PT1446380E - Processo para a preparação de tararato de formoterol de polimorfo - Google Patents

Processo para a preparação de tararato de formoterol de polimorfo Download PDF

Info

Publication number
PT1446380E
PT1446380E PT02786502T PT02786502T PT1446380E PT 1446380 E PT1446380 E PT 1446380E PT 02786502 T PT02786502 T PT 02786502T PT 02786502 T PT02786502 T PT 02786502T PT 1446380 E PT1446380 E PT 1446380E
Authority
PT
Portugal
Prior art keywords
polymorph
formoterol tartrate
formoterol
tartrate process
tartrate
Prior art date
Application number
PT02786502T
Other languages
English (en)
Portuguese (pt)
Inventor
Chris H Senanayake
Gerald J Tanoury
Donald W Kessler
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21892899&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1446380(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sepracor Inc filed Critical Sepracor Inc
Publication of PT1446380E publication Critical patent/PT1446380E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)
PT02786502T 2001-11-09 2002-10-23 Processo para a preparação de tararato de formoterol de polimorfo PT1446380E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/037,183 US6472563B1 (en) 2001-11-09 2001-11-09 Formoterol tartrate process and polymorph

Publications (1)

Publication Number Publication Date
PT1446380E true PT1446380E (pt) 2010-01-07

Family

ID=21892899

Family Applications (1)

Application Number Title Priority Date Filing Date
PT02786502T PT1446380E (pt) 2001-11-09 2002-10-23 Processo para a preparação de tararato de formoterol de polimorfo

Country Status (13)

