PT1962850E - Tratamento de tumores resistentes a drogas - Google Patents
Tratamento de tumores resistentes a drogas Download PDFInfo
- Publication number
- PT1962850E PT1962850E PT06830600T PT06830600T PT1962850E PT 1962850 E PT1962850 E PT 1962850E PT 06830600 T PT06830600 T PT 06830600T PT 06830600 T PT06830600 T PT 06830600T PT 1962850 E PT1962850 E PT 1962850E
- Authority
- PT
- Portugal
- Prior art keywords
- tumor
- topoisomerase
- treatment
- drug
- leukemia
- Prior art date
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- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical class OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 description 1
- 125000001841 imino group Chemical group [H]N=* 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000005917 in vivo anti-tumor Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
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- 238000001361 intraarterial administration Methods 0.000 description 1
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- 208000020816 lung neoplasm Diseases 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
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- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000005170 neoplastic cell Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
- 238000011580 nude mouse model Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000006179 pH buffering agent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
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- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
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- VHXNKPBCCMUMSW-FQEVSTJZSA-N rubitecan Chemical compound C1=CC([N+]([O-])=O)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VHXNKPBCCMUMSW-FQEVSTJZSA-N 0.000 description 1
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- 229920006395 saturated elastomer Polymers 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05027997 | 2005-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1962850E true PT1962850E (pt) | 2012-05-21 |
Family
ID=35911064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT06830600T PT1962850E (pt) | 2005-12-21 | 2006-12-13 | Tratamento de tumores resistentes a drogas |
Country Status (19)
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| EP (1) | EP1962850B1 (enExample) |
| JP (1) | JP5657205B2 (enExample) |
| KR (1) | KR101366868B1 (enExample) |
| CN (1) | CN101340910B (enExample) |
| AT (1) | ATE548038T1 (enExample) |
| AU (1) | AU2006328607B2 (enExample) |
| BR (1) | BRPI0620209A2 (enExample) |
| CA (1) | CA2631868C (enExample) |
| CY (1) | CY1112814T1 (enExample) |
| DK (1) | DK1962850T3 (enExample) |
| EA (1) | EA016487B1 (enExample) |
| ES (1) | ES2382819T3 (enExample) |
| HR (1) | HRP20120359T1 (enExample) |
| PL (1) | PL1962850T3 (enExample) |
| PT (1) | PT1962850E (enExample) |
| RS (1) | RS52272B (enExample) |
| SI (1) | SI1962850T1 (enExample) |
| WO (1) | WO2007071603A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008098701A1 (en) * | 2007-02-13 | 2008-08-21 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives |
| JP5765937B2 (ja) * | 2007-08-01 | 2015-08-19 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニＳｉｇｍａ−Ｔａｕ Ｉｎｄｕｓｔｒｉｅ Ｆａｒｍａｃｅｕｔｉｃｈｅ Ｒｉｕｎｉｔｅ Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ | 小児腫瘍の治療 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1282673B1 (it) * | 1996-02-23 | 1998-03-31 | Ist Naz Stud Cura Dei Tumori | Derivati della camptotecina e loro uso come agenti antitumorali |
| PT1044977E (pt) * | 1999-03-09 | 2002-09-30 | Sigma Tau Ind Farmaceuti | Derivados de camptotecina com actividade antitumoral |
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2006
- 2006-12-13 BR BRPI0620209-8A patent/BRPI0620209A2/pt not_active IP Right Cessation
- 2006-12-13 SI SI200631316T patent/SI1962850T1/sl unknown
- 2006-12-13 PT PT06830600T patent/PT1962850E/pt unknown
- 2006-12-13 EP EP06830600A patent/EP1962850B1/en active Active
- 2006-12-13 WO PCT/EP2006/069666 patent/WO2007071603A1/en not_active Ceased
- 2006-12-13 CN CN2006800482417A patent/CN101340910B/zh not_active Expired - Fee Related
- 2006-12-13 RS RS20120175A patent/RS52272B/sr unknown
- 2006-12-13 DK DK06830600.0T patent/DK1962850T3/da active
- 2006-12-13 CA CA2631868A patent/CA2631868C/en not_active Expired - Fee Related
- 2006-12-13 JP JP2008546388A patent/JP5657205B2/ja not_active Expired - Fee Related
- 2006-12-13 US US12/096,884 patent/US7888368B2/en not_active Expired - Fee Related
- 2006-12-13 ES ES06830600T patent/ES2382819T3/es active Active
- 2006-12-13 AU AU2006328607A patent/AU2006328607B2/en not_active Ceased
- 2006-12-13 EA EA200870073A patent/EA016487B1/ru not_active IP Right Cessation
- 2006-12-13 KR KR1020087016809A patent/KR101366868B1/ko not_active Expired - Fee Related
- 2006-12-13 HR HRP20120359TT patent/HRP20120359T1/hr unknown
- 2006-12-13 AT AT06830600T patent/ATE548038T1/de active
- 2006-12-13 PL PL06830600T patent/PL1962850T3/pl unknown
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2012
- 2012-06-01 CY CY20121100497T patent/CY1112814T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101340910A (zh) | 2009-01-07 |
| EP1962850A1 (en) | 2008-09-03 |
| HRP20120359T1 (hr) | 2012-06-30 |
| JP2009520754A (ja) | 2009-05-28 |
| CN101340910B (zh) | 2012-12-12 |
| WO2007071603A1 (en) | 2007-06-28 |
| DK1962850T3 (da) | 2012-06-18 |
| ES2382819T3 (es) | 2012-06-13 |
| EA016487B1 (ru) | 2012-05-30 |
| US7888368B2 (en) | 2011-02-15 |
| PL1962850T3 (pl) | 2012-07-31 |
| AU2006328607A1 (en) | 2007-06-28 |
| CA2631868C (en) | 2014-02-11 |
| HK1124776A1 (zh) | 2009-07-24 |
| CA2631868A1 (en) | 2007-06-28 |
| BRPI0620209A2 (pt) | 2011-11-01 |
| ATE548038T1 (de) | 2012-03-15 |
| AU2006328607B2 (en) | 2012-04-19 |
| JP5657205B2 (ja) | 2015-01-21 |
| EP1962850B1 (en) | 2012-03-07 |
| CY1112814T1 (el) | 2016-02-10 |
| EA200870073A1 (ru) | 2009-12-30 |
| RS52272B (sr) | 2012-10-31 |
| KR101366868B1 (ko) | 2014-02-21 |
| KR20080078055A (ko) | 2008-08-26 |
| SI1962850T1 (sl) | 2012-06-29 |
| US20080312265A1 (en) | 2008-12-18 |
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