PT1220830E - Utilização de elastase para abertura de artérias e veias obstruídas - Google Patents
Utilização de elastase para abertura de artérias e veias obstruídas Download PDFInfo
- Publication number
- PT1220830E PT1220830E PT00965396T PT00965396T PT1220830E PT 1220830 E PT1220830 E PT 1220830E PT 00965396 T PT00965396 T PT 00965396T PT 00965396 T PT00965396 T PT 00965396T PT 1220830 E PT1220830 E PT 1220830E
- Authority
- PT
- Portugal
- Prior art keywords
- vein
- artery
- use according
- medicament
- conduit
- Prior art date
Links
- 210000003462 vein Anatomy 0.000 title claims description 38
- 210000001367 artery Anatomy 0.000 title claims description 29
- 102000016387 Pancreatic elastase Human genes 0.000 title claims description 28
- 108010067372 Pancreatic elastase Proteins 0.000 title claims description 28
- 239000003814 drug Substances 0.000 claims description 48
- 102000016942 Elastin Human genes 0.000 claims description 16
- 108010014258 Elastin Proteins 0.000 claims description 16
- 229920002549 elastin Polymers 0.000 claims description 16
- 238000001631 haemodialysis Methods 0.000 claims description 16
- 230000000322 hemodialysis Effects 0.000 claims description 16
- 102000029816 Collagenase Human genes 0.000 claims description 15
- 108060005980 Collagenase Proteins 0.000 claims description 15
- 229960002424 collagenase Drugs 0.000 claims description 13
- 208000031481 Pathologic Constriction Diseases 0.000 claims description 12
- 230000036262 stenosis Effects 0.000 claims description 12
- 208000037804 stenosis Diseases 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 12
- 206010020718 hyperplasia Diseases 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 230000017854 proteolysis Effects 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 abstract description 28
- 102000004190 Enzymes Human genes 0.000 abstract description 24
- 108090000790 Enzymes Proteins 0.000 abstract description 24
- 238000000034 method Methods 0.000 abstract description 22
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 abstract description 13
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 abstract description 13
- 210000002744 extracellular matrix Anatomy 0.000 abstract description 13
- 239000000203 mixture Substances 0.000 abstract description 10
- 230000015572 biosynthetic process Effects 0.000 abstract description 7
- 230000000916 dilatatory effect Effects 0.000 abstract description 4
- 239000012530 fluid Substances 0.000 abstract description 2
- 206010061876 Obstruction Diseases 0.000 abstract 3
- 102000008186 Collagen Human genes 0.000 description 25
- 108010035532 Collagen Proteins 0.000 description 25
- 229920001436 collagen Polymers 0.000 description 25
- 229940124597 therapeutic agent Drugs 0.000 description 25
- 229940088598 enzyme Drugs 0.000 description 21
- 230000029087 digestion Effects 0.000 description 15
- 230000000694 effects Effects 0.000 description 13
- 238000001356 surgical procedure Methods 0.000 description 13
- 229940122618 Trypsin inhibitor Drugs 0.000 description 8
- 101710162629 Trypsin inhibitor Proteins 0.000 description 8
- 230000000593 degrading effect Effects 0.000 description 8
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 description 8
- 230000003902 lesion Effects 0.000 description 8
- 239000002753 trypsin inhibitor Substances 0.000 description 8
- 208000014674 injury Diseases 0.000 description 7
- 244000144725 Amygdalus communis Species 0.000 description 6
- 210000001953 common bile duct Anatomy 0.000 description 6
- 238000000338 in vitro Methods 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 230000007774 longterm Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 238000002399 angioplasty Methods 0.000 description 5
- 239000002872 contrast media Substances 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- 230000002792 vascular Effects 0.000 description 5
- 102000009123 Fibrin Human genes 0.000 description 4
- 108010073385 Fibrin Proteins 0.000 description 4
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 238000006731 degradation reaction Methods 0.000 description 4
- 229950003499 fibrin Drugs 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 239000004365 Protease Substances 0.000 description 3
- 241000618809 Vitales Species 0.000 description 3
- 230000003872 anastomosis Effects 0.000 description 3
- 210000000941 bile Anatomy 0.000 description 3
- 230000012292 cell migration Effects 0.000 description 3
- 230000004663 cell proliferation Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000010339 dilation Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 3
- 238000002697 interventional radiology Methods 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 229940099990 ogen Drugs 0.000 description 3
- 208000037803 restenosis Diseases 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 210000002435 tendon Anatomy 0.000 description 3
- 230000008733 trauma Effects 0.000 description 3
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 2
- 108010088842 Fibrinolysin Proteins 0.000 description 2
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 2
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 2
- 108090000631 Trypsin Proteins 0.000 description 2
- 102000004142 Trypsin Human genes 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 208000020832 chronic kidney disease Diseases 0.000 description 2
- 230000009089 cytolysis Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 208000028208 end stage renal disease Diseases 0.000 description 2
- 201000000523 end stage renal failure Diseases 0.000 description 2
- 239000003527 fibrinolytic agent Substances 0.000 description 2
- 230000003480 fibrinolytic effect Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000011221 initial treatment Methods 0.000 description 2
- 208000017169 kidney disease Diseases 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- MIKKOBKEXMRYFQ-WZTVWXICSA-N meglumine amidotrizoate Chemical compound C[NH2+]C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C([O-])=O)=C1I MIKKOBKEXMRYFQ-WZTVWXICSA-N 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 201000004240 prostatic hypertrophy Diseases 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000005063 solubilization Methods 0.000 description 2
- 230000007928 solubilization Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 239000012588 trypsin Substances 0.000 description 2
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 description 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010004032 Bromelains Proteins 0.000 description 1
- 108010084457 Cathepsins Proteins 0.000 description 1
- 102000005600 Cathepsins Human genes 0.000 description 1
- 108090001069 Chymopapain Proteins 0.000 description 1
- 108090000317 Chymotrypsin Proteins 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108010008532 Deoxyribonuclease I Proteins 0.000 description 1
- 102000007260 Deoxyribonuclease I Human genes 0.000 description 1
- 208000001708 Dupuytren contracture Diseases 0.000 description 1
- 229920000544 Gore-Tex Polymers 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 108010003272 Hyaluronate lyase Proteins 0.000 description 1
- 102000009066 Hyaluronoglucosaminidase Human genes 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 102000005348 Neuraminidase Human genes 0.000 description 1
- 108010006232 Neuraminidase Proteins 0.000 description 1
- 108010019160 Pancreatin Proteins 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 108010033276 Peptide Fragments Proteins 0.000 description 1
- 102000007079 Peptide Fragments Human genes 0.000 description 1
- 108010064785 Phospholipases Proteins 0.000 description 1
- 102000015439 Phospholipases Human genes 0.000 description 1
- 108010001014 Plasminogen Activators Proteins 0.000 description 1
- 102000001938 Plasminogen Activators Human genes 0.000 description 1
- 108010059712 Pronase Proteins 0.000 description 1
- 102000012479 Serine Proteases Human genes 0.000 description 1
- 108010022999 Serine Proteases Proteins 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 108010023197 Streptokinase Proteins 0.000 description 1
- 108090000787 Subtilisin Proteins 0.000 description 1
- 108090001109 Thermolysin Proteins 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- ISWQCIVKKSOKNN-UHFFFAOYSA-L Tiron Chemical compound [Na+].[Na+].OC1=CC(S([O-])(=O)=O)=CC(S([O-])(=O)=O)=C1O ISWQCIVKKSOKNN-UHFFFAOYSA-L 0.000 description 1
- 206010060872 Transplant failure Diseases 0.000 description 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 235000019835 bromelain Nutrition 0.000 description 1
- 210000000621 bronchi Anatomy 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000002192 cholecystectomy Methods 0.000 description 1
- -1 cholesterolsterase Proteins 0.000 description 1
- 229960002976 chymopapain Drugs 0.000 description 1
- 229960002376 chymotrypsin Drugs 0.000 description 1
- 108090001092 clostripain Proteins 0.000 description 1
- 230000037369 collagen remodeling Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 208000037765 diseases and disorders Diseases 0.000 description 1
- 108010007093 dispase Proteins 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000013213 extrapolation Methods 0.000 description 1
- 229940001501 fibrinolysin Drugs 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000027700 hepatic dysfunction Diseases 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 229960002773 hyaluronidase Drugs 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 229940055695 pancreatin Drugs 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229940012957 plasmin Drugs 0.000 description 1
- 229940127126 plasminogen activator Drugs 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229940000634 serratiopeptidase Drugs 0.000 description 1
- 108010038132 serratiopeptidase Proteins 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 229960005202 streptokinase Drugs 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 description 1
- 238000007631 vascular surgery Methods 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/486—Elastase (3.4.21.36 or 3.4.21.37)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- External Artificial Organs (AREA)
- Enzymes And Modification Thereof (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Materials For Medical Uses (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Processing Of Meat And Fish (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15593899P | 1999-09-24 | 1999-09-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1220830E true PT1220830E (pt) | 2007-06-11 |
Family
ID=22557384
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT00965396T PT1220830E (pt) | 1999-09-24 | 2000-09-24 | Utilização de elastase para abertura de artérias e veias obstruídas |
| PT101805331T PT2363142E (pt) | 1999-09-24 | 2000-09-24 | Elastase para a abertura de condutas biológicas obstruídas |
| PT07008805T PT1923068E (pt) | 1999-09-24 | 2000-09-24 | Sistema e métodos para a abertura de condutas biológicas obstruídas |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT101805331T PT2363142E (pt) | 1999-09-24 | 2000-09-24 | Elastase para a abertura de condutas biológicas obstruídas |
| PT07008805T PT1923068E (pt) | 1999-09-24 | 2000-09-24 | Sistema e métodos para a abertura de condutas biológicas obstruídas |
Country Status (11)
| Country | Link |
|---|---|
| EP (4) | EP1220830B1 (https=) |
| JP (2) | JP5763286B2 (https=) |
| AT (2) | ATE511854T1 (https=) |
| AU (1) | AU7612100A (https=) |
| CA (1) | CA2385488C (https=) |
| CY (3) | CY1106656T1 (https=) |
| DE (1) | DE60034694T2 (https=) |
| DK (3) | DK1220830T3 (https=) |
| ES (3) | ES2534938T3 (https=) |
| PT (3) | PT1220830E (https=) |
| WO (1) | WO2001021574A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7063838B1 (en) | 1999-09-24 | 2006-06-20 | Proteon Therapeutics Llc | Methods for treating an artery or vein in a human subject |
| AU2004213050B2 (en) * | 2003-02-20 | 2010-09-09 | Proteon Therapeutics, Inc. | Methods for the treatment and prevention of diseases of biological conduits |
| BRPI0515569A (pt) * | 2004-09-22 | 2008-07-29 | Proteon Therapeutics Inc | métodos para reduzir vasospasmo em um segmento de um conduto biológico, para reduzir a capacidade de um vaso sofrer vasospasmo em um segmento de um conduto biológico e para reduzir o acúmulo de hiperplasia ìntima em um segmento de um conduto biológico |
| US10071143B1 (en) | 2007-05-03 | 2018-09-11 | The Research Foundation For The State University Of New York | Methods for non-surgical treatment of carpal tunnel syndrome |
| US8501449B2 (en) | 2007-12-04 | 2013-08-06 | Proteon Therapeutics, Inc. | Recombinant elastase proteins and methods of manufacturing and use thereof |
| CA2861033C (en) | 2012-01-12 | 2017-07-25 | Auxilium International Holdings, Inc. | Clostridium histolyticum enzymes and methods for the use thereof |
| WO2014066622A2 (en) | 2012-10-24 | 2014-05-01 | The Research Foundation For The State University Of New York | Use of collagenase to treat glaucoma |
| ES3036011T3 (en) | 2017-03-01 | 2025-09-11 | Endo Operations Ltd | Apparatus and method for assessing and treating cellulite |
| KR20240001279A (ko) | 2017-03-28 | 2024-01-03 | 엔도 벤쳐즈 리미티드 | 개선된 콜라게나제 생성 방법 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5489261A (en) * | 1981-01-26 | 1996-02-06 | Trustees Of Boston University | Hydrogels capable of supporting cell growth |
| US4636195A (en) * | 1982-04-02 | 1987-01-13 | Harvey Wolinsky | Method and apparatus for removing arterial constriction |
| US4803294A (en) * | 1987-10-29 | 1989-02-07 | G. D. Searle & Co. | Process and intermediates for the preparation of halogenated protease inhibitors |
| JPH0286777A (ja) * | 1988-09-22 | 1990-03-27 | Sankyo Co Ltd | サル膵臓エラスターゼｉ |
| HK1003981A1 (en) * | 1989-01-27 | 1998-11-13 | Immunolytics, Inc. | Composition and method for treating benign prostatic hypertrophy |
| US5116615A (en) * | 1989-01-27 | 1992-05-26 | Immunolytics, Inc. | Method for treating benign prostatic hypertrophy |
| US5328470A (en) * | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| NL8900943A (nl) * | 1989-04-14 | 1990-11-01 | Euro Biopharm Technology B V | Protease inhibitor. |
| US5318531A (en) * | 1991-06-11 | 1994-06-07 | Cordis Corporation | Infusion balloon catheter |
| US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5422261A (en) * | 1993-04-16 | 1995-06-06 | Baxter International Inc. | Composition containing collagenase and chymopapain for hydrolyzing connective tissue to isolate cells |
| US5409926A (en) | 1993-07-19 | 1995-04-25 | Merck & Co., Inc. | AT-2 antagonist inhibition of vascular restenosis |
| ES2281898T3 (es) * | 1994-12-13 | 2007-10-01 | Human Genome Sciences, Inc. | Inhibidor tisular humano de metaloproteinasa-4. |
| US6020181A (en) * | 1995-05-17 | 2000-02-01 | New York Blood, Inc. | Inhibition of thrombus formation by medical related apparatus comprising treating with fibrinolytic matrix metalloproteinase |
| US5830468A (en) * | 1995-05-17 | 1998-11-03 | The New York Blood Center, Inc. | Fibrin(ogen) degradation by fibrinolytic matrix metalloproteinase |
| US5834449A (en) * | 1996-06-13 | 1998-11-10 | The Research Foundation Of State University Of New York | Treatment of aortic and vascular aneurysms with tetracycline compounds |
| ZA98376B (en) * | 1997-01-23 | 1998-07-23 | Hoffmann La Roche | Sulfamide-metalloprotease inhibitors |
-
2000
- 2000-09-24 AU AU76121/00A patent/AU7612100A/en not_active Abandoned
- 2000-09-24 ES ES10180533.1T patent/ES2534938T3/es not_active Expired - Lifetime
- 2000-09-24 ES ES00965396T patent/ES2284528T3/es not_active Expired - Lifetime
- 2000-09-24 DK DK00965396T patent/DK1220830T3/da active
- 2000-09-24 PT PT00965396T patent/PT1220830E/pt unknown
- 2000-09-24 EP EP20000965396 patent/EP1220830B1/en not_active Expired - Lifetime
- 2000-09-24 AT AT07008805T patent/ATE511854T1/de active
- 2000-09-24 WO PCT/US2000/026237 patent/WO2001021574A1/en not_active Ceased
- 2000-09-24 AT AT00965396T patent/ATE361095T1/de active
- 2000-09-24 DE DE2000634694 patent/DE60034694T2/de not_active Expired - Lifetime
- 2000-09-24 DK DK07008805T patent/DK1923068T3/da active
- 2000-09-24 DK DK10180533T patent/DK2363142T3/en active
- 2000-09-24 EP EP10180533.1A patent/EP2363142B8/en not_active Expired - Lifetime
- 2000-09-24 CA CA2385488A patent/CA2385488C/en not_active Expired - Fee Related
- 2000-09-24 PT PT101805331T patent/PT2363142E/pt unknown
- 2000-09-24 EP EP20100183002 patent/EP2332568A1/en not_active Withdrawn
- 2000-09-24 EP EP20070008805 patent/EP1923068B1/en not_active Expired - Lifetime
- 2000-09-24 ES ES07008805T patent/ES2364191T3/es not_active Expired - Lifetime
- 2000-09-24 PT PT07008805T patent/PT1923068E/pt unknown
- 2000-09-24 JP JP2001524955A patent/JP5763286B2/ja not_active Expired - Fee Related
-
2007
- 2007-06-14 CY CY20071100790T patent/CY1106656T1/el unknown
-
2011
- 2011-09-08 CY CY20111100865T patent/CY1112329T1/el unknown
-
2012
- 2012-04-04 JP JP2012085454A patent/JP5793461B2/ja not_active Expired - Fee Related
-
2015
- 2015-05-29 CY CY20151100477T patent/CY1117932T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8562983B2 (en) | System comprising elastase | |
| JP5793461B2 (ja) | 閉塞した生物学的管を開通するためのシステムと方法 | |
| JP5504119B2 (ja) | 生体導管の疾患を治療および予防するための方法 | |
| US20080095760A1 (en) | Methods of treating stroke | |
| US10179163B2 (en) | Methods of treatment with elastase | |
| Harmon et al. | Transurethral enzymatic ablation of the prostate: canine model | |
| Gardiner Jr et al. | Thrombolysis for peripheral arterial occlusions. | |
| HK1162302B (en) | Elastase for opening obstructed biological conduits | |
| JP2008513517A (ja) | 生物学的導管の疾患の治療方法及び予防方法 |