PT1392295E - Derivados de oxazole substituidos por acidos carboxilicos para serem utilizados como activadores de rapp alfa e gama no tratamento de diabetes - Google Patents

Derivados de oxazole substituidos por acidos carboxilicos para serem utilizados como activadores de rapp alfa e gama no tratamento de diabetes

Info

Publication number
PT1392295E
PT1392295E PT02742955T PT02742955T PT1392295E PT 1392295 E PT1392295 E PT 1392295E PT 02742955 T PT02742955 T PT 02742955T PT 02742955 T PT02742955 T PT 02742955T PT 1392295 E PT1392295 E PT 1392295E
Authority
PT
Portugal
Prior art keywords
rapp
activators
diabetes
alpha
treatment
Prior art date
Application number
PT02742955T
Other languages
English (en)
Portuguese (pt)
Inventor
Binggeli Alfred
Boehringer Markus
Grether Uwe
Hilpert Hans
Hans-Peter Maerki
Meyer Markus
Peter Mohr
Ricklin Fabienne
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PT1392295E publication Critical patent/PT1392295E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT02742955T 2001-05-15 2002-05-06 Derivados de oxazole substituidos por acidos carboxilicos para serem utilizados como activadores de rapp alfa e gama no tratamento de diabetes PT1392295E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01111745 2001-05-15

Publications (1)

Publication Number Publication Date
PT1392295E true PT1392295E (pt) 2006-09-29

Family

ID=8177436

Family Applications (1)

Application Number Title Priority Date Filing Date
PT02742955T PT1392295E (pt) 2001-05-15 2002-05-06 Derivados de oxazole substituidos por acidos carboxilicos para serem utilizados como activadores de rapp alfa e gama no tratamento de diabetes

Country Status (38)

Country Link
US (1) US6642389B2 (enExample)
EP (1) EP1392295B1 (enExample)
JP (2) JP4330883B2 (enExample)
KR (1) KR100654516B1 (enExample)
CN (1) CN100356917C (enExample)
AR (1) AR035892A1 (enExample)
AT (1) ATE327753T1 (enExample)
AU (1) AU2002342244B2 (enExample)
BG (1) BG66316B1 (enExample)
BR (1) BRPI0209821B1 (enExample)
CA (1) CA2445145C (enExample)
CY (1) CY1105160T1 (enExample)
CZ (1) CZ20033037A3 (enExample)
DE (1) DE60211891T2 (enExample)
DK (1) DK1392295T3 (enExample)
EC (1) ECSP034848A (enExample)
EG (1) EG25755A (enExample)
ES (1) ES2264482T3 (enExample)
GT (1) GT200200085A (enExample)
HR (1) HRP20030889B1 (enExample)
HU (1) HU230224B1 (enExample)
IL (2) IL158589A0 (enExample)
JO (1) JO2282B1 (enExample)
MA (1) MA27025A1 (enExample)
ME (1) ME01310B (enExample)
MX (1) MXPA03010435A (enExample)
MY (1) MY136761A (enExample)
NO (1) NO333833B1 (enExample)
NZ (1) NZ529033A (enExample)
PA (1) PA8544901A1 (enExample)
PE (1) PE20021152A1 (enExample)
PL (1) PL208074B1 (enExample)
PT (1) PT1392295E (enExample)
RU (1) RU2278859C2 (enExample)
SI (1) SI1392295T1 (enExample)
SK (1) SK287842B6 (enExample)
WO (1) WO2002092084A1 (enExample)
ZA (1) ZA200308538B (enExample)

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US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US7655658B2 (en) * 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
CA2462200A1 (en) * 2001-08-10 2003-02-20 Palatin Technologies, Inc. Peptidomimetics of biologically active metallopeptides
US7732451B2 (en) * 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
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AR041481A1 (es) 2002-10-07 2005-05-18 Hoffmann La Roche Derivados de acido arilpropionico-oxazol y su uso como agonistas de ppar
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KR100847976B1 (ko) * 2003-11-05 2008-07-22 에프. 호프만-라 로슈 아게 Ｐｐａｒ 작용제로서 페닐 유도체
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US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
HRP20090533T1 (hr) 2004-05-03 2009-11-30 F. Hoffmann - La Roche Ag Derivati indolila kao modulatori x-receptora
CN100436430C (zh) * 2004-05-24 2008-11-26 北京摩力克科技有限公司 作为hPPARα和hPPARγ激动剂的烷酰基取代的酪氨酸衍生物
CN100344618C (zh) * 2004-05-24 2007-10-24 北京摩力克科技有限公司 作为hPPARα和hPPARγ激动剂的N－芳丙烯酰基取代的酪氨酸衍生物
WO2006108491A1 (en) * 2005-04-11 2006-10-19 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Improved process for preparing oxazole nitriles
US20060241073A1 (en) * 2005-04-20 2006-10-26 Wanders Ronaldus J A Means and methods for counteracting fatty acid accumulation
US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
KR100847780B1 (ko) * 2006-10-26 2008-07-23 재단법인서울대학교산학협력재단 2-에톡시프로피온산 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 유효성분으로함유하는 당뇨병 예방 및 치료제
AU2008221718A1 (en) * 2007-03-07 2008-09-12 Dong-A Pharm. Co., Ltd. Novel phenylpropionic acid derivatives as peroxisome proliferator-activated gamma receptor modulators, method of the same, and pharmaceutical composition comprising the same
ES2390620T3 (es) * 2008-03-10 2012-11-14 Nestec S.A. Ácidos dicarboxílicos de cadena mediana y sus derivados y trastornos metabólicos
WO2009140163A1 (en) * 2008-05-15 2009-11-19 Merck & Co., Inc. Oxazolobenzimidazole derivatives
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CA2748896C (en) * 2009-01-23 2017-01-03 F. Hoffmann-La Roche Ag Pharmaceutical composition comprising aleglitazar
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CN102351852B (zh) * 2011-08-23 2014-06-18 上海交通大学 苯并呋喃类化合物及其制备方法、用途
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CN104619689B (zh) * 2012-09-12 2017-08-08 霍夫曼-拉罗奇有限公司 (S)‑2‑甲氧基‑3‑{4‑[2‑(5‑甲基‑2‑苯基‑噁唑‑4‑基)‑乙氧基]‑苯并[b]噻吩‑7‑基}‑丙酸的固体形式及其盐的固体形式
CN109588042A (zh) 2015-11-18 2019-04-05 豪夫迈·罗氏有限公司 用于治疗糖尿病肾病的阿格列扎
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WO2020201263A1 (en) 2019-04-01 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment and prevention of cardiac remodeling
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Also Published As

Publication number Publication date
BR0209821A (pt) 2004-06-01
JP2004529174A (ja) 2004-09-24
IL158589A (en) 2010-11-30
KR100654516B1 (ko) 2006-12-05
EG25755A (en) 2012-06-26
SK287842B6 (sk) 2011-12-05
NO20035086L (no) 2003-11-14
ATE327753T1 (de) 2006-06-15
NZ529033A (en) 2005-06-24
DK1392295T3 (da) 2006-10-02
DE60211891D1 (de) 2006-07-06
HK1067534A1 (en) 2005-04-15
AU2002342244B2 (en) 2005-06-16
JP4330883B2 (ja) 2009-09-16
JO2282B1 (en) 2005-09-12
EP1392295A1 (en) 2004-03-03
CA2445145C (en) 2008-10-14
CY1105160T1 (el) 2009-11-04
HUP0400992A3 (en) 2007-11-28
SI1392295T1 (sl) 2006-10-31
CZ20033037A3 (cs) 2004-06-16
PL208074B1 (pl) 2011-03-31
US20030055265A1 (en) 2003-03-20
BRPI0209821B1 (pt) 2016-09-27
PL367087A1 (en) 2005-02-21
RU2278859C2 (ru) 2006-06-27
NO333833B1 (no) 2013-09-30
BG108362A (bg) 2005-03-31
PE20021152A1 (es) 2003-02-07
MY136761A (en) 2008-11-28
HRP20030889B1 (hr) 2011-10-31
IL158589A0 (en) 2004-05-12
CN100356917C (zh) 2007-12-26
KR20030096397A (ko) 2003-12-24
ME01310B (me) 2011-10-10
ECSP034848A (es) 2003-12-24
PA8544901A1 (es) 2003-01-24
SK13852003A3 (en) 2004-10-05
MXPA03010435A (es) 2004-03-09
ZA200308538B (en) 2005-04-26
DE60211891T2 (de) 2007-05-24
RU2003134150A (ru) 2005-06-10
HU230224B1 (hu) 2015-10-28
NO20035086D0 (no) 2003-11-14
ES2264482T3 (es) 2007-01-01
HRP20030889A2 (en) 2005-08-31
CN1509173A (zh) 2004-06-30
AR035892A1 (es) 2004-07-21
MA27025A1 (fr) 2004-12-20
HUP0400992A2 (hu) 2004-08-30
US6642389B2 (en) 2003-11-04
EP1392295B1 (en) 2006-05-31
CA2445145A1 (en) 2002-11-21
WO2002092084A1 (en) 2002-11-21
GT200200085A (es) 2003-01-16
BG66316B1 (bg) 2013-04-30
JP2009138011A (ja) 2009-06-25

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