PT1828125E - Derivados de arilpiperazina e sua utilização como ligantes selectivos do receptor d3 da dopamina - Google Patents

Derivados de arilpiperazina e sua utilização como ligantes selectivos do receptor d3 da dopamina Download PDF

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Publication number
PT1828125E
PT1828125E PT05822892T PT05822892T PT1828125E PT 1828125 E PT1828125 E PT 1828125E PT 05822892 T PT05822892 T PT 05822892T PT 05822892 T PT05822892 T PT 05822892T PT 1828125 E PT1828125 E PT 1828125E
Authority
PT
Portugal
Prior art keywords
nrr
alkylene
polyfluoro
alkyl
dopamine
Prior art date
Application number
PT05822892T
Other languages
English (en)
Inventor
Jeanne-Marie Lecomte
Jean-Charles Schwartz
Denis Danvy
Marc Capet
Nicolas Levoin
Marcel Morvan
Isabelle Berrebi-Bertrand
Thierry Calmels
Philippe Robert
Catherine Dartois
Original Assignee
Bioprojet Soc Civ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioprojet Soc Civ filed Critical Bioprojet Soc Civ
Publication of PT1828125E publication Critical patent/PT1828125E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT05822892T 2004-12-01 2005-11-29 Derivados de arilpiperazina e sua utilização como ligantes selectivos do receptor d3 da dopamina PT1828125E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0412763A FR2878524B1 (fr) 2004-12-01 2004-12-01 Nouveaux derives d'arylpiperazine

Publications (1)

Publication Number Publication Date
PT1828125E true PT1828125E (pt) 2008-08-22

Family

ID=34951009

Family Applications (1)

Application Number Title Priority Date Filing Date
PT05822892T PT1828125E (pt) 2004-12-01 2005-11-29 Derivados de arilpiperazina e sua utilização como ligantes selectivos do receptor d3 da dopamina

Country Status (12)

Country Link
US (1) US20080214542A1 (pt)
EP (1) EP1828125B1 (pt)
AT (1) ATE391711T1 (pt)
DE (1) DE602005006018T2 (pt)
DK (1) DK1828125T3 (pt)
ES (1) ES2302254T3 (pt)
FR (1) FR2878524B1 (pt)
HR (1) HRP20080187T3 (pt)
PL (1) PL1828125T3 (pt)
PT (1) PT1828125E (pt)
SI (1) SI1828125T1 (pt)
WO (1) WO2006058993A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ555491A (en) * 2005-01-03 2010-01-29 Univ Siena Aryl piperazine derivatives for the treatment of neuropsychiatric disorders
EP1870405A1 (en) * 2006-06-22 2007-12-26 Bioprojet Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands
US20110059019A1 (en) * 2008-02-01 2011-03-10 Neurosearch A/S Novel aryl piperazine derivatives useful as modulators of dopamine and serotonin receptors
WO2009112568A1 (en) * 2008-03-14 2009-09-17 Neurosearch A/S Novel quinolinylamide derivatives useful as modulators of dopamine and serotonin receptors
US9227944B2 (en) 2008-10-10 2016-01-05 Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China Dopamine D3 receptor ligands and preparation and medical uses of the same
US8829001B2 (en) 2008-10-10 2014-09-09 The Institute of Pharmacology and Toxicology Academy of Military Medical Science P.L.A. China Dopamine D3 receptor ligands and preparation and medical uses of the same
WO2014079504A1 (en) * 2012-11-22 2014-05-30 Biofordrug S.R.L. Polycyclic ligands of 5-ht7 receptor and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07509705A (ja) * 1992-08-06 1995-10-26 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ドーパミンｄ３レセプター拮抗薬用５−（２−オキシフェニル）−ピロール誘導体
US5523229A (en) * 1994-03-22 1996-06-04 Trustees Of The University Of Pennsylvania Antibodies specific for oncofetal fibronectin
WO2001049679A1 (en) * 1999-12-30 2001-07-12 H. Lundbeck A/S 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives
KR20040081201A (ko) * 2002-02-13 2004-09-20 글락소 그룹 리미티드 항정신병제로서 벤젠술폰아미드 유도체
US20040204422A1 (en) * 2003-04-14 2004-10-14 Abbott Gmbh & Co. Kg. N-[(Piperazinyl)hetaryl]arylsulfonamide compounds

Also Published As

Publication number Publication date
US20080214542A1 (en) 2008-09-04
FR2878524B1 (fr) 2007-01-19
SI1828125T1 (sl) 2008-08-31
EP1828125A1 (fr) 2007-09-05
EP1828125B1 (fr) 2008-04-09
DE602005006018T2 (de) 2008-07-10
DK1828125T3 (da) 2008-08-04
FR2878524A1 (fr) 2006-06-02
ES2302254T3 (es) 2008-07-01
ATE391711T1 (de) 2008-04-15
WO2006058993A1 (fr) 2006-06-08
HRP20080187T3 (en) 2008-05-31
DE602005006018D1 (de) 2008-05-21
PL1828125T3 (pl) 2008-09-30

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