PT2007895E - Construção - Google Patents
Construção Download PDFInfo
- Publication number
- PT2007895E PT2007895E PT77321651T PT07732165T PT2007895E PT 2007895 E PT2007895 E PT 2007895E PT 77321651 T PT77321651 T PT 77321651T PT 07732165 T PT07732165 T PT 07732165T PT 2007895 E PT2007895 E PT 2007895E
- Authority
- PT
- Portugal
- Prior art keywords
- therapy
- compositions
- methods
- cystic fibrosis
- cystic
- Prior art date
Links
- 201000003883 Cystic fibrosis Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/30—Bird
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Environmental Sciences (AREA)
- Epidemiology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0606190.7A GB0606190D0 (en) | 2006-03-28 | 2006-03-28 | Construct |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2007895E true PT2007895E (pt) | 2014-12-12 |
Family
ID=36424724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT77321651T PT2007895E (pt) | 2006-03-28 | 2007-03-28 | Construção |
Country Status (8)
Country | Link |
---|---|
US (2) | US8871503B2 (pt) |
EP (1) | EP2007895B1 (pt) |
DK (1) | DK2007895T3 (pt) |
ES (1) | ES2527425T3 (pt) |
GB (1) | GB0606190D0 (pt) |
PT (1) | PT2007895E (pt) |
SI (1) | SI2007895T1 (pt) |
WO (1) | WO2007110628A2 (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0606190D0 (en) | 2006-03-28 | 2006-05-10 | Isis Innovation | Construct |
BR112012024166A2 (pt) * | 2010-03-23 | 2022-09-27 | Intrexon Corp | Vetores condicionalmente expressando proteínas terapêuticas, células hospedeiras compreendendo os vetores, e usos dos mesmos |
US20120213848A1 (en) * | 2010-11-16 | 2012-08-23 | Hanley Brian P | Treatment of Infection Using Single Chain Antibody Gene Therapy |
GB201118704D0 (en) * | 2011-10-28 | 2011-12-14 | Univ Oxford | Cystic fibrosis treatment |
US8435777B1 (en) * | 2012-01-20 | 2013-05-07 | Cayla | CPG-free gene for a new secreted reporter protein |
WO2014077863A1 (en) | 2012-11-19 | 2014-05-22 | Nature Technology Corporation | Replicative minicircle vectors with improved expression |
GB2526339A (en) | 2014-05-21 | 2015-11-25 | Imp Innovations Ltd | Lentiviral vectors |
US10525076B2 (en) | 2015-02-20 | 2020-01-07 | Rosalind Franklin University Of Medicine And Science | Antisense compounds targeting genes associated with cystic fibrosis |
CA3109138A1 (en) * | 2018-08-14 | 2020-02-20 | Loxegen Holdings Pty Ltd | Nanoparticles for transfection |
BR112022021918A2 (pt) * | 2020-04-27 | 2023-03-14 | Univ Iowa Res Found | Composições e métodos para o tratamento de fibrose cística |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4965199A (en) | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
DE3584341D1 (de) * | 1984-08-24 | 1991-11-14 | Upjohn Co | Rekombinante dna-verbindungen und expression von polypeptiden wie tpa. |
DE3431140A1 (de) * | 1984-08-24 | 1986-03-06 | Behringwerke Ag, 3550 Marburg | Enhancer fuer eukaryotische expressionssysteme |
US4868112A (en) | 1985-04-12 | 1989-09-19 | Genetics Institute, Inc. | Novel procoagulant proteins |
GR860984B (en) | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
US4994371A (en) | 1987-08-28 | 1991-02-19 | Davie Earl W | DNA preparation of Christmas factor and use of DNA sequences |
US5879680A (en) | 1987-12-23 | 1999-03-09 | The United States Of America As Represented By The Department Of Health And Human Services | Cloned DNA for synthesizing unique glucocerebrosidase |
JPH03504079A (ja) | 1988-03-21 | 1991-09-12 | カイロン コーポレイション | 組換えレトロウィルス |
US5236838A (en) | 1988-12-23 | 1993-08-17 | Genzyme Corporation | Enzymatically active recombinant glucocerebrosidase |
US5266491A (en) * | 1989-03-14 | 1993-11-30 | Mochida Pharmaceutical Co., Ltd. | DNA fragment and expression plasmid containing the DNA fragment |
JP3051411B2 (ja) | 1989-03-14 | 2000-06-12 | 持田製薬株式会社 | 新規dnaならびにそれを含有する発現プラスミド |
DK0465529T3 (da) | 1989-03-21 | 1998-10-05 | Vical Inc | Ekspression af exogene polynukleotidsekvenser i et hvirveldyr |
GB9020632D0 (en) | 1990-09-21 | 1990-10-31 | Hsc Res Dev Corp | Stable propagation of modified full length cystic fibrosis transmembrane conductance regulator protein cdna in heterologous systems |
US6984487B1 (en) * | 1989-08-22 | 2006-01-10 | Hsc Research Development Corporation | Cystic fibrosis gene |
US5543399A (en) * | 1989-08-22 | 1996-08-06 | Hsc Research & Development Limited Partnership | Cystic fibrosis transmembrane conductance regulator (CFTR) protein |
US5863770A (en) * | 1989-08-22 | 1999-01-26 | Hsc Research And Development Limited Partnership | Stable meterologous propagation of CFTR protein variant cDNA |
US5240846A (en) | 1989-08-22 | 1993-08-31 | The Regents Of The University Of Michigan | Gene therapy vector for cystic fibrosis |
US6063913A (en) * | 1989-08-22 | 2000-05-16 | Hsc Research And Development Limited Partnership | Stable heterologous propagation CFTR protein variant cDNA |
CA2061579C (en) | 1992-02-20 | 2008-07-22 | John R. Riordan | Cystic fibrosis transmembrane conductance regulator (cftr) protein |
EP1418183A1 (en) | 1989-08-22 | 2004-05-12 | HSC Research Development Corporation | Cystic fibrosis gene |
US5674898A (en) | 1990-03-05 | 1997-10-07 | Genzyme Corporation | Methods and therapeutic compositions for treating cystic fibrosis |
US7118911B1 (en) * | 1990-03-05 | 2006-10-10 | Genzyme Corporation | DNA molecules stabilized for propagation in bacterial cells that encode cystic fibrosis transmembrane conductance regulator |
US20070053879A1 (en) * | 1990-03-05 | 2007-03-08 | Genzyme Corporation | Diagnostic and treatment methods involving the cystic fibrosis transmembrane regulator |
US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
US5382524A (en) | 1990-10-24 | 1995-01-17 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of biologically active α-n-acetylgalactosaminidase |
US5401650A (en) | 1990-10-24 | 1995-03-28 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of biologically active α-galactosidase A |
US5661008A (en) | 1991-03-15 | 1997-08-26 | Kabi Pharmacia Ab | Recombinant human factor VIII derivatives |
US5773278A (en) | 1991-05-03 | 1998-06-30 | Mount Sinai Medical Center | Acid sphingomyelinase gene |
WO1993003709A1 (en) | 1991-08-16 | 1993-03-04 | Vical, Inc. | Composition and method for treating cystic fibrosis |
US5283185A (en) | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
CA2099503C (en) | 1991-11-14 | 2007-10-09 | Hamish Steele Scott | Synthetic alpha-l-iduronidase and genetic sequences encoding same |
AU671450B2 (en) | 1992-03-20 | 1996-08-29 | Baylor College Of Medicine | A DNA transporter system and method of use |
PT636028E (pt) | 1992-04-03 | 2004-07-30 | Univ California | Sistema de fornecimento de polinucleotidos auto-organizado |
EP0911413A3 (en) | 1992-12-03 | 2000-11-15 | Genzyme Corporation | Minimal adenovirus-based gene therapy vector |
AU7644494A (en) | 1993-09-08 | 1995-03-27 | Genzyme Corporation | A method for purifying a membrane-associated protein |
EP0716148B1 (en) | 1993-09-15 | 2004-01-02 | Chiron Corporation | Recombinant alphavirus vectors |
US5651981A (en) | 1994-03-29 | 1997-07-29 | Northwestern University | Cationic phospholipids for transfection |
JP3235934B2 (ja) | 1994-08-04 | 2001-12-04 | 三菱レイヨン株式会社 | ロドコッカス属細菌由来カナマイシン耐性遺伝子 |
US5527928A (en) | 1994-09-30 | 1996-06-18 | Nantz; Michael H. | Cationic transport reagents |
FR2738842B1 (fr) | 1995-09-15 | 1997-10-31 | Rhone Poulenc Rorer Sa | Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique |
US5851804A (en) | 1996-05-06 | 1998-12-22 | Apollon, Inc. | Chimeric kanamycin resistance gene |
CN1179470A (zh) | 1996-09-24 | 1998-04-22 | 赫彻斯特股份公司 | 用于基因治疗的含杂交启动子的核酸构建体 |
US6696423B1 (en) | 1997-08-29 | 2004-02-24 | Biogen, Inc. | Methods and compositions for therapies using genes encoding secreted proteins such as interferon-beta |
US5972995A (en) * | 1997-10-16 | 1999-10-26 | Children's Hospital Medical Center Of Northern California | Compositions and methods for cystic fibrosis therapy |
AU764686B2 (en) | 1998-08-28 | 2003-08-28 | Duke University | Adenoviruses deleted in the IVa2, 100K, polymerase and/or preterminal protein sequences |
US20020065236A1 (en) | 1998-09-09 | 2002-05-30 | Yew Nelson S. | CpG reduced plasmids and viral vectors |
EP1832657B1 (en) | 1998-09-09 | 2012-10-24 | Genzyme Corporation | Methylation of plasmid vectors |
