PT1139755E - Metodo de tratamento de infeccoes bacterianas com rifalazil administado uma a duas vezes por semana - Google Patents
Metodo de tratamento de infeccoes bacterianas com rifalazil administado uma a duas vezes por semanaInfo
- Publication number
- PT1139755E PT1139755E PT99968906T PT99968906T PT1139755E PT 1139755 E PT1139755 E PT 1139755E PT 99968906 T PT99968906 T PT 99968906T PT 99968906 T PT99968906 T PT 99968906T PT 1139755 E PT1139755 E PT 1139755E
- Authority
- PT
- Portugal
- Prior art keywords
- treatment
- rifalazil
- bacterial infections
- per week
- twice per
- Prior art date
Links
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2207/00—Organic non-macromolecular hydrocarbon compounds containing hydrogen, carbon and oxygen as ingredients in lubricant compositions
- C10M2207/10—Carboxylix acids; Neutral salts thereof
- C10M2207/24—Epoxidised acids; Ester derivatives thereof
- C10M2207/243—Epoxidised acids; Ester derivatives thereof used as base material
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- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2209/00—Organic macromolecular compounds containing oxygen as ingredients in lubricant compositions
- C10M2209/10—Macromolecular compoundss obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C10M2209/103—Polyethers, i.e. containing di- or higher polyoxyalkylene groups
- C10M2209/1033—Polyethers, i.e. containing di- or higher polyoxyalkylene groups used as base material
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2209/00—Organic macromolecular compounds containing oxygen as ingredients in lubricant compositions
- C10M2209/10—Macromolecular compoundss obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C10M2209/103—Polyethers, i.e. containing di- or higher polyoxyalkylene groups
- C10M2209/104—Polyethers, i.e. containing di- or higher polyoxyalkylene groups of alkylene oxides containing two carbon atoms only
- C10M2209/1045—Polyethers, i.e. containing di- or higher polyoxyalkylene groups of alkylene oxides containing two carbon atoms only used as base material
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2209/00—Organic macromolecular compounds containing oxygen as ingredients in lubricant compositions
- C10M2209/10—Macromolecular compoundss obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C10M2209/103—Polyethers, i.e. containing di- or higher polyoxyalkylene groups
- C10M2209/105—Polyethers, i.e. containing di- or higher polyoxyalkylene groups of alkylene oxides containing three carbon atoms only
- C10M2209/1055—Polyethers, i.e. containing di- or higher polyoxyalkylene groups of alkylene oxides containing three carbon atoms only used as base material
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- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
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- C10M2209/103—Polyethers, i.e. containing di- or higher polyoxyalkylene groups
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- C10M2209/1065—Polyethers, i.e. containing di- or higher polyoxyalkylene groups of alkylene oxides containing four carbon atoms only used as base material
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2209/00—Organic macromolecular compounds containing oxygen as ingredients in lubricant compositions
- C10M2209/10—Macromolecular compoundss obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C10M2209/103—Polyethers, i.e. containing di- or higher polyoxyalkylene groups
- C10M2209/107—Polyethers, i.e. containing di- or higher polyoxyalkylene groups of two or more specified different alkylene oxides covered by groups C10M2209/104 - C10M2209/106
- C10M2209/1075—Polyethers, i.e. containing di- or higher polyoxyalkylene groups of two or more specified different alkylene oxides covered by groups C10M2209/104 - C10M2209/106 used as base material
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2209/00—Organic macromolecular compounds containing oxygen as ingredients in lubricant compositions
- C10M2209/10—Macromolecular compoundss obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C10M2209/103—Polyethers, i.e. containing di- or higher polyoxyalkylene groups
- C10M2209/108—Polyethers, i.e. containing di- or higher polyoxyalkylene groups etherified
- C10M2209/1085—Polyethers, i.e. containing di- or higher polyoxyalkylene groups etherified used as base material
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2209/00—Organic macromolecular compounds containing oxygen as ingredients in lubricant compositions
- C10M2209/10—Macromolecular compoundss obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C10M2209/103—Polyethers, i.e. containing di- or higher polyoxyalkylene groups
- C10M2209/109—Polyethers, i.e. containing di- or higher polyoxyalkylene groups esterified
- C10M2209/1095—Polyethers, i.e. containing di- or higher polyoxyalkylene groups esterified used as base material
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2209/00—Organic macromolecular compounds containing oxygen as ingredients in lubricant compositions
- C10M2209/12—Polysaccharides, e.g. cellulose, biopolymers
- C10M2209/123—Polysaccharides, e.g. cellulose, biopolymers used as base material
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Virology (AREA)
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- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
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US11292198P | 1998-12-18 | 1998-12-18 |
Publications (1)
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PT1139755E true PT1139755E (pt) | 2006-08-31 |
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PT99968906T PT1139755E (pt) | 1998-12-18 | 1999-12-16 | Metodo de tratamento de infeccoes bacterianas com rifalazil administado uma a duas vezes por semana |
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US (3) | US6316433B1 (pt) |
EP (1) | EP1139755B9 (pt) |
JP (1) | JP2004538236A (pt) |
KR (1) | KR100634770B1 (pt) |
CN (1) | CN1334702A (pt) |
AT (1) | ATE324784T1 (pt) |
AU (1) | AU2710600A (pt) |
CA (1) | CA2355283C (pt) |
DE (1) | DE69931183T2 (pt) |
DK (1) | DK1139755T3 (pt) |
ES (1) | ES2264281T3 (pt) |
PT (1) | PT1139755E (pt) |
WO (1) | WO2000035408A2 (pt) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
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TW465235B (en) | 1998-09-17 | 2001-11-21 | United Video Properties Inc | Electronic program guide with digital storage |
US6316433B1 (en) * | 1998-12-18 | 2001-11-13 | Kaneka Corporation | Method for treatment of bacterial infections with once or twice-weekly administered rifalazil |
NZ523693A (en) * | 2000-07-10 | 2004-08-27 | Chiron Corp | Macrolide formulations for inhalation and methods of treatment of endobronchial infections |
US7122525B2 (en) * | 2001-11-21 | 2006-10-17 | Activbiotics, Inc. | Targeted therapeutics and uses thereof |
US20090149453A1 (en) * | 2002-05-23 | 2009-06-11 | Activbiotics Pharma Llc | Methods and compositions for treating bacterial infections and diseases associated therewith |
EP1531828A4 (en) * | 2002-05-23 | 2005-11-02 | Activbiotics Inc | METHODS OF TREATING BACTERIAL INFECTIONS AND ASSOCIATED DISEASES |
US20040077533A1 (en) * | 2002-05-23 | 2004-04-22 | Sayada Chalom B. | Methods and compositions for treating bacterial infections and diseases associated therewith |
AU2003239919A1 (en) * | 2002-06-03 | 2003-12-19 | Activbiotics, Inc. | Intravenous rifalazil formulation and methods of use thereof |
DE60330161D1 (de) * | 2002-08-29 | 2009-12-31 | Activbiotics Pharma Llc | Rifalazil zur behandlung von infektionen mit clostridium difficile |
US20070128124A1 (en) * | 2002-09-12 | 2007-06-07 | Kraus Carl N | Aerosolized capreomycin for inhibition of pulmonary tuberculosis |
WO2004024213A2 (en) * | 2002-09-12 | 2004-03-25 | The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services | Aerosolized capreomycin for inhibition of pulmonary tuberculosis |
TW200418485A (en) * | 2002-09-23 | 2004-10-01 | Activbiotics Inc | Rifalazil compositions and therapeutic regimens |
JP2006515294A (ja) * | 2002-12-12 | 2006-05-25 | アクティブバイオティクス インコーポレイティッド | アテローム性動脈硬化症およびその関連疾患を治療または予防するための方法および試薬 |
AU2003296963A1 (en) * | 2002-12-12 | 2004-07-09 | Activbiotics, Inc. | Methods and compositions for treating and preventing ear infections |
EP1663107A4 (en) * | 2003-08-22 | 2010-06-23 | Activbiotics Pharma Llc | RIFAMYCIN ANALOGS AND USES THEREOF |
US20050095245A1 (en) * | 2003-09-19 | 2005-05-05 | Riley Thomas C. | Pharmaceutical delivery system |
US20060140990A1 (en) * | 2003-09-19 | 2006-06-29 | Drugtech Corporation | Composition for topical treatment of mixed vaginal infections |
US7820652B2 (en) * | 2003-09-24 | 2010-10-26 | Activbiotics Pharma, Llc | Regimen for the administration of rifamycin-class antibiotics |
JP2007506782A (ja) * | 2003-09-25 | 2007-03-22 | アクティブバイオティクス インコーポレイティッド | リファラジル製剤 |
WO2005058231A2 (en) * | 2003-12-10 | 2005-06-30 | Activbiotics, Inc. | Rifamycin analogs and uses thereof |
CN1918172B (zh) * | 2003-12-23 | 2011-09-14 | 活跃生物工艺学公司 | 利福霉素类似物及其用途 |
CA2605341A1 (en) * | 2005-05-09 | 2006-11-16 | Drugtech Corporation | Modified-release pharmaceutical compositions |
WO2007012464A1 (en) * | 2005-07-26 | 2007-02-01 | Merckle Gmbh | Macrolide conjugates of pyrrolizine and indolizine compounds as inhibitors of 5-lipooxygenase and cyclooxygenase |
CN101287446A (zh) | 2005-09-29 | 2008-10-15 | 尼克塔治疗公司 | 抗生素制剂、单位剂量、试剂盒以及方法 |
US20070112018A1 (en) * | 2005-10-06 | 2007-05-17 | Andrew Sternlicht | Treatment of peripheral arterial occlusive disease |
BRPI0620908A2 (pt) * | 2006-01-05 | 2011-11-29 | Drugtech Corp | composição farmacêutica, sistema de distribuição antibacteriana e antifúngica vaginal e uso da composição farmacêutica |
CN101365425A (zh) * | 2006-01-05 | 2009-02-11 | 药物技术公司 | 用于生物粘附到外阴阴道表面的递药系统 |
MX2008012844A (es) * | 2006-04-06 | 2009-01-19 | Activbiotics Pharma Llc | Composiciones farmaceuticas y usos de ellas. |
BR112013008186A2 (pt) * | 2010-10-04 | 2016-06-21 | Activbiotics Pharma Llc | uso de ripazil e análogos para tratar problemas oculares |
WO2012103119A1 (en) * | 2011-01-24 | 2012-08-02 | Activbiotics Pharma, Llc | Compositions for administering rifalazil and other anti-tuberculosis agents in unit dosage form for oral administration |
WO2012103116A1 (en) * | 2011-01-24 | 2012-08-02 | Activbiotics Pharma, Llc | Pulmonary administration of rifalazil and analogs thereof |
ES2659763T3 (es) | 2011-02-14 | 2018-03-19 | The Regents Of The University Of Michigan | Composiciones y procedimientos para el tratamiento de obesidad y trastornos relacionados |
RU2496475C2 (ru) * | 2011-10-26 | 2013-10-27 | Александр Васильевич Иващенко | Фармацевтическая композиция и набор для лечения бактериальных инфекций |
WO2013086415A1 (en) * | 2011-12-09 | 2013-06-13 | The Regents Of The University Of Michigan | Antimicrobial compounds |
EP2991647B1 (en) | 2013-05-02 | 2019-04-24 | The Regents Of The University Of Michigan | Deuterated amlexanox with improved metabolic stability |
US10214536B2 (en) | 2016-01-29 | 2019-02-26 | The Regents Of The University Of Michigan | Amlexanox analogs |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
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CA1304363C (en) | 1988-11-01 | 1992-06-30 | Takehiko Yamane | 3'-hydroxybenzoxazinorifamycin derivative, process for preparing the same and antibacterial agent containing the same |
JP3347880B2 (ja) | 1994-06-22 | 2002-11-20 | 本田技研工業株式会社 | 車両用ルーフ、車両用ルーフの製造方法及び車両用ルーフの固定方法 |
US5508015A (en) | 1994-07-15 | 1996-04-16 | E. I. Du Pont De Nemours And Company | Process for controlling agglomeration in the manufacture of TiO2 |
KR100407849B1 (ko) * | 1995-09-01 | 2004-05-07 | 가네가후치 가가쿠고교 가부시키가이샤 | 헬리코박터의감염에기인하는질환의치료제 |
JP3963976B2 (ja) | 1995-12-08 | 2007-08-22 | 株式会社カネカ | クラミジア感染症治療剤 |
US6316433B1 (en) * | 1998-12-18 | 2001-11-13 | Kaneka Corporation | Method for treatment of bacterial infections with once or twice-weekly administered rifalazil |
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1999
- 1999-12-15 US US09/464,353 patent/US6316433B1/en not_active Expired - Lifetime
- 1999-12-16 ES ES99968906T patent/ES2264281T3/es not_active Expired - Lifetime
- 1999-12-16 KR KR1020017007717A patent/KR100634770B1/ko not_active IP Right Cessation
- 1999-12-16 EP EP99968906A patent/EP1139755B9/en not_active Expired - Lifetime
- 1999-12-16 WO PCT/US1999/030101 patent/WO2000035408A2/en active IP Right Grant
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- 1999-12-16 DE DE69931183T patent/DE69931183T2/de not_active Expired - Lifetime
- 1999-12-16 CN CN99815782A patent/CN1334702A/zh active Pending
- 1999-12-16 PT PT99968906T patent/PT1139755E/pt unknown
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2002
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Also Published As
Publication number | Publication date |
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EP1139755A2 (en) | 2001-10-10 |
WO2000035408A3 (en) | 2000-11-02 |
KR100634770B1 (ko) | 2006-10-17 |
AU2710600A (en) | 2000-07-03 |
ES2264281T3 (es) | 2006-12-16 |
ATE324784T1 (de) | 2006-06-15 |
DK1139755T3 (da) | 2006-08-21 |
EP1139755B9 (en) | 2006-07-05 |
KR20020002365A (ko) | 2002-01-09 |
US7772228B2 (en) | 2010-08-10 |
US20030203903A1 (en) | 2003-10-30 |
EP1139755A4 (en) | 2003-01-02 |
DE69931183D1 (de) | 2006-06-08 |
JP2004538236A (ja) | 2004-12-24 |
US6566354B1 (en) | 2003-05-20 |
US6316433B1 (en) | 2001-11-13 |
EP1139755B1 (en) | 2006-05-03 |
CA2355283A1 (en) | 2000-06-22 |
WO2000035408A2 (en) | 2000-06-22 |
CN1334702A (zh) | 2002-02-06 |
DE69931183T2 (de) | 2007-02-01 |
CA2355283C (en) | 2009-02-17 |
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