Country Link
US (10) US6472563B1 (enExample)
EP (3) EP2305635B1 (enExample)
JP (1) JP4271574B2 (enExample)
AT (1) ATE450497T1 (enExample)
AU (2) AU2002349914B2 (enExample)
CA (1) CA2477642C (enExample)
CY (1) CY1109832T1 (enExample)
DE (1) DE60234629D1 (enExample)
DK (1) DK1446380T3 (enExample)
ES (2) ES2336436T3 (enExample)
PT (1) PT1446380E (enExample)
SI (1) SI1446380T1 (enExample)
WO (1) WO2003042165A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6472563B1 (en) * 2001-11-09 2002-10-29 Sepracor Inc. Formoterol tartrate process and polymorph
US7524515B2 (en) * 2003-01-10 2009-04-28 Mutual Pharmaceuticals, Inc. Pharmaceutical safety dosage forms
GB0312148D0 (en) 2003-05-28 2003-07-02 Aventis Pharma Ltd Stabilized pharmaceutical products
GB0315889D0 (en) * 2003-07-08 2003-08-13 Aventis Pharma Ltd Stable pharmaceutical products
WO2005019227A1 (en) * 2003-08-22 2005-03-03 Orchid Chemicals & Pharmaceuticals Ltd Process for the preparation of cephalosporin antibiotic
UA83504C2 (en) * 2003-09-04 2008-07-25 Селджин Корпорейшн Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
US20060160841A1 (en) * 2005-01-19 2006-07-20 Chenkou Wei Crystallization via high-shear transformation
US7718649B1 (en) 2006-11-10 2010-05-18 Pisgah Labs, Inc. Physical states of a pharmaceutical drug substance
US8039461B1 (en) 2006-11-10 2011-10-18 Pisgah Laboratories, Inc. Physical states of a pharmaceutical drug substance
US8501994B2 (en) * 2007-08-28 2013-08-06 Sunovion Pharmaceuticals Inc. Acetamide stereoisomer
US7718822B2 (en) * 2007-08-28 2010-05-18 Sepracor Inc. Carbamate Stereoisomer
CN101393186A (zh) * 2007-09-21 2009-03-25 北京德众万全药物技术开发有限公司 一种hplc法分离分析酒石酸福莫特罗手性异构体的方法
NZ587561A (en) * 2008-02-26 2012-10-26 Elevation Pharmaceuticals Inc Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations (an muscarinic antagnoist)
US20100055045A1 (en) 2008-02-26 2010-03-04 William Gerhart Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations
US20110014246A1 (en) * 2008-02-28 2011-01-20 Actavis Group Ptc Ehf Amorphous arformoterol l-(+)-tartrate
US8883863B1 (en) 2008-04-03 2014-11-11 Pisgah Laboratories, Inc. Safety of psuedoephedrine drug products
WO2010128355A2 (en) 2008-12-26 2010-11-11 Actavis Group Ptc Ehf Improved processes for preparing substantially pure arformoterol and its intermediates
EP2482799B1 (en) * 2009-10-02 2014-06-18 Chiesi Farmaceutici S.p.A. Pharmaceutical aerosol formulations of formoterol and beclometasone dipropionate
IT1399912B1 (it) * 2010-04-29 2013-05-09 Lundbeck Pharmaceuticals Italy S Pa Processo di preparazione di ritodrina cloridrato.
EP2915525B1 (en) 2011-09-19 2021-08-11 Orexo AB Sublingual abuse-resistant tablets comprising buprenorphine and naloxone
ES2677714T3 (es) 2012-03-12 2018-08-06 Laboratorios Lesvi S.L. Nueva forma polimórfica de un agonista del adrenorreceptor beta-2 de acción prolongada
US9006462B2 (en) 2013-02-28 2015-04-14 Dermira, Inc. Glycopyrrolate salts
US8558008B2 (en) 2013-02-28 2013-10-15 Dermira, Inc. Crystalline glycopyrrolate tosylate
CA2902795C (en) 2013-02-28 2021-06-15 Dermira, Inc. Glycopyrrolate salts
WO2014184756A2 (en) * 2013-05-17 2014-11-20 Glenmark Pharmaceuticals Limited; Glenmark Generics Limited Process for the preparation of arformoterol or salt thereof
CN107151219A (zh) * 2017-05-23 2017-09-12 北京万全德众医药生物技术有限公司 酒石酸阿福特罗的精制方法
CN111909049B (zh) * 2020-09-03 2023-04-25 扬州中宝药业股份有限公司 一种酒石酸阿福特罗精制的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2005492A6 (es) 1987-12-23 1989-03-01 Lasa Lab Procedimiento de obtencion de n-(2-hidroxi-5-(1-hidroxi-2((2- (4-metoxifenil)-1metiletil)amino)etil)fenil)foramida (i).
ES2031407A6 (es) 1988-10-05 1992-12-01 Lasa Lab Mejoras introducidas en el objeto de la patente principal n{ 8703715 por: procedimiento de obtencion de n-(2-hidroxi-5-(1-hidroxi-2-((2-(4-metoxifenil)-1-metiletil)amino)etil)fenil)formamida".
SE8901060D0 (sv) 1989-03-28 1989-03-28 Draco Ab New compounds
US5434304A (en) * 1990-09-26 1995-07-18 Aktiebolaget Astra Process for preparing formoterol and related compounds
SE9003057D0 (sv) 1990-09-26 1990-09-26 Astra Ab New process
US6040344A (en) 1996-11-11 2000-03-21 Sepracor Inc. Formoterol process
DK1102579T3 (da) * 1998-08-04 2003-07-14 Jago Res Ag Medicinske aerosolformuleringer
US6472563B1 (en) 2001-11-09 2002-10-29 Sepracor Inc. Formoterol tartrate process and polymorph

Also Published As

Publication number Publication date
AU2008253696A1 (en) 2009-01-08
AU2002349914B2 (en) 2008-09-04
ATE450497T1 (de) 2009-12-15
US20100249459A1 (en) 2010-09-30
EP1446380A1 (en) 2004-08-18
US20050148667A1 (en) 2005-07-07
SI1446380T1 (sl) 2010-03-31
CY1109832T1 (el) 2014-09-10
US7342132B2 (en) 2008-03-11
US20120108670A1 (en) 2012-05-03
WO2003042165A1 (en) 2003-05-22
US20090156862A1 (en) 2009-06-18
DK1446380T3 (da) 2010-01-04
US7964753B2 (en) 2011-06-21
US20060264507A1 (en) 2006-11-23
US20040176450A1 (en) 2004-09-09
US6720453B2 (en) 2004-04-13
ES2336436T3 (es) 2010-04-13
US7145036B2 (en) 2006-12-05
US7479572B2 (en) 2009-01-20
JP2005509025A (ja) 2005-04-07
ES2685100T3 (es) 2018-10-05
DE60234629D1 (de) 2010-01-14
AU2008253696B2 (en) 2012-04-12
US20080114187A1 (en) 2008-05-15
CA2477642C (en) 2014-02-11
US20100204336A1 (en) 2010-08-12
EP2305635B1 (en) 2018-06-13
CA2477642A1 (en) 2003-05-22
US20030149304A1 (en) 2003-08-07
EP2165999A1 (en) 2010-03-24
US6472563B1 (en) 2002-10-29
EP2305635A3 (en) 2011-07-20
EP2305635A2 (en) 2011-04-06
EP1446380B1 (en) 2009-12-02
JP4271574B2 (ja) 2009-06-03
US7732641B2 (en) 2010-06-08
US8110706B2 (en) 2012-02-07

Similar Documents

Publication Publication Date Title
PT1446380E (pt) Processo para a preparação de tararato de formoterol de polimorfo
MY140236A (en) Diarylether compounds useful as opioid receptor antagonists
CA2333004A1 (en) Formoterol polymorphs
EP1380564A4 (en) BINAPHTOL DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
LU92520I2 (fr) Bédaquiline, ou son sel d'addition d'acide ou de base pharmaceutiquement acceptable, y compris le fumarate de bédaquiline
CA2429844A1 (en) Mch antagonists and their use in the treatment of obesity
CA2450093A1 (en) Stable polymorph of flibanserin, technical process for its preparation and the use thereof for preparing medicaments
HUP0303496A3 (en) Crystalline venlafaxine base and novel polymorphs of venlafaxine hydrochloride, processes for preparing thereof
GB2383041B (en) Process for the preparation of gabapentin
WO2002066429A8 (de) Verfahren zur herstellung von nicht hydratisiertem fexofenadin-hydrochlorid und eine so erhaetliche neue kristalline form
CA2462998A1 (en) Novel estrogenic compounds
MXPA04005305A (es) Nuevo polimorfo cristalino de clorhidrato de venlafaxina y metodos para preparacion del mismo.
HRP20040565A2 (en) Crystalline venlafaxine base and novel polymorphsof venlafaxine hidrochloride, processes for preparing thereof
AU2003298178A1 (en) Process for the preparation of an essentially pure polymorph of an n-pyrazolyl-n'-naphthyl-urea
IL157709A0 (en) Process for the preparation of 1,2-benzisoxazole-3-acetic acid
MXPA04005307A (es) Clorhidrato de venlafaxina en forma de monohidrato y sus metodos de preparacion.
SI1453791T1 (sl) Acetil l karnitin sol z dikarboksilično organskokislino in postopek za njeno pripravo
HUP0303478A3 (en) Method of producing n-substituted 2,6-dialkyl morpholines
WO2002053537A8 (en) Process for preparing (±) trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidine
ZA200300218B (en) Novel N-(2-phenyl-3-aminopropyl)naphtamides.
EP1630169A3 (en) Intermediates for LHRH antagonist synthesis, process for their production, and process for LHRH antagonist production
WO2005058896A3 (en) Synthesis of a polymorph of 4-amino-5-chloro-2-methoxy-n-(1-azabicyclo[3.3.1]non-4-yl)benzamide hydrochloride hydrate
DE60235119D1 (en) Bipyridinylderivate als hochselektive cyclooxygenase-2-inhibitoren
AU2002333732A1 (en) Method for the production of isophorondiamine (ipda, 3-aminomethyl-3,5,5-trimethylcyclohexylamine)
PL354821A1 (en) Method of producing new alpha,omega-alkene diamino-n,n'-bis (1-aryl methyl phosponium) acids