DE60037012D1 - Inhibitoren der endothelin-1 synthese - Google Patents
Inhibitoren der endothelin-1 syntheseInfo
- Publication number
- DE60037012D1 DE60037012D1 DE60037012T DE60037012T DE60037012D1 DE 60037012 D1 DE60037012 D1 DE 60037012D1 DE 60037012 T DE60037012 T DE 60037012T DE 60037012 T DE60037012 T DE 60037012T DE 60037012 D1 DE60037012 D1 DE 60037012D1
- Authority
- DE
- Germany
- Prior art keywords
- endothelin
- synthesis
- inhibitors
- mrna
- symptoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12500099P | 1999-03-18 | 1999-03-18 | |
US125000P | 1999-03-18 | ||
PCT/US2000/040074 WO2000055314A2 (en) | 1999-03-18 | 2000-03-17 | Inhibitors of endothelin-1 synthesis |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60037012D1 true DE60037012D1 (de) | 2007-12-20 |
DE60037012T2 DE60037012T2 (de) | 2008-10-30 |
Family
ID=22417780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60037012T Expired - Fee Related DE60037012T2 (de) | 1999-03-18 | 2000-03-17 | Inhibitoren der endothelin-1 synthese |
Country Status (8)
Country | Link |
---|---|
US (1) | US7423141B2 (de) |
EP (1) | EP1163333B1 (de) |
AT (1) | ATE377645T1 (de) |
AU (1) | AU3934000A (de) |
DE (1) | DE60037012T2 (de) |
ES (1) | ES2296613T3 (de) |
PT (1) | PT1163333E (de) |
WO (1) | WO2000055314A2 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2526534C (en) | 2003-05-22 | 2011-07-12 | United Therapeutics Corporation | Compounds and methods for delivery of prostacyclin analogs |
EP3168618B1 (de) | 2006-04-04 | 2018-11-21 | Singulex, Inc. | Hochempfindliche verfahren zur troponinanalyse |
US7838250B1 (en) | 2006-04-04 | 2010-11-23 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
JP2010518122A (ja) * | 2007-02-09 | 2010-05-27 | ユナイテッド セラピューティクス コーポレーション | 間質性肺疾患および喘息のためのトレプロスチニル処置 |
JP5678045B2 (ja) | 2009-06-08 | 2015-02-25 | シンギュレックス・インコーポレイテッド | 高感度バイオマーカーパネル |
WO2016083624A1 (en) * | 2014-11-28 | 2016-06-02 | Silence Therapeutics Gmbh | Means for inhibiting the expression of edn1 |
US10883084B2 (en) | 2018-10-05 | 2021-01-05 | Xenotherapeutics, Inc. | Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same |
JP7431837B2 (ja) | 2018-10-05 | 2024-02-15 | ゼノセラピューティクス インコーポレイテッド | 異種移植製品及び異種移植方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4306075A (en) * | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
US5034506A (en) * | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
JP2632167B2 (ja) * | 1987-11-30 | 1997-07-23 | 鐘淵化学工業株式会社 | 熱硬化性組成物 |
EP0347243B1 (de) * | 1988-06-17 | 1993-01-13 | The Wellcome Foundation Limited | Prostaglandinanaloge zur Verwendung in der Medizin |
US5378825A (en) | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
US5747340A (en) * | 1994-06-03 | 1998-05-05 | Syntex (U.S.A.) Inc. | Targeted gene expression using preproendothelin-1 promoters |
JPH10508830A (ja) * | 1994-09-14 | 1998-09-02 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 炎症過程を抑制するためのエンドセリン−1の阻害 |
US5688499A (en) * | 1996-03-13 | 1997-11-18 | Queen's University At Kingston | Antagonism of endothelin actions |
US5994076A (en) * | 1997-05-21 | 1999-11-30 | Clontech Laboratories, Inc. | Methods of assaying differential expression |
GB9718487D0 (en) * | 1997-09-02 | 1997-11-05 | Univ Sheffield | Pulmonary hypertension |
AU1373499A (en) * | 1997-11-14 | 1999-06-07 | United Therapeutics Corporation | Use of 9-deoxy-2', 9-alpha-methano-3- oxa-4,5,6- trinor-3, 7-(1',3'-interphenylene) -13,14-dihydro- prostaglandin f1 to treat peripheral vascular disease |
US6551795B1 (en) * | 1998-02-18 | 2003-04-22 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics |
-
2000
- 2000-03-17 ES ES00918545T patent/ES2296613T3/es not_active Expired - Lifetime
- 2000-03-17 PT PT00918545T patent/PT1163333E/pt unknown
- 2000-03-17 WO PCT/US2000/040074 patent/WO2000055314A2/en active IP Right Grant
- 2000-03-17 EP EP00918545A patent/EP1163333B1/de not_active Expired - Lifetime
- 2000-03-17 AU AU39340/00A patent/AU3934000A/en not_active Abandoned
- 2000-03-17 DE DE60037012T patent/DE60037012T2/de not_active Expired - Fee Related
- 2000-03-17 AT AT00918545T patent/ATE377645T1/de not_active IP Right Cessation
-
2002
- 2002-11-18 US US10/295,942 patent/US7423141B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1163333B1 (de) | 2007-11-07 |
US20030109480A1 (en) | 2003-06-12 |
WO2000055314A9 (en) | 2002-08-08 |
EP1163333A2 (de) | 2001-12-19 |
WO2000055314A3 (en) | 2001-02-22 |
AU3934000A (en) | 2000-10-04 |
PT1163333E (pt) | 2008-02-19 |
WO2000055314A2 (en) | 2000-09-21 |
ES2296613T3 (es) | 2008-05-01 |
US7423141B2 (en) | 2008-09-09 |
ATE377645T1 (de) | 2007-11-15 |
DE60037012T2 (de) | 2008-10-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |