PT1163333E - ''inibidores da síntese de endotelina-1'' - Google Patents

''inibidores da síntese de endotelina-1'' Download PDF

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Publication number
PT1163333E
PT1163333E PT00918545T PT00918545T PT1163333E PT 1163333 E PT1163333 E PT 1163333E PT 00918545 T PT00918545 T PT 00918545T PT 00918545 T PT00918545 T PT 00918545T PT 1163333 E PT1163333 E PT 1163333E
Authority
PT
Portugal
Prior art keywords
endothelin
synthesis
inhibitors
mrna
symptoms
Prior art date
Application number
PT00918545T
Other languages
English (en)
Inventor
Roger Corder
Adrian P L Smith
Timothy W Higenbottam
Martine Rothblatt
Sir John William Harvey Vane
Delphine Dominique Marthe Lees
Original Assignee
Queen Mary & Westfield College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Queen Mary & Westfield College filed Critical Queen Mary & Westfield College
Publication of PT1163333E publication Critical patent/PT1163333E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT00918545T 1999-03-18 2000-03-17 ''inibidores da síntese de endotelina-1'' PT1163333E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12500099P 1999-03-18 1999-03-18

Publications (1)

Publication Number Publication Date
PT1163333E true PT1163333E (pt) 2008-02-19

Family

ID=22417780

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00918545T PT1163333E (pt) 1999-03-18 2000-03-17 ''inibidores da síntese de endotelina-1''

Country Status (8)

Country Link
US (1) US7423141B2 (pt)
EP (1) EP1163333B1 (pt)
AT (1) ATE377645T1 (pt)
AU (1) AU3934000A (pt)
DE (1) DE60037012T2 (pt)
ES (1) ES2296613T3 (pt)
PT (1) PT1163333E (pt)
WO (1) WO2000055314A2 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2670872T3 (es) 2003-05-22 2018-06-01 United Therapeutics Corporation Polimorfo de una sal de dietanolamina de treprostinil
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
ES2560864T3 (es) 2006-04-04 2016-02-23 Singulex, Inc. Sistema de alta sensibilidad y métodos de análisis de la troponina
EP2491932A3 (en) * 2007-02-09 2012-12-12 United Therapeutics Corporation Use of biomarkers for monitoring the course of treatment of a pulmonary disease upon treatment with treprostinil
AU2010259022B2 (en) 2009-06-08 2016-05-12 Singulex, Inc. Highly sensitive biomarker panels
WO2016083624A1 (en) * 2014-11-28 2016-06-02 Silence Therapeutics Gmbh Means for inhibiting the expression of edn1
US10883084B2 (en) 2018-10-05 2021-01-05 Xenotherapeutics, Inc. Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same
EP3860336A1 (en) 2018-10-05 2021-08-11 Xenotherapeutics, Inc. Xenotransplantation products and methods

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4306075A (en) * 1980-03-28 1981-12-15 The Upjohn Company Composition and process
US5034506A (en) * 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
JP2632167B2 (ja) * 1987-11-30 1997-07-23 鐘淵化学工業株式会社 熱硬化性組成物
KR0158870B1 (ko) * 1988-06-17 1998-12-01 마틴 에이. 로쓰블랫 폐순환 승압의 치료, 예방 또는 진단용 조성물
US5378825A (en) 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
US5747340A (en) * 1994-06-03 1998-05-05 Syntex (U.S.A.) Inc. Targeted gene expression using preproendothelin-1 promoters
WO1996008268A1 (en) * 1994-09-14 1996-03-21 President And Fellows Of Harvard College Inhibition of endothelin-1 to reduce inflammatory processes
US5688499A (en) * 1996-03-13 1997-11-18 Queen's University At Kingston Antagonism of endothelin actions
US5994076A (en) * 1997-05-21 1999-11-30 Clontech Laboratories, Inc. Methods of assaying differential expression
GB9718487D0 (en) * 1997-09-02 1997-11-05 Univ Sheffield Pulmonary hypertension
CN1142781C (zh) * 1997-11-14 2004-03-24 联合治疗公司 9－脱氧－2′,9－α－亚甲基－3－氧杂－4,5,6－三去甲－3,7－(1′,3′－间亚苯基)－13,14－二氢－前列腺素F1在治疗外周血管疾病中的用途
US6551795B1 (en) * 1998-02-18 2003-04-22 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics

Also Published As

Publication number Publication date
DE60037012D1 (de) 2007-12-20
WO2000055314A3 (en) 2001-02-22
EP1163333B1 (en) 2007-11-07
WO2000055314A9 (en) 2002-08-08
AU3934000A (en) 2000-10-04
WO2000055314A2 (en) 2000-09-21
US7423141B2 (en) 2008-09-09
ES2296613T3 (es) 2008-05-01
ATE377645T1 (de) 2007-11-15
EP1163333A2 (en) 2001-12-19
US20030109480A1 (en) 2003-06-12
DE60037012T2 (de) 2008-10-30

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