PT1153017E - Compostos biciclicos e sua utilizacao como ligandos do receptor de integrina - Google Patents
Compostos biciclicos e sua utilizacao como ligandos do receptor de integrinaInfo
- Publication number
- PT1153017E PT1153017E PT00903864T PT00903864T PT1153017E PT 1153017 E PT1153017 E PT 1153017E PT 00903864 T PT00903864 T PT 00903864T PT 00903864 T PT00903864 T PT 00903864T PT 1153017 E PT1153017 E PT 1153017E
- Authority
- PT
- Portugal
- Prior art keywords
- optionally substituted
- compounds
- receptor ligands
- integrin receptor
- bicyclic compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 102000006495 integrins Human genes 0.000 title 1
- 108010044426 integrins Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- 125000004450 alkenylene group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 102000016359 Fibronectins Human genes 0.000 abstract 1
- 108010067306 Fibronectins Proteins 0.000 abstract 1
- 108010008212 Integrin alpha4beta1 Proteins 0.000 abstract 1
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 abstract 1
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9903532.1A GB9903532D0 (en) | 1999-02-16 | 1999-02-16 | Chemical compounds |
| US14144599P | 1999-06-29 | 1999-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1153017E true PT1153017E (pt) | 2006-07-31 |
Family
ID=26315145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT00903864T PT1153017E (pt) | 1999-02-16 | 2000-02-16 | Compostos biciclicos e sua utilizacao como ligandos do receptor de integrina |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6593354B2 (https=) |
| EP (1) | EP1153017B1 (https=) |
| JP (1) | JP2002537292A (https=) |
| AT (1) | ATE325105T1 (https=) |
| AU (1) | AU775208B2 (https=) |
| CA (1) | CA2362862A1 (https=) |
| DE (1) | DE60027700T2 (https=) |
| DK (1) | DK1153017T3 (https=) |
| ES (1) | ES2263447T3 (https=) |
| PT (1) | PT1153017E (https=) |
| WO (1) | WO2000049005A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2231179T3 (es) * | 1999-04-12 | 2005-05-16 | Aventis Pharma Limited | Compuestos de heteroarilo biciclicos sustituidos como antagonistas de la integrina. |
| GB9908355D0 (en) * | 1999-04-12 | 1999-06-09 | Rhone Poulenc Rorer Ltd | Chemical compounds |
| GB0001346D0 (en) * | 2000-01-21 | 2000-03-08 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004686D0 (en) * | 2000-02-28 | 2000-04-19 | Aventis Pharma Ltd | Chemical compounds |
| JP4212358B2 (ja) | 2000-12-28 | 2009-01-21 | 第一三共株式会社 | Ｖｌａ−４阻害薬 |
| US7351719B2 (en) | 2002-10-31 | 2008-04-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds |
| CA2528586A1 (en) | 2003-07-24 | 2005-02-03 | Daiichi Pharmaceutical Co., Ltd. | Cyclohexanecarboxylic acid compound |
| US7592373B2 (en) | 2003-12-23 | 2009-09-22 | Boehringer Ingelheim International Gmbh | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds |
| DE10360745A1 (de) * | 2003-12-23 | 2005-07-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Amid-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| CA2558585C (en) * | 2004-02-27 | 2010-10-12 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders |
| DE102004017934A1 (de) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| US7524862B2 (en) | 2004-04-14 | 2009-04-28 | Boehringer Ingelheim International Gmbh | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
| US20070021612A1 (en) * | 2004-11-04 | 2007-01-25 | University Of Notre Dame Du Lac | Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof |
| US7235688B1 (en) | 2004-11-04 | 2007-06-26 | University Of Notre Dame Du Lac | Process for preparing histone deacetylase inhibitors and intermediates thereof |
| DE102006021878A1 (de) * | 2006-05-11 | 2007-11-15 | Sanofi-Aventis | Phenylamino-benzoxazol substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| UY32138A (es) | 2008-09-25 | 2010-04-30 | Boehringer Ingelheim Int | Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables |
| UY32470A (es) * | 2009-03-05 | 2010-10-29 | Boehringer Ingelheim Int | Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones |
| US8759537B2 (en) | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
| US8586604B2 (en) | 2010-08-20 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
| US8466186B2 (en) | 2010-12-10 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Compounds |
| UY33779A (es) | 2010-12-10 | 2012-07-31 | Boehringer Ingelheim Int | ?2-(fenilamino)-1H-bencimidazol-5-carboxamidas novedosas? |
| US8486968B2 (en) | 2010-12-10 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Compounds |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4025637A (en) | 1973-10-23 | 1977-05-24 | Lilly Industries, Ltd. | 2,5 OR 2,6 Disubstituted benzoxazoles |
| US4100168A (en) | 1974-09-20 | 1978-07-11 | Lilly Industries Ltd. | 2,5 OR 2,6-Disubstituted benzoxazoles |
| US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| DE69706407T2 (de) * | 1996-03-29 | 2002-05-29 | G.D. Searle & Co., Chicago | META-SUBSTITUIERTE PHENYLENDERIVATE UND IHRE VERWENDUNG ALS ALPHAvBETA3 INTERGRIN-ANTAGONISTEN ODER INHIBITOREN |
| JPH10330369A (ja) | 1997-04-04 | 1998-12-15 | Sumitomo Pharmaceut Co Ltd | 複素環化合物 |
| GB9723789D0 (en) | 1997-11-12 | 1998-01-07 | Zeneca Ltd | Chemical compounds |
| GB9916374D0 (en) * | 1998-07-23 | 1999-09-15 | Zeneca Ltd | Chemical compounds |
| JP2002521375A (ja) * | 1998-07-23 | 2002-07-16 | アストラゼネカ アクチエボラーク | 化合物 |
-
2000
- 2000-02-16 WO PCT/GB2000/000553 patent/WO2000049005A1/en not_active Ceased
- 2000-02-16 PT PT00903864T patent/PT1153017E/pt unknown
- 2000-02-16 AT AT00903864T patent/ATE325105T1/de not_active IP Right Cessation
- 2000-02-16 AU AU25617/00A patent/AU775208B2/en not_active Ceased
- 2000-02-16 DK DK00903864T patent/DK1153017T3/da active
- 2000-02-16 DE DE60027700T patent/DE60027700T2/de not_active Expired - Fee Related
- 2000-02-16 JP JP2000599745A patent/JP2002537292A/ja active Pending
- 2000-02-16 CA CA002362862A patent/CA2362862A1/en not_active Abandoned
- 2000-02-16 ES ES00903864T patent/ES2263447T3/es not_active Expired - Lifetime
- 2000-02-16 EP EP00903864A patent/EP1153017B1/en not_active Expired - Lifetime
-
2001
- 2001-08-09 US US09/925,110 patent/US6593354B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60027700T2 (de) | 2007-05-03 |
| AU2561700A (en) | 2000-09-04 |
| EP1153017A1 (en) | 2001-11-14 |
| US6593354B2 (en) | 2003-07-15 |
| ATE325105T1 (de) | 2006-06-15 |
| WO2000049005A1 (en) | 2000-08-24 |
| JP2002537292A (ja) | 2002-11-05 |
| ES2263447T3 (es) | 2006-12-16 |
| CA2362862A1 (en) | 2000-08-24 |
| EP1153017B1 (en) | 2006-05-03 |
| DK1153017T3 (da) | 2006-07-17 |
| DE60027700D1 (de) | 2006-06-08 |
| AU775208B2 (en) | 2004-07-22 |
| US20020137782A1 (en) | 2002-09-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT1153017E (pt) | Compostos biciclicos e sua utilizacao como ligandos do receptor de integrina | |
| ATE325796T1 (de) | Derivate von triazolyl-imidazopyridine und von triazolylpurine als ligande des adenosine a2a rezeptoren und ihre verwendung als medicamente | |
| ATE314365T1 (de) | Cyanopyrrole als progesteronrezeptoragonisten | |
| IL149289A0 (en) | Urea compounds having muscarinic receptor antagonist activity | |
| KR20050085991A (en) | Compounds exhibiting thrombopoietin receptor agonism | |
| BRPI0514738A (pt) | derivados de amida de 3-fenil-diidropirimido[4,5-d]pirimidinonas, sua fabricação e aplicação como agentes farmacêuticos | |
| MY146494A (en) | Indole sulfonamide modulators of progesterone receptors | |
| YU41299A (sh) | Atropizomeri 3-aril-4(3h)-hinazolinona i njihova upotreba kao ampa-receptor antagonista | |
| NO20050418L (no) | Kondenserte pyridiner og pyrimidiner med TIE2(TEK) aktivitet | |
| MX2010006230A (es) | Derivados de arilamida substituidos con triazol y su uso como antagonistas de receptor purinergico p2x3 y/o p2x2/3. | |
| MY148988A (en) | Terphenyl derivatives for treatment of alzheimer's disease | |
| AP1816A (en) | 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists. | |
| EA200701853A1 (ru) | Производные циклопентапиридина и тетрагидрохинолина | |
| ATE175661T1 (de) | Benzamid-derivate als vasopressin-antagonisten | |
| EP1189900A4 (en) | HETEROCYCLIC AMINOPYRROLIDINE DERIVATIVES FOR USE AS MELATONERGIC AGENTS | |
| NZ519126A (en) | Novel IL-8 receptor antagonists | |
| TW200531694A (en) | Acetylinic piperazine compounds and their use as metabotropic glutamate receptor antagonists | |
| ATE375985T1 (de) | Oxazolylarylpropionsäure derivate und ihre verwendung als ppar agonisten | |
| YU39503A (sh) | Derivati pirimidina | |
| ATE384708T1 (de) | Piperazinderivate als aktivitätsmodulatoren der chemokinrezeptoren | |
| DE602005007064D1 (de) | Chromanderivate und ihre verwendung als liganden des 5-ht-rezeptors | |
| WO2005010154A3 (en) | 7 and 8 membered heterocyclic cyclopentyl benzylamide modulators of chemokine receptor activity | |
| DE69813886D1 (de) | Naphthalin derivate | |
| DE60031699D1 (de) | Hydroxyacetamidobenzolsulfonamidderivate | |
| MXPA05005340A (es) | Nuevos derivados antagonistas del receptor de la vitronectina, sus procedimientos de preparacion, su aplicacion como medicamentos y los compuestos farmaceuticos que los contienen. |