PT1264828E - Inibidor de uroquinase - Google Patents
Inibidor de uroquinaseInfo
- Publication number
- PT1264828E PT1264828E PT02016038T PT02016038T PT1264828E PT 1264828 E PT1264828 E PT 1264828E PT 02016038 T PT02016038 T PT 02016038T PT 02016038 T PT02016038 T PT 02016038T PT 1264828 E PT1264828 E PT 1264828E
- Authority
- PT
- Portugal
- Prior art keywords
- optionally
- alkyl
- substituted
- aryl
- ring
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 abstract 6
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 229960005356 urokinase Drugs 0.000 abstract 6
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 101100440695 Dictyostelium discoideum corB gene Proteins 0.000 abstract 2
- -1 Sulfonyl-substituted 3-amidino-phenylalanine Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 238000003745 diagnosis Methods 0.000 abstract 2
- 230000006806 disease prevention Effects 0.000 abstract 2
- 210000002751 lymph Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000008685 targeting Effects 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- IVWWFWFVSWOTLP-YVZVNANGSA-N (3'as,4r,7'as)-2,2,2',2'-tetramethylspiro[1,3-dioxolane-4,6'-4,7a-dihydro-3ah-[1,3]dioxolo[4,5-c]pyran]-7'-one Chemical compound C([C@@H]1OC(O[C@@H]1C1=O)(C)C)O[C@]21COC(C)(C)O2 IVWWFWFVSWOTLP-YVZVNANGSA-N 0.000 abstract 1
- DSSGKVAUNCQJTG-UHFFFAOYSA-N C(C)OC(=O)N1CCN(CC1)C(C(N)(CC1=CC(=CC=C1)C(N)=N)S(=O)(=O)C1=C(C=C(C=C1C(C)C)C(C)C)C(C)C)=O Chemical compound C(C)OC(=O)N1CCN(CC1)C(C(N)(CC1=CC(=CC=C1)C(N)=N)S(=O)(=O)C1=C(C=C(C=C1C(C)C)C(C)C)C(C)C)=O DSSGKVAUNCQJTG-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001409 amidines Chemical class 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005553 heteroaryloxy group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000006678 phenoxycarbonyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
- A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98113519 | 1998-07-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1264828E true PT1264828E (pt) | 2004-08-31 |
Family
ID=8232314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT02016038T PT1264828E (pt) | 1998-07-20 | 1999-07-20 | Inibidor de uroquinase |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6624169B1 (pt) |
| EP (2) | EP1098651B1 (pt) |
| JP (1) | JP4603162B2 (pt) |
| AT (2) | ATE264103T1 (pt) |
| AU (1) | AU754958B2 (pt) |
| BR (1) | BR9912327B1 (pt) |
| CA (1) | CA2338073C (pt) |
| DE (2) | DE59903981D1 (pt) |
| ES (2) | ES2219607T3 (pt) |
| MX (1) | MXPA01000553A (pt) |
| PT (1) | PT1264828E (pt) |
| WO (1) | WO2000004954A2 (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2188003T3 (es) * | 1998-09-18 | 2003-06-16 | Pentapharm Ag | Inhibidores de la uroquinasa. |
| DE10013715A1 (de) | 2000-03-20 | 2001-09-27 | Wilex Biotechnology Gmbh | Hochselektive Inhibitoren des Urokinase-Plasminogenaktivators |
| DE10029014A1 (de) * | 2000-06-15 | 2001-12-20 | Univ Schiller Jena | Urokinase-Hemmstoffe |
| EP1373234B1 (de) | 2001-03-21 | 2008-02-13 | Wilex AG | Urokinase-inhibitoren |
| WO2003076391A2 (de) | 2002-03-11 | 2003-09-18 | Curacyte Ag | Hemmstoffe der urokinase, ihre herstellung und verwendung |
| DE10225876A1 (de) * | 2002-06-11 | 2003-12-24 | Wilex Ag | Guanidinophenylalaninverbindungen als Urokinase-Inhibitoren |
| DE10233632A1 (de) * | 2002-07-24 | 2004-02-05 | Wilex Ag | Formulierungen von Phenylalanin-Derivaten |
| AU2003253326A1 (en) * | 2002-07-25 | 2004-02-16 | Wilex Ag | Method for the production of phenylalanine derivatives |
| DE10238048A1 (de) * | 2002-07-25 | 2004-02-05 | Wilex Ag | Verfahren zur Herstellung von Phenylalanin-Derivaten |
| DE10301300B4 (de) | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
| DE10322191B4 (de) * | 2003-05-16 | 2014-02-27 | The Medicines Company (Leipzig) Gmbh | N-sulfonylierte Aminosäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| DE10323898A1 (de) | 2003-05-26 | 2004-12-23 | Wilex Ag | Hydroxyamidin- und Hydroxyguanidin-Verbindungen als Urokinase-Hemmstoffe |
| DE10342108A1 (de) | 2003-09-11 | 2005-04-14 | Curacyte Chemistry Gmbh | Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung |
| EP1637529A1 (en) * | 2004-09-20 | 2006-03-22 | 4Sc Ag | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof |
| DE102004045720A1 (de) * | 2004-09-21 | 2006-03-23 | Wilex Ag | Stabile Dosierungsform von Phenylalanin-Derivaten |
| ATE442842T1 (de) | 2005-06-24 | 2009-10-15 | Wilex Ag | Verwendung von urokinase-inhibitoren zur behandlung und/oder vorbeugung von amyotrophischer lateralsklerose (als) |
| DE102006050672A1 (de) | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
| WO2011150245A2 (en) * | 2010-05-26 | 2011-12-01 | Expression Pathology, Inc. | Urokinase-type plasminogen activator protein/plasminogen activator inhibitor type-1 protein-selected reaction monitoring assay |
| EP2590945B1 (en) | 2010-07-07 | 2014-04-30 | The Medicines Company (Leipzig) GmbH | Serine protease inhibitors |
| CA2977061C (en) | 2015-03-30 | 2023-05-23 | Sunnybrook Research Institute | Method for treating cancer |
| WO2017052261A1 (ko) * | 2015-09-24 | 2017-03-30 | 주식회사 엘지화학 | 화합물 및 이를 포함하는 유기 전자 소자 |
| RU2727474C2 (ru) * | 2015-10-06 | 2020-07-21 | Редхилл Байофарма Лтд. | Виды комбинированной терапии для лечения рака |
| MX2022011173A (es) | 2020-03-10 | 2022-10-18 | Redhill Biopharma Ltd | Tratamiento de infeccion por coronavirus. |
| US11471448B2 (en) | 2020-12-15 | 2022-10-18 | Redhill Biopharma Ltd. | Sphingosine kinase 2 inhibitor for treating coronavirus infection in moderately severe patients with pneumonia |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU541738B2 (en) | 1979-09-20 | 1985-01-17 | Nippon Chemiphar Co. Ltd. | Cyclohexane carboxylic acid derivatives |
| EP0183271B1 (en) * | 1984-11-30 | 1990-05-16 | Shosuke Okamoto | Lysin derivative and proteinase inhibitor |
| WO1992008709A1 (de) * | 1990-11-15 | 1992-05-29 | Pentapharm Ag | Meta-substituierte phenylalanin-derivate |
| ATE223392T1 (de) | 1993-02-10 | 2002-09-15 | Pentapharm Ag | Piperazide von substituierten phenylalanin- derivativen als thrombin inhibitoren |
| US5550213A (en) * | 1993-12-27 | 1996-08-27 | Rutgers, The State University Of New Jersey | Inhibitors of urokinase plasminogen activator |
| WO1996005189A1 (de) | 1994-08-09 | 1996-02-22 | Pentapharm Ag | Neue inhibitoren vom benzamidintyp |
| DE9418185U1 (de) * | 1994-11-12 | 1995-02-23 | Richard Wolf Gmbh, 75438 Knittlingen | Behälter für medizinische Instrumente |
| CH689611A5 (de) * | 1995-03-01 | 1999-07-15 | Pentapharm Ag | Urokinase-Inhibitoren. |
| ES2188003T3 (es) * | 1998-09-18 | 2003-06-16 | Pentapharm Ag | Inhibidores de la uroquinasa. |
-
1999
- 1999-07-20 US US09/743,800 patent/US6624169B1/en not_active Expired - Lifetime
- 1999-07-20 JP JP2000560945A patent/JP4603162B2/ja not_active Expired - Lifetime
- 1999-07-20 EP EP99936570A patent/EP1098651B1/de not_active Expired - Lifetime
- 1999-07-20 ES ES02016038T patent/ES2219607T3/es not_active Expired - Lifetime
- 1999-07-20 EP EP02016038A patent/EP1264828B1/de not_active Expired - Lifetime
- 1999-07-20 DE DE59903981T patent/DE59903981D1/de not_active Expired - Lifetime
- 1999-07-20 PT PT02016038T patent/PT1264828E/pt unknown
- 1999-07-20 BR BRPI9912327-4B1A patent/BR9912327B1/pt not_active IP Right Cessation
- 1999-07-20 WO PCT/EP1999/005145 patent/WO2000004954A2/de active IP Right Grant
- 1999-07-20 AT AT02016038T patent/ATE264103T1/de active
- 1999-07-20 ES ES99936570T patent/ES2189455T3/es not_active Expired - Lifetime
- 1999-07-20 CA CA2338073A patent/CA2338073C/en not_active Expired - Fee Related
- 1999-07-20 MX MXPA01000553A patent/MXPA01000553A/es active IP Right Grant
- 1999-07-20 AU AU51615/99A patent/AU754958B2/en not_active Ceased
- 1999-07-20 DE DE59909210T patent/DE59909210D1/de not_active Expired - Lifetime
- 1999-07-20 AT AT99936570T patent/ATE230599T1/de active
-
2002
- 2002-07-26 US US10/202,850 patent/US6680320B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA01000553A (es) | 2002-04-24 |
