JP5657205B2 - 薬物耐性腫瘍の治療 - Google Patents

薬物耐性腫瘍の治療 Download PDF

Info

Publication number
JP5657205B2
JP5657205B2 JP2008546388A JP2008546388A JP5657205B2 JP 5657205 B2 JP5657205 B2 JP 5657205B2 JP 2008546388 A JP2008546388 A JP 2008546388A JP 2008546388 A JP2008546388 A JP 2008546388A JP 5657205 B2 JP5657205 B2 JP 5657205B2
Authority
JP
Japan
Prior art keywords
treatment
tumor
topoisomerase
pharmaceutical composition
camptothecin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2008546388A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009520754A (ja
JP2009520754A5 (enExample
Inventor
クラウディオ・ピサーノ
ロレダナ・ヴェシ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of JP2009520754A publication Critical patent/JP2009520754A/ja
Publication of JP2009520754A5 publication Critical patent/JP2009520754A5/ja
Application granted granted Critical
Publication of JP5657205B2 publication Critical patent/JP5657205B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2008546388A 2005-12-21 2006-12-13 薬物耐性腫瘍の治療 Expired - Fee Related JP5657205B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05027997.5 2005-12-21
EP05027997 2005-12-21
PCT/EP2006/069666 WO2007071603A1 (en) 2005-12-21 2006-12-13 Treatment of drug-resistant tumors

Publications (3)

Publication Number Publication Date
JP2009520754A JP2009520754A (ja) 2009-05-28
JP2009520754A5 JP2009520754A5 (enExample) 2010-01-28
JP5657205B2 true JP5657205B2 (ja) 2015-01-21

Family

ID=35911064

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008546388A Expired - Fee Related JP5657205B2 (ja) 2005-12-21 2006-12-13 薬物耐性腫瘍の治療

Country Status (19)

Country Link
US (1) US7888368B2 (enExample)
EP (1) EP1962850B1 (enExample)
JP (1) JP5657205B2 (enExample)
KR (1) KR101366868B1 (enExample)
CN (1) CN101340910B (enExample)
AT (1) ATE548038T1 (enExample)
AU (1) AU2006328607B2 (enExample)
BR (1) BRPI0620209A2 (enExample)
CA (1) CA2631868C (enExample)
CY (1) CY1112814T1 (enExample)
DK (1) DK1962850T3 (enExample)
EA (1) EA016487B1 (enExample)
ES (1) ES2382819T3 (enExample)
HR (1) HRP20120359T1 (enExample)
PL (1) PL1962850T3 (enExample)
PT (1) PT1962850E (enExample)
RS (1) RS52272B (enExample)
SI (1) SI1962850T1 (enExample)
WO (1) WO2007071603A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008098701A1 (en) * 2007-02-13 2008-08-21 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives
JP5765937B2 (ja) * 2007-08-01 2015-08-19 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニＳｉｇｍａ−Ｔａｕ Ｉｎｄｕｓｔｒｉｅ Ｆａｒｍａｃｅｕｔｉｃｈｅ Ｒｉｕｎｉｔｅ Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ 小児腫瘍の治療

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1282673B1 (it) * 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
PT1044977E (pt) * 1999-03-09 2002-09-30 Sigma Tau Ind Farmaceuti Derivados de camptotecina com actividade antitumoral

Also Published As

Publication number Publication date
CN101340910A (zh) 2009-01-07
EP1962850A1 (en) 2008-09-03
HRP20120359T1 (hr) 2012-06-30
JP2009520754A (ja) 2009-05-28
CN101340910B (zh) 2012-12-12
WO2007071603A1 (en) 2007-06-28
DK1962850T3 (da) 2012-06-18
ES2382819T3 (es) 2012-06-13
EA016487B1 (ru) 2012-05-30
US7888368B2 (en) 2011-02-15
PL1962850T3 (pl) 2012-07-31
AU2006328607A1 (en) 2007-06-28
CA2631868C (en) 2014-02-11
HK1124776A1 (zh) 2009-07-24
CA2631868A1 (en) 2007-06-28
BRPI0620209A2 (pt) 2011-11-01
PT1962850E (pt) 2012-05-21
ATE548038T1 (de) 2012-03-15
AU2006328607B2 (en) 2012-04-19
EP1962850B1 (en) 2012-03-07
CY1112814T1 (el) 2016-02-10
EA200870073A1 (ru) 2009-12-30
RS52272B (sr) 2012-10-31
KR101366868B1 (ko) 2014-02-21
KR20080078055A (ko) 2008-08-26
SI1962850T1 (sl) 2012-06-29
US20080312265A1 (en) 2008-12-18

Similar Documents

Publication Publication Date Title
CA2824760C (en) Imidazo [4, 5 -c] quinolin- 2 -one compound and its use as pi3 kinase / mtor dual inhibitor
US20110009353A1 (en) Targeting cdk4 and cdk6 in cancer therapy
US20130035348A1 (en) Antimetastatic compounds
JP7345901B2 (ja) キナーゼ阻害剤として有用な置換大員環類
Kawato et al. Inhibitory activity of camptothecin derivatives against acetylcholinesterase in dogs and their binding activity to acetylcholine receptors in rats
CN113616652A (zh) Sms2抑制剂在制备治疗高侵袭性乳腺癌药物中的应用
Kurtzberg et al. Bone marrow and tumor cell colony-forming units and human tumor xenograft efficacy of noncamptothecin and camptothecin topoisomerase I inhibitors
JP2021100972A (ja) がん処置のためのＴＧＦβ阻害剤およびＣＤＫ阻害剤の組合せ
JP5657205B2 (ja) 薬物耐性腫瘍の治療
CN113230249A (zh) 土荆皮乙酸在作为或制备Hedgehog信号通路抑制剂中的应用
US8507495B2 (en) Sensitizer, kit and use for cancer therapy
US8853233B2 (en) Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives
HK1124776B (en) Treatment of drug-resistant tumors
Das et al. Berzosertib. ATR kinase inhibitor, Treatment of solid tumors
US20050288310A1 (en) Methods of treating cellular proliferative disease using naphthalimide and PARP-1 inhibitors
CN113318103A (zh) 小分子化合物yj-5-41在制备抗胃癌药物中的应用
AU778629B2 (en) Cocaine receptor binding ligands
CN121108109A (zh) 一种靶向alk蛋白的protac化合物及其抗肿瘤应用
CA2801426A1 (en) Combination cancer therapies with wortmannin analogs
JPH03502806A (ja) ガンの処理

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091203

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20091203

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120529

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120823

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20120918

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130117

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20130204

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20130315

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20140120

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140418

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140423

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20141126

R150 Certificate of patent or registration of utility model

Ref document number: 5657205

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees