PT100698A - Compostos de indol substituidos na posicao 3- com 7-carbonil(piridin-3-il)pirrolo{1,2-c}tiazol, 7-carbonil(piridin-3-il)pirrolo{1,2-c}oxazolina ou 7-carbonil(piridin-3-il)pirrolo{1,2-c}pirrol, composicoes farmaceuticas que os contem e seu uso - Google Patents

Compostos de indol substituidos na posicao 3- com 7-carbonil(piridin-3-il)pirrolo{1,2-c}tiazol, 7-carbonil(piridin-3-il)pirrolo{1,2-c}oxazolina ou 7-carbonil(piridin-3-il)pirrolo{1,2-c}pirrol, composicoes farmaceuticas que os contem e seu uso

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Publication number
PT100698A
PT100698A PT100698A PT10069892A PT100698A PT 100698 A PT100698 A PT 100698A PT 100698 A PT100698 A PT 100698A PT 10069892 A PT10069892 A PT 10069892A PT 100698 A PT100698 A PT 100698A
Authority
PT
Portugal
Prior art keywords
pyridin
carbonyl
pyrrole
pct
pyrrolo
Prior art date
Application number
PT100698A
Other languages
English (en)
Other versions
PT100698B (pt
Inventor
James B Summers
Douglas H Steinman
Michael B Martin
George M Carrera Jr
James H Holms
Daisy Pireh
Robin H Heyman
George S Sheppard
Steve K Davidsen
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of PT100698A publication Critical patent/PT100698A/pt
Publication of PT100698B publication Critical patent/PT100698B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT100698A 1991-07-17 1992-07-16 Compostos de indol substituidos na posicao 3- com 7-carbonil(piridin-3-il)pirrolo{1,2-c}tiazol, 7-carbonil(piridin-3-il)pirrolo{1,2-c}oxazolina ou 7-carbonil(piridin-3-il)pirrolo{1,2-c}pirrol, composicoes farmaceuticas que os contem e seu uso PT100698B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73168191A 1991-07-17 1991-07-17

Publications (2)

Publication Number Publication Date
PT100698A true PT100698A (pt) 1993-10-29
PT100698B PT100698B (pt) 1999-07-30

Family

ID=24940541

Family Applications (1)

Application Number Title Priority Date Filing Date
PT100698A PT100698B (pt) 1991-07-17 1992-07-16 Compostos de indol substituidos na posicao 3- com 7-carbonil(piridin-3-il)pirrolo{1,2-c}tiazol, 7-carbonil(piridin-3-il)pirrolo{1,2-c}oxazolina ou 7-carbonil(piridin-3-il)pirrolo{1,2-c}pirrol, composicoes farmaceuticas que os contem e seu uso

Country Status (15)

Country Link
US (1) US5459152A (pt)
EP (1) EP0595924B1 (pt)
JP (1) JP3135917B2 (pt)
KR (1) KR100251603B1 (pt)
AT (1) ATE178796T1 (pt)
AU (1) AU651243B2 (pt)
CA (1) CA2112562A1 (pt)
DE (1) DE69228932T2 (pt)
DK (1) DK0595924T3 (pt)
ES (1) ES2131530T3 (pt)
GR (1) GR3030208T3 (pt)
IE (1) IE922293A1 (pt)
IL (1) IL102494A0 (pt)
PT (1) PT100698B (pt)
WO (1) WO1993001813A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486525A (en) * 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles
US5567711A (en) * 1995-04-19 1996-10-22 Abbott Laboratories Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
US6630496B1 (en) 1996-08-26 2003-10-07 Genetics Institute Llc Inhibitors of phospholipase enzymes
US6828344B1 (en) 1998-02-25 2004-12-07 Genetics Institute, Llc Inhibitors of phospholipase enzymes
US6916841B2 (en) * 1998-02-25 2005-07-12 Genetics Institute, Llc Inhibitors of phospholipase enzymes
US6500853B1 (en) 1998-02-28 2002-12-31 Genetics Institute, Llc Inhibitors of phospholipase enzymes
WO2001012600A1 (en) * 1999-08-12 2001-02-22 Cor Therapeutics, Inc. INHIBITORS OF FACTOR Xa
DE10004157A1 (de) * 2000-02-01 2001-08-02 Merckle Gmbh Chem Pharm Fabrik 4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie
US20130178453A1 (en) * 2010-02-09 2013-07-11 Ironwood Pharmaceuticals, Inc. Cannabinoid Agonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2541280B1 (fr) * 1983-01-13 1985-06-21 Rhone Poulenc Sante Nouveaux derives du 1h, 3h-pyrrolo (1,2c) thiazolecarboxamide-7, leur preparation et les medicaments qui les contiennent
FR2617484B1 (fr) * 1987-07-02 1989-10-20 Rhone Poulenc Sante Procede de preparation de l'acide (pyridyl-3)-3 1h-3h-pyrrolo (1,2-c) thiazolecarboxylique-7 dextrogyre
FR2626004B1 (fr) * 1988-01-20 1991-08-02 Rhone Poulenc Sante Procede de preparation du (pyridyl-3)-3 1h, 3h-pyrrolo (1,2-c) thiazolecarbonitrile-7
JP3061631B2 (ja) * 1989-10-11 2000-07-10 山之内製薬株式会社 新規なヘテロ環化合物およびその製造法

Also Published As

Publication number Publication date
AU651243B2 (en) 1994-07-14
JPH06510027A (ja) 1994-11-10
IL102494A0 (en) 1993-01-14
ES2131530T3 (es) 1999-08-01
EP0595924A1 (en) 1994-05-11
CA2112562A1 (en) 1993-02-04
EP0595924A4 (en) 1994-08-24
IE922293A1 (en) 1993-01-27
AU2339192A (en) 1993-02-23
PT100698B (pt) 1999-07-30
US5459152A (en) 1995-10-17
JP3135917B2 (ja) 2001-02-19
EP0595924B1 (en) 1999-04-14
KR100251603B1 (ko) 2000-05-01
GR3030208T3 (en) 1999-08-31
DE69228932D1 (de) 1999-05-20
WO1993001813A1 (en) 1993-02-04
ATE178796T1 (de) 1999-04-15
DE69228932T2 (de) 1999-11-11
DK0595924T3 (da) 1999-11-01

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