| BR9912327B1 (pt) | 2013-11-12 |
| EP1264828A1 (de) | 2002-12-11 |
| ATE230599T1 (de) | 2003-01-15 |
| ES2219607T3 (es) | 2004-12-01 |
| JP4603162B2 (ja) | 2010-12-22 |
| ATE264103T1 (de) | 2004-04-15 |
| JP2002521348A (ja) | 2002-07-16 |
| BR9912327A (pt) | 2001-05-02 |
| CA2338073C (en) | 2010-09-21 |
| AU754958B2 (en) | 2002-11-28 |
| WO2000004954A3 (de) | 2000-06-22 |
| DE59903981D1 (de) | 2003-02-13 |
| DE59909210D1 (de) | 2004-05-19 |
| US6624169B1 (en) | 2003-09-23 |
| CA2338073A1 (en) | 2000-02-03 |
| EP1264828B1 (de) | 2004-04-14 |
| WO2000004954A2 (de) | 2000-02-03 |
| US20030013723A1 (en) | 2003-01-16 |
| ES2189455T3 (es) | 2003-07-01 |
| AU5161599A (en) | 2000-02-14 |
| EP1098651A2 (de) | 2001-05-16 |
| US6680320B2 (en) | 2004-01-20 |
| EP1098651B1 (de) | 2003-01-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT1264828E (pt) | Inibidor de uroquinase | |
| AU4437896A (en) | Piperidine derivatives having tachykinin antagonist activity | |
| DK436289A (da) | Cycloalkyl-substituerede glutaramidderivater, farmaceutiske praeparater indeholdende disse forbindelser, forbindelserne til medicinsk anvendelse og deres anvendelse til fremstilling af laegemidler til behandling af hypertension, hjertesvigt eller renal insufficiens | |
| AR002971A1 (es) | COMPUESTOS DE 3-(1,2,3,6)-TETRAHIDROPIRIDIN-4-ILO Y 3-PIPERIDIN-4-ILO-1H- INDOL, AGONISTAS DE 5HT(1f) FORMULACIONES FARMACEUTICAS QUE LOS CONTIENEN YMETODOS PARA ACTIVAR DICHOS RECEPTORES 5HT(1f) Y/O PARA TRATAR LAS MIGRANAS Y DESORDENES ASOCIADOS CON ELLA. | |
| DE60322359D1 (de) | Imidazopyridinderivate als kinaseinhibitoren | |
| EA200000110A1 (ru) | Бициклические бензамиды производных 3- или 4-замещенного 4-(аминометил) пиперидина с гастрокинетическими свойствами | |
| ATE319705T1 (de) | Chinolyl-propylpiperidinderivate und deren verwendung als antimikrobielle wirkstoffe | |
| YU32196A (sh) | Upotreba jedinjenja za pripremanje leka korisnog za inhibiranje migracije vaskularnih ćelija glatkog mišića | |
| ATE150301T1 (de) | Aminoalkanesulfonsäurederivate und pharmazeutische zusammensetzungen davon zur prävention oder behandlung von herzerkrankungen | |
| HUP0100276A2 (hu) | Szubsztituált krománszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| ATE409187T1 (de) | N-(substituierte benzyl)-8-hydroxy-1,6- naphthyridin-7- carbonsäureamide als hiv- integrase-hemmer | |
| ATE287886T1 (de) | Verwendung von 5-thio, sulfinyl- und sulfonylpyrazolo 3,4-b) pyridinen als cyclin- abhängige kinase-hemmer | |
| MX9306310A (es) | Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen | |
| HUP0402515A2 (hu) | Szubsztituált új N-[4-(1H-imidazol-1-il)-2-fluor-fenil]-3-(trifluor-metil)-1H-pirazol-5-karboxamidok Xa faktor inhibitorok, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények | |
| DK0506434T3 (da) | Thiazolidinon- og oxazolidinon-derivater, fremstilling deraf og deres anvendelse som vasodilaterende midler | |
| MX9304190A (es) | Derivados novedosos de 4-[3-benzofuranil]piperidinilo y 4-[3-benzotientil]piperidinilo. | |
| NO982863L (no) | Nye forbindelser med analgetisk effekt | |
| CO5280088A1 (es) | Inhibidores de proteasa | |
| YU67402A (sh) | Nova upotreba (r)-(-)-2-/5-(4-fluorofenil)-3- piridilmetilaminometil/-hromana i njegovih fiziološki prihvatljivih soli | |
| DE60126199D1 (de) | Therapeutische behandlung von eosinophilie durch verwendung von chymase-inhibitoren als aktiven bestandteilen | |
| FR2757164B1 (fr) | Nouveaux derives de n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| DE60120757D1 (de) | 4-substituierte chinolone zur behandlung von autoimmunerkrankungen | |
| NO953913D0 (no) | Perhydroisoindolderivater, deres fremstilling samt farmasöytiske preparater inneholdende derivatene | |
| RU2317083C2 (ru) | Применение производных n-(индолкарбонил)пиперазина | |
| ATE356805T1 (de) | Oxophenylcyclohexylpropanolaminderivate, deren herstellung und verwendung in therapeutika |