PT1071704E - Novos inibidores e reguladores negativos das metaloproteinases da matriz - Google Patents

Novos inibidores e reguladores negativos das metaloproteinases da matriz

Info

Publication number
PT1071704E
PT1071704E PT99910394T PT99910394T PT1071704E PT 1071704 E PT1071704 E PT 1071704E PT 99910394 T PT99910394 T PT 99910394T PT 99910394 T PT99910394 T PT 99910394T PT 1071704 E PT1071704 E PT 1071704E
Authority
PT
Portugal
Prior art keywords
regulators
inhibitors
mmp
novel
matrix
Prior art date
Application number
PT99910394T
Other languages
English (en)
Inventor
Timo Sorsa
Erkki Koivunen
Tuula Salo
Original Assignee
Ctt Cancer Targeting Tech Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ctt Cancer Targeting Tech Oy filed Critical Ctt Cancer Targeting Tech Oy
Publication of PT1071704E publication Critical patent/PT1071704E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT99910394T 1998-03-18 1999-03-17 Novos inibidores e reguladores negativos das metaloproteinases da matriz PT1071704E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI980604A FI980604A0 (fi) 1998-03-18 1998-03-18 Nya matrismetalloproteinasinhibitorer och -regulatorer

Publications (1)

Publication Number Publication Date
PT1071704E true PT1071704E (pt) 2003-11-28

Family

ID=8551311

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99910394T PT1071704E (pt) 1998-03-18 1999-03-17 Novos inibidores e reguladores negativos das metaloproteinases da matriz

Country Status (12)

Country Link
US (1) US6624144B1 (pt)
EP (1) EP1071704B1 (pt)
JP (1) JP2002506881A (pt)
AT (1) ATE243709T1 (pt)
AU (1) AU2936599A (pt)
CA (1) CA2323239C (pt)
DE (1) DE69909076T2 (pt)
DK (1) DK1071704T3 (pt)
ES (1) ES2203088T3 (pt)
FI (1) FI980604A0 (pt)
PT (1) PT1071704E (pt)
WO (1) WO1999047550A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9907908D0 (en) * 1999-04-07 1999-06-02 Bataille Regis Organic compounds
DE10020447A1 (de) * 2000-03-31 2001-10-11 Henkel Kgaa Verwendung von Protease-Inhibitoren in der Kosmetik und Pharmazie
EP1174129A1 (en) * 2000-07-17 2002-01-23 Zenner, Hans Peter, Prof. Dr. med. Use of a matrix-metalloprotease inhibitor for the treatment of cancer
US7041787B2 (en) * 2000-12-29 2006-05-09 Kimberly-Clark Worldwide, Inc. Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases
FI113840B (fi) * 2001-03-26 2004-06-30 Ctt Cancer Targeting Tech Oy Matriisi-metalloproteinaasi-inhibiittorien käyttö liposomien kohdentamisessa
US6906036B2 (en) * 2001-08-16 2005-06-14 Kimberly-Clark Worldwide, Inc. Anti-aging and wound healing compounds
US20050277623A1 (en) * 2001-12-20 2005-12-15 Hanauske-Abel Hartmut M Treatment for averting or delaying premature delivery
EP2395083B1 (en) * 2002-01-08 2017-04-12 Agrivida, Inc. Transgenic plants expressing CIVPS or intein modified proteins and related method
US20040224378A1 (en) * 2002-06-07 2004-11-11 Athersys, Inc. Methods for using ADAMTS-12, an integrin and metalloprotease with thrombspondin motifs
FI20021726A0 (fi) * 2002-09-27 2002-09-27 Ctt Cancer Targeting Tech Oy Menetelmä peptidien tuottamiseksi
CN1314704C (zh) * 2002-11-20 2007-05-09 中国人民解放军军事医学科学院放射与辐射医学研究所 基质金属蛋白酶2的小肽抑制剂
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
ES2537514T3 (es) 2003-04-04 2015-06-09 Incyte Corporation Composiciones, métodos y kits relacionados con la escisión de HER-2
WO2005019247A2 (en) * 2003-08-15 2005-03-03 Board Of Regents, The University Of Texas System Cyclic peptide and imaging compound compositions and uses for targeted imaging and therapy
FI20040572A0 (fi) * 2004-04-23 2004-04-23 Ctt Cancer Targeting Tech Oy Matriisi-metalloproteinaasin aktiviteetin inhibiittorit
FR2932182A1 (fr) * 2008-06-10 2009-12-11 Commissariat Energie Atomique Cyclopeptides utilisables en tant qu'inhibiteurs d'enzymes proteases du type mmp
KR101363455B1 (ko) 2011-09-09 2014-02-21 (주)케어젠 매트릭스 메탈로프로테아제 활성 억제 펩타이드 및 이의 용도
CN108484729B (zh) * 2018-03-23 2019-09-17 中国药科大学 一种基质金属蛋白酶9的多肽抑制剂及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666897A (en) 1983-12-29 1987-05-19 Research Foundation Of State University Inhibition of mammalian collagenolytic enzymes by tetracyclines
DK0784629T3 (da) 1994-10-05 1999-10-25 Darwin Discovery Ltd Peptidylforbindelser og deres terapeutiske anvendelse som inhibitorer af metalloproteaser
US5652227A (en) 1995-01-30 1997-07-29 Teronen; Olli Pekka Inhibition of the degradation of connective tissue matrix protein components in mammals

Also Published As

Publication number Publication date
AU2936599A (en) 1999-10-11
WO1999047550A1 (en) 1999-09-23
EP1071704A1 (en) 2001-01-31
US6624144B1 (en) 2003-09-23
ATE243709T1 (de) 2003-07-15
CA2323239C (en) 2008-04-15
EP1071704B1 (en) 2003-06-25
DE69909076T2 (de) 2004-05-06
DK1071704T3 (da) 2003-10-20
JP2002506881A (ja) 2002-03-05
ES2203088T3 (es) 2004-04-01
CA2323239A1 (en) 1999-09-23
DE69909076D1 (de) 2003-07-31
FI980604A0 (fi) 1998-03-18

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