DE602005006018D1 - Arylpiperazinderivate und deren verwendung als für den dopamin-d3-rezeptor selektive liganden - Google Patents

Arylpiperazinderivate und deren verwendung als für den dopamin-d3-rezeptor selektive liganden

Info

Publication number
DE602005006018D1
DE602005006018D1 DE602005006018T DE602005006018T DE602005006018D1 DE 602005006018 D1 DE602005006018 D1 DE 602005006018D1 DE 602005006018 T DE602005006018 T DE 602005006018T DE 602005006018 T DE602005006018 T DE 602005006018T DE 602005006018 D1 DE602005006018 D1 DE 602005006018D1
Authority
DE
Germany
Prior art keywords
nrr
alkylene
polyfluoro
alkyl
dopamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602005006018T
Other languages
English (en)
Other versions
DE602005006018T2 (de
Inventor
Marc Capet
Denis Danvy
Catherine Dartois
Nicolas Levoin
Marcel Morvan
Isabelle Berrebi-Bertrand
Thierry Calmels
Philippe Robert
Jean-Charles Schwartz
Jeanne-Marie Lecomte
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioprojet SC
Original Assignee
Bioprojet SC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioprojet SC filed Critical Bioprojet SC
Publication of DE602005006018D1 publication Critical patent/DE602005006018D1/de
Application granted granted Critical
Publication of DE602005006018T2 publication Critical patent/DE602005006018T2/de
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE602005006018T 2004-12-01 2005-11-29 Arylpiperazinderivate und deren verwendung als für den dopamin-d3-rezeptor selektive liganden Expired - Fee Related DE602005006018T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0412763A FR2878524B1 (fr) 2004-12-01 2004-12-01 Nouveaux derives d'arylpiperazine
FR0412763 2004-12-01
PCT/FR2005/002964 WO2006058993A1 (fr) 2004-12-01 2005-11-29 Derives d’arylpiperazine et leur utilisation comme ligands selectifs du recepteur d3 de la dopamine

Publications (2)

Publication Number Publication Date
DE602005006018D1 true DE602005006018D1 (de) 2008-05-21
DE602005006018T2 DE602005006018T2 (de) 2008-07-10

Family

ID=34951009

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005006018T Expired - Fee Related DE602005006018T2 (de) 2004-12-01 2005-11-29 Arylpiperazinderivate und deren verwendung als für den dopamin-d3-rezeptor selektive liganden

Country Status (12)

Country Link
US (1) US20080214542A1 (de)
EP (1) EP1828125B1 (de)
AT (1) ATE391711T1 (de)
DE (1) DE602005006018T2 (de)
DK (1) DK1828125T3 (de)
ES (1) ES2302254T3 (de)
FR (1) FR2878524B1 (de)
HR (1) HRP20080187T3 (de)
PL (1) PL1828125T3 (de)
PT (1) PT1828125E (de)
SI (1) SI1828125T1 (de)
WO (1) WO2006058993A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ555491A (en) * 2005-01-03 2010-01-29 Univ Siena Aryl piperazine derivatives for the treatment of neuropsychiatric disorders
EP1870405A1 (de) * 2006-06-22 2007-12-26 Bioprojet Carbonylierte (Aza)cyclohexane als Dopamin D3 Rezeptorliganden
WO2009095438A1 (en) * 2008-02-01 2009-08-06 Neurosearch A/S Novel aryl piperazine derivatives useful as modulators of dopamine and serotonin receptors
WO2009112568A1 (en) * 2008-03-14 2009-09-17 Neurosearch A/S Novel quinolinylamide derivatives useful as modulators of dopamine and serotonin receptors
US9227944B2 (en) 2008-10-10 2016-01-05 Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China Dopamine D3 receptor ligands and preparation and medical uses of the same
CN102264733B (zh) 2008-10-10 2014-07-30 中国人民解放军军事医学科学院毒物药物研究所 新型多巴胺d3受体配体，其制备方法及其医药用途
WO2014079504A1 (en) * 2012-11-22 2014-05-30 Biofordrug S.R.L. Polycyclic ligands of 5-ht7 receptor and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0654023B1 (de) * 1992-08-06 1998-09-16 Smithkline Beecham Plc 5-(2-oxyphenyl)-pyrrol-derivate als dopamin-d3-rezeptor-antagonisten
US5523229A (en) * 1994-03-22 1996-06-04 Trustees Of The University Of Pennsylvania Antibodies specific for oncofetal fibronectin
CA2395869C (en) * 1999-12-30 2006-07-25 H. Lundbeck A/S 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives
US20050222124A1 (en) * 2002-02-13 2005-10-06 Bromidge Steven M Benzenesulfonamide derivatives as antipsychotic agents
US20040204422A1 (en) * 2003-04-14 2004-10-14 Abbott Gmbh & Co. Kg. N-[(Piperazinyl)hetaryl]arylsulfonamide compounds

Also Published As

Publication number Publication date
US20080214542A1 (en) 2008-09-04
EP1828125B1 (de) 2008-04-09
ES2302254T3 (es) 2008-07-01
WO2006058993A1 (fr) 2006-06-08
FR2878524B1 (fr) 2007-01-19
PT1828125E (pt) 2008-08-22
HRP20080187T3 (en) 2008-05-31
FR2878524A1 (fr) 2006-06-02
EP1828125A1 (de) 2007-09-05
DE602005006018T2 (de) 2008-07-10
PL1828125T3 (pl) 2008-09-30
DK1828125T3 (da) 2008-08-04
ATE391711T1 (de) 2008-04-15
SI1828125T1 (sl) 2008-08-31

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee