PT1451302E - Folhas reconstituídas in vitro de epitélio corneal humano e método de produção das mesmas - Google Patents

Folhas reconstituídas in vitro de epitélio corneal humano e método de produção das mesmas Download PDF

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Publication number
PT1451302E
PT1451302E PT01274401T PT01274401T PT1451302E PT 1451302 E PT1451302 E PT 1451302E PT 01274401 T PT01274401 T PT 01274401T PT 01274401 T PT01274401 T PT 01274401T PT 1451302 E PT1451302 E PT 1451302E
Authority
PT
Portugal
Prior art keywords
producing
same
corneal epithelium
human corneal
vitro reconstituted
Prior art date
Application number
PT01274401T
Other languages
English (en)
Portuguese (pt)
Inventor
Michele De Luca
Graziella Pellegrini
Original Assignee
Holostem Terapie Avanzate Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Holostem Terapie Avanzate Srl filed Critical Holostem Terapie Avanzate Srl
Publication of PT1451302E publication Critical patent/PT1451302E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/56—Fibrin; Thrombin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Prostheses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PT01274401T 2001-08-03 2001-11-28 Folhas reconstituídas in vitro de epitélio corneal humano e método de produção das mesmas PT1451302E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2001RM000476A ITRM20010476A1 (it) 2001-08-03 2001-08-03 Lamine di epitelio corneale umano ricostruite e metodo per il loro ottenimento.

Publications (1)

Publication Number Publication Date
PT1451302E true PT1451302E (pt) 2008-09-08

Family

ID=11455714

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01274401T PT1451302E (pt) 2001-08-03 2001-11-28 Folhas reconstituídas in vitro de epitélio corneal humano e método de produção das mesmas

Country Status (12)

Country Link
US (1) US6610538B2 (enExample)
EP (1) EP1451302B1 (enExample)
AT (1) ATE397058T1 (enExample)
CY (1) CY1108257T1 (enExample)
DE (1) DE60134280D1 (enExample)
DK (1) DK1451302T3 (enExample)
ES (1) ES2307570T3 (enExample)
FR (1) FR15C0055I2 (enExample)
IT (1) ITRM20010476A1 (enExample)
NL (1) NL300754I2 (enExample)
PT (1) PT1451302E (enExample)
WO (1) WO2003012083A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050186672A1 (en) * 2004-01-27 2005-08-25 Reliance Life Sciences Pvt. Ltd. Tissue system with undifferentiated stem cells derived from corneal limbus
US8187875B2 (en) * 2004-02-26 2012-05-29 Reliance Life Sciences Pvt. Ltd. Dopaminergic neurons derived from corneal limbus, methods of isolation and uses thereof
KR100840979B1 (ko) * 2004-02-26 2008-06-24 리라이언스 라이프 사이언시스 프라이빗. 리미티드 각막 윤부에서 유도된 다능성 배아 유사 줄기 세포, 분리방법 및 이들의 용도
US20060216821A1 (en) * 2004-02-26 2006-09-28 Reliance Life Sciences Pvt. Ltd. Pluripotent embryonic-like stem cells derived from corneal limbus, methods of isolation and uses thereof
ITRM20040273A1 (it) * 2004-06-03 2004-09-03 Farmigea Spa Metodo per l'isolamento e l'espansione ex vivo di cellule staminali corneali umane e loro relativi usi.
KR20080097226A (ko) * 2006-02-24 2008-11-04 리라이언스 라이프 사이언시스 프라이빗. 리미티드 결막 조직 시스템
WO2011040888A1 (en) * 2009-10-01 2011-04-07 Singapore Health Services Pte Ltd A biodegradable composition or combination and uses thereof
RU2505303C2 (ru) * 2011-09-13 2014-01-27 Общество с ограниченной ответственностью "Офтальмологические биотехнологии" Способ получения биотрансплантата для роговицы
FR2993282B1 (fr) 2012-07-13 2017-11-10 Expanscience Lab Procede d'identification de marqueurs moleculaires de la peau d'enfant
FR3011008B1 (fr) 2013-09-24 2017-12-29 Expanscience Lab Procedes d'evaluation des effets deleteres des uv sur la peau d'enfant
FR3016373B1 (fr) 2014-01-10 2018-01-19 Laboratoires Expanscience Modele de peau de mammelon reconstitue
FR3019186B1 (fr) 2014-03-31 2019-06-07 Laboratoires Expanscience Procedes d'evaluation des effets deleteres de l'urine sur la peau d'enfant
FR3045669B1 (fr) 2015-12-16 2019-04-05 Laboratoires Expanscience Procedes d'evaluation des effets de la deshydratation sur la peau d'enfant
FR3053053B1 (fr) 2016-06-23 2018-07-13 Laboratoires Expanscience Modeles de la dermatite atopique juvenile
FR3068045B1 (fr) 2017-06-22 2021-06-04 Expanscience Lab Modeles de peau sensible reconstituee
EP3867357B1 (en) * 2018-10-19 2024-09-25 Regents of the University of Minnesota Methods of isolating and using descemet's membrane and compositions including isolated descemet's membrane
FR3133198B1 (fr) 2022-03-04 2025-11-21 Pierre Fabre Dermo Cosmetique Modele de peau reconstituee
FR3138149A1 (fr) 2022-07-25 2024-01-26 Pierre Fabre Dermo-Cosmetique Méthode d’évaluation in vitro de l’activité photoprotectrice d’un actif

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1255657B (it) 1992-05-29 1995-11-09 Colture di tessuto di mucosa congiuntivale differenziata, procedimentoper la loro preparazione e supporti per il loro uso.
US5827641A (en) 1992-11-13 1998-10-27 Parenteau; Nancy L. In vitro cornea equivalent model
CA2227827A1 (en) 1998-01-23 1999-07-23 Unknown In vitro artificial cornea and sclera

Also Published As

Publication number Publication date
ITRM20010476A0 (it) 2001-08-03
DE60134280D1 (de) 2008-07-10
EP1451302A1 (en) 2004-09-01
NL300754I2 (enExample) 2016-09-01
ES2307570T3 (es) 2008-12-01
US6610538B2 (en) 2003-08-26
ITRM20010476A1 (it) 2003-02-03
FR15C0055I2 (fr) 2016-06-24
US20030027333A1 (en) 2003-02-06
ATE397058T1 (de) 2008-06-15
DK1451302T3 (da) 2008-09-08
EP1451302B1 (en) 2008-05-28
FR15C0055I1 (enExample) 2015-09-11
CY1108257T1 (el) 2014-02-12
WO2003012083A1 (en) 2003-02-13

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