PT2069531E - Ltqs para resistência à mastite em gado - Google Patents
Ltqs para resistência à mastite em gado Download PDFInfo
- Publication number
- PT2069531E PT2069531E PT77024768T PT07702476T PT2069531E PT 2069531 E PT2069531 E PT 2069531E PT 77024768 T PT77024768 T PT 77024768T PT 07702476 T PT07702476 T PT 07702476T PT 2069531 E PT2069531 E PT 2069531E
- Authority
- PT
- Portugal
- Prior art keywords
- marker
- genetic
- markers
- mastitis
- genetic marker
- Prior art date
Links
- 241000283690 Bos taurus Species 0.000 title claims abstract description 140
- 208000004396 mastitis Diseases 0.000 title claims abstract description 104
- 239000003550 marker Substances 0.000 claims abstract description 180
- 230000002068 genetic effect Effects 0.000 claims abstract description 138
- 238000000034 method Methods 0.000 claims abstract description 68
- 108091092878 Microsatellite Proteins 0.000 claims abstract description 31
- 238000009395 breeding Methods 0.000 claims abstract description 6
- 230000001488 breeding effect Effects 0.000 claims abstract description 6
- 238000009007 Diagnostic Kit Methods 0.000 claims abstract description 5
- 238000001514 detection method Methods 0.000 claims abstract description 3
- 210000000349 chromosome Anatomy 0.000 claims description 87
- 101000876418 Homo sapiens Laforin Proteins 0.000 claims description 11
- 101000882389 Homo sapiens Laforin, isoform 9 Proteins 0.000 claims description 11
- 101001005389 Homo sapiens Protein LTV1 homolog Proteins 0.000 claims description 11
- 102100025932 Protein LTV1 homolog Human genes 0.000 claims description 11
- 108091034117 Oligonucleotide Proteins 0.000 claims description 9
- 230000003321 amplification Effects 0.000 claims description 9
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 9
- 101000987700 Homo sapiens Peroxisomal biogenesis factor 3 Proteins 0.000 claims description 6
- 102100029577 Peroxisomal biogenesis factor 3 Human genes 0.000 claims description 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 5
- 102100035192 Laforin Human genes 0.000 claims 2
- 238000004458 analytical method Methods 0.000 description 133
- 102000054766 genetic haplotypes Human genes 0.000 description 62
- 239000002773 nucleotide Substances 0.000 description 39
- 125000003729 nucleotide group Chemical group 0.000 description 39
- 230000000694 effects Effects 0.000 description 27
- 238000012360 testing method Methods 0.000 description 22
- 108020004414 DNA Proteins 0.000 description 21
- 210000001082 somatic cell Anatomy 0.000 description 19
- 239000000523 sample Substances 0.000 description 18
- 239000013615 primer Substances 0.000 description 17
- 108700028369 Alleles Proteins 0.000 description 15
- 235000013336 milk Nutrition 0.000 description 15
- 210000004080 milk Anatomy 0.000 description 15
- 239000008267 milk Substances 0.000 description 15
- 108090000623 proteins and genes Proteins 0.000 description 13
- 239000011159 matrix material Substances 0.000 description 10
- 108020004707 nucleic acids Proteins 0.000 description 10
- 102000039446 nucleic acids Human genes 0.000 description 10
- 150000007523 nucleic acids Chemical class 0.000 description 10
- 102100038889 Laforin, isoform 9 Human genes 0.000 description 9
- 238000013507 mapping Methods 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 7
- 239000000654 additive Substances 0.000 description 7
- 235000013365 dairy product Nutrition 0.000 description 7
- 238000000611 regression analysis Methods 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- -1 Rgsl7 Proteins 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 230000000996 additive effect Effects 0.000 description 6
- 238000005054 agglomeration Methods 0.000 description 6
- 230000002776 aggregation Effects 0.000 description 6
- 238000009396 hybridization Methods 0.000 description 6
- 210000000481 breast Anatomy 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 230000000295 complement effect Effects 0.000 description 5
- 230000003234 polygenic effect Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 4
- 241000042032 Petrocephalus catostoma Species 0.000 description 4
- 244000309464 bull Species 0.000 description 4
- 230000035606 childbirth Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000001558 permutation test Methods 0.000 description 4
- TVZRAEYQIKYCPH-UHFFFAOYSA-N 3-(trimethylsilyl)propane-1-sulfonic acid Chemical compound C[Si](C)(C)CCCS(O)(=O)=O TVZRAEYQIKYCPH-UHFFFAOYSA-N 0.000 description 3
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 3
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 238000004925 denaturation Methods 0.000 description 3
- 230000036425 denaturation Effects 0.000 description 3
- 210000005075 mammary gland Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002751 oligonucleotide probe Substances 0.000 description 3
- 230000008775 paternal effect Effects 0.000 description 3
- 239000002987 primer (paints) Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 238000005204 segregation Methods 0.000 description 3
- 210000000582 semen Anatomy 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 239000003155 DNA primer Substances 0.000 description 2
- 101000799057 Homo sapiens tRNA-specific adenosine deaminase 2 Proteins 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 238000000137 annealing Methods 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000004581 coalescence Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 102000054765 polymorphisms of proteins Human genes 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 239000010902 straw Substances 0.000 description 2
- 102100034045 tRNA-specific adenosine deaminase 2 Human genes 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 108091093088 Amplicon Proteins 0.000 description 1
- 102100026468 Androgen-induced gene 1 protein Human genes 0.000 description 1
- 208000031504 Asymptomatic Infections Diseases 0.000 description 1
- 208000031462 Bovine Mastitis Diseases 0.000 description 1
- 102100033471 Cbp/p300-interacting transactivator 2 Human genes 0.000 description 1
- 101150091877 Ccn2 gene Proteins 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 108020001019 DNA Primers Proteins 0.000 description 1
- 238000007400 DNA extraction Methods 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 101150064205 ESR1 gene Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 101150097883 Epm2a gene Proteins 0.000 description 1
- 102100038595 Estrogen receptor Human genes 0.000 description 1
- 101150114877 Ezr gene Proteins 0.000 description 1
- 101000718108 Homo sapiens Androgen-induced gene 1 protein Proteins 0.000 description 1
- 101000944098 Homo sapiens Cbp/p300-interacting transactivator 2 Proteins 0.000 description 1
- 101000882584 Homo sapiens Estrogen receptor Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 101100406473 Mus musculus Oprm1 gene Proteins 0.000 description 1
- 101100091501 Mus musculus Ros1 gene Proteins 0.000 description 1
- 101100477529 Mus musculus Shprh gene Proteins 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 101150051239 PEX3 gene Proteins 0.000 description 1
- 108091093037 Peptide nucleic acid Proteins 0.000 description 1
- 108010059712 Pronase Proteins 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 108010006785 Taq Polymerase Proteins 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000001364 causal effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000002759 chromosomal effect Effects 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 235000020247 cow milk Nutrition 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000012248 genetic selection Methods 0.000 description 1
- 238000003205 genotyping method Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 238000007403 mPCR Methods 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000013521 mastic Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000037125 natural defense Effects 0.000 description 1
- 230000004983 pleiotropic effect Effects 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000007894 restriction fragment length polymorphism technique Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 101150084623 vip gene Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200600164 | 2006-02-06 | ||
| DKPA200700147 | 2007-01-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2069531E true PT2069531E (pt) | 2013-06-04 |
Family
ID=38110214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT77024768T PT2069531E (pt) | 2006-02-06 | 2007-02-05 | Ltqs para resistência à mastite em gado |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100003675A1 (enExample) |
| EP (1) | EP2069531B1 (enExample) |
| JP (1) | JP2009525733A (enExample) |
| AR (1) | AR059326A1 (enExample) |
| AU (1) | AU2007214118B2 (enExample) |
| CA (1) | CA2677523A1 (enExample) |
| DK (1) | DK2069531T3 (enExample) |
| ES (1) | ES2425105T3 (enExample) |
| NZ (1) | NZ571106A (enExample) |
| PL (1) | PL2069531T3 (enExample) |
| PT (1) | PT2069531E (enExample) |
| SI (1) | SI2069531T1 (enExample) |
| WO (1) | WO2007090399A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8010403B2 (en) | 2006-12-29 | 2011-08-30 | American Express Travel Related Services Company, Inc. | System and method for targeting transaction account product holders to receive upgraded transaction account products |
| AU2009284493A1 (en) * | 2008-08-19 | 2010-02-25 | Aarhus Universitet | Methods for determining a breeding value based on a plurality of genetic markers |
| WO2010108498A1 (en) * | 2009-03-26 | 2010-09-30 | Aarhus Universitet | Genetic markers for mastitis resistance |
| EP2890811A1 (en) * | 2012-08-28 | 2015-07-08 | Aarhus Universitet | Genetic markers for mastitis resistance |
| CN104611425B (zh) * | 2015-01-15 | 2017-08-08 | 中国农业大学 | 一种与中国荷斯坦奶牛金葡菌乳房炎抗性相关的snp分子标记及其应用 |
-
2007
- 2007-02-05 NZ NZ571106A patent/NZ571106A/en not_active IP Right Cessation
- 2007-02-05 CA CA002677523A patent/CA2677523A1/en not_active Abandoned
- 2007-02-05 EP EP07702476.8A patent/EP2069531B1/en not_active Not-in-force
- 2007-02-05 ES ES07702476T patent/ES2425105T3/es active Active
- 2007-02-05 JP JP2008553616A patent/JP2009525733A/ja active Pending
- 2007-02-05 AU AU2007214118A patent/AU2007214118B2/en not_active Ceased
- 2007-02-05 PT PT77024768T patent/PT2069531E/pt unknown
- 2007-02-05 WO PCT/DK2007/000058 patent/WO2007090399A2/en not_active Ceased
- 2007-02-05 PL PL07702476T patent/PL2069531T3/pl unknown
- 2007-02-05 DK DK07702476.8T patent/DK2069531T3/da active
- 2007-02-05 SI SI200731258T patent/SI2069531T1/sl unknown
- 2007-02-05 US US12/223,689 patent/US20100003675A1/en not_active Abandoned
- 2007-02-06 AR ARP070100476A patent/AR059326A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007090399A8 (en) | 2007-10-25 |
| WO2007090399A2 (en) | 2007-08-16 |
| NZ571106A (en) | 2011-10-28 |
| AU2007214118A1 (en) | 2007-08-16 |
| JP2009525733A (ja) | 2009-07-16 |
| EP2069531B1 (en) | 2013-04-10 |
| AU2007214118B2 (en) | 2013-02-14 |
| DK2069531T3 (da) | 2013-06-24 |
| SI2069531T1 (sl) | 2013-10-30 |
| CA2677523A1 (en) | 2007-08-16 |
| EP2069531A2 (en) | 2009-06-17 |
| PL2069531T3 (pl) | 2013-10-31 |
| ES2425105T3 (es) | 2013-10-11 |
| US20100003675A1 (en) | 2010-01-07 |
| WO2007090399A3 (en) | 2008-02-28 |
| AR059326A1 (es) | 2008-03-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Otsu et al. | Cosegregation of porcine malignant hyperthermia and a probable causal mutation in the skeletal muscle ryanodine receptor gene in backcross families | |
| KR101213217B1 (ko) | 한우의 육량 또는 육질의 조기 선발에 유용한 단일염기다형성 마커 | |
| JP2015526099A (ja) | 乳房炎抵抗性の遺伝子マーカ | |
| CN108251539A (zh) | 一种与鸡屠体性状相关的snp标记及其应用、检测引物、检测试剂盒 | |
| AU2009275988B2 (en) | A genetic marker test for Brachyspina and fertility in cattle | |
| CN103602745B (zh) | 一种用于检测鸡pmel17基因显性白羽位点基因型的引物、试剂盒及检测方法 | |
| PT2069531E (pt) | Ltqs para resistência à mastite em gado | |
| Vögeli et al. | Co‐segregation of the malignant hyperthermia and the Arg615‐Cys615 mutation in the skeletal muscle calcium release channel protein in five European Landrace and Pietrain pig breeds | |
| Goddard et al. | Genome‐wide association studies and linkage disequilibrium in cattle | |
| CN119307625B (zh) | 一种snp分子标记组合在鸡冠高度辅助育种中的应用 | |
| JP2009525733A5 (enExample) | ||
| JP2008526252A (ja) | ウシの成長に関するdnaマーカー | |
| US20020142315A1 (en) | DNA marker for cattle growth | |
| WO2010108498A1 (en) | Genetic markers for mastitis resistance | |
| KR20160048316A (ko) | 한우 마블링 예측을 위한 마커 및 그 진단방법 | |
| CA2832242C (en) | Detecting the brachyspina mutation | |
| JP2009525732A (ja) | 乳房の健康特性 | |
| CN119177297B (zh) | 一种snp分子标记组合在鸡冠厚度辅助育种中的应用 | |
| CN101415842A (zh) | 牛乳房炎抗性的qtl | |
| CN120310929B (zh) | 一种奶牛乳蛋白率相关snp分子标记、检测产品及应用 | |
| Kumar et al. | Molecular genetic characterization of four White Leghorn strains using microsatellite markers | |
| CN115851962A (zh) | 一种与鸡的腹脂重性状相关的分子标记及其应用 | |
| CN119265315A (zh) | 一种snp分子标记组合在鸡冠长度辅助育种中的应用 | |
| EP2149611A1 (en) | A genetic marker test for brachyspina and fertility in cattle | |
| Soattin | The use of molecular markers for analyzing genes and genomes of livestock |