4-b]indole-1,4-dione

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HU227841B1 (en) 1997-11-12 2012-05-02 Bayer Pharma AG 2-phenyl substituted imidazotriazinones, process for their preparation and pharmaceutical compositions thereof
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US20060292213A1 (en) * 2004-06-23 2006-12-28 Myogen, Inc. Enoximone formulations and their use in the treatment of PDE-III mediated diseases
TW200621261A (en) 2004-08-26 2006-07-01 Encysive Pharmaceuticals Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof
US20060205733A1 (en) * 2004-08-26 2006-09-14 Encysive Pharmaceuticals Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof
JP2008528604A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
DK2013208T3 (da) * 2006-04-21 2011-08-15 Pfizer Prod Inc Pyridin[3,4-B]pyrazinoner
EP2091539A1 (en) * 2006-12-12 2009-08-26 Gilead Colorado, Inc. Ambrisentan combined with a renin inhibitor for hypertensive disorder
JP2010512414A (ja) 2006-12-12 2010-04-22 ギリード・コロラド・インコーポレーテッド 肺高血圧を処置するための組成物
CN101801936B (zh) 2007-07-31 2012-10-03 吉利德科罗拉多公司 安立生坦的代谢物和衍生物
WO2010062640A1 (en) 2008-10-28 2010-06-03 Gilead Colorado, Inc. Methods for treating idiopathic pulmonary fibrosis and associated complications
EA026074B1 (ru) 2010-10-15 2017-02-28 Джилид Сайэнс, Инк. Способы, включающие применение композиции амбризентана и тадалафила для лечения легочной артериальной гипертензии

Also Published As

Publication number Publication date
US20170136016A1 (en) 2017-05-18
LU93081I2 (fr) 2016-07-20
US20080139593A1 (en) 2008-06-12
CY2016017I2 (el) 2016-10-05
US20100152217A1 (en) 2010-06-17
HUE025355T2 (en) 2016-02-29
DK2101777T3 (en) 2015-08-17
WO2008073928A1 (en) 2008-06-19
US20150224100A1 (en) 2015-08-13
US9504685B2 (en) 2016-11-29
US9993475B2 (en) 2018-06-12
EP2101777A1 (en) 2009-09-23
ES2544724T3 (es) 2015-09-03
AU2007333115A1 (en) 2008-06-19
US20110245253A1 (en) 2011-10-06
US20130116257A1 (en) 2013-05-09
SI2101777T1 (sl) 2015-08-31
CA2669536A1 (en) 2008-06-19
JP2010512414A (ja) 2010-04-22
EP2952193A1 (en) 2015-12-09
PL2101777T3 (pl) 2015-10-30
US8377933B2 (en) 2013-02-19
US20140296244A1 (en) 2014-10-02
CY2016017I1 (el) 2016-10-05
HUS1600027I1 (hu) 2016-06-28
AU2007333115B2 (en) 2013-01-10
US9474752B2 (en) 2016-10-25
HK1218393A1 (en) 2017-02-17
CA2669536C (en) 2016-05-31
EP2101777B1 (en) 2015-05-20

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