WO2002000897A2 (en) | 2000-06-23 | 2002-01-03 | Maxygen, Inc. | Novel chimeric promoters |
FR2821855B1 (fr) | 2001-03-09 | 2004-04-02 | Cayla | Genes synthetiques et plasmides bacteriens depourvus de cpg |
JP2003144141A (ja) * | 2001-11-14 | 2003-05-20 | Gencom Co | RNAi効果が増強したES細胞 |
CN1774500B (zh) | 2003-02-14 | 2011-03-02 | 比奥根艾迪克Ma公司 | 用于瞬时或稳定表达外源分子的表达盒和载体 |
US7312202B2 (en) * | 2003-02-18 | 2007-12-25 | Board Of Regents, The University Of Texas System | Rationally designed and chemically synthesized promoter for genetic vaccine and gene therapy |
CN1274814C (zh) * | 2003-09-23 | 2006-09-13 | 李宁 | 一种提高转基因动物生产效率的方法 |
US7407801B2 (en) * | 2003-12-05 | 2008-08-05 | University Of Iowa Research Foundation | Truncated CMV promoters and vectors containing same |
AU2005270430B2 (en) | 2004-08-03 | 2008-06-12 | Geneart Ag | Method for modulating gene expression by modifying the CpG content |
GB0606190D0 (en) | 2006-03-28 | 2006-05-10 | Isis Innovation | Construct |
CA2665620A1 (en) * | 2006-10-12 | 2008-04-17 | Copernicus Therapeutics Inc. | Codon optimized cftr |
-
2006
- 2006-03-28 GB GBGB0606190.7A patent/GB0606190D0/en not_active Ceased
-
2007
- 2007-03-28 DK DK07732165.1T patent/DK2007895T3/en active
- 2007-03-28 SI SI200731609T patent/SI2007895T1/sl unknown
- 2007-03-28 ES ES07732165.1T patent/ES2527425T3/es active Active
- 2007-03-28 EP EP07732165.1A patent/EP2007895B1/en active Active
- 2007-03-28 US US12/294,498 patent/US8871503B2/en active Active
- 2007-03-28 WO PCT/GB2007/001104 patent/WO2007110628A2/en active Application Filing
- 2007-03-28 PT PT77321651T patent/PT2007895E/pt unknown
-
2014
- 2014-10-20 US US14/519,117 patent/US11214815B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
SI2007895T1 (sl) | 2015-04-30 |
EP2007895B1 (en) | 2014-11-26 |
US20100292307A1 (en) | 2010-11-18 |
ES2527425T3 (es) | 2015-01-23 |
US20150232878A1 (en) | 2015-08-20 |
WO2007110628A2 (en) | 2007-10-04 |
DK2007895T3 (en) | 2015-01-12 |
US11214815B2 (en) | 2022-01-04 |
EP2007895A2 (en) | 2008-12-31 |
GB0606190D0 (en) | 2006-05-10 |
WO2007110628A3 (en) | 2008-04-10 |
US8871503B2 (en) | 2014-10-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2224924A4 (en) | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | |
SI2007895T1 (sl) | Sestavki in metode za terapijo cistične fibroze | |
PL2182981T3 (pl) | Sposoby i kompozycje do leczenia i diagnozowania zwłóknienia | |
EP1986952A4 (en) | METHOD FOR THE TREATMENT OF MUCOVISCIDOSIS | |
PT2101766T (pt) | Composições e métodos de utilização de (r)-pramipexole | |
HK1125044A1 (en) | Methods and compositions for administration of iron | |
EP1977746B8 (en) | Methods and compositions for reduction of side effects of therapeutic treatments | |
HK1143315A1 (en) | Isothiazolopyridinones useful for the treatment of (inter alia) cystic fibrosis | |
IL202684A0 (en) | Anti-cd20 therapeutic compositions and methods of use thereof | |
EP1732524A4 (en) | METHOD AND COMPOSITIONS FOR TREATING IONIC WEIGHT | |
IL193936A0 (en) | Compositions and methods for the treatment of immunoinflammatory disorders | |
IL191072A0 (en) | Therapeutic compositions and methods | |
WO2009063492A9 (en) | Novel agents for treatment of ailments and dysfunctions | |
EP2016187A4 (en) | COMPOSITIONS AND METHODS FOR ENZYMATIC TREATMENT OF PULMONARY DISEASES | |
IL189364A0 (en) | Estrogen compositions and therapeutic methods of use thereof | |
HK1165293A1 (en) | Composition for the treatment of cystic fibrosis | |
PL2101766T3 (pl) | Kompozycje i sposoby stosowania (R)-pramipeksolu | |
IL198723A0 (en) | Methods and compositions for therapeutic treatment | |
GB0619500D0 (en) | Treatment of fibrosis | |
EP2124968A4 (en) | COMPOSITIONS AND METHODS FOR THE TREATMENT OF MUSCLE ATROPHY | |
EP2096927A4 (en) | THERAPEUTIC COMPOSITIONS AND METHODS OF TREATING WITH CAPSIANOSIDE COMPOUNDS | |
PL2572724T3 (pl) | Leczenie zwłóknień i chorób wątroby | |
EP2032151A4 (en) | COMBINATION THERAPY PROCESS AND FORMULATION | |
ZA200904921B (en) | Methods and compositions for treating IL-4 or IL-13 related fibrosis related pathologies | |
GB0504657D0 (en) | Compositions and methods of treatment |